| Reaction Details |
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 | Report a problem with these data |
| Target | Growth factor receptor-bound protein 2 |
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| Ligand | BDBM50099451 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_72366 |
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| IC50 | 84±n/a nM |
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| Citation |  Schoepfer, J; Gay, B; End, N; Muller, E; Scheffel, G; Caravatti, G; Furet, P Convergent synthesis of potent peptide inhibitors of the Grb2-SH2 domain by palladium catalyzed coupling of a terminal alkyne. Bioorg Med Chem Lett11:1201-3 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Growth factor receptor-bound protein 2 |
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| Name: | Growth factor receptor-bound protein 2 |
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| Synonyms: | ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2 |
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| Type: | Protein |
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| Mol. Mass.: | 25205.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P62993 |
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| Residue: | 217 |
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| Sequence: | MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
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| BDBM50099451 |
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| n/a |
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| Name | BDBM50099451 |
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| Synonyms: | CHEMBL19214 | {4-[(S)-2-Acetylamino-2-(1-{(S)-2-carbamoyl-1-[3-(6,7-dimethoxy-naphthalen-1-yl)-propylcarbamoyl]-ethylcarbamoyl}-cyclohexylcarbamoyl)-ethyl]-benzyl}-phosphonic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C38H50N5O10P |
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| Mol. Mass. | 767.8049 |
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| SMILES | COc1cc2cccc(CCCNC(=O)[C@H](CC(N)=O)NC(=O)C3(CCCCC3)NC(=O)[C@H](Cc3ccc(CP(O)(O)=O)cc3)NC(C)=O)c2cc1OC |
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| Structure | 
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