Affinity Data by PubMed id=11300873

PubMed code 11300873

Found 8 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50098391 ((S)-4-(2-(azetidin-2-yl)ethoxy)-7-chloro-2-oxo-N-(...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.440	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro inhibition of binding of the compound to GnRH receptor in human				J Med Chem 44: 917-22 (2001) BindingDB Entry DOI: 10.7270/Q2H70F3D
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50098391 ((S)-4-(2-(azetidin-2-yl)ethoxy)-7-chloro-2-oxo-N-(...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro inhibition of gonadotropin-releasing hormone receptor in rhesus monkey				J Med Chem 44: 917-22 (2001) BindingDB Entry DOI: 10.7270/Q2H70F3D
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50098391 ((S)-4-(2-(azetidin-2-yl)ethoxy)-7-chloro-2-oxo-N-(...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Functional antagonism at the human GnRH receptor (PI turnover)				J Med Chem 44: 917-22 (2001) BindingDB Entry DOI: 10.7270/Q2H70F3D
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50098391 ((S)-4-(2-(azetidin-2-yl)ethoxy)-7-chloro-2-oxo-N-(...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro inhibition of binding of the compound to GnRH receptor in rat				J Med Chem 44: 917-22 (2001) BindingDB Entry DOI: 10.7270/Q2H70F3D
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50098391 ((S)-4-(2-(azetidin-2-yl)ethoxy)-7-chloro-2-oxo-N-(...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Functional antagonism at the rhesus monkey gonadotropin-releasing hormone receptor				J Med Chem 44: 917-22 (2001) BindingDB Entry DOI: 10.7270/Q2H70F3D
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50098391 ((S)-4-(2-(azetidin-2-yl)ethoxy)-7-chloro-2-oxo-N-(...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro inhibition of binding of the compound to gonadotropin-releasing hormone receptor in dog				J Med Chem 44: 917-22 (2001) BindingDB Entry DOI: 10.7270/Q2H70F3D
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50098391 ((S)-4-(2-(azetidin-2-yl)ethoxy)-7-chloro-2-oxo-N-(...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	81	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Functional antagonism at GnRH receptor in rat (PI turnover)				J Med Chem 44: 917-22 (2001) BindingDB Entry DOI: 10.7270/Q2H70F3D
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50098391 ((S)-4-(2-(azetidin-2-yl)ethoxy)-7-chloro-2-oxo-N-(...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Functional antagonism at gonadotropin-releasing hormone receptor in dog (PI turnover)				J Med Chem 44: 917-22 (2001) BindingDB Entry DOI: 10.7270/Q2H70F3D
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%