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PubMed code 11354377

Compile data set for download or QSAR
Found 8 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Growth factor receptor-bound protein 2


(Homo sapiens (Human))		BDBM50085874
PNG
(2-{4-[(S)-2-(1-{(S)-2-Carbamoyl-1-[3-(5-methyl-ind...)
Show SMILES Cc1ccc2n(CCCNC(=O)[C@H](CC(N)=O)NC(=O)C3(CCCCC3)NC(=O)[C@H](Cc3ccc(cc3)C(C(O)=O)C(O)=O)NC(=O)C(O)=O)ccc2c1
Show InChI InChI=1S/C37H44N6O11/c1-21-6-11-27-24(18-21)12-17-43(27)16-5-15-39-30(45)26(20-28(38)44)41-36(54)37(13-3-2-4-14-37)42-31(46)25(40-32(47)35(52)53)19-22-7-9-23(10-8-22)29(33(48)49)34(50)51/h6-12,17-18,25-26,29H,2-5,13-16,19-20H2,1H3,(H2,38,44)(H,39,45)(H,40,47)(H,41,54)(H,42,46)(H,48,49)(H,50,51)(H,52,53)/t25-,26-/m0/s1
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n/an/a 8n/an/an/an/an/an/a



NOVARTIS Pharma AG

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Src homology (SH2) domain of Growth factor receptor bound protein 2 by ELISA binding assay

Bioorg Med Chem Lett 11: 1201-3 (2001)


BindingDB Entry DOI: 10.7270/Q2G1603X
More data for this
Ligand-Target Pair
Growth factor receptor-bound protein 2


(Homo sapiens (Human))		BDBM50099450
PNG
(CHEMBL19378 | {4-[(S)-2-Acetylamino-2-(1-{(S)-2-ca...)
Show SMILES CC(=O)N[C@@H](Cc1ccc(CP(O)(O)=O)cc1)C(=O)NC1(CCCCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCc1ccc2cccc(O)c2c1
Show InChI InChI=1S/C36H46N5O9P/c1-23(42)39-29(20-25-10-12-26(13-11-25)22-51(48,49)50)34(46)41-36(16-3-2-4-17-36)35(47)40-30(21-32(37)44)33(45)38-18-6-7-24-14-15-27-8-5-9-31(43)28(27)19-24/h5,8-15,19,29-30,43H,2-4,6-7,16-18,20-22H2,1H3,(H2,37,44)(H,38,45)(H,39,42)(H,40,47)(H,41,46)(H2,48,49,50)/t29-,30-/m0/s1
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n/an/a 11n/an/an/an/an/an/a



NOVARTIS Pharma AG

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Src homology (SH2) domain of Growth factor receptor bound protein 2 by ELISA binding assay

Bioorg Med Chem Lett 11: 1201-3 (2001)


BindingDB Entry DOI: 10.7270/Q2G1603X
More data for this
Ligand-Target Pair
Growth factor receptor-bound protein 2


(Homo sapiens (Human))		BDBM50099448
PNG
(CHEMBL276300 | {4-[(S)-2-Acetylamino-2-(1-{(S)-2-c...)
Show SMILES CC(=O)N[C@@H](Cc1ccc(CP(O)(O)=O)cc1)C(=O)NC1(CCCCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCc1cccc2ccc(O)cc12
Show InChI InChI=1S/C36H46N5O9P/c1-23(42)39-30(19-24-10-12-25(13-11-24)22-51(48,49)50)34(46)41-36(16-3-2-4-17-36)35(47)40-31(21-32(37)44)33(45)38-18-6-9-26-7-5-8-27-14-15-28(43)20-29(26)27/h5,7-8,10-15,20,30-31,43H,2-4,6,9,16-19,21-22H2,1H3,(H2,37,44)(H,38,45)(H,39,42)(H,40,47)(H,41,46)(H2,48,49,50)/t30-,31-/m0/s1
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n/an/a 25n/an/an/an/an/an/a



NOVARTIS Pharma AG

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Src homology (SH2) domain of Growth factor receptor bound protein 2 by ELISA binding assay

Bioorg Med Chem Lett 11: 1201-3 (2001)


BindingDB Entry DOI: 10.7270/Q2G1603X
More data for this
Ligand-Target Pair
Growth factor receptor-bound protein 2


(Homo sapiens (Human))		BDBM50099452
PNG
(CGP-78850 | CHEMBL276046 | {4-[(S)-2-Acetylamino-2...)
Show SMILES CC(=O)N[C@@H](Cc1ccc(CP(O)(O)=O)cc1)C(=O)NC1(CCCCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCc1c(O)ccc2ccccc12
Show InChI InChI=1S/C36H46N5O9P/c1-23(42)39-29(20-24-11-13-25(14-12-24)22-51(48,49)50)34(46)41-36(17-5-2-6-18-36)35(47)40-30(21-32(37)44)33(45)38-19-7-10-28-27-9-4-3-8-26(27)15-16-31(28)43/h3-4,8-9,11-16,29-30,43H,2,5-7,10,17-22H2,1H3,(H2,37,44)(H,38,45)(H,39,42)(H,40,47)(H,41,46)(H2,48,49,50)/t29-,30-/m0/s1
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n/an/a 43n/an/an/an/an/an/a



NOVARTIS Pharma AG

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Src homology (SH2) domain of Growth factor receptor bound protein 2 by ELISA binding assay

Bioorg Med Chem Lett 11: 1201-3 (2001)


BindingDB Entry DOI: 10.7270/Q2G1603X
More data for this
Ligand-Target Pair
Growth factor receptor-bound protein 2


(Homo sapiens (Human))		BDBM50099447
PNG
(CHEMBL278567 | {4-[(S)-2-Acetylamino-2-(1-{(S)-2-c...)
Show SMILES CC(=O)N[C@@H](Cc1ccc(CP(O)(O)=O)cc1)C(=O)NC1(CCCCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCc1cccc2cc(O)ccc12
Show InChI InChI=1S/C36H46N5O9P/c1-23(42)39-30(19-24-10-12-25(13-11-24)22-51(48,49)50)34(46)41-36(16-3-2-4-17-36)35(47)40-31(21-32(37)44)33(45)38-18-6-9-26-7-5-8-27-20-28(43)14-15-29(26)27/h5,7-8,10-15,20,30-31,43H,2-4,6,9,16-19,21-22H2,1H3,(H2,37,44)(H,38,45)(H,39,42)(H,40,47)(H,41,46)(H2,48,49,50)/t30-,31-/m0/s1
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n/an/a 43n/an/an/an/an/an/a



NOVARTIS Pharma AG

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Src homology (SH2) domain of Growth factor receptor bound protein 2 by ELISA binding assay

Bioorg Med Chem Lett 11: 1201-3 (2001)


BindingDB Entry DOI: 10.7270/Q2G1603X
More data for this
Ligand-Target Pair
Growth factor receptor-bound protein 2


(Homo sapiens (Human))		BDBM50072861
PNG
(CHEMBL19417 | [(S)-4-(2-Acetylamino-2-{1-[2-carbam...)
Show SMILES CC(=O)N[C@@H](Cc1ccc(CP(O)(O)=O)cc1)C(=O)NC1(CCCCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCc1cccc2ccccc12
Show InChI InChI=1S/C36H46N5O8P/c1-24(42)39-30(21-25-14-16-26(17-15-25)23-50(47,48)49)34(45)41-36(18-5-2-6-19-36)35(46)40-31(22-32(37)43)33(44)38-20-8-12-28-11-7-10-27-9-3-4-13-29(27)28/h3-4,7,9-11,13-17,30-31H,2,5-6,8,12,18-23H2,1H3,(H2,37,43)(H,38,44)(H,39,42)(H,40,46)(H,41,45)(H2,47,48,49)/t30-,31-/m0/s1
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n/an/a 43n/an/an/an/an/an/a



NOVARTIS Pharma AG

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Src homology (SH2) domain of Growth factor receptor bound protein 2 by ELISA binding assay

Bioorg Med Chem Lett 11: 1201-3 (2001)


BindingDB Entry DOI: 10.7270/Q2G1603X
More data for this
Ligand-Target Pair
Growth factor receptor-bound protein 2


(Homo sapiens (Human))		BDBM50099451
PNG
(CHEMBL19214 | {4-[(S)-2-Acetylamino-2-(1-{(S)-2-ca...)
Show SMILES COc1cc2cccc(CCCNC(=O)[C@H](CC(N)=O)NC(=O)C3(CCCCC3)NC(=O)[C@H](Cc3ccc(CP(O)(O)=O)cc3)NC(C)=O)c2cc1OC
Show InChI InChI=1S/C38H50N5O10P/c1-24(44)41-30(19-25-12-14-26(15-13-25)23-54(49,50)51)36(47)43-38(16-5-4-6-17-38)37(48)42-31(22-34(39)45)35(46)40-18-8-11-27-9-7-10-28-20-32(52-2)33(53-3)21-29(27)28/h7,9-10,12-15,20-21,30-31H,4-6,8,11,16-19,22-23H2,1-3H3,(H2,39,45)(H,40,46)(H,41,44)(H,42,48)(H,43,47)(H2,49,50,51)/t30-,31-/m0/s1
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n/an/a 84n/an/an/an/an/an/a



NOVARTIS Pharma AG

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Src homology (SH2) domain of Growth factor receptor bound protein 2 by ELISA binding assay

Bioorg Med Chem Lett 11: 1201-3 (2001)


BindingDB Entry DOI: 10.7270/Q2G1603X
More data for this
Ligand-Target Pair
Growth factor receptor-bound protein 2


(Homo sapiens (Human))		BDBM50099449
PNG
(CHEMBL281577 | {4-[(S)-2-Acetylamino-2-(1-{(S)-2-c...)
Show SMILES COc1ccc2c(CCCNC(=O)[C@H](CC(N)=O)NC(=O)C3(CCCCC3)NC(=O)[C@H](Cc3ccc(CP(O)(O)=O)cc3)NC(C)=O)cccc2c1
Show InChI InChI=1S/C37H48N5O9P/c1-24(43)40-31(20-25-11-13-26(14-12-25)23-52(48,49)50)35(46)42-37(17-4-3-5-18-37)36(47)41-32(22-33(38)44)34(45)39-19-7-10-27-8-6-9-28-21-29(51-2)15-16-30(27)28/h6,8-9,11-16,21,31-32H,3-5,7,10,17-20,22-23H2,1-2H3,(H2,38,44)(H,39,45)(H,40,43)(H,41,47)(H,42,46)(H2,48,49,50)/t31-,32-/m0/s1
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n/an/a 130n/an/an/an/an/an/a



NOVARTIS Pharma AG

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Src homology (SH2) domain of Growth factor receptor bound protein 2 by ELISA binding assay

Bioorg Med Chem Lett 11: 1201-3 (2001)


BindingDB Entry DOI: 10.7270/Q2G1603X
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%