Found 51 hits Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Carbonic anhydrase 1/12/13/14/2/3/4/5A, mitochondrial/5B, mitochondrial/6/7/9
(262/262 = 100%)† (Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
KEGG
UniProtKB/SwissProt
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| 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Compound was evaluated for the inhibition of Carbonic anhydrase (Non competitive) |
J Med Chem 29: 1488-94 (1986)
BindingDB Entry DOI: 10.7270/Q2HQ424N |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(262/262 = 100%)† (Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
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| 5.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant carbonic anhydrase 13 preincubated for 15 mins by CO2 hydration method |
Bioorg Med Chem 19: 3105-19 (2011)
Article DOI: 10.1016/j.bmc.2011.04.005 BindingDB Entry DOI: 10.7270/Q2FF3SQ6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(262/262 = 100%)† (Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
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| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffith University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant carbonic anhydrase 13 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay |
J Med Chem 59: 5462-70 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00443 BindingDB Entry DOI: 10.7270/Q2TF0084 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(262/262 = 100%)† (Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
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| 16 | n/a | n/a | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Tampere and Tampere University Hospital
| Assay Description Reactions were measured using 0.2 mM phenol red (Absmax at 557 nm) as the indicator, in 10 mM HEPES, 0.1 M Na2SO4, pH 7.5, for a period of 10-100 s. ... |
J Enzyme Inhib Med Chem 26: 862-70 (2011)
Article DOI: 10.3109/14756366.2011.588227 BindingDB Entry DOI: 10.7270/Q2S181DX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(262/262 = 100%)† (Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
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| 17 | -43.6 | n/a | n/a | n/a | n/a | n/a | 7.4 | 20 |
Università degli Studi di Firenze
| Assay Description The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ... |
J Enzyme Inhib Med Chem 19: 269-73 (2004)
Article DOI: 10.1080/14756360410001689559 BindingDB Entry DOI: 10.7270/Q20C4TBB |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(239/262 = 91%)† (Mus musculus (mouse)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CNR
| Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... |
J Med Chem 52: 5990-8 (2009)
Article DOI: 10.1021/jm900641r BindingDB Entry DOI: 10.7270/Q2GF0RVR |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(239/262 = 91%)† (Mus musculus (mouse)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universite Montpellier II
| Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... |
J Med Chem 49: 7024-31 (2006)
Article DOI: 10.1021/jm060807n BindingDB Entry DOI: 10.7270/Q24T6GKT |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(239/262 = 91%)† (Mus musculus (mouse)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Firenze
| Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... |
Bioorg Med Chem Lett 18: 4282-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.105 BindingDB Entry DOI: 10.7270/Q27D2SF1 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(262/262 = 100%)† (Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
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| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida
Curated by ChEMBL
| Assay Description Inhibition of human carbonic anhydrase13 preincubated for 15 mins by stopped-flow CO2 hydration assay |
Bioorg Med Chem 21: 7210-5 (2013)
Article DOI: 10.1016/j.bmc.2013.08.033 BindingDB Entry DOI: 10.7270/Q2T43X16 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(262/262 = 100%)† (Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
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| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human CA13 preincubated for 15 mins by stopped-flow CO2 hydration method |
Bioorg Med Chem 22: 334-40 (2014)
Article DOI: 10.1016/j.bmc.2013.11.016 BindingDB Entry DOI: 10.7270/Q2K64N27 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(262/262 = 100%)† (Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
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| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florence
Curated by ChEMBL
| Assay Description Inhibition of recombinant human CA13 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydra... |
ACS Med Chem Lett 9: 1035-1038 (2018)
Article DOI: 10.1021/acsmedchemlett.8b00334 BindingDB Entry DOI: 10.7270/Q2959M8K |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(262/262 = 100%)† (Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
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| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Firenze, Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Via U. Schiff 6, 50019 Sesto Fiorentino, Florence, Italy. Electronic address: claudiu.sup
Curated by ChEMBL
| Assay Description Inhibition of human CA13 by stopped-flow CO2 hydrase assay |
Bioorg Med Chem 25: 5064-5067 (2017)
Article DOI: 10.1016/j.bmc.2016.10.023 BindingDB Entry DOI: 10.7270/Q24170HK |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(239/262 = 91%)† (Mus musculus (mouse)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istituto di Biostrutture e Bioimmagini-CNR
Curated by ChEMBL
| Assay Description Inhibition of full length mouse carbonic anhydrase 13 preincubated for 15 mins by CO2 hydration stopped-flow assay |
Bioorg Med Chem Lett 20: 3601-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.04.114 BindingDB Entry DOI: 10.7270/Q2NV9K7Q |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(262/262 = 100%)† (Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
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| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida
Curated by ChEMBL
| Assay Description Inhibition of human recombinant carbonic anhydrase 13 after 15 mins by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 20: 4376-81 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.082 BindingDB Entry DOI: 10.7270/Q2C24XCB |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(239/262 = 91%)† (Mus musculus (mouse)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istituto di Biostrutture e Bioimmagini-CNR
Curated by ChEMBL
| Assay Description Inhibition of mouse full length carbonic anhydrase 13 by stopped flow CO2 hydrase assay |
Bioorg Med Chem Lett 18: 2669-74 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.023 BindingDB Entry DOI: 10.7270/Q23R0TRX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(239/262 = 91%)† (Mus musculus (mouse)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of mouse CA13 by stopped-flow CO2 hydration assay |
Bioorg Med Chem 18: 2159-64 (2010)
Article DOI: 10.1016/j.bmc.2010.01.076 BindingDB Entry DOI: 10.7270/Q2GQ6ZP1 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(239/262 = 91%)† (Mus musculus (mouse)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of mouse recombinant full length CA13 by stopped flow CO2 hydration assay |
Bioorg Med Chem Lett 19: 1371-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.038 BindingDB Entry DOI: 10.7270/Q2JW8FS8 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(262/262 = 100%)† (Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
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| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA13 by stopped flow CO2 hydrase assay |
J Med Chem 53: 850-4 (2010)
Article DOI: 10.1021/jm901524f BindingDB Entry DOI: 10.7270/Q2PV6M96 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(239/262 = 91%)† (Mus musculus (mouse)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of mouse carbonic anhydrase 13 |
Bioorg Med Chem 15: 4336-50 (2007)
Article DOI: 10.1016/j.bmc.2007.04.020 BindingDB Entry DOI: 10.7270/Q28916QG |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(239/262 = 91%)† (Mus musculus (mouse)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Ki value against mouse carbonic anhydrase XIII |
Bioorg Med Chem Lett 15: 971-6 (2005)
Article DOI: 10.1016/j.bmcl.2004.12.052 BindingDB Entry DOI: 10.7270/Q25H7H1N |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(239/262 = 91%)† (Mus musculus (mouse)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Ki value against mouse carbonic anhydrase XIII |
Bioorg Med Chem Lett 15: 971-6 (2005)
Article DOI: 10.1016/j.bmcl.2004.12.052 BindingDB Entry DOI: 10.7270/Q25H7H1N |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(239/262 = 91%)† (Mus musculus (mouse)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tampere
Curated by ChEMBL
| Assay Description Inhibitory activity against murine carbonic anhydrase XIII (mCA XIII) by using CO2 hydrase assay method |
Bioorg Med Chem Lett 14: 3757-62 (2004)
Article DOI: 10.1016/j.bmcl.2004.04.106 BindingDB Entry DOI: 10.7270/Q24Q7VJ8 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(262/262 = 100%)† (Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
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| PDB Article PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | 7.5 | n/a |
Ecole Nationale Sup£rieure de Chimie de Montpellier
Curated by ChEMBL
| Assay Description Inhibition of human carbonic anhydrase 13 preincubated for 15 mins at pH 7.5 by stopped flow CO2 hydration method |
Bioorg Med Chem Lett 21: 5210-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.045 BindingDB Entry DOI: 10.7270/Q2XP75B3 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(262/262 = 100%)† (Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
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| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida
Curated by ChEMBL
| Assay Description Inhibition of human recombinant cytosolic carbonic anhydrase 13 preincubated for 15 mins by stopped-flow CO2 hydration assay |
Bioorg Med Chem 19: 3732-8 (2011)
Article DOI: 10.1016/j.bmc.2011.05.006 BindingDB Entry DOI: 10.7270/Q2BG2PCH |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(239/262 = 91%)† (Mus musculus (mouse)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
Reactome pathway KEGG
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| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of mouse carbonic anhydrase 13 by stopped flow CO2 hydration method |
J Med Chem 53: 5511-22 (2010)
Article DOI: 10.1021/jm1003667 BindingDB Entry DOI: 10.7270/Q22N52FB |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(239/262 = 91%)† (Mus musculus (mouse)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
Reactome pathway KEGG
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| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tampere and Tampere University Hospital
Curated by ChEMBL
| Assay Description Inhibition of mouse carbonic anhydrase 13 by stopped flow CO2 hydration assay |
Bioorg Med Chem Lett 19: 4102-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.002 BindingDB Entry DOI: 10.7270/Q23778S7 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(262/262 = 100%)† (Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
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| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffith University
Curated by ChEMBL
| Assay Description Inhibition of carbonic anhydrase-13 (unknown origin) |
J Med Chem 58: 7580-90 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01228 BindingDB Entry DOI: 10.7270/Q2QC0591 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(262/262 = 100%)† (Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
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| 17 | -41.2 | n/a | n/a | n/a | n/a | n/a | 7.5 | 4 |
Ecole Nationale Supérieure de Chimie de Montpellier
| Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity. Phenol red (at a concentration of... |
J Enzyme Inhib Med Chem 28: 397-401 (2013)
Article DOI: 10.3109/14756366.2011.650692 BindingDB Entry DOI: 10.7270/Q20Z726F |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(262/262 = 100%)† (Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
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| 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of human recombinant carbonic anhydrase 13 pre-incubated for 15 mins by stopped-flow CO2 hydration assay |
Bioorg Med Chem 22: 6768-75 (2015)
Article DOI: 10.1016/j.bmc.2014.10.041 BindingDB Entry DOI: 10.7270/Q2697560 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(262/262 = 100%)† (Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
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| 21 | n/a | n/a | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Tampere and Tampere University Hospital
| Assay Description Reactions were measured using 0.2 mM phenol red (Absmax at 557 nm) as the indicator, in 10 mM HEPES, 0.1 M Na2SO4, pH 7.5, for a period of 10-100 s. ... |
J Enzyme Inhib Med Chem 26: 862-70 (2011)
Article DOI: 10.3109/14756366.2011.588227 BindingDB Entry DOI: 10.7270/Q2S181DX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(262/262 = 100%)† (Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
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| 163 | n/a | n/a | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Tampere and Tampere University Hospital
| Assay Description Reactions were measured using 0.2 mM phenol red (Absmax at 557 nm) as the indicator, in 10 mM HEPES, 0.1 M Na2SO4, pH 7.5, for a period of 10-100 s. ... |
J Enzyme Inhib Med Chem 26: 862-70 (2011)
Article DOI: 10.3109/14756366.2011.588227 BindingDB Entry DOI: 10.7270/Q2S181DX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13 + BH
(262/262 = 100%)† (Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 164 | n/a | n/a | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Tampere and Tampere University Hospital
| Assay Description Reactions were measured using 0.2 mM phenol red (Absmax at 557 nm) as the indicator, in 10 mM HEPES, 0.1 M Na2SO4, pH 7.5, for a period of 10-100 s. ... |
J Enzyme Inhib Med Chem 26: 862-70 (2011)
Article DOI: 10.3109/14756366.2011.588227 BindingDB Entry DOI: 10.7270/Q2S181DX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(262/262 = 100%)† (Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
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| 174 | n/a | n/a | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Tampere and Tampere University Hospital
| Assay Description Reactions were measured using 0.2 mM phenol red (Absmax at 557 nm) as the indicator, in 10 mM HEPES, 0.1 M Na2SO4, pH 7.5, for a period of 10-100 s. ... |
J Enzyme Inhib Med Chem 26: 862-70 (2011)
Article DOI: 10.3109/14756366.2011.588227 BindingDB Entry DOI: 10.7270/Q2S181DX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13 + BH
(262/262 = 100%)† (Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
Reactome pathway KEGG
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| 179 | n/a | n/a | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Tampere and Tampere University Hospital
| Assay Description Reactions were measured using 0.2 mM phenol red (Absmax at 557 nm) as the indicator, in 10 mM HEPES, 0.1 M Na2SO4, pH 7.5, for a period of 10-100 s. ... |
J Enzyme Inhib Med Chem 26: 862-70 (2011)
Article DOI: 10.3109/14756366.2011.588227 BindingDB Entry DOI: 10.7270/Q2S181DX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 1/12/13/14/2/3/4/5A, mitochondrial/5B, mitochondrial/6/7/9
(262/262 = 100%)† (Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
KEGG
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| PDB PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
Istituto Chimico Internazionale Dr. G. Rende
Curated by ChEMBL
| Assay Description Inhibition of Carbonic anhydrase enzyme in rabbits |
J Med Chem 35: 2697-703 (1992)
BindingDB Entry DOI: 10.7270/Q2K076G9 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(239/262 = 91%)† (Mus musculus (mouse)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
Reactome pathway KEGG
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| PDB Article PubMed
| n/a | n/a | 490 | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of mouse carbonic anhydrase 13 assessed as 4-nitrophenyl acetate hydrolysis |
Bioorg Med Chem Lett 18: 2267-71 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.012 BindingDB Entry DOI: 10.7270/Q2G44Q10 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(239/262 = 91%)† (Mus musculus (mouse)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| PDB Article PubMed
| n/a | n/a | 1.05E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of mouse carbonic anhydrase 13 assessed as 4-nitrophenyl phosphate hydrolysis |
Bioorg Med Chem Lett 18: 2267-71 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.012 BindingDB Entry DOI: 10.7270/Q2G44Q10 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(262/262 = 100%)† (Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
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| n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a |
Vilnius University
Curated by ChEMBL
| Assay Description Binding affinity to human N-terminal full length His-tagged CA13 (1 to 262 residues) expressed in Escherichia coli BL21(DE3) assessed as intrinsic th... |
J Med Chem 61: 2292-2302 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01408 BindingDB Entry DOI: 10.7270/Q23T9KNS |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(262/262 = 100%)† (Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
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| n/a | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a |
Vilnius University
Curated by ChEMBL
| Assay Description Binding affinity to human recombinant carbonic anhydrase 13 by thermal shift assay |
Bioorg Med Chem 18: 7413-21 (2010)
Article DOI: 10.1016/j.bmc.2010.09.011 BindingDB Entry DOI: 10.7270/Q2TB1734 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(262/262 = 100%)† (Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
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| n/a | n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a |
Vilnius University
Curated by ChEMBL
| Assay Description Binding affinity to human recombinant carbonic anhydrase 13 by isothermal titration calorimetry assay |
Bioorg Med Chem 18: 7413-21 (2010)
Article DOI: 10.1016/j.bmc.2010.09.011 BindingDB Entry DOI: 10.7270/Q2TB1734 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(262/262 = 100%)† (Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
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| n/a | n/a | n/a | 36.5 | n/a | n/a | n/a | n/a | n/a |
Vilnius University
Curated by ChEMBL
| Assay Description Binding affinity to human N-terminal full length His-tagged CA13 (1 to 262 residues) expressed in Escherichia coli BL21(DE3) assessed as thermodynami... |
J Med Chem 61: 2292-2302 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01408 BindingDB Entry DOI: 10.7270/Q23T9KNS |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(262/262 = 100%)† (Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
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| n/a | n/a | n/a | 50 | n/a | n/a | n/a | 7.0 | n/a |
Vilnius University Institute of Biotechnology
Curated by ChEMBL
| Assay Description Binding affinity to human recombinant CA13 at 37 degC and pH 7.0 by thermal shift assay |
Bioorg Med Chem 21: 2093-106 (2013)
Article DOI: 10.1016/j.bmc.2013.01.008 BindingDB Entry DOI: 10.7270/Q2PV6MQK |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(262/262 = 100%)† (Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
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| n/a | n/a | n/a | n/a | n/a | 0.0150 | n/a | n/a | n/a |
Vilnius University
Curated by ChEMBL
| Assay Description Binding affinity to human N-terminal full length His-tagged CA13 (1 to 262 residues) expressed in Escherichia coli BL21(DE3) assessed as dissociation... |
J Med Chem 61: 2292-2302 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01408 BindingDB Entry DOI: 10.7270/Q23T9KNS |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(262/262 = 100%)† (Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
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| n/a | n/a | n/a | n/a | n/a | 0.0150 | n/a | n/a | n/a |
Vilnius University
Curated by ChEMBL
| Assay Description Binding affinity to human N-terminal full length His-tagged CA13 (1 to 262 residues) expressed in Escherichia coli BL21(DE3) assessed as intrinsic di... |
J Med Chem 61: 2292-2302 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01408 BindingDB Entry DOI: 10.7270/Q23T9KNS |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(262/262 = 100%)† (Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
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| n/a | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a |
Vilnius University
Curated by ChEMBL
| Assay Description Inhibition of human carbonic anhydrase 13 at pH7 and 37 degC by isothermal titration calorimetry |
J Med Chem 57: 9435-46 (2014)
Article DOI: 10.1021/jm501003k BindingDB Entry DOI: 10.7270/Q280547S |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(262/262 = 100%)† (Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
UniProtKB/SwissProt
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Vilnius University
Curated by ChEMBL
| Assay Description Inhibition of human carbonic anhydrase 13 at pH7 and 37 degC by fluorescent thermal shift assay |
J Med Chem 57: 9435-46 (2014)
Article DOI: 10.1021/jm501003k BindingDB Entry DOI: 10.7270/Q280547S |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(262/262 = 100%)† (Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
UniProtKB/SwissProt
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Vilnius University
| Assay Description The thermal shift assay (TSA) measurements were performed in a Corbett Rotor-Gene 6000 (QIAGEN Rotor-Gene Q, Sydney, Australia) instrument using the ... |
J Enzyme Inhib Med Chem 29: 124-31 (2014)
Article DOI: 10.3109/14756366.2012.757223 BindingDB Entry DOI: 10.7270/Q2RV0MMK |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(262/262 = 100%)† (Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
UniProtKB/SwissProt
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| n/a | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a |
Vilnius University
Curated by ChEMBL
| Assay Description Binding affinity to recombinant human full length N-terminal His-tagged carbonic anhydrase 13 (1 to 262 residues) expressed in Escherichia coli BL21 ... |
Bioorg Med Chem 26: 675-687 (2018)
Article DOI: 10.1016/j.bmc.2017.12.035 BindingDB Entry DOI: 10.7270/Q2H997S0 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(262/262 = 100%)† (Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
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| n/a | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a |
Vilnius University
Curated by ChEMBL
| Assay Description Binding affinity to human recombinant carbonic anhydrase 13 by thermal shift assay |
Bioorg Med Chem 21: 6937-47 (2013)
Article DOI: 10.1016/j.bmc.2013.09.029 BindingDB Entry DOI: 10.7270/Q2S46VZ9 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(262/262 = 100%)† (Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
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| PDB Article PubMed
| n/a | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a |
Vilnius University
Curated by ChEMBL
| Assay Description Binding affinity to recombinant human full length N-terminal His-tagged carbonic anhydrase 13 (1 to 262 residues) expressed in Escherichia coli BL21 ... |
Bioorg Med Chem 26: 675-687 (2018)
Article DOI: 10.1016/j.bmc.2017.12.035 BindingDB Entry DOI: 10.7270/Q2H997S0 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Carbonic anhydrase 13
(262/262 = 100%)† (Homo sapiens (Human)) | BDBM10880
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
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| PDB Article PubMed
| n/a | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a |
Vilnius University
Curated by ChEMBL
| Assay Description Inhibition of human carbonic anhydrase 13 at pH7 and 25 degC by stopped-flow kinetic inhibition assay |
J Med Chem 57: 9435-46 (2014)
Article DOI: 10.1021/jm501003k BindingDB Entry DOI: 10.7270/Q280547S |
More data for this Ligand-Target Pair | 3D Structure (crystal) |