Found 35 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat)) | BDBM50421506
(CHEMBL61861 | ORG-24598)Show SMILES CN(CC[C@@H](Oc1ccc(cc1)C(F)(F)F)c1ccccc1)CC([O-])=O Show InChI InChI=1S/C19H20F3NO3/c1-23(13-18(24)25)12-11-17(14-5-3-2-4-6-14)26-16-9-7-15(8-10-16)19(20,21)22/h2-10,17H,11-13H2,1H3,(H,24,25)/p-1/t17-/m1/s1 | PDB
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| <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Research and Development Group
Curated by ChEMBL
| Assay Description
Binding affinity of compound towards 5-hydroxytryptamine 1A receptor was determined |
Bioorg Med Chem Lett 11: 2007-9 (2001)
BindingDB Entry DOI: 10.7270/Q2X0687Q |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat)) | BDBM50421506
(CHEMBL61861 | ORG-24598)Show SMILES CN(CC[C@@H](Oc1ccc(cc1)C(F)(F)F)c1ccccc1)CC([O-])=O Show InChI InChI=1S/C19H20F3NO3/c1-23(13-18(24)25)12-11-17(14-5-3-2-4-6-14)26-16-9-7-15(8-10-16)19(20,21)22/h2-10,17H,11-13H2,1H3,(H,24,25)/p-1/t17-/m1/s1 | PDB
Reactome pathway
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| <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Research and Development Group
Curated by ChEMBL
| Assay Description
Binding affinity of compound towards serotonin 5-hydroxytryptamine 2A receptor was determined |
Bioorg Med Chem Lett 11: 2007-9 (2001)
BindingDB Entry DOI: 10.7270/Q2X0687Q |
More data for this
Ligand-Target Pair | |
D(4) dopamine receptor
(RAT) | BDBM50421506
(CHEMBL61861 | ORG-24598)Show SMILES CN(CC[C@@H](Oc1ccc(cc1)C(F)(F)F)c1ccccc1)CC([O-])=O Show InChI InChI=1S/C19H20F3NO3/c1-23(13-18(24)25)12-11-17(14-5-3-2-4-6-14)26-16-9-7-15(8-10-16)19(20,21)22/h2-10,17H,11-13H2,1H3,(H,24,25)/p-1/t17-/m1/s1 | Reactome pathway
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| <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Research and Development Group
Curated by ChEMBL
| Assay Description
Binding affinity of compound towards Dopamine receptor D4 was determined |
Bioorg Med Chem Lett 11: 2007-9 (2001)
BindingDB Entry DOI: 10.7270/Q2X0687Q |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Homo sapiens (Human)) | BDBM50421506
(CHEMBL61861 | ORG-24598)Show SMILES CN(CC[C@@H](Oc1ccc(cc1)C(F)(F)F)c1ccccc1)CC([O-])=O Show InChI InChI=1S/C19H20F3NO3/c1-23(13-18(24)25)12-11-17(14-5-3-2-4-6-14)26-16-9-7-15(8-10-16)19(20,21)22/h2-10,17H,11-13H2,1H3,(H,24,25)/p-1/t17-/m1/s1 | PDB
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| <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Research and Development Group
Curated by ChEMBL
| Assay Description
Binding affinity of compound towards Beta-1 adrenergic receptor was determined |
Bioorg Med Chem Lett 11: 2007-9 (2001)
BindingDB Entry DOI: 10.7270/Q2X0687Q |
More data for this
Ligand-Target Pair | |
Alpha-1B adrenergic receptor
(Homo sapiens (Human)) | BDBM50421506
(CHEMBL61861 | ORG-24598)Show SMILES CN(CC[C@@H](Oc1ccc(cc1)C(F)(F)F)c1ccccc1)CC([O-])=O Show InChI InChI=1S/C19H20F3NO3/c1-23(13-18(24)25)12-11-17(14-5-3-2-4-6-14)26-16-9-7-15(8-10-16)19(20,21)22/h2-10,17H,11-13H2,1H3,(H,24,25)/p-1/t17-/m1/s1 | UniProtKB/SwissProt
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| <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Research and Development Group
Curated by ChEMBL
| Assay Description
The compound was tested for the binding affinity towards Alpha-1B adrenergic receptor |
Bioorg Med Chem Lett 11: 2007-9 (2001)
BindingDB Entry DOI: 10.7270/Q2X0687Q |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat)) | BDBM50421506
(CHEMBL61861 | ORG-24598)Show SMILES CN(CC[C@@H](Oc1ccc(cc1)C(F)(F)F)c1ccccc1)CC([O-])=O Show InChI InChI=1S/C19H20F3NO3/c1-23(13-18(24)25)12-11-17(14-5-3-2-4-6-14)26-16-9-7-15(8-10-16)19(20,21)22/h2-10,17H,11-13H2,1H3,(H,24,25)/p-1/t17-/m1/s1 | PDB
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| <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Research and Development Group
Curated by ChEMBL
| Assay Description
Binding affinity of compound towards serotonin 5-hydroxytryptamine 7 receptor was determined |
Bioorg Med Chem Lett 11: 2007-9 (2001)
BindingDB Entry DOI: 10.7270/Q2X0687Q |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 2C
(Rattus norvegicus (Rat)) | BDBM50421506
(CHEMBL61861 | ORG-24598)Show SMILES CN(CC[C@@H](Oc1ccc(cc1)C(F)(F)F)c1ccccc1)CC([O-])=O Show InChI InChI=1S/C19H20F3NO3/c1-23(13-18(24)25)12-11-17(14-5-3-2-4-6-14)26-16-9-7-15(8-10-16)19(20,21)22/h2-10,17H,11-13H2,1H3,(H,24,25)/p-1/t17-/m1/s1 | PDB
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| <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Research and Development Group
Curated by ChEMBL
| Assay Description
Binding affinity of compound towards serotonin 5-hydroxytryptamine 2C receptor was determined |
Bioorg Med Chem Lett 11: 2007-9 (2001)
BindingDB Entry DOI: 10.7270/Q2X0687Q |
More data for this
Ligand-Target Pair | |
D(2) dopamine receptor
(Rattus norvegicus (rat)) | BDBM50421506
(CHEMBL61861 | ORG-24598)Show SMILES CN(CC[C@@H](Oc1ccc(cc1)C(F)(F)F)c1ccccc1)CC([O-])=O Show InChI InChI=1S/C19H20F3NO3/c1-23(13-18(24)25)12-11-17(14-5-3-2-4-6-14)26-16-9-7-15(8-10-16)19(20,21)22/h2-10,17H,11-13H2,1H3,(H,24,25)/p-1/t17-/m1/s1 | PDB
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Organon Research and Development Group
Curated by ChEMBL
| Assay Description
Binding affinity of compound towards Dopamine receptor D2S was determined |
Bioorg Med Chem Lett 11: 2007-9 (2001)
BindingDB Entry DOI: 10.7270/Q2X0687Q |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(RAT) | BDBM50421506
(CHEMBL61861 | ORG-24598)Show SMILES CN(CC[C@@H](Oc1ccc(cc1)C(F)(F)F)c1ccccc1)CC([O-])=O Show InChI InChI=1S/C19H20F3NO3/c1-23(13-18(24)25)12-11-17(14-5-3-2-4-6-14)26-16-9-7-15(8-10-16)19(20,21)22/h2-10,17H,11-13H2,1H3,(H,24,25)/p-1/t17-/m1/s1 | PDB
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| <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Research and Development Group
Curated by ChEMBL
| Assay Description
Binding affinity of compound towards serotonin 5-hydroxytryptamine 6 receptor was determined |
Bioorg Med Chem Lett 11: 2007-9 (2001)
BindingDB Entry DOI: 10.7270/Q2X0687Q |
More data for this
Ligand-Target Pair | |
Beta-2 adrenergic receptor
(Homo sapiens (Human)) | BDBM50421506
(CHEMBL61861 | ORG-24598)Show SMILES CN(CC[C@@H](Oc1ccc(cc1)C(F)(F)F)c1ccccc1)CC([O-])=O Show InChI InChI=1S/C19H20F3NO3/c1-23(13-18(24)25)12-11-17(14-5-3-2-4-6-14)26-16-9-7-15(8-10-16)19(20,21)22/h2-10,17H,11-13H2,1H3,(H,24,25)/p-1/t17-/m1/s1 | PDB
MMDB
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| <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Research and Development Group
Curated by ChEMBL
| Assay Description
Binding affinity of compound towards Beta-2 adrenergic receptor was determined |
Bioorg Med Chem Lett 11: 2007-9 (2001)
BindingDB Entry DOI: 10.7270/Q2X0687Q |
More data for this
Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Homo sapiens (Human)) | BDBM50421506
(CHEMBL61861 | ORG-24598)Show SMILES CN(CC[C@@H](Oc1ccc(cc1)C(F)(F)F)c1ccccc1)CC([O-])=O Show InChI InChI=1S/C19H20F3NO3/c1-23(13-18(24)25)12-11-17(14-5-3-2-4-6-14)26-16-9-7-15(8-10-16)19(20,21)22/h2-10,17H,11-13H2,1H3,(H,24,25)/p-1/t17-/m1/s1 | PDB
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| <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Research and Development Group
Curated by ChEMBL
| Assay Description
Binding affinity of compound towards Binding affinity towards Alpha-1A adrenergic receptor was determined |
Bioorg Med Chem Lett 11: 2007-9 (2001)
BindingDB Entry DOI: 10.7270/Q2X0687Q |
More data for this
Ligand-Target Pair | |
Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50421506
(CHEMBL61861 | ORG-24598)Show SMILES CN(CC[C@@H](Oc1ccc(cc1)C(F)(F)F)c1ccccc1)CC([O-])=O Show InChI InChI=1S/C19H20F3NO3/c1-23(13-18(24)25)12-11-17(14-5-3-2-4-6-14)26-16-9-7-15(8-10-16)19(20,21)22/h2-10,17H,11-13H2,1H3,(H,24,25)/p-1/t17-/m1/s1 | PDB
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| <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Research and Development Group
Curated by ChEMBL
| Assay Description
Binding affinity of compound towards Alpha-2C adrenergic receptor was determined |
Bioorg Med Chem Lett 11: 2007-9 (2001)
BindingDB Entry DOI: 10.7270/Q2X0687Q |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50421498
(CHEMBL59858 | ORG-24669)Show SMILES CN(CCC(Oc1ccc(cc1)C(F)(F)F)c1ccc(Cl)cc1)CC([O-])=O Show InChI InChI=1S/C19H19ClF3NO3/c1-24(12-18(25)26)11-10-17(13-2-6-15(20)7-3-13)27-16-8-4-14(5-9-16)19(21,22)23/h2-9,17H,10-12H2,1H3,(H,25,26)/p-1 | PDB
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| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Research and Development Group
Curated by ChEMBL
| Assay Description
Inhibition of [3H]glycine uptake using CHO cells transfected with GlyT-1b transporter |
Bioorg Med Chem Lett 11: 2007-9 (2001)
BindingDB Entry DOI: 10.7270/Q2X0687Q |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50421506
(CHEMBL61861 | ORG-24598)Show SMILES CN(CC[C@@H](Oc1ccc(cc1)C(F)(F)F)c1ccccc1)CC([O-])=O Show InChI InChI=1S/C19H20F3NO3/c1-23(13-18(24)25)12-11-17(14-5-3-2-4-6-14)26-16-9-7-15(8-10-16)19(20,21)22/h2-10,17H,11-13H2,1H3,(H,24,25)/p-1/t17-/m1/s1 | PDB
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| n/a | n/a | 126 | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Research and Development Group
Curated by ChEMBL
| Assay Description
Inhibition of [3H]glycine uptake using CHO cells transfected with GlyT-1b transporter |
Bioorg Med Chem Lett 11: 2007-9 (2001)
BindingDB Entry DOI: 10.7270/Q2X0687Q |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50421509
(CHEMBL58459 | ORG-24915)Show SMILES CN(CC[C@@H](Oc1ccc(cc1)-c1ccccc1)c1ccccc1)CC([O-])=O Show InChI InChI=1S/C24H25NO3/c1-25(18-24(26)27)17-16-23(21-10-6-3-7-11-21)28-22-14-12-20(13-15-22)19-8-4-2-5-9-19/h2-15,23H,16-18H2,1H3,(H,26,27)/p-1/t23-/m1/s1 | PDB
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| n/a | n/a | 151 | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Research and Development Group
Curated by ChEMBL
| Assay Description
Inhibition of [3H]glycine uptake using CHO cells transfected with GlyT-1b transporter |
Bioorg Med Chem Lett 11: 2007-9 (2001)
BindingDB Entry DOI: 10.7270/Q2X0687Q |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50421499
(CHEMBL302908 | ORG-24645)Show SMILES CN(CCC(Oc1ccc(cc1)C(F)(F)F)c1ccc(F)cc1)CC([O-])=O Show InChI InChI=1S/C19H19F4NO3/c1-24(12-18(25)26)11-10-17(13-2-6-15(20)7-3-13)27-16-8-4-14(5-9-16)19(21,22)23/h2-9,17H,10-12H2,1H3,(H,25,26)/p-1 | PDB
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Organon Research and Development Group
Curated by ChEMBL
| Assay Description
Inhibition of [3H]glycine uptake using CHO cells transfected with GlyT-1b transporter |
Bioorg Med Chem Lett 11: 2007-9 (2001)
BindingDB Entry DOI: 10.7270/Q2X0687Q |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50421489
(CHEMBL59821 | ORG-24461)Show SMILES CN(CCC(Oc1ccc(cc1)C(F)(F)F)c1ccccc1)CC([O-])=O Show InChI InChI=1S/C19H20F3NO3/c1-23(13-18(24)25)12-11-17(14-5-3-2-4-6-14)26-16-9-7-15(8-10-16)19(20,21)22/h2-10,17H,11-13H2,1H3,(H,24,25)/p-1 | PDB
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| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Research and Development Group
Curated by ChEMBL
| Assay Description
Inhibition of [3H]glycine uptake using CHO cells transfected with GlyT-1b transporter |
Bioorg Med Chem Lett 11: 2007-9 (2001)
BindingDB Entry DOI: 10.7270/Q2X0687Q |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50421497
(CHEMBL64750 | ORG-24658)Show SMILES CN(CCC(Oc1ccc(Cl)c(c1)C(F)(F)F)c1ccccc1)CC([O-])=O Show InChI InChI=1S/C19H19ClF3NO3/c1-24(12-18(25)26)10-9-17(13-5-3-2-4-6-13)27-14-7-8-16(20)15(11-14)19(21,22)23/h2-8,11,17H,9-10,12H2,1H3,(H,25,26)/p-1 | PDB
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| n/a | n/a | 398 | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Research and Development Group
Curated by ChEMBL
| Assay Description
Inhibition of [3H]glycine uptake using CHO cells transfected with GlyT-1b transporter |
Bioorg Med Chem Lett 11: 2007-9 (2001)
BindingDB Entry DOI: 10.7270/Q2X0687Q |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50421502
(CHEMBL61860 | ORG-24835)Show SMILES CN(CC[C@@H](Oc1ccc(cc1)C(C)(C)C)c1ccccc1)CC([O-])=O Show InChI InChI=1S/C22H29NO3/c1-22(2,3)18-10-12-19(13-11-18)26-20(17-8-6-5-7-9-17)14-15-23(4)16-21(24)25/h5-13,20H,14-16H2,1-4H3,(H,24,25)/p-1/t20-/m1/s1 | PDB
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| n/a | n/a | 447 | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Research and Development Group
Curated by ChEMBL
| Assay Description
Inhibition of [3H]glycine uptake using CHO cells transfected with GlyT-1b transporter |
Bioorg Med Chem Lett 11: 2007-9 (2001)
BindingDB Entry DOI: 10.7270/Q2X0687Q |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50421495
(CHEMBL60441 | ORG-24706)Show SMILES COc1ccc(cc1)C(CCN(C)CC([O-])=O)Oc1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C20H22F3NO4/c1-24(13-19(25)26)12-11-18(14-3-7-16(27-2)8-4-14)28-17-9-5-15(6-10-17)20(21,22)23/h3-10,18H,11-13H2,1-2H3,(H,25,26)/p-1 | PDB
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Organon Research and Development Group
Curated by ChEMBL
| Assay Description
Inhibition of [3H]glycine uptake using CHO cells transfected with GlyT-1b transporter |
Bioorg Med Chem Lett 11: 2007-9 (2001)
BindingDB Entry DOI: 10.7270/Q2X0687Q |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50421491
(CHEMBL60445 | ORG-24668)Show SMILES CN(CCC(Oc1ccc(Cl)c(Cl)c1)c1ccccc1)CC([O-])=O Show InChI InChI=1S/C18H19Cl2NO3/c1-21(12-18(22)23)10-9-17(13-5-3-2-4-6-13)24-14-7-8-15(19)16(20)11-14/h2-8,11,17H,9-10,12H2,1H3,(H,22,23)/p-1 | PDB
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Organon Research and Development Group
Curated by ChEMBL
| Assay Description
Inhibition of [3H]glycine uptake using CHO cells transfected with GlyT-1b transporter |
Bioorg Med Chem Lett 11: 2007-9 (2001)
BindingDB Entry DOI: 10.7270/Q2X0687Q |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50421500
(CHEMBL62571 | ORG-24914)Show SMILES CN(CC[C@H](Oc1ccc(cc1)-c1ccccc1)c1ccccc1)CC([O-])=O Show InChI InChI=1S/C24H25NO3/c1-25(18-24(26)27)17-16-23(21-10-6-3-7-11-21)28-22-14-12-20(13-15-22)19-8-4-2-5-9-19/h2-15,23H,16-18H2,1H3,(H,26,27)/p-1/t23-/m0/s1 | PDB
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Organon Research and Development Group
Curated by ChEMBL
| Assay Description
Inhibition of [3H]glycine uptake using CHO cells transfected with GlyT-1b transporter |
Bioorg Med Chem Lett 11: 2007-9 (2001)
BindingDB Entry DOI: 10.7270/Q2X0687Q |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50421490
(CHEMBL64154 | ORG-24750)Show SMILES CN(CCC(Cc1ccc(cc1)C(F)(F)F)c1ccccc1)CC([O-])=O Show InChI InChI=1S/C20H22F3NO2/c1-24(14-19(25)26)12-11-17(16-5-3-2-4-6-16)13-15-7-9-18(10-8-15)20(21,22)23/h2-10,17H,11-14H2,1H3,(H,25,26)/p-1 | PDB
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Organon Research and Development Group
Curated by ChEMBL
| Assay Description
Inhibition of [3H]glycine uptake using CHO cells transfected with GlyT-1b transporter |
Bioorg Med Chem Lett 11: 2007-9 (2001)
BindingDB Entry DOI: 10.7270/Q2X0687Q |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50421503
(CHEMBL64451 | ORG-24667)Show InChI InChI=1S/C18H20ClNO3/c1-20(13-18(21)22)12-11-17(14-5-3-2-4-6-14)23-16-9-7-15(19)8-10-16/h2-10,17H,11-13H2,1H3,(H,21,22)/p-1 | PDB
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| n/a | n/a | 1.26E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Research and Development Group
Curated by ChEMBL
| Assay Description
Inhibition of [3H]glycine uptake using CHO cells transfected with GlyT-1b transporter |
Bioorg Med Chem Lett 11: 2007-9 (2001)
BindingDB Entry DOI: 10.7270/Q2X0687Q |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50421501
(CHEMBL304470 | ORG-24642)Show InChI InChI=1S/C19H23NO3/c1-15-8-10-17(11-9-15)23-18(16-6-4-3-5-7-16)12-13-20(2)14-19(21)22/h3-11,18H,12-14H2,1-2H3,(H,21,22)/p-1 | PDB
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| n/a | n/a | 2.51E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Research and Development Group
Curated by ChEMBL
| Assay Description
Inhibition of [3H]glycine uptake using CHO cells transfected with GlyT-1b transporter |
Bioorg Med Chem Lett 11: 2007-9 (2001)
BindingDB Entry DOI: 10.7270/Q2X0687Q |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50421504
(CHEMBL408571 | ORG-24747)Show SMILES CN(CCC(Oc1cccc(c1)C(F)(F)F)c1ccccc1)CC([O-])=O Show InChI InChI=1S/C19H20F3NO3/c1-23(13-18(24)25)11-10-17(14-6-3-2-4-7-14)26-16-9-5-8-15(12-16)19(20,21)22/h2-9,12,17H,10-11,13H2,1H3,(H,24,25)/p-1 | PDB
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| n/a | n/a | 2.51E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Research and Development Group
Curated by ChEMBL
| Assay Description
Inhibition of [3H]glycine uptake using CHO cells transfected with GlyT-1b transporter |
Bioorg Med Chem Lett 11: 2007-9 (2001)
BindingDB Entry DOI: 10.7270/Q2X0687Q |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50421492
(CHEMBL64272 | ORG-24597)Show SMILES CN(CC[C@H](Oc1ccc(cc1)C(F)(F)F)c1ccccc1)CC([O-])=O Show InChI InChI=1S/C19H20F3NO3/c1-23(13-18(24)25)12-11-17(14-5-3-2-4-6-14)26-16-9-7-15(8-10-16)19(20,21)22/h2-10,17H,11-13H2,1H3,(H,24,25)/p-1/t17-/m0/s1 | PDB
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| n/a | n/a | 2.63E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Research and Development Group
Curated by ChEMBL
| Assay Description
Inhibition of [3H]glycine uptake using CHO cells transfected with GlyT-1b transporter |
Bioorg Med Chem Lett 11: 2007-9 (2001)
BindingDB Entry DOI: 10.7270/Q2X0687Q |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50421505
(CHEMBL60948 | ORG-24641)Show InChI InChI=1S/C19H23NO4/c1-20(14-19(21)22)13-12-18(15-6-4-3-5-7-15)24-17-10-8-16(23-2)9-11-17/h3-11,18H,12-14H2,1-2H3,(H,21,22)/p-1 | PDB
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| n/a | n/a | 3.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Research and Development Group
Curated by ChEMBL
| Assay Description
Inhibition of [3H]glycine uptake using CHO cells transfected with GlyT-1b transporter |
Bioorg Med Chem Lett 11: 2007-9 (2001)
BindingDB Entry DOI: 10.7270/Q2X0687Q |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50421496
(CHEMBL64717 | ORG-24660)Show SMILES CCN(CCC(Oc1ccc(cc1)C(F)(F)F)c1ccccc1)CC([O-])=O Show InChI InChI=1S/C20H22F3NO3/c1-2-24(14-19(25)26)13-12-18(15-6-4-3-5-7-15)27-17-10-8-16(9-11-17)20(21,22)23/h3-11,18H,2,12-14H2,1H3,(H,25,26)/p-1 | PDB
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| n/a | n/a | 5.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Research and Development Group
Curated by ChEMBL
| Assay Description
Inhibition of [3H]glycine uptake using CHO cells transfected with GlyT-1b transporter |
Bioorg Med Chem Lett 11: 2007-9 (2001)
BindingDB Entry DOI: 10.7270/Q2X0687Q |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50421508
(CHEMBL61270 | ORG-24836)Show SMILES CN(CC[C@H](Oc1ccc(cc1)C(C)(C)C)c1ccccc1)CC([O-])=O Show InChI InChI=1S/C22H29NO3/c1-22(2,3)18-10-12-19(13-11-18)26-20(17-8-6-5-7-9-17)14-15-23(4)16-21(24)25/h5-13,20H,14-16H2,1-4H3,(H,24,25)/p-1/t20-/m0/s1 | PDB
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| n/a | n/a | 1.17E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Research and Development Group
Curated by ChEMBL
| Assay Description
Inhibition of [3H]glycine uptake using CHO cells transfected with GlyT-1b transporter |
Bioorg Med Chem Lett 11: 2007-9 (2001)
BindingDB Entry DOI: 10.7270/Q2X0687Q |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50421494
(CHEMBL293691 | ORG-24730)Show InChI InChI=1S/C18H20ClNO3/c1-20(13-18(21)22)12-11-16(14-7-3-2-4-8-14)23-17-10-6-5-9-15(17)19/h2-10,16H,11-13H2,1H3,(H,21,22)/p-1 | PDB
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| n/a | n/a | 1.26E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Research and Development Group
Curated by ChEMBL
| Assay Description
Inhibition of [3H]glycine uptake using CHO cells transfected with GlyT-1b transporter |
Bioorg Med Chem Lett 11: 2007-9 (2001)
BindingDB Entry DOI: 10.7270/Q2X0687Q |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50421493
(CHEMBL64234 | ORG-24520)Show InChI InChI=1S/C19H23NO4/c1-20(14-19(21)22)13-12-16(15-8-4-3-5-9-15)24-18-11-7-6-10-17(18)23-2/h3-11,16H,12-14H2,1-2H3,(H,21,22)/p-1 | PDB
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| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Research and Development Group
Curated by ChEMBL
| Assay Description
Inhibition of [3H]glycine uptake using CHO cells transfected with GlyT-1b transporter |
Bioorg Med Chem Lett 11: 2007-9 (2001)
BindingDB Entry DOI: 10.7270/Q2X0687Q |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50421507
(CHEMBL64028 | ORG-24629)Show SMILES CN(CCC(Oc1ccc(cc1)C(F)(F)F)c1ccccc1)CCC([O-])=O Show InChI InChI=1S/C20H22F3NO3/c1-24(14-12-19(25)26)13-11-18(15-5-3-2-4-6-15)27-17-9-7-16(8-10-17)20(21,22)23/h2-10,18H,11-14H2,1H3,(H,25,26)/p-1 | PDB
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| n/a | n/a | 3.16E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Research and Development Group
Curated by ChEMBL
| Assay Description
Inhibition of [3H]glycine uptake using CHO cells transfected with GlyT-1b transporter |
Bioorg Med Chem Lett 11: 2007-9 (2001)
BindingDB Entry DOI: 10.7270/Q2X0687Q |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50403865
(CHEMBL64102 | ORG-24628)Show SMILES CN(CCCC([O-])=O)CCC(Oc1ccc(cc1)C(F)(F)F)c1ccccc1 Show InChI InChI=1S/C21H24F3NO3/c1-25(14-5-8-20(26)27)15-13-19(16-6-3-2-4-7-16)28-18-11-9-17(10-12-18)21(22,23)24/h2-4,6-7,9-12,19H,5,8,13-15H2,1H3,(H,26,27)/p-1 | PDB
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| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Research and Development Group
Curated by ChEMBL
| Assay Description
Inhibition of [3H]glycine uptake using CHO cells transfected with GlyT-1b transporter |
Bioorg Med Chem Lett 11: 2007-9 (2001)
BindingDB Entry DOI: 10.7270/Q2X0687Q |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50403866
(CHEMBL60614 | ORG-24872)Show SMILES CN(CCC(Oc1ccc(cc1)S(C)(=O)=O)c1ccccc1)CC([O-])=O Show InChI InChI=1S/C19H23NO5S/c1-20(14-19(21)22)13-12-18(15-6-4-3-5-7-15)25-16-8-10-17(11-9-16)26(2,23)24/h3-11,18H,12-14H2,1-2H3,(H,21,22)/p-1 | PDB
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| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Research and Development Group
Curated by ChEMBL
| Assay Description
Inhibition of [3H]glycine uptake using CHO cells transfected with GlyT-1b transporter |
Bioorg Med Chem Lett 11: 2007-9 (2001)
BindingDB Entry DOI: 10.7270/Q2X0687Q |
More data for this
Ligand-Target Pair | |
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