Affinity Data by PubMed id=11708905

PubMed code 11708905

Found 20 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
5-hydroxytryptamine receptor 1F (Homo sapiens (Human))	BDBM50106483 (4-Fluoro-N-[3-(1-methyl-piperidin-4-yl)-1H-indol-4...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards human 5-hydroxytryptamine 1F receptor				J Med Chem 44: 4031-4 (2001) BindingDB Entry DOI: 10.7270/Q22Z168B
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1F (Homo sapiens (Human))	BDBM50106484 (CHEMBL421287 \| N-[3-(2-Dimethylamino-ethyl)-1H-ind...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	3.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards human 5-hydroxytryptamine 1F receptor				J Med Chem 44: 4031-4 (2001) BindingDB Entry DOI: 10.7270/Q22Z168B
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1F (Homo sapiens (Human))	BDBM50106482 (CHEMBL339980 \| N-[3-(2-Dimethylamino-ethyl)-2-meth...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	8.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards human 5-hydroxytryptamine 1F receptor using [3H]-5-HT radioligand				J Med Chem 44: 4031-4 (2001) BindingDB Entry DOI: 10.7270/Q22Z168B
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1F (Homo sapiens (Human))	BDBM50005835 ((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...) Show SMILES CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents	DrugBank PubMed	25.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards human 5-hydroxytryptamine 1F receptor was determined				J Med Chem 44: 4031-4 (2001) BindingDB Entry DOI: 10.7270/Q22Z168B
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50106482 (CHEMBL339980 \| N-[3-(2-Dimethylamino-ethyl)-2-meth...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	265	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards human 5-hydroxytryptamine 1A receptor was determined using [3H]-5-HT as radioligand				J Med Chem 44: 4031-4 (2001) BindingDB Entry DOI: 10.7270/Q22Z168B
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 4 (Homo sapiens (Human))	BDBM50106482 (CHEMBL339980 \| N-[3-(2-Dimethylamino-ethyl)-2-meth...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	380	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards human 5-hydroxytryptamine 4 receptor using [3H]5-HT as radioligand				J Med Chem 44: 4031-4 (2001) BindingDB Entry DOI: 10.7270/Q22Z168B
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50106482 (CHEMBL339980 \| N-[3-(2-Dimethylamino-ethyl)-2-meth...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	676	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards human 5-hydroxytryptamine 2B receptor using [3H]5-HT as radioligand				J Med Chem 44: 4031-4 (2001) BindingDB Entry DOI: 10.7270/Q22Z168B
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50106482 (CHEMBL339980 \| N-[3-(2-Dimethylamino-ethyl)-2-meth...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards human 5-hydroxytryptamine 2A receptor using [125I]DOI as radioligand				J Med Chem 44: 4031-4 (2001) BindingDB Entry DOI: 10.7270/Q22Z168B
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1B (Homo sapiens (Human))	BDBM50106482 (CHEMBL339980 \| N-[3-(2-Dimethylamino-ethyl)-2-meth...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.06E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards human 5-hydroxytryptamine 1B receptor using [3H]5-HT radioligand				J Med Chem 44: 4031-4 (2001) BindingDB Entry DOI: 10.7270/Q22Z168B
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50106482 (CHEMBL339980 \| N-[3-(2-Dimethylamino-ethyl)-2-meth...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.46E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards human 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligand				J Med Chem 44: 4031-4 (2001) BindingDB Entry DOI: 10.7270/Q22Z168B
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (Homo sapiens (Human))	BDBM50106482 (CHEMBL339980 \| N-[3-(2-Dimethylamino-ethyl)-2-meth...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.62E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards human 5-hydroxytryptamine 1D receptor was determined using [3H]5-HT as radioligand				J Med Chem 44: 4031-4 (2001) BindingDB Entry DOI: 10.7270/Q22Z168B
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50106482 (CHEMBL339980 \| N-[3-(2-Dimethylamino-ethyl)-2-meth...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.77E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards human 5-hydroxytryptamine 6 receptor using [3H]LSD as radioligand				J Med Chem 44: 4031-4 (2001) BindingDB Entry DOI: 10.7270/Q22Z168B
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50106482 (CHEMBL339980 \| N-[3-(2-Dimethylamino-ethyl)-2-meth...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards human 5-HT2C receptor was determined using [125I]- DOI as radioligand				J Med Chem 44: 4031-4 (2001) BindingDB Entry DOI: 10.7270/Q22Z168B
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1E (Homo sapiens (Human))	BDBM50106482 (CHEMBL339980 \| N-[3-(2-Dimethylamino-ethyl)-2-meth...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>4.83E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards human 5-hydroxytryptamine 1E receptor was determined using [3H]5-HT as radioligand				J Med Chem 44: 4031-4 (2001) BindingDB Entry DOI: 10.7270/Q22Z168B
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (RAT)	BDBM50106482 (CHEMBL339980 \| N-[3-(2-Dimethylamino-ethyl)-2-meth...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards rat histamine H1 receptor was determined using [3H]pyrilamine as radioligand				J Med Chem 44: 4031-4 (2001) BindingDB Entry DOI: 10.7270/Q22Z168B
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50106482 (CHEMBL339980 \| N-[3-(2-Dimethylamino-ethyl)-2-meth...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	3.80E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards rat dopamine D2 receptor was determined using [3H]raclopride as radioligand				J Med Chem 44: 4031-4 (2001) BindingDB Entry DOI: 10.7270/Q22Z168B
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50106482 (CHEMBL339980 \| N-[3-(2-Dimethylamino-ethyl)-2-meth...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards rat dopamine receptor D1 was determined using [3H]SCH-23390 radioligand				J Med Chem 44: 4031-4 (2001) BindingDB Entry DOI: 10.7270/Q22Z168B
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1F (Homo sapiens (Human))	BDBM10755 (14C-5-hydroxy tryptamine creatinine disulfate \| 2-...) Show SMILES NCCc1c[nH]c2ccc(O)cc12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	n/a	n/a	7.90	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description In vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptor				J Med Chem 44: 4031-4 (2001) BindingDB Entry DOI: 10.7270/Q22Z168B
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1F (Homo sapiens (Human))	BDBM50106482 (CHEMBL339980 \| N-[3-(2-Dimethylamino-ethyl)-2-meth...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description In vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptor				J Med Chem 44: 4031-4 (2001) BindingDB Entry DOI: 10.7270/Q22Z168B
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1F (Homo sapiens (Human))	BDBM50005835 ((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...) Show SMILES CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents	DrugBank PubMed	n/a	n/a	n/a	n/a	35	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description In vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptor				J Med Chem 44: 4031-4 (2001) BindingDB Entry DOI: 10.7270/Q22Z168B
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%