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PubMed code 10956191

Compile data set for download or QSAR
Found 31 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50422274
PNG
(GONADORELIN | Human gonadoliberin-i)
Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O
Show InChI InChI=1S/C55H75N17O13/c1-29(2)19-38(49(80)67-37(9-5-17-60-55(57)58)54(85)72-18-6-10-43(72)53(84)62-25-44(56)75)66-46(77)26-63-47(78)39(20-30-11-13-33(74)14-12-30)68-52(83)42(27-73)71-50(81)40(21-31-23-61-35-8-4-3-7-34(31)35)69-51(82)41(22-32-24-59-28-64-32)70-48(79)36-15-16-45(76)65-36/h3-4,7-8,11-14,23-24,28-29,36-43,61,73-74H,5-6,9-10,15-22,25-27H2,1-2H3,(H2,56,75)(H,59,64)(H,62,84)(H,63,78)(H,65,76)(H,66,77)(H,67,80)(H,68,83)(H,69,82)(H,70,79)(H,71,81)(H4,57,58,60)/t36-,37-,38-,39-,40-,41-,42-,43-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Institute of Science

Curated by ChEMBL


Assay Description
Concentration of the peptide which displaces 50% of 125 I-[D-Lys6] gonadotropin-releasing hormone bound to rat pituitary membranes

J Med Chem 43: 2831-6 (2000)


BindingDB Entry DOI: 10.7270/Q29P30W3
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50090745
PNG
(1-[2-(2-{2-[2-(2-Acetylamino-3-naphthalen-2-yl-pro...)
Show SMILES C[C@H](NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@@H](Cc1ccccn1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(C)=O)C(N)=O
Show InChI InChI=1S/C48H59ClN12O8/c1-28(42(50)64)56-46(68)40-13-8-22-61(40)47(69)36(12-7-21-54-48(51)52)58-41(63)27-55-43(65)39(26-35-11-5-6-20-53-35)60-45(67)38(24-30-15-18-34(49)19-16-30)59-44(66)37(57-29(2)62)25-31-14-17-32-9-3-4-10-33(32)23-31/h3-6,9-11,14-20,23,28,36-40H,7-8,12-13,21-22,24-27H2,1-2H3,(H2,50,64)(H,55,65)(H,56,68)(H,57,62)(H,58,63)(H,59,66)(H,60,67)(H4,51,52,54)/t28-,36+,37-,38+,39+,40+/m0/s1
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n/an/a 7n/an/an/an/an/an/a



Institute of Science

Curated by ChEMBL


Assay Description
Concentration of the peptide which displaces 50% of 125 I-[D-Lys6] gonadotropin-releasing hormone bound to rat pituitary membranes

J Med Chem 43: 2831-6 (2000)


BindingDB Entry DOI: 10.7270/Q29P30W3
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50090748
PNG
(1-[2-(2-{2-[2-(2-Acetylamino-3-naphthalen-2-yl-pro...)
Show SMILES CCCCC(NC(=O)[C@@H](Cc1ccccn1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](C)C(N)=O
Show InChI InChI=1S/C52H67ClN12O8/c1-4-5-15-39(46(68)62-40(16-10-25-58-52(55)56)51(73)65-26-11-17-44(65)50(72)59-31(2)45(54)67)61-49(71)43(30-38-14-8-9-24-57-38)64-48(70)42(28-33-19-22-37(53)23-20-33)63-47(69)41(60-32(3)66)29-34-18-21-35-12-6-7-13-36(35)27-34/h6-9,12-14,18-24,27,31,39-44H,4-5,10-11,15-17,25-26,28-30H2,1-3H3,(H2,54,67)(H,59,72)(H,60,66)(H,61,71)(H,62,68)(H,63,69)(H,64,70)(H4,55,56,58)/t31-,39?,40+,41-,42+,43+,44+/m0/s1
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n/an/a 11n/an/an/an/an/an/a



Institute of Science

Curated by ChEMBL


Assay Description
Concentration of the peptide which displaces 50% of 125 I-[D-Lys6] gonadotropin-releasing hormone bound to rat pituitary membranes

J Med Chem 43: 2831-6 (2000)


BindingDB Entry DOI: 10.7270/Q29P30W3
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50090736
PNG
(1-{2-(2-{2-[2-(2-Acetylamino-3-naphthalen-2-yl-pro...)
Show SMILES C[C@H](NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCCNNC(=O)c1cccnc1)NC(=O)[C@H](C)NC(=O)[C@@H](Cc1ccccn1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(C)=O)C(N)=O
Show InChI InChI=1S/C55H65ClN12O9/c1-33(48(57)70)61-54(76)47-17-11-27-68(47)55(77)43(16-7-9-26-60-67-50(72)40-14-10-24-58-32-40)64-49(71)34(2)62-51(73)46(31-42-15-6-8-25-59-42)66-53(75)45(29-36-19-22-41(56)23-20-36)65-52(74)44(63-35(3)69)30-37-18-21-38-12-4-5-13-39(38)28-37/h4-6,8,10,12-15,18-25,28,32-34,43-47,60H,7,9,11,16-17,26-27,29-31H2,1-3H3,(H2,57,70)(H,61,76)(H,62,73)(H,63,69)(H,64,71)(H,65,74)(H,66,75)(H,67,72)/t33-,34-,43+,44-,45+,46+,47+/m0/s1
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n/an/a 14n/an/an/an/an/an/a



Institute of Science

Curated by ChEMBL


Assay Description
Concentration of the peptide which displaces 50% of 125 I-[D-Lys6] gonadotropin-releasing hormone bound to rat pituitary membranes

J Med Chem 43: 2831-6 (2000)


BindingDB Entry DOI: 10.7270/Q29P30W3
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50090732
PNG
(1-[2-(2-{2-[2-(2-Acetylamino-3-naphthalen-2-yl-pro...)
Show SMILES C[C@H](NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@@H](Cc1ccccn1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(C)=O)C(N)=O
Show InChI InChI=1S/C48H59ClN12O8/c1-28(42(50)64)56-46(68)40-13-8-22-61(40)47(69)36(12-7-21-54-48(51)52)58-41(63)27-55-43(65)39(26-35-11-5-6-20-53-35)60-45(67)38(24-30-15-18-34(49)19-16-30)59-44(66)37(57-29(2)62)25-31-14-17-32-9-3-4-10-33(32)23-31/h3-6,9-11,14-20,23,28,36-40H,7-8,12-13,21-22,24-27H2,1-2H3,(H2,50,64)(H,55,65)(H,56,68)(H,57,62)(H,58,63)(H,59,66)(H,60,67)(H4,51,52,54)/t28-,36-,37-,38+,39+,40+/m0/s1
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n/an/a 16n/an/an/an/an/an/a



Institute of Science

Curated by ChEMBL


Assay Description
Concentration of the peptide which displaces 50% of 125 I-[D-Lys6] gonadotropin-releasing hormone bound to rat pituitary membranes

J Med Chem 43: 2831-6 (2000)


BindingDB Entry DOI: 10.7270/Q29P30W3
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50090724
PNG
(1-[2-(2-{2-[2-(2-Acetylamino-3-naphthalen-2-yl-pro...)
Show SMILES C[C@H](NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@@H](Cc1ccccn1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(C)=O)C(N)=O
Show InChI InChI=1S/C49H61ClN12O8/c1-28(42(51)64)56-47(69)41-14-9-23-62(41)48(70)37(13-8-22-55-49(52)53)59-43(65)29(2)57-44(66)40(27-36-12-6-7-21-54-36)61-46(68)39(25-31-16-19-35(50)20-17-31)60-45(67)38(58-30(3)63)26-32-15-18-33-10-4-5-11-34(33)24-32/h4-7,10-12,15-21,24,28-29,37-41H,8-9,13-14,22-23,25-27H2,1-3H3,(H2,51,64)(H,56,69)(H,57,66)(H,58,63)(H,59,65)(H,60,67)(H,61,68)(H4,52,53,55)/t28-,29-,37+,38-,39+,40+,41+/m0/s1
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n/an/a 17n/an/an/an/an/an/a



Institute of Science

Curated by ChEMBL


Assay Description
Concentration of the peptide which displaces 50% of 125 I-[D-Lys6] gonadotropin-releasing hormone bound to rat pituitary membranes

J Med Chem 43: 2831-6 (2000)


BindingDB Entry DOI: 10.7270/Q29P30W3
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50090730
PNG
(1-[2-(2-{2-[2-(2-Acetylamino-3-naphthalen-2-yl-pro...)
Show SMILES C[C@H](NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H](Cc1ccccn1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(C)=O)C(N)=O
Show InChI InChI=1S/C49H61ClN10O8/c1-29(43(52)62)54-48(67)42-15-10-24-60(42)49(68)38(14-6-8-22-51)57-44(63)30(2)55-45(64)41(28-37-13-7-9-23-53-37)59-47(66)40(26-32-17-20-36(50)21-18-32)58-46(65)39(56-31(3)61)27-33-16-19-34-11-4-5-12-35(34)25-33/h4-5,7,9,11-13,16-21,23,25,29-30,38-42H,6,8,10,14-15,22,24,26-28,51H2,1-3H3,(H2,52,62)(H,54,67)(H,55,64)(H,56,61)(H,57,63)(H,58,65)(H,59,66)/t29-,30-,38+,39-,40+,41+,42+/m0/s1
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n/an/a 20n/an/an/an/an/an/a



Institute of Science

Curated by ChEMBL


Assay Description
Concentration of the peptide which displaces 50% of 125 I-[D-Lys6] gonadotropin-releasing hormone bound to rat pituitary membranes

J Med Chem 43: 2831-6 (2000)


BindingDB Entry DOI: 10.7270/Q29P30W3
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50090734
PNG
(1-[2-(2-{2-[2-(2-Acetylamino-3-naphthalen-2-yl-pro...)
Show SMILES C[C@H](NC(=O)[C@H]1CCCN1C(=O)C(CCCNC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](Cc1ccccn1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(C)=O)C(N)=O
Show InChI InChI=1S/C49H60ClN11O9/c1-28(42(51)63)55-47(68)41-14-9-23-61(41)48(69)37(13-8-22-54-49(52)70)58-43(64)29(2)56-44(65)40(27-36-12-6-7-21-53-36)60-46(67)39(25-31-16-19-35(50)20-17-31)59-45(66)38(57-30(3)62)26-32-15-18-33-10-4-5-11-34(33)24-32/h4-7,10-12,15-21,24,28-29,37-41H,8-9,13-14,22-23,25-27H2,1-3H3,(H2,51,63)(H,55,68)(H,56,65)(H,57,62)(H,58,64)(H,59,66)(H,60,67)(H3,52,54,70)/t28-,29-,37?,38-,39+,40+,41+/m0/s1
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n/an/a 23n/an/an/an/an/an/a



Institute of Science

Curated by ChEMBL


Assay Description
Concentration of the peptide which displaces 50% of 125 I-[D-Lys6] gonadotropin-releasing hormone bound to rat pituitary membranes

J Med Chem 43: 2831-6 (2000)


BindingDB Entry DOI: 10.7270/Q29P30W3
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50090723
PNG
(1-{2-[2-{2-[2-(2-Acetylamino-3-naphthalen-2-yl-pro...)
Show SMILES C[C@H](NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](Cc1ccccn1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(C)=O)C(N)=O
Show InChI InChI=1S/C55H65ClN12O9/c1-32(48(57)71)62-53(76)47-13-8-26-68(47)54(77)42(12-7-25-61-55(58)59)64-50(73)44(29-35-17-22-41(70)23-18-35)66-52(75)46(31-40-11-5-6-24-60-40)67-51(74)45(28-34-15-20-39(56)21-16-34)65-49(72)43(63-33(2)69)30-36-14-19-37-9-3-4-10-38(37)27-36/h3-6,9-11,14-24,27,32,42-47,70H,7-8,12-13,25-26,28-31H2,1-2H3,(H2,57,71)(H,62,76)(H,63,69)(H,64,73)(H,65,72)(H,66,75)(H,67,74)(H4,58,59,61)/t32-,42+,43-,44-,45+,46+,47+/m0/s1
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n/an/a 25n/an/an/an/an/an/a



Institute of Science

Curated by ChEMBL


Assay Description
Concentration of the peptide which displaces 50% of 125 I-[D-Lys6] gonadotropin-releasing hormone bound to rat pituitary membranes

J Med Chem 43: 2831-6 (2000)


BindingDB Entry DOI: 10.7270/Q29P30W3
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50090728
PNG
(1-[2-(2-{2-[2-(2-Acetylamino-3-naphthalen-2-yl-pro...)
Show SMILES C[C@H](NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(C)=O)C(N)=O
Show InChI InChI=1S/C49H61N11O8/c1-30(43(50)63)55-47(67)41-20-12-24-60(41)48(68)37(19-11-23-53-49(51)52)57-42(62)29-54-44(64)38(26-32-13-5-3-6-14-32)58-46(66)40(27-33-15-7-4-8-16-33)59-45(65)39(56-31(2)61)28-34-21-22-35-17-9-10-18-36(35)25-34/h3-10,13-18,21-22,25,30,37-41H,11-12,19-20,23-24,26-29H2,1-2H3,(H2,50,63)(H,54,64)(H,55,67)(H,56,61)(H,57,62)(H,58,66)(H,59,65)(H4,51,52,53)/t30-,37+,38+,39-,40+,41+/m0/s1
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n/an/a 28n/an/an/an/an/an/a



Institute of Science

Curated by ChEMBL


Assay Description
Concentration of the peptide which displaces 50% of 125 I-[D-Lys6] gonadotropin-releasing hormone bound to rat pituitary membranes

J Med Chem 43: 2831-6 (2000)


BindingDB Entry DOI: 10.7270/Q29P30W3
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50090752
PNG
(1-[2-(2-{2-[2-(2-Acetylamino-3-naphthalen-2-yl-pro...)
Show SMILES C[C@H](NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](C)NC(=O)[C@@H](Cc1ccccn1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(C)=O)C(N)=O
Show InChI InChI=1S/C49H61ClN12O8/c1-28(42(51)64)56-47(69)41-14-9-23-62(41)48(70)37(13-8-22-55-49(52)53)59-43(65)29(2)57-44(66)40(27-36-12-6-7-21-54-36)61-46(68)39(25-31-16-19-35(50)20-17-31)60-45(67)38(58-30(3)63)26-32-15-18-33-10-4-5-11-34(33)24-32/h4-7,10-12,15-21,24,28-29,37-41H,8-9,13-14,22-23,25-27H2,1-3H3,(H2,51,64)(H,56,69)(H,57,66)(H,58,63)(H,59,65)(H,60,67)(H,61,68)(H4,52,53,55)/t28-,29+,37+,38-,39+,40+,41+/m0/s1
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n/an/a 28n/an/an/an/an/an/a



Institute of Science

Curated by ChEMBL


Assay Description
Concentration of the peptide which displaces 50% of 125 I-[D-Lys6] gonadotropin-releasing hormone bound to rat pituitary membranes

J Med Chem 43: 2831-6 (2000)


BindingDB Entry DOI: 10.7270/Q29P30W3
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50090725
PNG
(1-{2-[2-({2-[2-(2-Acetylamino-3-naphthalen-2-yl-pr...)
Show SMILES C[C@H](NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(N)=N)NC(=O)CN(C)C(=O)[C@@H](Cc1ccccn1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(C)=O)C(N)=O
Show InChI InChI=1S/C49H61ClN12O8/c1-29(43(51)65)56-46(68)41-14-9-23-62(41)48(70)37(13-8-22-55-49(52)53)58-42(64)28-61(3)47(69)40(27-36-12-6-7-21-54-36)60-45(67)39(25-31-16-19-35(50)20-17-31)59-44(66)38(57-30(2)63)26-32-15-18-33-10-4-5-11-34(33)24-32/h4-7,10-12,15-21,24,29,37-41H,8-9,13-14,22-23,25-28H2,1-3H3,(H2,51,65)(H,56,68)(H,57,63)(H,58,64)(H,59,66)(H,60,67)(H4,52,53,55)/t29-,37+,38-,39+,40+,41+/m0/s1
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n/an/a 31n/an/an/an/an/an/a



Institute of Science

Curated by ChEMBL


Assay Description
Concentration of the peptide which displaces 50% of 125 I-[D-Lys6] gonadotropin-releasing hormone bound to rat pituitary membranes

J Med Chem 43: 2831-6 (2000)


BindingDB Entry DOI: 10.7270/Q29P30W3
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50090737
PNG
(1-[2-(3-{2-[2-(2-Acetylamino-3-naphthalen-2-yl-pro...)
Show SMILES C[C@H](NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(N)=N)NC(=O)CCNC(=O)[C@@H](Cc1ccccn1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(C)=O)C(N)=O
Show InChI InChI=1S/C49H61ClN12O8/c1-29(43(51)65)57-47(69)41-13-8-24-62(41)48(70)37(12-7-22-56-49(52)53)59-42(64)20-23-55-44(66)40(28-36-11-5-6-21-54-36)61-46(68)39(26-31-15-18-35(50)19-16-31)60-45(67)38(58-30(2)63)27-32-14-17-33-9-3-4-10-34(33)25-32/h3-6,9-11,14-19,21,25,29,37-41H,7-8,12-13,20,22-24,26-28H2,1-2H3,(H2,51,65)(H,55,66)(H,57,69)(H,58,63)(H,59,64)(H,60,67)(H,61,68)(H4,52,53,56)/t29-,37+,38-,39+,40+,41+/m0/s1
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n/an/a 38n/an/an/an/an/an/a



Institute of Science

Curated by ChEMBL


Assay Description
Concentration of the peptide which displaces 50% of 125 I-[D-Lys6] gonadotropin-releasing hormone bound to rat pituitary membranes

J Med Chem 43: 2831-6 (2000)


BindingDB Entry DOI: 10.7270/Q29P30W3
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50090727
PNG
(1-{2-[(1-{2-[2-(2-Acetylamino-3-naphthalen-2-yl-pr...)
Show SMILES C[C@H](NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(N)=N)NC(=O)C1(CCC1)NC(=O)[C@@H](Cc1ccccn1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(C)=O)C(N)=O
Show InChI InChI=1S/C51H63ClN12O8/c1-30(43(53)66)58-47(70)42-14-8-25-64(42)48(71)38(13-7-24-57-50(54)55)62-49(72)51(21-9-22-51)63-46(69)41(29-37-12-5-6-23-56-37)61-45(68)40(27-32-16-19-36(52)20-17-32)60-44(67)39(59-31(2)65)28-33-15-18-34-10-3-4-11-35(34)26-33/h3-6,10-12,15-20,23,26,30,38-42H,7-9,13-14,21-22,24-25,27-29H2,1-2H3,(H2,53,66)(H,58,70)(H,59,65)(H,60,67)(H,61,68)(H,62,72)(H,63,69)(H4,54,55,57)/t30-,38+,39-,40+,41+,42+/m0/s1
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n/an/a 42n/an/an/an/an/an/a



Institute of Science

Curated by ChEMBL


Assay Description
Concentration of the peptide which displaces 50% of 125 I-[D-Lys6] gonadotropin-releasing hormone bound to rat pituitary membranes

J Med Chem 43: 2831-6 (2000)


BindingDB Entry DOI: 10.7270/Q29P30W3
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50090747
PNG
(1-(2-{2-[2-(2-Acetylamino-3-naphthalen-2-yl-propio...)
Show SMILES C[C@H](NC(=O)[C@H]1CCCN1C(=O)CNC(=O)[C@@H](Cc1ccccn1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(C)=O)C(N)=O
Show InChI InChI=1S/C42H47ClN8O7/c1-25(38(44)54)47-42(58)36-11-7-19-51(36)37(53)24-46-39(55)35(23-32-10-5-6-18-45-32)50-41(57)34(21-27-13-16-31(43)17-14-27)49-40(56)33(48-26(2)52)22-28-12-15-29-8-3-4-9-30(29)20-28/h3-6,8-10,12-18,20,25,33-36H,7,11,19,21-24H2,1-2H3,(H2,44,54)(H,46,55)(H,47,58)(H,48,52)(H,49,56)(H,50,57)/t25-,33-,34+,35+,36+/m0/s1
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n/an/a 45n/an/an/an/an/an/a



Institute of Science

Curated by ChEMBL


Assay Description
Concentration of the peptide which displaces 50% of 125 I-[D-Lys6] gonadotropin-releasing hormone bound to rat pituitary membranes

J Med Chem 43: 2831-6 (2000)


BindingDB Entry DOI: 10.7270/Q29P30W3
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50090744
PNG
(1-(2-{2-[2-(2-Acetylamino-3-naphthalen-2-yl-propio...)
Show SMILES C[C@H](NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc1ccccn1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(C)=O)C(N)=O
Show InChI InChI=1S/C46H56ClN11O7/c1-27(40(48)60)53-44(64)39-13-8-22-58(39)45(65)35(12-7-21-52-46(49)50)55-43(63)38(26-34-11-5-6-20-51-34)57-42(62)37(24-29-15-18-33(47)19-16-29)56-41(61)36(54-28(2)59)25-30-14-17-31-9-3-4-10-32(31)23-30/h3-6,9-11,14-20,23,27,35-39H,7-8,12-13,21-22,24-26H2,1-2H3,(H2,48,60)(H,53,64)(H,54,59)(H,55,63)(H,56,61)(H,57,62)(H4,49,50,52)/t27-,35-,36-,37+,38+,39+/m0/s1
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n/an/a 70n/an/an/an/an/an/a



Institute of Science

Curated by ChEMBL


Assay Description
Concentration of the peptide which displaces 50% of 125 I-[D-Lys6] gonadotropin-releasing hormone bound to rat pituitary membranes

J Med Chem 43: 2831-6 (2000)


BindingDB Entry DOI: 10.7270/Q29P30W3
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50090750
PNG
(1-[2-(2-{2-[2-(2-Acetylamino-3-naphthalen-2-yl-pro...)
Show SMILES C[C@H](NC(=O)[C@H]1CCCN1C(=O)C(CCCNC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc1ccccn1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(C)=O)C(N)=O
Show InChI InChI=1S/C52H67ClN14O9/c1-30(44(54)69)61-49(74)43-15-9-25-67(43)50(75)39(14-8-24-60-52(57)76)64-45(70)38(13-7-23-59-51(55)56)63-48(73)42(29-37-12-5-6-22-58-37)66-47(72)41(27-32-17-20-36(53)21-18-32)65-46(71)40(62-31(2)68)28-33-16-19-34-10-3-4-11-35(34)26-33/h3-6,10-12,16-22,26,30,38-43H,7-9,13-15,23-25,27-29H2,1-2H3,(H2,54,69)(H,61,74)(H,62,68)(H,63,73)(H,64,70)(H,65,71)(H,66,72)(H4,55,56,59)(H3,57,60,76)/t30-,38-,39?,40-,41+,42+,43+/m0/s1
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n/an/a 72n/an/an/an/an/an/a



Institute of Science

Curated by ChEMBL


Assay Description
Concentration of the peptide which displaces 50% of 125 I-[D-Lys6] gonadotropin-releasing hormone bound to rat pituitary membranes

J Med Chem 43: 2831-6 (2000)


BindingDB Entry DOI: 10.7270/Q29P30W3
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50090739
PNG
(1-[2-(2-{2-[2-(2-Acetylamino-3-naphthalen-2-yl-pro...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](Cc1ccccn1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](C)C(N)=O
Show InChI InChI=1S/C52H67ClN12O8/c1-30(2)25-40(46(68)61-39(14-9-23-58-52(55)56)51(73)65-24-10-15-44(65)50(72)59-31(3)45(54)67)62-49(71)43(29-38-13-7-8-22-57-38)64-48(70)42(27-33-17-20-37(53)21-18-33)63-47(69)41(60-32(4)66)28-34-16-19-35-11-5-6-12-36(35)26-34/h5-8,11-13,16-22,26,30-31,39-44H,9-10,14-15,23-25,27-29H2,1-4H3,(H2,54,67)(H,59,72)(H,60,66)(H,61,68)(H,62,71)(H,63,69)(H,64,70)(H4,55,56,58)/t31-,39+,40-,41-,42+,43+,44+/m0/s1
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n/an/a 74n/an/an/an/an/an/a



Institute of Science

Curated by ChEMBL


Assay Description
Concentration of the peptide which displaces 50% of 125 I-[D-Lys6] gonadotropin-releasing hormone bound to rat pituitary membranes

J Med Chem 43: 2831-6 (2000)


BindingDB Entry DOI: 10.7270/Q29P30W3
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50090733
PNG
(1-[2-(2-{2-[2-(2-Acetylamino-3-naphthalen-2-yl-pro...)
Show SMILES CC(C)C[C@@H](NC(=O)[C@@H](Cc1ccccn1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](C)C(N)=O
Show InChI InChI=1S/C52H67ClN12O8/c1-30(2)25-40(46(68)61-39(14-9-23-58-52(55)56)51(73)65-24-10-15-44(65)50(72)59-31(3)45(54)67)62-49(71)43(29-38-13-7-8-22-57-38)64-48(70)42(27-33-17-20-37(53)21-18-33)63-47(69)41(60-32(4)66)28-34-16-19-35-11-5-6-12-36(35)26-34/h5-8,11-13,16-22,26,30-31,39-44H,9-10,14-15,23-25,27-29H2,1-4H3,(H2,54,67)(H,59,72)(H,60,66)(H,61,68)(H,62,71)(H,63,69)(H,64,70)(H4,55,56,58)/t31-,39+,40+,41-,42+,43+,44+/m0/s1
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n/an/a 81n/an/an/an/an/an/a



Institute of Science

Curated by ChEMBL


Assay Description
Concentration of the peptide which displaces 50% of 125 I-[D-Lys6] gonadotropin-releasing hormone bound to rat pituitary membranes

J Med Chem 43: 2831-6 (2000)


BindingDB Entry DOI: 10.7270/Q29P30W3
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50090746
PNG
(1-[2-(2-{2-[2-(2-Acetylamino-3-naphthalen-2-yl-pro...)
Show SMILES CCCCC(NC(=O)[C@H](C)NC(=O)[C@@H](Cc1ccccn1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](C)C(N)=O
Show InChI InChI=1S/C49H60ClN9O8/c1-5-6-15-38(49(67)59-24-11-16-42(59)48(66)53-29(2)43(51)61)56-44(62)30(3)54-45(63)41(28-37-14-9-10-23-52-37)58-47(65)40(26-32-18-21-36(50)22-19-32)57-46(64)39(55-31(4)60)27-33-17-20-34-12-7-8-13-35(34)25-33/h7-10,12-14,17-23,25,29-30,38-42H,5-6,11,15-16,24,26-28H2,1-4H3,(H2,51,61)(H,53,66)(H,54,63)(H,55,60)(H,56,62)(H,57,64)(H,58,65)/t29-,30-,38?,39-,40+,41+,42+/m0/s1
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n/an/a 88n/an/an/an/an/an/a



Institute of Science

Curated by ChEMBL


Assay Description
Concentration of the peptide which displaces 50% of 125 I-[D-Lys6] gonadotropin-releasing hormone bound to rat pituitary membranes

J Med Chem 43: 2831-6 (2000)


BindingDB Entry DOI: 10.7270/Q29P30W3
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50090738
PNG
(Ac-D-Nal2-D-Cpa-D-Pal-Pro-Arg-Pro-D-Ala-NH2 | CHEM...)
Show SMILES C[C@H](NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@H]1CCCN1C(=O)[C@@H](Cc1ccccn1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(C)=O)C(N)=O
Show InChI InChI=1S/C51H63ClN12O8/c1-30(44(53)66)58-47(69)42-14-8-24-63(42)49(71)38(13-7-23-57-51(54)55)60-48(70)43-15-9-25-64(43)50(72)41(29-37-12-5-6-22-56-37)62-46(68)40(27-32-17-20-36(52)21-18-32)61-45(67)39(59-31(2)65)28-33-16-19-34-10-3-4-11-35(34)26-33/h3-6,10-12,16-22,26,30,38-43H,7-9,13-15,23-25,27-29H2,1-2H3,(H2,53,66)(H,58,69)(H,59,65)(H,60,70)(H,61,67)(H,62,68)(H4,54,55,57)/t30-,38+,39-,40+,41+,42+,43+/m0/s1
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n/an/a 110n/an/an/an/an/an/a



Institute of Science

Curated by ChEMBL


Assay Description
Concentration of the peptide which displaces 50% of 125 I-[D-Lys6] gonadotropin-releasing hormone bound to rat pituitary membranes

J Med Chem 43: 2831-6 (2000)


BindingDB Entry DOI: 10.7270/Q29P30W3
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50090743
PNG
(1-[2-(2-{2-[2-(2-Acetylamino-3-naphthalen-2-yl-pro...)
Show SMILES CC(C)NCCCC[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](Cc1ccccn1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](C)C(N)=O
Show InChI InChI=1S/C52H67ClN10O8/c1-31(2)55-24-11-9-16-41(52(71)63-26-12-17-45(63)51(70)57-32(3)46(54)65)60-47(66)33(4)58-48(67)44(30-40-15-8-10-25-56-40)62-50(69)43(28-35-19-22-39(53)23-20-35)61-49(68)42(59-34(5)64)29-36-18-21-37-13-6-7-14-38(37)27-36/h6-8,10,13-15,18-23,25,27,31-33,41-45,55H,9,11-12,16-17,24,26,28-30H2,1-5H3,(H2,54,65)(H,57,70)(H,58,67)(H,59,64)(H,60,66)(H,61,68)(H,62,69)/t32-,33-,41+,42-,43+,44+,45+/m0/s1
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n/an/a 130n/an/an/an/an/an/a



Institute of Science

Curated by ChEMBL


Assay Description
Concentration of the peptide which displaces 50% of 125 I-[D-Lys6] gonadotropin-releasing hormone bound to rat pituitary membranes

J Med Chem 43: 2831-6 (2000)


BindingDB Entry DOI: 10.7270/Q29P30W3
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50090729
PNG
(1-(2-{2-[2-(2-Acetylamino-3-naphthalen-2-yl-propio...)
Show SMILES C[C@H](NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](Cc1ccccn1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(C)=O)C(N)=O
Show InChI InChI=1S/C46H56ClN11O7/c1-27(40(48)60)53-44(64)39-13-8-22-58(39)45(65)35(12-7-21-52-46(49)50)55-43(63)38(26-34-11-5-6-20-51-34)57-42(62)37(24-29-15-18-33(47)19-16-29)56-41(61)36(54-28(2)59)25-30-14-17-31-9-3-4-10-32(31)23-30/h3-6,9-11,14-20,23,27,35-39H,7-8,12-13,21-22,24-26H2,1-2H3,(H2,48,60)(H,53,64)(H,54,59)(H,55,63)(H,56,61)(H,57,62)(H4,49,50,52)/t27-,35+,36-,37+,38+,39+/m0/s1
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n/an/a 130n/an/an/an/an/an/a



Institute of Science

Curated by ChEMBL


Assay Description
Concentration of the peptide which displaces 50% of 125 I-[D-Lys6] gonadotropin-releasing hormone bound to rat pituitary membranes

J Med Chem 43: 2831-6 (2000)


BindingDB Entry DOI: 10.7270/Q29P30W3
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50090749
PNG
(1-[2-(2-{2-[2-(2-Acetylamino-3-naphthalen-2-yl-pro...)
Show SMILES C[C@H](NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(N)=N)NC(=O)c1ccccc1NC(=O)[C@@H](Cc1ccccn1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(C)=O)C(N)=O
Show InChI InChI=1S/C53H61ClN12O8/c1-31(46(55)68)60-51(73)45-17-10-26-66(45)52(74)41(16-9-25-59-53(56)57)63-47(69)39-14-5-6-15-40(39)62-50(72)44(30-38-13-7-8-24-58-38)65-49(71)43(28-33-19-22-37(54)23-20-33)64-48(70)42(61-32(2)67)29-34-18-21-35-11-3-4-12-36(35)27-34/h3-8,11-15,18-24,27,31,41-45H,9-10,16-17,25-26,28-30H2,1-2H3,(H2,55,68)(H,60,73)(H,61,67)(H,62,72)(H,63,69)(H,64,70)(H,65,71)(H4,56,57,59)/t31-,41+,42-,43+,44+,45+/m0/s1
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n/an/a 140n/an/an/an/an/an/a



Institute of Science

Curated by ChEMBL


Assay Description
Concentration of the peptide which displaces 50% of 125 I-[D-Lys6] gonadotropin-releasing hormone bound to rat pituitary membranes

J Med Chem 43: 2831-6 (2000)


BindingDB Entry DOI: 10.7270/Q29P30W3
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50090751
PNG
(1-[2-(2-{2-[2-(2-Acetylamino-3-phenyl-propionylami...)
Show SMILES C[C@H](NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(N)=O
Show InChI InChI=1S/C45H59N11O8/c1-28(39(46)59)51-43(63)37-21-13-23-56(37)44(64)33(20-12-22-49-45(47)48)53-38(58)27-50-40(60)34(24-30-14-6-3-7-15-30)54-42(62)36(26-32-18-10-5-11-19-32)55-41(61)35(52-29(2)57)25-31-16-8-4-9-17-31/h3-11,14-19,28,33-37H,12-13,20-27H2,1-2H3,(H2,46,59)(H,50,60)(H,51,63)(H,52,57)(H,53,58)(H,54,62)(H,55,61)(H4,47,48,49)/t28-,33+,34+,35-,36+,37+/m0/s1
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n/an/a 230n/an/an/an/an/an/a



Institute of Science

Curated by ChEMBL


Assay Description
Concentration of the peptide which displaces 50% of 125 I-[D-Lys6] gonadotropin-releasing hormone bound to rat pituitary membranes

J Med Chem 43: 2831-6 (2000)


BindingDB Entry DOI: 10.7270/Q29P30W3
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50090753
PNG
(1-[2-(2-{2-[2-(2-Amino-3-naphthalen-2-yl-propionyl...)
Show SMILES C[C@H](NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc2ccccc2c1)C(N)=O
Show InChI InChI=1S/C47H59N11O7/c1-29(41(49)60)54-45(64)39-19-11-23-58(39)46(65)36(18-10-22-52-47(50)51)55-40(59)28-53-43(62)37(26-30-12-4-2-5-13-30)57-44(63)38(27-31-14-6-3-7-15-31)56-42(61)35(48)25-32-20-21-33-16-8-9-17-34(33)24-32/h2-9,12-17,20-21,24,29,35-39H,10-11,18-19,22-23,25-28,48H2,1H3,(H2,49,60)(H,53,62)(H,54,64)(H,55,59)(H,56,61)(H,57,63)(H4,50,51,52)/t29-,35-,36+,37+,38+,39+/m0/s1
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n/an/a 280n/an/an/an/an/an/a



Institute of Science

Curated by ChEMBL


Assay Description
Concentration of the peptide which displaces 50% of 125 I-[D-Lys6] gonadotropin-releasing hormone bound to rat pituitary membranes

J Med Chem 43: 2831-6 (2000)


BindingDB Entry DOI: 10.7270/Q29P30W3
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50090735
PNG
(1-[2-(2-{2-[2-(2-Acetylamino-3-naphthalen-1-yl-pro...)
Show SMILES C[C@H](NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(C)=O)C(N)=O
Show InChI InChI=1S/C49H61N11O8/c1-30(43(50)63)55-47(67)41-23-13-25-60(41)48(68)37(22-12-24-53-49(51)52)57-42(62)29-54-44(64)38(26-32-14-5-3-6-15-32)58-45(65)39(27-33-16-7-4-8-17-33)59-46(66)40(56-31(2)61)28-35-20-11-19-34-18-9-10-21-36(34)35/h3-11,14-21,30,37-41H,12-13,22-29H2,1-2H3,(H2,50,63)(H,54,64)(H,55,67)(H,56,61)(H,57,62)(H,58,65)(H,59,66)(H4,51,52,53)/t30-,37+,38+,39+,40-,41+/m0/s1
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n/an/a 370n/an/an/an/an/an/a



Institute of Science

Curated by ChEMBL


Assay Description
Concentration of the peptide which displaces 50% of 125 I-[D-Lys6] gonadotropin-releasing hormone bound to rat pituitary membranes

J Med Chem 43: 2831-6 (2000)


BindingDB Entry DOI: 10.7270/Q29P30W3
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50090740
PNG
(1-{2-[2-(2-{2-[2-Acetylamino-3-(1H-indol-3-yl)-pro...)
Show SMILES C[C@H](NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O)C(N)=O
Show InChI InChI=1S/C47H60N12O8/c1-28(41(48)62)54-45(66)39-20-12-22-59(39)46(67)35(19-11-21-51-47(49)50)56-40(61)27-53-42(63)36(23-30-13-5-3-6-14-30)57-43(64)37(24-31-15-7-4-8-16-31)58-44(65)38(55-29(2)60)25-32-26-52-34-18-10-9-17-33(32)34/h3-10,13-18,26,28,35-39,52H,11-12,19-25,27H2,1-2H3,(H2,48,62)(H,53,63)(H,54,66)(H,55,60)(H,56,61)(H,57,64)(H,58,65)(H4,49,50,51)/t28-,35+,36+,37+,38-,39+/m0/s1
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n/an/a 450n/an/an/an/an/an/a



Institute of Science

Curated by ChEMBL


Assay Description
Concentration of the peptide which displaces 50% of 125 I-[D-Lys6] gonadotropin-releasing hormone bound to rat pituitary membranes

J Med Chem 43: 2831-6 (2000)


BindingDB Entry DOI: 10.7270/Q29P30W3
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50090742
PNG
(1-(2-{2-[2-(2-Acetylamino-3-naphthalen-2-yl-propio...)
Show SMILES C[C@H](NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCCN)NC(=O)[C@@H](Cc1ccccn1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(C)=O)C(N)=O
Show InChI InChI=1S/C46H56ClN9O7/c1-28(41(49)58)51-45(62)40-14-9-23-56(40)46(63)36(13-5-7-21-48)53-44(61)39(27-35-12-6-8-22-50-35)55-43(60)38(25-30-16-19-34(47)20-17-30)54-42(59)37(52-29(2)57)26-31-15-18-32-10-3-4-11-33(32)24-31/h3-4,6,8,10-12,15-20,22,24,28,36-40H,5,7,9,13-14,21,23,25-27,48H2,1-2H3,(H2,49,58)(H,51,62)(H,52,57)(H,53,61)(H,54,59)(H,55,60)/t28-,36+,37-,38+,39+,40+/m0/s1
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n/an/a 550n/an/an/an/an/an/a



Institute of Science

Curated by ChEMBL


Assay Description
Concentration of the peptide which displaces 50% of 125 I-[D-Lys6] gonadotropin-releasing hormone bound to rat pituitary membranes

J Med Chem 43: 2831-6 (2000)


BindingDB Entry DOI: 10.7270/Q29P30W3
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50090726
PNG
(1-(2-{2-[2-(2-Acetylamino-3-naphthalen-2-yl-propio...)
Show SMILES C[C@H](NC(=O)[C@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@@H](Cc1ccccn1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(C)=O)C(N)=O
Show InChI InChI=1S/C43H49ClN8O7/c1-25(38(45)54)47-42(58)37-12-8-20-52(37)43(59)26(2)48-39(55)36(24-33-11-6-7-19-46-33)51-41(57)35(22-28-14-17-32(44)18-15-28)50-40(56)34(49-27(3)53)23-29-13-16-30-9-4-5-10-31(30)21-29/h4-7,9-11,13-19,21,25-26,34-37H,8,12,20,22-24H2,1-3H3,(H2,45,54)(H,47,58)(H,48,55)(H,49,53)(H,50,56)(H,51,57)/t25-,26-,34-,35+,36+,37+/m0/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



Institute of Science

Curated by ChEMBL


Assay Description
Concentration of the peptide which displaces 50% of 125 I-[D-Lys6] gonadotropin-releasing hormone bound to rat pituitary membranes

J Med Chem 43: 2831-6 (2000)


BindingDB Entry DOI: 10.7270/Q29P30W3
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50090741
PNG
(CHEMBL409979 | [1-(1-{1-[({1-[2-(1-Carbamoyl-ethyl...)
Show SMILES C[C@H](NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)OCC1c2ccccc2-c2ccccc12)C(N)=O
Show InChI InChI=1S/C62H69N11O9/c1-38(55(63)75)68-59(79)53-27-15-31-73(53)60(80)49(26-14-30-66-61(64)65)69-54(74)36-67-56(76)50(33-39-16-4-2-5-17-39)70-57(77)51(34-40-18-6-3-7-19-40)71-58(78)52(35-41-28-29-42-20-8-9-21-43(42)32-41)72-62(81)82-37-48-46-24-12-10-22-44(46)45-23-11-13-25-47(45)48/h2-13,16-25,28-29,32,38,48-53H,14-15,26-27,30-31,33-37H2,1H3,(H2,63,75)(H,67,76)(H,68,79)(H,69,74)(H,70,77)(H,71,78)(H,72,81)(H4,64,65,66)/t38-,49+,50+,51+,52-,53+/m0/s1
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n/an/a 2.20E+3n/an/an/an/an/an/a



Institute of Science

Curated by ChEMBL


Assay Description
Concentration of the peptide which displaces 50% of 125 I-[D-Lys6] gonadotropin-releasing hormone bound to rat pituitary membranes

J Med Chem 43: 2831-6 (2000)


BindingDB Entry DOI: 10.7270/Q29P30W3
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%