Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (325/325 = 100%)† (Homo sapiens (Human)) | BDBM50397838 (CHEMBL2179105 | PF-04447943 | US10513524, Referenc...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 8.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant PDE9A expressed in Sf9 cells using [3H]cGMP as substrate after 30 mins by scintillation proximity assay | J Med Chem 55: 9045-54 (2012) Article DOI: 10.1021/jm3007799 BindingDB Entry DOI: 10.7270/Q24J0G79 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (325/325 = 100%)† (Homo sapiens (Human)) | BDBM50397838 (CHEMBL2179105 | PF-04447943 | US10513524, Referenc...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
H. LUNDBECK A/S US Patent | Assay Description A PDE9 assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (... | US Patent US10513524 (2019) BindingDB Entry DOI: 10.7270/Q2G44SNW | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |