Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dihydrofolate reductase (190/192 = 99%)† (Candida albicans) | BDBM18046 (5-((4-methylphenyl)thio)-quinazoline 2,4-diamine, ...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank MMDB PDB Article PubMed | n/a | n/a | 23 | n/a | n/a | n/a | n/a | 6.4 | 30 |
GSK | Assay Description IC50 is the concentration of inhibitor that decreases the velocity of the standard assay by 50%. The enzyme, NADPH, and varying concentrations of inh... | J Med Chem 44: 2928-32 (2001) Article DOI: 10.1021/jm0101444 BindingDB Entry DOI: 10.7270/Q2XW4H2K | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Retinal dehydrogenase 2 (Homo sapiens (Human)) | BDBM50406340 (CHEMBL5286018) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibition of dihydrofolate reductase in Candida albicans (in vitro). | Citation and Details | |||||||||||
More data for this Ligand-Target Pair |