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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cyclin-dependent kinase 2 (298/298 = 100%)† (Homo sapiens (Human)) | BDBM5594 (2-arylamino-pyrimidine deriv. 9d | 4-{[4-amino-6-(...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet  | CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cambridge Curated by ChEMBL | Assay Description Inhibition of CDK2 | J Med Chem 49: 5141-53 (2006) Article DOI: 10.1021/jm060190+ BindingDB Entry DOI: 10.7270/Q27S7NDM | |||||||||||
| More data for this Ligand-Target Pair |  3D Structure (crystal) | ||||||||||||
| Cyclin-A2 [171-432]/Cyclin-dependent kinase 2 (298/298 = 100%)† (Homo sapiens (Human)) | BDBM5594 (2-arylamino-pyrimidine deriv. 9d | 4-{[4-amino-6-(...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 34 | n/a | n/a | n/a | n/a | 7.5 | 30 |
University of Newcastle | Assay Description The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ... | Bioorg Med Chem Lett 13: 3079-82 (2003) Article DOI: 10.1016/s0960-894x(03)00651-6 BindingDB Entry DOI: 10.7270/Q2R78CDT | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
