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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| cAMP-dependent protein kinase catalytic subunit alpha (347/351 = 99%)† (Bos taurus (bovine)) | BDBM15131 (5-indazolyl pyridine 3 | 5-{5-[(2S)-2-amino-3-(1H-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet  | Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Abbott Laboratories | Assay Description The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi... | J Med Chem 50: 2990-3003 (2007) Article DOI: 10.1021/jm0701019 BindingDB Entry DOI: 10.7270/Q24X562F | |||||||||||
| More data for this Ligand-Target Pair |  3D Structure (crystal) | ||||||||||||
| cAMP-dependent protein kinase catalytic subunit alpha (347/351 = 99%)† (Bos taurus (bovine)) | BDBM15131 (5-indazolyl pyridine 3 | 5-{5-[(2S)-2-amino-3-(1H-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 27 | n/a | n/a | n/a | n/a | 7.2 | 22 |
Astex | Assay Description The recombinant alpha catalytic subunit of bovine PKA was assayed with a peptide substrate and test compound in the presence of 40 uM ATP/ [gamma-33P... | J Mol Biol 367: 882-94 (2007) Article DOI: 10.1016/j.jmb.2007.01.004 BindingDB Entry DOI: 10.7270/Q29Z934H | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
