Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Interleukin-1 receptor-associated kinase 4 (301/301 = 100%)† (Homo sapiens (Human)) | BDBM50040867 (CHEMBL3353206 | US9586948, Example 25) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 32 | n/a | n/a | n/a | n/a | 7.2 | n/a |
MERCK SHARP & DOHME CORP. US Patent | Assay Description The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp... | US Patent US9586948 (2017) BindingDB Entry DOI: 10.7270/Q2RF5X2W | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Interleukin-1 receptor-associated kinase 4 (301/301 = 100%)† (Homo sapiens (Human)) | BDBM50040867 (CHEMBL3353206 | US9586948, Example 25) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Nimbus Discovery Curated by ChEMBL | Assay Description Inhibition of IRAK4 (unknown origin) | J Med Chem 58: 96-110 (2015) Article DOI: 10.1021/jm5016044 BindingDB Entry DOI: 10.7270/Q2P84DHS | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |