Found 14 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50081229
(10-(tert-butyl)-2,6-dimethyl-(6E,10Z)-2,6,10-dodec...)Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](=[#6]\[#6]-[#8]P([#8-])(=O)[#8]P([#8-])([#8-])=O)C([#6])([#6])[#6] Show InChI InChI=1S/C18H34O7P2/c1-15(2)9-7-10-16(3)11-8-12-17(18(4,5)6)13-14-24-27(22,23)25-26(19,20)21/h9,11,13H,7-8,10,12,14H2,1-6H3,(H,22,23)(H2,19,20,21)/p-3/b16-11+,17-13- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Parke-Davis Pharmaceutical Research
Curated by ChEMBL
| Assay Description
Inhibition of recombinant farnesyltransferase (mFTase) in scintillation proximity assay |
J Med Chem 42: 3800-8 (1999)
BindingDB Entry DOI: 10.7270/Q2Z89D3S |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50081234
(3-[(Z)-ethylidene]-7,11-dimethyl-(6E)-1,6,10-dodec...)Show SMILES [#6]\[#6](-[#6])=[#6]/[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6]=[#6])=[#6]\[#6]-[#8]P([#8-])(=O)[#8]P([#8-])([#8-])=O Show InChI InChI=1S/C16H28O7P2/c1-5-16(11-7-10-15(4)9-6-8-14(2)3)12-13-22-25(20,21)23-24(17,18)19/h5,8,10,12H,1,6-7,9,11,13H2,2-4H3,(H,20,21)(H2,17,18,19)/p-3/b15-10+,16-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 173 | n/a | n/a | n/a | n/a | n/a | n/a |
Parke-Davis Pharmaceutical Research
Curated by ChEMBL
| Assay Description
Inhibition of recombinant farnesyltransferase (mFTase) in scintillation proximity assay |
J Med Chem 42: 3800-8 (1999)
BindingDB Entry DOI: 10.7270/Q2Z89D3S |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50081235
(3-substituted farnesyl diphosphate analogue | 4-[(...)Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6]-[#6]=[#6])=[#6]\[#6]-[#8]P([#8-])(=O)[#8]P([#8-])([#8-])=O Show InChI InChI=1S/C17H30O7P2/c1-5-8-17(12-7-11-16(4)10-6-9-15(2)3)13-14-23-26(21,22)24-25(18,19)20/h5,9,11,13H,1,6-8,10,12,14H2,2-4H3,(H,21,22)(H2,18,19,20)/p-3/b16-11+,17-13+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 189 | n/a | n/a | n/a | n/a | n/a | n/a |
Parke-Davis Pharmaceutical Research
Curated by ChEMBL
| Assay Description
Inhibition of recombinant farnesyltransferase (mFTase) in scintillation proximity assay |
J Med Chem 42: 3800-8 (1999)
BindingDB Entry DOI: 10.7270/Q2Z89D3S |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50081227
(10-ethyl-2,6-dimethyl-(6E,10E)-2,6,10-dodecatriene...)Show SMILES [#6]-[#6]\[#6](-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6])=[#6]/[#6]-[#8]P([#8-])(=O)[#8]P([#8-])([#8-])=O Show InChI InChI=1S/C16H30O7P2/c1-5-16(11-7-10-15(4)9-6-8-14(2)3)12-13-22-25(20,21)23-24(17,18)19/h8,10,12H,5-7,9,11,13H2,1-4H3,(H,20,21)(H2,17,18,19)/p-3/b15-10+,16-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 215 | n/a | n/a | n/a | n/a | n/a | n/a |
Parke-Davis Pharmaceutical Research
Curated by ChEMBL
| Assay Description
Inhibition of recombinant farnesyltransferase (mFTase) in scintillation proximity assay |
J Med Chem 42: 3800-8 (1999)
BindingDB Entry DOI: 10.7270/Q2Z89D3S |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50081226
(1-[1-[(Z)-ethylidene]-5,9-dimethyl-(4E)-4,8-decadi...)Show SMILES [#6]\[#6](-[#6])=[#6]/[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](=[#6]\[#6]-[#8]P([#8-])(=O)[#8]P([#8-])([#8-])=O)-c1ccccc1 Show InChI InChI=1S/C20H30O7P2/c1-17(2)9-7-10-18(3)11-8-14-20(19-12-5-4-6-13-19)15-16-26-29(24,25)27-28(21,22)23/h4-6,9,11-13,15H,7-8,10,14,16H2,1-3H3,(H,24,25)(H2,21,22,23)/p-3/b18-11+,20-15- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 299 | n/a | n/a | n/a | n/a | n/a | n/a |
Parke-Davis Pharmaceutical Research
Curated by ChEMBL
| Assay Description
Inhibition of recombinant farnesyltransferase (mFTase) in scintillation proximity assay |
J Med Chem 42: 3800-8 (1999)
BindingDB Entry DOI: 10.7270/Q2Z89D3S |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50081238
(4-[(Z)-ethylidene]-8,12,16-trimethyl-(7E,11E)-1,7,...)Show SMILES [#6]\[#6](-[#6])=[#6]/[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6]-[#6]=[#6])=[#6]\[#6]-[#8]P([#8-])(=O)[#8]P([#8-])([#8-])=O Show InChI InChI=1S/C22H38O7P2/c1-6-10-22(17-18-28-31(26,27)29-30(23,24)25)16-9-15-21(5)14-8-13-20(4)12-7-11-19(2)3/h6,11,13,15,17H,1,7-10,12,14,16,18H2,2-5H3,(H,26,27)(H2,23,24,25)/p-3/b20-13+,21-15+,22-17+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 453 | n/a | n/a | n/a | n/a | n/a | n/a |
Parke-Davis Pharmaceutical Research
Curated by ChEMBL
| Assay Description
Inhibition of recombinant farnesyltransferase (mFTase) in scintillation proximity assay |
J Med Chem 42: 3800-8 (1999)
BindingDB Entry DOI: 10.7270/Q2Z89D3S |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50081233
(3-[(Z)-ethylidene]-7,11,15-trimethyl-(6E,10E)-1,6,...)Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6]=[#6])=[#6]\[#6]-[#8]P([#8-])(=O)[#8]P([#8-])([#8-])=O Show InChI InChI=1S/C21H36O7P2/c1-6-21(16-17-27-30(25,26)28-29(22,23)24)15-9-14-20(5)13-8-12-19(4)11-7-10-18(2)3/h6,10,12,14,16H,1,7-9,11,13,15,17H2,2-5H3,(H,25,26)(H2,22,23,24)/p-3/b19-12+,20-14+,21-16+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 715 | n/a | n/a | n/a | n/a | n/a | n/a |
Parke-Davis Pharmaceutical Research
Curated by ChEMBL
| Assay Description
Inhibition of recombinant farnesyltransferase (mFTase) in scintillation proximity assay |
J Med Chem 42: 3800-8 (1999)
BindingDB Entry DOI: 10.7270/Q2Z89D3S |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50081233
(3-[(Z)-ethylidene]-7,11,15-trimethyl-(6E,10E)-1,6,...)Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6]=[#6])=[#6]\[#6]-[#8]P([#8-])(=O)[#8]P([#8-])([#8-])=O Show InChI InChI=1S/C21H36O7P2/c1-6-21(16-17-27-30(25,26)28-29(22,23)24)15-9-14-20(5)13-8-12-19(4)11-7-10-18(2)3/h6,10,12,14,16H,1,7-9,11,13,15,17H2,2-5H3,(H,25,26)(H2,22,23,24)/p-3/b19-12+,20-14+,21-16+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3.05E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Parke-Davis Pharmaceutical Research
Curated by ChEMBL
| Assay Description
Inhibition of recombinant Geranylgeranyl transferase type I in scintillation proximity assay |
J Med Chem 42: 3800-8 (1999)
BindingDB Entry DOI: 10.7270/Q2Z89D3S |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50081238
(4-[(Z)-ethylidene]-8,12,16-trimethyl-(7E,11E)-1,7,...)Show SMILES [#6]\[#6](-[#6])=[#6]/[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6]-[#6]=[#6])=[#6]\[#6]-[#8]P([#8-])(=O)[#8]P([#8-])([#8-])=O Show InChI InChI=1S/C22H38O7P2/c1-6-10-22(17-18-28-31(26,27)29-30(23,24)25)16-9-15-21(5)14-8-13-20(4)12-7-11-19(2)3/h6,11,13,15,17H,1,7-10,12,14,16,18H2,2-5H3,(H,26,27)(H2,23,24,25)/p-3/b20-13+,21-15+,22-17+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3.38E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Parke-Davis Pharmaceutical Research
Curated by ChEMBL
| Assay Description
Inhibition of recombinant Geranylgeranyl transferase type I in scintillation proximity assay |
J Med Chem 42: 3800-8 (1999)
BindingDB Entry DOI: 10.7270/Q2Z89D3S |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50081229
(10-(tert-butyl)-2,6-dimethyl-(6E,10Z)-2,6,10-dodec...)Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](=[#6]\[#6]-[#8]P([#8-])(=O)[#8]P([#8-])([#8-])=O)C([#6])([#6])[#6] Show InChI InChI=1S/C18H34O7P2/c1-15(2)9-7-10-16(3)11-8-12-17(18(4,5)6)13-14-24-27(22,23)25-26(19,20)21/h9,11,13H,7-8,10,12,14H2,1-6H3,(H,22,23)(H2,19,20,21)/p-3/b16-11+,17-13- | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Parke-Davis Pharmaceutical Research
Curated by ChEMBL
| Assay Description
Inhibition of recombinant Geranylgeranyl transferase type I in scintillation proximity assay |
J Med Chem 42: 3800-8 (1999)
BindingDB Entry DOI: 10.7270/Q2Z89D3S |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50081235
(3-substituted farnesyl diphosphate analogue | 4-[(...)Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6]-[#6]=[#6])=[#6]\[#6]-[#8]P([#8-])(=O)[#8]P([#8-])([#8-])=O Show InChI InChI=1S/C17H30O7P2/c1-5-8-17(12-7-11-16(4)10-6-9-15(2)3)13-14-23-26(21,22)24-25(18,19)20/h5,9,11,13H,1,6-8,10,12,14H2,2-4H3,(H,21,22)(H2,18,19,20)/p-3/b16-11+,17-13+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Parke-Davis Pharmaceutical Research
Curated by ChEMBL
| Assay Description
Inhibition of recombinant Geranylgeranyl transferase type I in scintillation proximity assay |
J Med Chem 42: 3800-8 (1999)
BindingDB Entry DOI: 10.7270/Q2Z89D3S |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50081226
(1-[1-[(Z)-ethylidene]-5,9-dimethyl-(4E)-4,8-decadi...)Show SMILES [#6]\[#6](-[#6])=[#6]/[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](=[#6]\[#6]-[#8]P([#8-])(=O)[#8]P([#8-])([#8-])=O)-c1ccccc1 Show InChI InChI=1S/C20H30O7P2/c1-17(2)9-7-10-18(3)11-8-14-20(19-12-5-4-6-13-19)15-16-26-29(24,25)27-28(21,22)23/h4-6,9,11-13,15H,7-8,10,14,16H2,1-3H3,(H,24,25)(H2,21,22,23)/p-3/b18-11+,20-15- | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Parke-Davis Pharmaceutical Research
Curated by ChEMBL
| Assay Description
Inhibition of recombinant Geranylgeranyl transferase type I in scintillation proximity assay |
J Med Chem 42: 3800-8 (1999)
BindingDB Entry DOI: 10.7270/Q2Z89D3S |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50081234
(3-[(Z)-ethylidene]-7,11-dimethyl-(6E)-1,6,10-dodec...)Show SMILES [#6]\[#6](-[#6])=[#6]/[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6]=[#6])=[#6]\[#6]-[#8]P([#8-])(=O)[#8]P([#8-])([#8-])=O Show InChI InChI=1S/C16H28O7P2/c1-5-16(11-7-10-15(4)9-6-8-14(2)3)12-13-22-25(20,21)23-24(17,18)19/h5,8,10,12H,1,6-7,9,11,13H2,2-4H3,(H,20,21)(H2,17,18,19)/p-3/b15-10+,16-12+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Parke-Davis Pharmaceutical Research
Curated by ChEMBL
| Assay Description
Inhibition of recombinant Geranylgeranyl transferase type I in scintillation proximity assay |
J Med Chem 42: 3800-8 (1999)
BindingDB Entry DOI: 10.7270/Q2Z89D3S |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50081227
(10-ethyl-2,6-dimethyl-(6E,10E)-2,6,10-dodecatriene...)Show SMILES [#6]-[#6]\[#6](-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6])=[#6]/[#6]-[#8]P([#8-])(=O)[#8]P([#8-])([#8-])=O Show InChI InChI=1S/C16H30O7P2/c1-5-16(11-7-10-15(4)9-6-8-14(2)3)12-13-22-25(20,21)23-24(17,18)19/h8,10,12H,5-7,9,11,13H2,1-4H3,(H,20,21)(H2,17,18,19)/p-3/b15-10+,16-12+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Parke-Davis Pharmaceutical Research
Curated by ChEMBL
| Assay Description
Inhibition of recombinant Geranylgeranyl transferase type I in scintillation proximity assay |
J Med Chem 42: 3800-8 (1999)
BindingDB Entry DOI: 10.7270/Q2Z89D3S |
More data for this
Ligand-Target Pair | |
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