Found 9 hits Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Urokinase-type plasminogen activator [179-424,C299A,N323Q]
(243/245 > 99%)† (Homo sapiens (Human)) | BDBM50138670
(6-Carbamimidoyl-naphthalene-2-carboxylic acid phen...)Show InChI InChI=1S/C18H15N3O/c19-17(20)14-8-6-13-11-15(9-7-12(13)10-14)18(22)21-16-4-2-1-3-5-16/h1-11H,(H3,19,20)(H,21,22) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB D3R
| 628 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
D3R
| Assay Description Photometric_Method1 |
D3R 227: (2015)
BindingDB Entry DOI: 10.7270/Q24B305P |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Urokinase-type plasminogen activator
(243/245 > 99%)† (Homo sapiens (Human)) | BDBM50138670
(6-Carbamimidoyl-naphthalene-2-carboxylic acid phen...)Show InChI InChI=1S/C18H15N3O/c19-17(20)14-8-6-13-11-15(9-7-12(13)10-14)18(22)21-16-4-2-1-3-5-16/h1-11H,(H3,19,20)(H,21,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB PubMed
| 628 | -35.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
CSAR
| Assay Description Abbott uPA__Urokinase Human - Ki(uM) |
CSAR 1: (2012)
|
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Urokinase-type plasminogen activator
(243/245 > 99%)† (Homo sapiens (Human)) | BDBM50138670
(6-Carbamimidoyl-naphthalene-2-carboxylic acid phen...)Show InChI InChI=1S/C18H15N3O/c19-17(20)14-8-6-13-11-15(9-7-12(13)10-14)18(22)21-16-4-2-1-3-5-16/h1-11H,(H3,19,20)(H,21,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| 630 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards Urokinase-type plasminogen activator (urokinase) |
Bioorg Med Chem Lett 14: 3063-8 (2004)
Article DOI: 10.1016/j.bmcl.2004.04.030 BindingDB Entry DOI: 10.7270/Q29K49PG |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Urokinase-type plasminogen activator
(243/245 > 99%)† (Homo sapiens (Human)) | BDBM50138670
(6-Carbamimidoyl-naphthalene-2-carboxylic acid phen...)Show InChI InChI=1S/C18H15N3O/c19-17(20)14-8-6-13-11-15(9-7-12(13)10-14)18(22)21-16-4-2-1-3-5-16/h1-11H,(H3,19,20)(H,21,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| 631 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of urokinase |
J Med Chem 52: 3159-65 (2009)
Article DOI: 10.1021/jm801444x BindingDB Entry DOI: 10.7270/Q2FF3TM8 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Urokinase-type plasminogen activator
(243/245 > 99%)† (Homo sapiens (Human)) | BDBM50138670
(6-Carbamimidoyl-naphthalene-2-carboxylic acid phen...)Show InChI InChI=1S/C18H15N3O/c19-17(20)14-8-6-13-11-15(9-7-12(13)10-14)18(22)21-16-4-2-1-3-5-16/h1-11H,(H3,19,20)(H,21,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| 631 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity to human urokinase-type plasminogen activator (microPa). |
J Med Chem 47: 303-24 (2004)
Article DOI: 10.1021/jm0300072 BindingDB Entry DOI: 10.7270/Q2BR8RMH |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Urokinase-type plasminogen activator
(243/245 > 99%)† (Homo sapiens (Human)) | BDBM50138670
(6-Carbamimidoyl-naphthalene-2-carboxylic acid phen...)Show InChI InChI=1S/C18H15N3O/c19-17(20)14-8-6-13-11-15(9-7-12(13)10-14)18(22)21-16-4-2-1-3-5-16/h1-11H,(H3,19,20)(H,21,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| 631 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity value against urokinase plasminogen activator |
Bioorg Med Chem Lett 15: 93-8 (2004)
Article DOI: 10.1016/j.bmcl.2004.10.026 BindingDB Entry DOI: 10.7270/Q2R210W5 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Urokinase-type plasminogen activator
(243/245 > 99%)† (Homo sapiens (Human)) | BDBM50138670
(6-Carbamimidoyl-naphthalene-2-carboxylic acid phen...)Show InChI InChI=1S/C18H15N3O/c19-17(20)14-8-6-13-11-15(9-7-12(13)10-14)18(22)21-16-4-2-1-3-5-16/h1-11H,(H3,19,20)(H,21,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| 631 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp
Curated by ChEMBL
| Assay Description Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop... |
Bioorg Med Chem 20: 1557-68 (2012)
Article DOI: 10.1016/j.bmc.2011.12.040 BindingDB Entry DOI: 10.7270/Q2QR4XK1 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Urokinase-type plasminogen activator
(243/245 > 99%)† (Homo sapiens (Human)) | BDBM50138670
(6-Carbamimidoyl-naphthalene-2-carboxylic acid phen...)Show InChI InChI=1S/C18H15N3O/c19-17(20)14-8-6-13-11-15(9-7-12(13)10-14)18(22)21-16-4-2-1-3-5-16/h1-11H,(H3,19,20)(H,21,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp
Curated by ChEMBL
| Assay Description Competitive inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins... |
Bioorg Med Chem 20: 1557-68 (2012)
Article DOI: 10.1016/j.bmc.2011.12.040 BindingDB Entry DOI: 10.7270/Q2QR4XK1 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Urokinase-type plasminogen activator
(243/245 > 99%)† (Homo sapiens (Human)) | BDBM50138670
(6-Carbamimidoyl-naphthalene-2-carboxylic acid phen...)Show InChI InChI=1S/C18H15N3O/c19-17(20)14-8-6-13-11-15(9-7-12(13)10-14)18(22)21-16-4-2-1-3-5-16/h1-11H,(H3,19,20)(H,21,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp
Curated by ChEMBL
| Assay Description Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop... |
Bioorg Med Chem 20: 1557-68 (2012)
Article DOI: 10.1016/j.bmc.2011.12.040 BindingDB Entry DOI: 10.7270/Q2QR4XK1 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |