| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium- and chloride-dependent glycine transporter 1 |
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| Ligand | BDBM50421509 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_72765 |
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| IC50 | 151±n/a nM |
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| Citation |  Brown, A; Carlyle, I; Clark, J; Hamilton, W; Gibson, S; McGarry, G; McEachen, S; Rae, D; Thorn, S; Walker, G Discovery and SAR of org 24598-a selective glycine uptake inhibitor. Bioorg Med Chem Lett11:2007-9 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium- and chloride-dependent glycine transporter 1 |
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| Name: | Sodium- and chloride-dependent glycine transporter 1 |
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| Synonyms: | GlyT-1 | GlyT1 | Glycine Transporters (GlyT1c) | Glycine transporter 1 | SC6A9_HUMAN | SLC6A9 | Sodium- and chloride-dependent glycine transporter 1 | Sodium- and chloride-dependent glycine transporter 1 (GlyT1) | Sodium- and chloride-dependent glycine transporter 1 (GlyT1c) | Sodium-and chloride-dependent glycine transporter 1 (GlyT-1c) | Solute carrier family 6 member 9 |
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| Type: | Enzyme |
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| Mol. Mass.: | 78270.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P48067 |
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| Residue: | 706 |
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| Sequence: | MSGGDTRAAIARPRMAAAHGPVAPSSPEQVTLLPVQRSFFLPPFSGATPSTSLAESVLKV
WHGAYNSGLLPQLMAQHSLAMAQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGL
GNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKG
VGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTN
GSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLV
VFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKV
WGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGF
MANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETL
VTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVIS
CIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITY
NHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLE
HRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI
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| BDBM50421509 |
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| n/a |
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| Name | BDBM50421509 |
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| Synonyms: | CHEMBL58459 | ORG-24915 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H24NO3 |
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| Mol. Mass. | 374.4528 |
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| SMILES | CN(CC[C@@H](Oc1ccc(cc1)-c1ccccc1)c1ccccc1)CC([O-])=O |
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| Structure | 
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