Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Prostaglandin G/H synthase 2 (560/560 = 100%)† (Mus musculus (Mouse)) | BDBM50172473 ((-)-(2R)-2-(2-fluorobiphenyl-4-yl)propanoic acid |...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of COX2-mediated 2-arachidonoylglycerol oxygenation in LPS/IFN-gamma-stimulated mouse RAW264.7 cells assessed as 2-AG to PGE2-G/PGD2-G con... | ACS Med Chem Lett 3: 759-763 (2012) Article DOI: 10.1021/ml3001616 BindingDB Entry DOI: 10.7270/Q2FJ2HWS | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Prostaglandin G/H synthase 2 (491/560 = 88%)† (Homo sapiens (Human)) | BDBM50172473 ((-)-(2R)-2-(2-fluorobiphenyl-4-yl)propanoic acid |...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 1.23E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A. Curated by ChEMBL | Assay Description Concentration required to inhibit cyclooxygenase-2 in human blood | J Med Chem 48: 5705-20 (2005) Article DOI: 10.1021/jm0502541 BindingDB Entry DOI: 10.7270/Q2CC106W | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |