Affinity Data by PubMed id=10987415

PubMed code 10987415

Found 18 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (Homo sapiens (Human))	BDBM50057479 (7-Bromo-9,10-dihydro-phenanthrene-2-carboxylic aci...) Show SMILES OC(=O)c1ccc-2c(CCc3cc(Br)ccc-23)c1 Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	26	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Canterbury Curated by ChEMBL					Assay Description In vitro inhibitory activity against Steroid 5-alpha-reductase type I				Bioorg Med Chem Lett 10: 1909-11 (2001) BindingDB Entry DOI: 10.7270/Q2M044PB
University of Canterbury Curated by ChEMBL					More data for this Ligand-Target Pair
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (Homo sapiens (Human))	BDBM50044879 ((4aR,10bR)-8-Chloro-4,10b-dimethyl-1,4,4a,5,6,10b-...) Show SMILES CN1[C@@H]2CCc3cc(Cl)ccc3[C@@]2(C)CCC1=O Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
University of Canterbury Curated by ChEMBL					Assay Description In vitro inhibitory activity against Steroid 5-alpha-reductase type I				Bioorg Med Chem Lett 10: 1909-11 (2001) BindingDB Entry DOI: 10.7270/Q2M044PB
University of Canterbury Curated by ChEMBL					More data for this Ligand-Target Pair
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (Homo sapiens (Human))	BDBM50070051 ((4aR,10bR)-4,10b-Dimethyl-8-((E)-styryl)-1,4,4a,5,...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
University of Canterbury Curated by ChEMBL					Assay Description In vitro inhibitory activity against Steroid 5-alpha-reductase type I				Bioorg Med Chem Lett 10: 1909-11 (2001) BindingDB Entry DOI: 10.7270/Q2M044PB
University of Canterbury Curated by ChEMBL					More data for this Ligand-Target Pair
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (Homo sapiens (Human))	BDBM50091707 (1-Methyl-5-[4-((E)-styryl)-phenyl]-piperidin-2-one...) Show SMILES CN1CC(CCC1=O)c1ccc(\C=C\c2ccccc2)cc1 Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	107	n/a	n/a	n/a	n/a	n/a	n/a
University of Canterbury Curated by ChEMBL					Assay Description In vitro inhibitory activity against Steroid 5-alpha-reductase type I				Bioorg Med Chem Lett 10: 1909-11 (2001) BindingDB Entry DOI: 10.7270/Q2M044PB
University of Canterbury Curated by ChEMBL					More data for this Ligand-Target Pair
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (Homo sapiens (Human))	BDBM50091704 ((R)-8-Chloro-4,10b-dimethyl-1,4,6,10b-tetrahydro-2...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
University of Canterbury Curated by ChEMBL					Assay Description In vitro inhibitory activity against Steroid 5-alpha-reductase type I				Bioorg Med Chem Lett 10: 1909-11 (2001) BindingDB Entry DOI: 10.7270/Q2M044PB
University of Canterbury Curated by ChEMBL					More data for this Ligand-Target Pair
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (Homo sapiens (Human))	BDBM50091706 (7-((E)-Styryl)-9,10-dihydro-phenanthrene-2-carboxy...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	152	n/a	n/a	n/a	n/a	n/a	n/a
University of Canterbury Curated by ChEMBL					Assay Description In vitro inhibitory activity against Steroid 5-alpha-reductase type I				Bioorg Med Chem Lett 10: 1909-11 (2001) BindingDB Entry DOI: 10.7270/Q2M044PB
University of Canterbury Curated by ChEMBL					More data for this Ligand-Target Pair
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (Homo sapiens (Human))	BDBM50070051 ((4aR,10bR)-4,10b-Dimethyl-8-((E)-styryl)-1,4,4a,5,...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
University of Canterbury Curated by ChEMBL					Assay Description Compound was evaluated in vitro for its inhibitory activity against Steroid 5-alpha-reductase type 2				Bioorg Med Chem Lett 10: 1909-11 (2001) BindingDB Entry DOI: 10.7270/Q2M044PB
University of Canterbury Curated by ChEMBL					More data for this Ligand-Target Pair
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (Homo sapiens (Human))	BDBM50091708 ((4aR,10bR)-8-Chloro-4,10b-dimethyl-1,4,4a,5,6,10b-...) Show SMILES CN1[C@@H]2CCc3cc(Cl)ccc3[C@@]2(C)CCC1=S Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	183	n/a	n/a	n/a	n/a	n/a	n/a
University of Canterbury Curated by ChEMBL					Assay Description In vitro inhibitory activity against Steroid 5-alpha-reductase type I				Bioorg Med Chem Lett 10: 1909-11 (2001) BindingDB Entry DOI: 10.7270/Q2M044PB
University of Canterbury Curated by ChEMBL					More data for this Ligand-Target Pair
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (Homo sapiens (Human))	BDBM50091710 (1-Methyl-5-(4-phenylazo-phenyl)-piperidin-2-one \| ...) Show SMILES CN1CC(CCC1=O)c1ccc(cc1)\N=N\c1ccccc1 Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	302	n/a	n/a	n/a	n/a	n/a	n/a
University of Canterbury Curated by ChEMBL					Assay Description In vitro inhibitory activity against Steroid 5-alpha-reductase type I				Bioorg Med Chem Lett 10: 1909-11 (2001) BindingDB Entry DOI: 10.7270/Q2M044PB
University of Canterbury Curated by ChEMBL					More data for this Ligand-Target Pair
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (Homo sapiens (Human))	BDBM50091706 (7-((E)-Styryl)-9,10-dihydro-phenanthrene-2-carboxy...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	340	n/a	n/a	n/a	n/a	n/a	n/a
University of Canterbury Curated by ChEMBL					Assay Description Compound was evaluated in vitro for its inhibitory activity against Steroid 5-alpha-reductase type 2				Bioorg Med Chem Lett 10: 1909-11 (2001) BindingDB Entry DOI: 10.7270/Q2M044PB
University of Canterbury Curated by ChEMBL					More data for this Ligand-Target Pair
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (Homo sapiens (Human))	BDBM50091705 ((R)-8-Chloro-4,10b-dimethyl-1,4,6,10b-tetrahydro-2...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	377	n/a	n/a	n/a	n/a	n/a	n/a
University of Canterbury Curated by ChEMBL					Assay Description In vitro inhibitory activity against Steroid 5-alpha-reductase type I				Bioorg Med Chem Lett 10: 1909-11 (2001) BindingDB Entry DOI: 10.7270/Q2M044PB
University of Canterbury Curated by ChEMBL					More data for this Ligand-Target Pair
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (Homo sapiens (Human))	BDBM50044876 ((4aR,10bR)-4-Methyl-1,4,4a,5,6,10b-hexahydro-2H-be...) Show SMILES CN1[C@@H]2CCc3ccccc3[C@H]2CCC1=O Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	560	n/a	n/a	n/a	n/a	n/a	n/a
University of Canterbury Curated by ChEMBL					Assay Description In vitro inhibitory activity against Steroid 5-alpha-reductase type I				Bioorg Med Chem Lett 10: 1909-11 (2001) BindingDB Entry DOI: 10.7270/Q2M044PB
University of Canterbury Curated by ChEMBL					More data for this Ligand-Target Pair
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (Homo sapiens (Human))	BDBM50091710 (1-Methyl-5-(4-phenylazo-phenyl)-piperidin-2-one \| ...) Show SMILES CN1CC(CCC1=O)c1ccc(cc1)\N=N\c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	579	n/a	n/a	n/a	n/a	n/a	n/a
University of Canterbury Curated by ChEMBL					Assay Description Compound was evaluated in vitro for its inhibitory activity against Steroid 5-alpha-reductase type 2				Bioorg Med Chem Lett 10: 1909-11 (2001) BindingDB Entry DOI: 10.7270/Q2M044PB
University of Canterbury Curated by ChEMBL					More data for this Ligand-Target Pair
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (Homo sapiens (Human))	BDBM50091707 (1-Methyl-5-[4-((E)-styryl)-phenyl]-piperidin-2-one...) Show SMILES CN1CC(CCC1=O)c1ccc(\C=C\c2ccccc2)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	617	n/a	n/a	n/a	n/a	n/a	n/a
University of Canterbury Curated by ChEMBL					Assay Description Compound was evaluated in vitro for its inhibitory activity against Steroid 5-alpha-reductase type 2				Bioorg Med Chem Lett 10: 1909-11 (2001) BindingDB Entry DOI: 10.7270/Q2M044PB
University of Canterbury Curated by ChEMBL					More data for this Ligand-Target Pair
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (Homo sapiens (Human))	BDBM50091703 ((4aR,10bR)-4-Methyl-1,4,4a,5,6,10b-hexahydro-2H-be...) Show SMILES CN1[C@@H]2CCc3ccccc3[C@H]2CCC1=S Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.45E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Canterbury Curated by ChEMBL					Assay Description In vitro inhibitory activity against Steroid 5-alpha-reductase type I				Bioorg Med Chem Lett 10: 1909-11 (2001) BindingDB Entry DOI: 10.7270/Q2M044PB
University of Canterbury Curated by ChEMBL					More data for this Ligand-Target Pair
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (Homo sapiens (Human))	BDBM50091709 (5-(4-Chloro-phenyl)-1-methyl-piperidin-2-one \| CHE...) Show SMILES CN1CC(CCC1=O)c1ccc(Cl)cc1 Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.69E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Canterbury Curated by ChEMBL					Assay Description In vitro inhibitory activity against Steroid 5-alpha-reductase type I				Bioorg Med Chem Lett 10: 1909-11 (2001) BindingDB Entry DOI: 10.7270/Q2M044PB
University of Canterbury Curated by ChEMBL					More data for this Ligand-Target Pair
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (Homo sapiens (Human))	BDBM50091702 (1-Methyl-5-phenyl-piperidin-2-one \| CHEMBL55261) Show SMILES CN1CC(CCC1=O)c1ccccc1 Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.48E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Canterbury Curated by ChEMBL					Assay Description In vitro inhibitory activity against Steroid 5-alpha-reductase type I				Bioorg Med Chem Lett 10: 1909-11 (2001) BindingDB Entry DOI: 10.7270/Q2M044PB
University of Canterbury Curated by ChEMBL					More data for this Ligand-Target Pair
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (Homo sapiens (Human))	BDBM50091711 (5-(4-Chloro-phenyl)-1-methyl-piperidine-2-thione \|...) Show SMILES CN1CC(CCC1=S)c1ccc(Cl)cc1 Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	3.36E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Canterbury Curated by ChEMBL					Assay Description In vitro inhibitory activity against Steroid 5-alpha-reductase type I				Bioorg Med Chem Lett 10: 1909-11 (2001) BindingDB Entry DOI: 10.7270/Q2M044PB
University of Canterbury Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%