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PubMed code 11784148

Compile data set for download or QSAR
Found 81 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50108664
PNG
(1'-benzylspiro[3,4-dihydro-1H-isochromene-1,4'-(he...)
Show SMILES C(N1CCC2(CC1)OCCc1ccccc21)c1ccccc1
Show InChI InChI=1S/C20H23NO/c1-2-6-17(7-3-1)16-21-13-11-20(12-14-21)19-9-5-4-8-18(19)10-15-22-20/h1-9H,10-16H2
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 0.690n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 1 affinity in guinea pig brain by employing [3H](+)-pentazocine as radioligand.

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50108659
PNG
(1'-benzyl-3-methoxy-3H-spiro[2-benzofuran-1,4'-pip...)
Show SMILES COC1OC2(CCN(Cc3ccccc3)CC2)c2ccccc12
Show InChI InChI=1S/C20H23NO2/c1-22-19-17-9-5-6-10-18(17)20(23-19)11-13-21(14-12-20)15-16-7-3-2-4-8-16/h2-10,19H,11-15H2,1H3
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 1.10n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 1 affinity in guinea pig brain by employing [3H](+)-pentazocine as radioligand.

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50108653
PNG
(1'-benzyl-3-methoxyspiro[3,4-dihydro-1H-isochromen...)
Show SMILES COC1Cc2ccccc2C2(CCN(Cc3ccccc3)CC2)O1
Show InChI InChI=1S/C21H25NO2/c1-23-20-15-18-9-5-6-10-19(18)21(24-20)11-13-22(14-12-21)16-17-7-3-2-4-8-17/h2-10,20H,11-16H2,1H3
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 1.30n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 1 affinity in guinea pig brain by employing [3H](+)-pentazocine as radioligand.

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50108655
PNG
(1'-benzylspiro[1H-isochromene-1,4'-(hexahydropyrid...)
Show SMILES C(N1CCC2(CC1)OC=Cc1ccccc21)c1ccccc1 |c:9|
Show InChI InChI=1S/C20H21NO/c1-2-6-17(7-3-1)16-21-13-11-20(12-14-21)19-9-5-4-8-18(19)10-15-22-20/h1-10,15H,11-14,16H2
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 1.90n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 1 affinity in guinea pig brain by employing [3H](+)-pentazocine as radioligand.

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50108654
PNG
(1-[3-methoxyspiro[3,4-dihydro-1H-isochromene-1,4'-...)
Show SMILES COC1Cc2ccccc2C2(CCN(CCCc3ccccc3)CC2)O1
Show InChI InChI=1S/C23H29NO2/c1-25-22-18-20-11-5-6-12-21(20)23(26-22)13-16-24(17-14-23)15-7-10-19-8-3-2-4-9-19/h2-6,8-9,11-12,22H,7,10,13-18H2,1H3
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 2.10n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 1 affinity in guinea pig brain by employing [3H](+)-pentazocine as radioligand.

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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 2.20n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 1 affinity in guinea pig brain by employing [3H](+)-pentazocine as radioligand.

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50108660
PNG
(1'-benzylspiro[3,4-dihydro-1H-isochromene-1,4'-(he...)
Show SMILES OC1Cc2ccccc2C2(CCN(Cc3ccccc3)CC2)O1
Show InChI InChI=1S/C20H23NO2/c22-19-14-17-8-4-5-9-18(17)20(23-19)10-12-21(13-11-20)15-16-6-2-1-3-7-16/h1-9,19,22H,10-15H2
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 2.20n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 1 affinity in guinea pig brain by employing [3H](+)-pentazocine as radioligand.

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50035131
PNG
((+)-(6R,11S)-6,11-dimethyl-3-(3-methyl-but-2-enyl)...)
Show SMILES [#6]-[#6@@H]1-[#6@@H]-2-[#6]-c3ccc(-[#8])cc3[C@@]1([#6])[#6]-[#6]-[#7]-2-[#6]\[#6]=[#6](/[#6])-[#6] |r,TLB:16:15:10.4.3:1|
Show InChI InChI=1S/C19H27NO/c1-13(2)7-9-20-10-8-19(4)14(3)18(20)11-15-5-6-16(21)12-17(15)19/h5-7,12,14,18,21H,8-11H2,1-4H3/t14-,18+,19+/m1/s1
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 3.60n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 1 affinity in guinea pig brain by employing [3H](+)-pentazocine as radioligand.

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50108668
PNG
(1'-benzyl-3-ethoxyspiro[3,4-dihydro-1H-isochromene...)
Show SMILES CCOC1Cc2ccccc2C2(CCN(Cc3ccccc3)CC2)O1
Show InChI InChI=1S/C22H27NO2/c1-2-24-21-16-19-10-6-7-11-20(19)22(25-21)12-14-23(15-13-22)17-18-8-4-3-5-9-18/h3-11,21H,2,12-17H2,1H3
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 5.80n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 1 affinity in guinea pig brain by employing [3H](+)-pentazocine as radioligand.

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50108669
PNG
(1-[3-methoxyspiro[3,4-dihydro-1H-isochromene-1,4'-...)
Show SMILES COC1Cc2ccccc2C2(CCN(CCc3ccccc3)CC2)O1
Show InChI InChI=1S/C22H27NO2/c1-24-21-17-19-9-5-6-10-20(19)22(25-21)12-15-23(16-13-22)14-11-18-7-3-2-4-8-18/h2-10,21H,11-17H2,1H3
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 6.60n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 1 affinity in guinea pig brain by employing [3H](+)-pentazocine as radioligand.

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50108665
PNG
(1'-benzylspiro[1,3-dihydroisobenzofuran-1,4'-(hexa...)
Show SMILES OC1OC2(CCN(Cc3ccccc3)CC2)c2ccccc12
Show InChI InChI=1S/C19H21NO2/c21-18-16-8-4-5-9-17(16)19(22-18)10-12-20(13-11-19)14-15-6-2-1-3-7-15/h1-9,18,21H,10-14H2
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 7.30n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 1 affinity in guinea pig brain by employing [3H](+)-pentazocine as radioligand.

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50108652
PNG
(1-[3-methoxyspiro[3,4-dihydro-1H-isochromene-1,4'-...)
Show SMILES COC1Cc2ccccc2C2(CCN(CCCCc3ccccc3)CC2)O1
Show InChI InChI=1S/C24H31NO2/c1-26-23-19-21-12-5-6-13-22(21)24(27-23)14-17-25(18-15-24)16-8-7-11-20-9-3-2-4-10-20/h2-6,9-10,12-13,23H,7-8,11,14-19H2,1H3
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 10n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 1 affinity in guinea pig brain by employing [3H](+)-pentazocine as radioligand.

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50108670
PNG
(1'-(3-phenylpropyl)spiro[3,4-dihydro-1H-isochromen...)
Show SMILES OC1Cc2ccccc2C2(CCN(CCCc3ccccc3)CC2)O1
Show InChI InChI=1S/C22H27NO2/c24-21-17-19-10-4-5-11-20(19)22(25-21)12-15-23(16-13-22)14-6-9-18-7-2-1-3-8-18/h1-5,7-8,10-11,21,24H,6,9,12-17H2
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 12n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 1 affinity in guinea pig brain by employing [3H](+)-pentazocine as radioligand.

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50108663
PNG
(3-[3-methoxyspiro[3,4-dihydro-1H-isochromene-1,4'-...)
Show SMILES COC1Cc2ccccc2C2(CCN(C\C=C\c3ccccc3)CC2)O1
Show InChI InChI=1S/C23H27NO2/c1-25-22-18-20-11-5-6-12-21(20)23(26-22)13-16-24(17-14-23)15-7-10-19-8-3-2-4-9-19/h2-12,22H,13-18H2,1H3/b10-7+
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 13n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 1 affinity in guinea pig brain by employing [3H](+)-pentazocine as radioligand.

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50108658
PNG
(1'-benzylspiro[1,3-dihydroisobenzofuran-1,4'-(hexa...)
Show SMILES O=C1OC2(CCN(Cc3ccccc3)CC2)c2ccccc12
Show InChI InChI=1S/C19H19NO2/c21-18-16-8-4-5-9-17(16)19(22-18)10-12-20(13-11-19)14-15-6-2-1-3-7-15/h1-9H,10-14H2
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 21n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 1 affinity in guinea pig brain by employing [3H](+)-pentazocine as radioligand.

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50108656
PNG
(1'-benzylspiro[3,4-dihydro-1H-isochromene-1,4'-(he...)
Show SMILES O=C1Cc2ccccc2C2(CCN(Cc3ccccc3)CC2)O1
Show InChI InChI=1S/C20H21NO2/c22-19-14-17-8-4-5-9-18(17)20(23-19)10-12-21(13-11-20)15-16-6-2-1-3-7-16/h1-9H,10-15H2
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 29n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 1 affinity in guinea pig brain by employing [3H](+)-pentazocine as radioligand.

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)		BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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 34n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 2 affinity in rat liver by employing [3H]ditolylguanidine as radioligand

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50108662
PNG
(1'-phenethylspiro[3,4-dihydro-1H-isochromene-1,4'-...)
Show SMILES OC1Cc2ccccc2C2(CCN(CCc3ccccc3)CC2)O1
Show InChI InChI=1S/C21H25NO2/c23-20-16-18-8-4-5-9-19(18)21(24-20)11-14-22(15-12-21)13-10-17-6-2-1-3-7-17/h1-9,20,23H,10-16H2
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 44n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 1 affinity in guinea pig brain by employing [3H](+)-pentazocine as radioligand.

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)		BDBM81982
PNG
(CAS_97-39-2 | DITOLYLGUANIDINE | DTG | Di-o-tolylg...)
Show SMILES Cc1ccccc1NC(N)=Nc1ccccc1C |w:10.11|
Show InChI InChI=1S/C15H17N3/c1-11-7-3-5-9-13(11)17-15(16)18-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H3,16,17,18)
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 64n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 2 affinity in rat liver by employing [3H]ditolylguanidine as radioligand

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)		BDBM50108670
PNG
(1'-(3-phenylpropyl)spiro[3,4-dihydro-1H-isochromen...)
Show SMILES OC1Cc2ccccc2C2(CCN(CCCc3ccccc3)CC2)O1
Show InChI InChI=1S/C22H27NO2/c24-21-17-19-10-4-5-11-20(19)22(25-21)12-15-23(16-13-22)14-6-9-18-7-2-1-3-8-18/h1-5,7-8,10-11,21,24H,6,9,12-17H2
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 83n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 2 affinity in rat liver by employing [3H]ditolylguanidine as radioligand

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50108661
PNG
(1'-benzyl-3-benzyloxyspiro[3,4-dihydro-1H-isochrom...)
Show SMILES C(OC1Cc2ccccc2C2(CCN(Cc3ccccc3)CC2)O1)c1ccccc1
Show InChI InChI=1S/C27H29NO2/c1-3-9-22(10-4-1)20-28-17-15-27(16-18-28)25-14-8-7-13-24(25)19-26(30-27)29-21-23-11-5-2-6-12-23/h1-14,26H,15-21H2
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 95n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 1 affinity in guinea pig brain by employing [3H](+)-pentazocine as radioligand.

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)		BDBM50108664
PNG
(1'-benzylspiro[3,4-dihydro-1H-isochromene-1,4'-(he...)
Show SMILES C(N1CCC2(CC1)OCCc1ccccc21)c1ccccc1
Show InChI InChI=1S/C20H23NO/c1-2-6-17(7-3-1)16-21-13-11-20(12-14-21)19-9-5-4-8-18(19)10-15-22-20/h1-9H,10-16H2
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 100n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 2 affinity in rat liver by employing [3H]ditolylguanidine as radioligand

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)		BDBM50108662
PNG
(1'-phenethylspiro[3,4-dihydro-1H-isochromene-1,4'-...)
Show SMILES OC1Cc2ccccc2C2(CCN(CCc3ccccc3)CC2)O1
Show InChI InChI=1S/C21H25NO2/c23-20-16-18-8-4-5-9-19(18)21(24-20)11-14-22(15-12-21)13-10-17-6-2-1-3-7-17/h1-9,20,23H,10-16H2
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 107n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 2 affinity in rat liver by employing [3H]ditolylguanidine as radioligand

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM81982
PNG
(CAS_97-39-2 | DITOLYLGUANIDINE | DTG | Di-o-tolylg...)
Show SMILES Cc1ccccc1NC(N)=Nc1ccccc1C |w:10.11|
Show InChI InChI=1S/C15H17N3/c1-11-7-3-5-9-13(11)17-15(16)18-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H3,16,17,18)
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 164n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 1 affinity in guinea pig brain by employing [3H](+)-pentazocine as radioligand.

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50002238
PNG
((R)1-(4-Fluoro-phenyl)-4-[4-(5-fluoro-pyrimidin-2-...)
Show SMILES OC(CCCN1CCN(CC1)c1ncc(F)cn1)c1ccc(F)cc1
Show InChI InChI=1S/C18H22F2N4O/c19-15-5-3-14(4-6-15)17(25)2-1-7-23-8-10-24(11-9-23)18-21-12-16(20)13-22-18/h3-6,12-13,17,25H,1-2,7-11H2
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 265n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 1 affinity in guinea pig brain by employing [3H](+)-pentazocine as radioligand.

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)		BDBM50108655
PNG
(1'-benzylspiro[1H-isochromene-1,4'-(hexahydropyrid...)
Show SMILES C(N1CCC2(CC1)OC=Cc1ccccc21)c1ccccc1 |c:9|
Show InChI InChI=1S/C20H21NO/c1-2-6-17(7-3-1)16-21-13-11-20(12-14-21)19-9-5-4-8-18(19)10-15-22-20/h1-10,15H,11-14,16H2
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 302n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 2 affinity in rat liver by employing [3H]ditolylguanidine as radioligand

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)		BDBM50108654
PNG
(1-[3-methoxyspiro[3,4-dihydro-1H-isochromene-1,4'-...)
Show SMILES COC1Cc2ccccc2C2(CCN(CCCc3ccccc3)CC2)O1
Show InChI InChI=1S/C23H29NO2/c1-25-22-18-20-11-5-6-12-21(20)23(26-22)13-16-24(17-14-23)15-7-10-19-8-3-2-4-9-19/h2-6,8-9,11-12,22H,7,10,13-18H2,1H3
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 307n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 2 affinity in rat liver by employing [3H]ditolylguanidine as radioligand

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)		BDBM50108652
PNG
(1-[3-methoxyspiro[3,4-dihydro-1H-isochromene-1,4'-...)
Show SMILES COC1Cc2ccccc2C2(CCN(CCCCc3ccccc3)CC2)O1
Show InChI InChI=1S/C24H31NO2/c1-26-23-19-21-12-5-6-13-22(21)24(27-23)14-17-25(18-15-24)16-8-7-11-20-9-3-2-4-10-20/h2-6,9-10,12-13,23H,7-8,11,14-19H2,1H3
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 311n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 2 affinity in rat liver by employing [3H]ditolylguanidine as radioligand

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)		BDBM50002238
PNG
((R)1-(4-Fluoro-phenyl)-4-[4-(5-fluoro-pyrimidin-2-...)
Show SMILES OC(CCCN1CCN(CC1)c1ncc(F)cn1)c1ccc(F)cc1
Show InChI InChI=1S/C18H22F2N4O/c19-15-5-3-14(4-6-15)17(25)2-1-7-23-8-10-24(11-9-23)18-21-12-16(20)13-22-18/h3-6,12-13,17,25H,1-2,7-11H2
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 391n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 2 affinity in rat liver by employing [3H]ditolylguanidine as radioligand

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)		BDBM50108669
PNG
(1-[3-methoxyspiro[3,4-dihydro-1H-isochromene-1,4'-...)
Show SMILES COC1Cc2ccccc2C2(CCN(CCc3ccccc3)CC2)O1
Show InChI InChI=1S/C22H27NO2/c1-24-21-17-19-9-5-6-10-20(19)22(25-21)12-15-23(16-13-22)14-11-18-7-3-2-4-8-18/h2-10,21H,11-17H2,1H3
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 410n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 2 affinity in rat liver by employing [3H]ditolylguanidine as radioligand

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)		BDBM50108660
PNG
(1'-benzylspiro[3,4-dihydro-1H-isochromene-1,4'-(he...)
Show SMILES OC1Cc2ccccc2C2(CCN(Cc3ccccc3)CC2)O1
Show InChI InChI=1S/C20H23NO2/c22-19-14-17-8-4-5-9-18(17)20(23-19)10-12-21(13-11-20)15-16-6-2-1-3-7-16/h1-9,19,22H,10-15H2
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 513n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 2 affinity in rat liver by employing [3H]ditolylguanidine as radioligand

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)		BDBM50108665
PNG
(1'-benzylspiro[1,3-dihydroisobenzofuran-1,4'-(hexa...)
Show SMILES OC1OC2(CCN(Cc3ccccc3)CC2)c2ccccc12
Show InChI InChI=1S/C19H21NO2/c21-18-16-8-4-5-9-17(16)19(22-18)10-12-20(13-11-19)14-15-6-2-1-3-7-15/h1-9,18,21H,10-14H2
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 761n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 2 affinity in rat liver by employing [3H]ditolylguanidine as radioligand

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)		BDBM50108656
PNG
(1'-benzylspiro[3,4-dihydro-1H-isochromene-1,4'-(he...)
Show SMILES O=C1Cc2ccccc2C2(CCN(Cc3ccccc3)CC2)O1
Show InChI InChI=1S/C20H21NO2/c22-19-14-17-8-4-5-9-18(17)20(23-19)10-12-21(13-11-20)15-16-6-2-1-3-7-16/h1-9H,10-15H2
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 1.16E+3n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 2 affinity in rat liver by employing [3H]ditolylguanidine as radioligand

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)		BDBM50108659
PNG
(1'-benzyl-3-methoxy-3H-spiro[2-benzofuran-1,4'-pip...)
Show SMILES COC1OC2(CCN(Cc3ccccc3)CC2)c2ccccc12
Show InChI InChI=1S/C20H23NO2/c1-22-19-17-9-5-6-10-18(17)20(23-19)11-13-21(14-12-20)15-16-7-3-2-4-8-16/h2-10,19H,11-15H2,1H3
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 1.28E+3n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 2 affinity in rat liver by employing [3H]ditolylguanidine as radioligand

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)		BDBM50108658
PNG
(1'-benzylspiro[1,3-dihydroisobenzofuran-1,4'-(hexa...)
Show SMILES O=C1OC2(CCN(Cc3ccccc3)CC2)c2ccccc12
Show InChI InChI=1S/C19H19NO2/c21-18-16-8-4-5-9-17(16)19(22-18)10-12-20(13-11-19)14-15-6-2-1-3-7-15/h1-9H,10-14H2
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 1.46E+3n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 2 affinity in rat liver by employing [3H]ditolylguanidine as radioligand

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)		BDBM50108668
PNG
(1'-benzyl-3-ethoxyspiro[3,4-dihydro-1H-isochromene...)
Show SMILES CCOC1Cc2ccccc2C2(CCN(Cc3ccccc3)CC2)O1
Show InChI InChI=1S/C22H27NO2/c1-2-24-21-16-19-10-6-7-11-20(19)22(25-21)12-14-23(15-13-22)17-18-8-4-3-5-9-18/h3-11,21H,2,12-17H2,1H3
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 2.96E+3n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 2 affinity in rat liver by employing [3H]ditolylguanidine as radioligand

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)		BDBM50108653
PNG
(1'-benzyl-3-methoxyspiro[3,4-dihydro-1H-isochromen...)
Show SMILES COC1Cc2ccccc2C2(CCN(Cc3ccccc3)CC2)O1
Show InChI InChI=1S/C21H25NO2/c1-23-20-15-18-9-5-6-10-19(18)21(24-20)11-13-22(14-12-21)16-17-7-3-2-4-8-17/h2-10,20H,11-16H2,1H3
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 3.50E+3n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 2 affinity in rat liver by employing [3H]ditolylguanidine as radioligand

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)		BDBM50108663
PNG
(3-[3-methoxyspiro[3,4-dihydro-1H-isochromene-1,4'-...)
Show SMILES COC1Cc2ccccc2C2(CCN(C\C=C\c3ccccc3)CC2)O1
Show InChI InChI=1S/C23H27NO2/c1-25-22-18-20-11-5-6-12-21(20)23(26-22)13-16-24(17-14-23)15-7-10-19-8-3-2-4-9-19/h2-12,22H,13-18H2,1H3/b10-7+
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 4.00E+3n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 2 affinity in rat liver by employing [3H]ditolylguanidine as radioligand

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50108667
PNG
(3-methoxy-1'-methylspiro[3,4-dihydro-1H-isochromen...)
Show SMILES COC1Cc2ccccc2C2(CCN(C)CC2)O1
Show InChI InChI=1S/C15H21NO2/c1-16-9-7-15(8-10-16)13-6-4-3-5-12(13)11-14(17-2)18-15/h3-6,14H,7-11H2,1-2H3
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 4.40E+3n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 1 affinity in guinea pig brain by employing [3H](+)-pentazocine as radioligand.

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)		BDBM50108661
PNG
(1'-benzyl-3-benzyloxyspiro[3,4-dihydro-1H-isochrom...)
Show SMILES C(OC1Cc2ccccc2C2(CCN(Cc3ccccc3)CC2)O1)c1ccccc1
Show InChI InChI=1S/C27H29NO2/c1-3-9-22(10-4-1)20-28-17-15-27(16-18-28)25-14-8-7-13-24(25)19-26(30-27)29-21-23-11-5-2-6-12-23/h1-14,26H,15-21H2
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 9.89E+3n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 2 affinity in rat liver by employing [3H]ditolylguanidine as radioligand

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)		BDBM50108657
PNG
(3-methoxyspiro[3,4-dihydro-1H-isochromene-1,4'-(he...)
Show SMILES COC1Cc2ccccc2C2(CCNCC2)O1
Show InChI InChI=1S/C14H19NO2/c1-16-13-10-11-4-2-3-5-12(11)14(17-13)6-8-15-9-7-14/h2-5,13,15H,6-10H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 2 affinity in rat liver by employing [3H]ditolylguanidine as radioligand

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)		BDBM50108666
PNG
(3-methoxy-1'-phenylspiro[3,4-dihydro-1H-isochromen...)
Show SMILES COC1Cc2ccccc2C2(CCN(CC2)c2ccccc2)O1
Show InChI InChI=1S/C20H23NO2/c1-22-19-15-16-7-5-6-10-18(16)20(23-19)11-13-21(14-12-20)17-8-3-2-4-9-17/h2-10,19H,11-15H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 2 affinity in rat liver by employing [3H]ditolylguanidine as radioligand

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)		BDBM50108667
PNG
(3-methoxy-1'-methylspiro[3,4-dihydro-1H-isochromen...)
Show SMILES COC1Cc2ccccc2C2(CCN(C)CC2)O1
Show InChI InChI=1S/C15H21NO2/c1-16-9-7-15(8-10-16)13-6-4-3-5-12(13)11-14(17-2)18-15/h3-6,14H,7-11H2,1-2H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 2 affinity in rat liver by employing [3H]ditolylguanidine as radioligand

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50108666
PNG
(3-methoxy-1'-phenylspiro[3,4-dihydro-1H-isochromen...)
Show SMILES COC1Cc2ccccc2C2(CCN(CC2)c2ccccc2)O1
Show InChI InChI=1S/C20H23NO2/c1-22-19-15-16-7-5-6-10-18(16)20(23-19)11-13-21(14-12-20)17-8-3-2-4-9-17/h2-10,19H,11-15H2,1H3
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 1.01E+4n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 1 affinity in guinea pig brain by employing [3H](+)-pentazocine as radioligand.

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50108657
PNG
(3-methoxyspiro[3,4-dihydro-1H-isochromene-1,4'-(he...)
Show SMILES COC1Cc2ccccc2C2(CCNCC2)O1
Show InChI InChI=1S/C14H19NO2/c1-16-13-10-11-4-2-3-5-12(11)14(17-13)6-8-15-9-7-14/h2-5,13,15H,6-10H2,1H3
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 1.98E+4n/an/an/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Sigma opioid receptor type 1 affinity in guinea pig brain by employing [3H](+)-pentazocine as radioligand.

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50108654
PNG
(1-[3-methoxyspiro[3,4-dihydro-1H-isochromene-1,4'-...)
Show SMILES COC1Cc2ccccc2C2(CCN(CCCc3ccccc3)CC2)O1
Show InChI InChI=1S/C23H29NO2/c1-25-22-18-20-11-5-6-12-21(20)23(26-22)13-16-24(17-14-23)15-7-10-19-8-3-2-4-9-19/h2-6,8-9,11-12,22H,7,10,13-18H2,1H3
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n/an/a 460n/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Inhibition of ketanserin binding to 5-hydroxytryptamine 2A receptor

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Mus musculus (Mouse))		BDBM50108659
PNG
(1'-benzyl-3-methoxy-3H-spiro[2-benzofuran-1,4'-pip...)
Show SMILES COC1OC2(CCN(Cc3ccccc3)CC2)c2ccccc12
Show InChI InChI=1S/C20H23NO2/c1-22-19-17-9-5-6-10-18(17)20(23-19)11-13-21(14-12-20)15-16-7-3-2-4-8-16/h2-10,19H,11-15H2,1H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Inhibition of 5-OH-DPAT binding to 5-hydroxytryptamine 1A receptor

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Mus musculus (Mouse))		BDBM50108653
PNG
(1'-benzyl-3-methoxyspiro[3,4-dihydro-1H-isochromen...)
Show SMILES COC1Cc2ccccc2C2(CCN(Cc3ccccc3)CC2)O1
Show InChI InChI=1S/C21H25NO2/c1-23-20-15-18-9-5-6-10-19(18)21(24-20)11-13-22(14-12-21)16-17-7-3-2-4-8-17/h2-10,20H,11-16H2,1H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Inhibition of 5-OH-DPAT binding to 5-hydroxytryptamine 1A receptor

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Mus musculus (Mouse))		BDBM50108654
PNG
(1-[3-methoxyspiro[3,4-dihydro-1H-isochromene-1,4'-...)
Show SMILES COC1Cc2ccccc2C2(CCN(CCCc3ccccc3)CC2)O1
Show InChI InChI=1S/C23H29NO2/c1-25-22-18-20-11-5-6-12-21(20)23(26-22)13-16-24(17-14-23)15-7-10-19-8-3-2-4-9-19/h2-6,8-9,11-12,22H,7,10,13-18H2,1H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Inhibition of 5-OH-DPAT binding to 5-hydroxytryptamine 1A receptor

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50108654
PNG
(1-[3-methoxyspiro[3,4-dihydro-1H-isochromene-1,4'-...)
Show SMILES COC1Cc2ccccc2C2(CCN(CCCc3ccccc3)CC2)O1
Show InChI InChI=1S/C23H29NO2/c1-25-22-18-20-11-5-6-12-21(20)23(26-22)13-16-24(17-14-23)15-7-10-19-8-3-2-4-9-19/h2-6,8-9,11-12,22H,7,10,13-18H2,1H3
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n/an/a 1.60E+3n/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
The compound was tested for inhibition of dopamine reuptake

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50108653
PNG
(1'-benzyl-3-methoxyspiro[3,4-dihydro-1H-isochromen...)
Show SMILES COC1Cc2ccccc2C2(CCN(Cc3ccccc3)CC2)O1
Show InChI InChI=1S/C21H25NO2/c1-23-20-15-18-9-5-6-10-19(18)21(24-20)11-13-22(14-12-21)16-17-7-3-2-4-8-17/h2-10,20H,11-16H2,1H3
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n/an/a 3.00E+3n/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Inhibition of idazoxane binding to noradrenaline alpha-2 receptor

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50108654
PNG
(1-[3-methoxyspiro[3,4-dihydro-1H-isochromene-1,4'-...)
Show SMILES COC1Cc2ccccc2C2(CCN(CCCc3ccccc3)CC2)O1
Show InChI InChI=1S/C23H29NO2/c1-25-22-18-20-11-5-6-12-21(20)23(26-22)13-16-24(17-14-23)15-7-10-19-8-3-2-4-9-19/h2-6,8-9,11-12,22H,7,10,13-18H2,1H3
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n/an/a 3.10E+3n/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Inhibition of idazoxane binding to noradrenaline alpha-2 receptor

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50108653
PNG
(1'-benzyl-3-methoxyspiro[3,4-dihydro-1H-isochromen...)
Show SMILES COC1Cc2ccccc2C2(CCN(Cc3ccccc3)CC2)O1
Show InChI InChI=1S/C21H25NO2/c1-23-20-15-18-9-5-6-10-19(18)21(24-20)11-13-22(14-12-21)16-17-7-3-2-4-8-17/h2-10,20H,11-16H2,1H3
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n/an/a 5.90E+3n/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
The compound was tested for inhibition of dopamine reuptake

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))		BDBM50108659
PNG
(1'-benzyl-3-methoxy-3H-spiro[2-benzofuran-1,4'-pip...)
Show SMILES COC1OC2(CCN(Cc3ccccc3)CC2)c2ccccc12
Show InChI InChI=1S/C20H23NO2/c1-22-19-17-9-5-6-10-18(17)20(23-19)11-13-21(14-12-20)15-16-7-3-2-4-8-16/h2-10,19H,11-15H2,1H3
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n/an/a 6.20E+3n/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Inhibition of idazoxane binding to noradrenaline alpha-2 receptor

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50108653
PNG
(1'-benzyl-3-methoxyspiro[3,4-dihydro-1H-isochromen...)
Show SMILES COC1Cc2ccccc2C2(CCN(Cc3ccccc3)CC2)O1
Show InChI InChI=1S/C21H25NO2/c1-23-20-15-18-9-5-6-10-19(18)21(24-20)11-13-22(14-12-21)16-17-7-3-2-4-8-17/h2-10,20H,11-16H2,1H3
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n/an/a 6.60E+3n/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Inhibition of ketanserin binding to 5-hydroxytryptamine 2A receptor

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))		BDBM50108654
PNG
(1-[3-methoxyspiro[3,4-dihydro-1H-isochromene-1,4'-...)
Show SMILES COC1Cc2ccccc2C2(CCN(CCCc3ccccc3)CC2)O1
Show InChI InChI=1S/C23H29NO2/c1-25-22-18-20-11-5-6-12-21(20)23(26-22)13-16-24(17-14-23)15-7-10-19-8-3-2-4-9-19/h2-6,8-9,11-12,22H,7,10,13-18H2,1H3
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n/an/a 8.00E+3n/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Inhibition of mepyramine binding to Histamine H1 receptor

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM50108654
PNG
(1-[3-methoxyspiro[3,4-dihydro-1H-isochromene-1,4'-...)
Show SMILES COC1Cc2ccccc2C2(CCN(CCCc3ccccc3)CC2)O1
Show InChI InChI=1S/C23H29NO2/c1-25-22-18-20-11-5-6-12-21(20)23(26-22)13-16-24(17-14-23)15-7-10-19-8-3-2-4-9-19/h2-6,8-9,11-12,22H,7,10,13-18H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Inhibition of GR-65630 binding to 5-hydroxytryptamine 3 receptor

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))		BDBM50108653
PNG
(1'-benzyl-3-methoxyspiro[3,4-dihydro-1H-isochromen...)
Show SMILES COC1Cc2ccccc2C2(CCN(Cc3ccccc3)CC2)O1
Show InChI InChI=1S/C21H25NO2/c1-23-20-15-18-9-5-6-10-19(18)21(24-20)11-13-22(14-12-21)16-17-7-3-2-4-8-17/h2-10,20H,11-16H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Inhibition of [125I]NKA binding to human Tachykinin receptor 2 (NK2)

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50108659
PNG
(1'-benzyl-3-methoxy-3H-spiro[2-benzofuran-1,4'-pip...)
Show SMILES COC1OC2(CCN(Cc3ccccc3)CC2)c2ccccc12
Show InChI InChI=1S/C20H23NO2/c1-22-19-17-9-5-6-10-18(17)20(23-19)11-13-21(14-12-20)15-16-7-3-2-4-8-16/h2-10,19H,11-15H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Inhibition of [Sar9,Met(O2)11]-SP binding to human Tachykinin receptor 1 (NK1)

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM50108659
PNG
(1'-benzyl-3-methoxy-3H-spiro[2-benzofuran-1,4'-pip...)
Show SMILES COC1OC2(CCN(Cc3ccccc3)CC2)c2ccccc12
Show InChI InChI=1S/C20H23NO2/c1-22-19-17-9-5-6-10-18(17)20(23-19)11-13-21(14-12-20)15-16-7-3-2-4-8-16/h2-10,19H,11-15H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Inhibition of GR-65630 binding to 5-hydroxytryptamine 3 receptor

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))		BDBM50108659
PNG
(1'-benzyl-3-methoxy-3H-spiro[2-benzofuran-1,4'-pip...)
Show SMILES COC1OC2(CCN(Cc3ccccc3)CC2)c2ccccc12
Show InChI InChI=1S/C20H23NO2/c1-22-19-17-9-5-6-10-18(17)20(23-19)11-13-21(14-12-20)15-16-7-3-2-4-8-16/h2-10,19H,11-15H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Inhibition of ketanserin binding to 5-hydroxytryptamine 2A receptor

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2C


(Rattus norvegicus (Rat))		BDBM50108653
PNG
(1'-benzyl-3-methoxyspiro[3,4-dihydro-1H-isochromen...)
Show SMILES COC1Cc2ccccc2C2(CCN(Cc3ccccc3)CC2)O1
Show InChI InChI=1S/C21H25NO2/c1-23-20-15-18-9-5-6-10-19(18)21(24-20)11-13-22(14-12-21)16-17-7-3-2-4-8-17/h2-10,20H,11-16H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Inhibition of MK 801 binding to NMDA, PCP receptor

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))		BDBM50108659
PNG
(1'-benzyl-3-methoxy-3H-spiro[2-benzofuran-1,4'-pip...)
Show SMILES COC1OC2(CCN(Cc3ccccc3)CC2)c2ccccc12
Show InChI InChI=1S/C20H23NO2/c1-22-19-17-9-5-6-10-18(17)20(23-19)11-13-21(14-12-20)15-16-7-3-2-4-8-16/h2-10,19H,11-15H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Inhibition of [125I]-NKA binding to human Tachykinin receptor 2 (NK2)

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))		BDBM50108653
PNG
(1'-benzyl-3-methoxyspiro[3,4-dihydro-1H-isochromen...)
Show SMILES COC1Cc2ccccc2C2(CCN(Cc3ccccc3)CC2)O1
Show InChI InChI=1S/C21H25NO2/c1-23-20-15-18-9-5-6-10-19(18)21(24-20)11-13-22(14-12-21)16-17-7-3-2-4-8-17/h2-10,20H,11-16H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Inhibition of mepyramine binding to Histamine H1 receptor

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))		BDBM50108659
PNG
(1'-benzyl-3-methoxy-3H-spiro[2-benzofuran-1,4'-pip...)
Show SMILES COC1OC2(CCN(Cc3ccccc3)CC2)c2ccccc12
Show InChI InChI=1S/C20H23NO2/c1-22-19-17-9-5-6-10-18(17)20(23-19)11-13-21(14-12-20)15-16-7-3-2-4-8-16/h2-10,19H,11-15H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Inhibition of mepyramine binding to Histamine H1 receptor

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Mus musculus (Mouse))		BDBM50108653
PNG
(1'-benzyl-3-methoxyspiro[3,4-dihydro-1H-isochromen...)
Show SMILES COC1Cc2ccccc2C2(CCN(Cc3ccccc3)CC2)O1
Show InChI InChI=1S/C21H25NO2/c1-23-20-15-18-9-5-6-10-19(18)21(24-20)11-13-22(14-12-21)16-17-7-3-2-4-8-17/h2-10,20H,11-16H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Inhibition of SCH 23390 binding to Dopamine receptor D1

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50108659
PNG
(1'-benzyl-3-methoxy-3H-spiro[2-benzofuran-1,4'-pip...)
Show SMILES COC1OC2(CCN(Cc3ccccc3)CC2)c2ccccc12
Show InChI InChI=1S/C20H23NO2/c1-22-19-17-9-5-6-10-18(17)20(23-19)11-13-21(14-12-20)15-16-7-3-2-4-8-16/h2-10,19H,11-15H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
The compound was tested for inhibition of dopamine reuptake

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Mus musculus (Mouse))		BDBM50108654
PNG
(1-[3-methoxyspiro[3,4-dihydro-1H-isochromene-1,4'-...)
Show SMILES COC1Cc2ccccc2C2(CCN(CCCc3ccccc3)CC2)O1
Show InChI InChI=1S/C23H29NO2/c1-25-22-18-20-11-5-6-12-21(20)23(26-22)13-16-24(17-14-23)15-7-10-19-8-3-2-4-9-19/h2-6,8-9,11-12,22H,7,10,13-18H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Inhibition of SCH 23390 binding to Dopamine receptor D1

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50108654
PNG
(1-[3-methoxyspiro[3,4-dihydro-1H-isochromene-1,4'-...)
Show SMILES COC1Cc2ccccc2C2(CCN(CCCc3ccccc3)CC2)O1
Show InChI InChI=1S/C23H29NO2/c1-25-22-18-20-11-5-6-12-21(20)23(26-22)13-16-24(17-14-23)15-7-10-19-8-3-2-4-9-19/h2-6,8-9,11-12,22H,7,10,13-18H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Inhibition of [125I][MePhe7]-NKB binding to human Tachykinin receptor 3 (NK3)

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2C


(Rattus norvegicus (Rat))		BDBM50108659
PNG
(1'-benzyl-3-methoxy-3H-spiro[2-benzofuran-1,4'-pip...)
Show SMILES COC1OC2(CCN(Cc3ccccc3)CC2)c2ccccc12
Show InChI InChI=1S/C20H23NO2/c1-22-19-17-9-5-6-10-18(17)20(23-19)11-13-21(14-12-20)15-16-7-3-2-4-8-16/h2-10,19H,11-15H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Inhibition of MK 801 binding to NMDA, PCP receptor

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50108659
PNG
(1'-benzyl-3-methoxy-3H-spiro[2-benzofuran-1,4'-pip...)
Show SMILES COC1OC2(CCN(Cc3ccccc3)CC2)c2ccccc12
Show InChI InChI=1S/C20H23NO2/c1-22-19-17-9-5-6-10-18(17)20(23-19)11-13-21(14-12-20)15-16-7-3-2-4-8-16/h2-10,19H,11-15H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Inhibition of [125I][MePhe7]-NKB binding to human Tachykinin receptor 3 (NK3)

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-4


(Mus musculus)		BDBM50108659
PNG
(1'-benzyl-3-methoxy-3H-spiro[2-benzofuran-1,4'-pip...)
Show SMILES COC1OC2(CCN(Cc3ccccc3)CC2)c2ccccc12
Show InChI InChI=1S/C20H23NO2/c1-22-19-17-9-5-6-10-18(17)20(23-19)11-13-21(14-12-20)15-16-7-3-2-4-8-16/h2-10,19H,11-15H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Inhibition of MDL 105519 binding to NMDA, glycine receptor

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Mus musculus (Mouse))		BDBM50108659
PNG
(1'-benzyl-3-methoxy-3H-spiro[2-benzofuran-1,4'-pip...)
Show SMILES COC1OC2(CCN(Cc3ccccc3)CC2)c2ccccc12
Show InChI InChI=1S/C20H23NO2/c1-22-19-17-9-5-6-10-18(17)20(23-19)11-13-21(14-12-20)15-16-7-3-2-4-8-16/h2-10,19H,11-15H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Inhibition of SCH 23390 binding to Dopamine receptor D1

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))		BDBM50108653
PNG
(1'-benzyl-3-methoxyspiro[3,4-dihydro-1H-isochromen...)
Show SMILES COC1Cc2ccccc2C2(CCN(Cc3ccccc3)CC2)O1
Show InChI InChI=1S/C21H25NO2/c1-23-20-15-18-9-5-6-10-19(18)21(24-20)11-13-22(14-12-21)16-17-7-3-2-4-8-17/h2-10,20H,11-16H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Inhibition of [125I][MePhe7]-NKB binding to human Tachykinin receptor 3 (NK3)

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50108653
PNG
(1'-benzyl-3-methoxyspiro[3,4-dihydro-1H-isochromen...)
Show SMILES COC1Cc2ccccc2C2(CCN(Cc3ccccc3)CC2)O1
Show InChI InChI=1S/C21H25NO2/c1-23-20-15-18-9-5-6-10-19(18)21(24-20)11-13-22(14-12-21)16-17-7-3-2-4-8-17/h2-10,20H,11-16H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Inhibition of [Sar9,Met(O2)11]-SP binding to human Tachykinin receptor 1 (NK1)

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Substance-P receptor


(Homo sapiens (Human))		BDBM50108654
PNG
(1-[3-methoxyspiro[3,4-dihydro-1H-isochromene-1,4'-...)
Show SMILES COC1Cc2ccccc2C2(CCN(CCCc3ccccc3)CC2)O1
Show InChI InChI=1S/C23H29NO2/c1-25-22-18-20-11-5-6-12-21(20)23(26-22)13-16-24(17-14-23)15-7-10-19-8-3-2-4-9-19/h2-6,8-9,11-12,22H,7,10,13-18H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Inhibition of [Sar9,Met(O2)11]-SP binding to human Tachykinin receptor 1 (NK1)

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Substance-K receptor


(Homo sapiens (Human))		BDBM50108654
PNG
(1-[3-methoxyspiro[3,4-dihydro-1H-isochromene-1,4'-...)
Show SMILES COC1Cc2ccccc2C2(CCN(CCCc3ccccc3)CC2)O1
Show InChI InChI=1S/C23H29NO2/c1-25-22-18-20-11-5-6-12-21(20)23(26-22)13-16-24(17-14-23)15-7-10-19-8-3-2-4-9-19/h2-6,8-9,11-12,22H,7,10,13-18H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Inhibition of [125I]-NKA binding to human Tachykinin receptor 2 (NK2)

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-4


(Mus musculus)		BDBM50108653
PNG
(1'-benzyl-3-methoxyspiro[3,4-dihydro-1H-isochromen...)
Show SMILES COC1Cc2ccccc2C2(CCN(Cc3ccccc3)CC2)O1
Show InChI InChI=1S/C21H25NO2/c1-23-20-15-18-9-5-6-10-19(18)21(24-20)11-13-22(14-12-21)16-17-7-3-2-4-8-17/h2-10,20H,11-16H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Inhibition of MDL 105519 binding to NMDA, glycine receptor

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Glycine receptor subunit alpha-4


(Mus musculus)		BDBM50108654
PNG
(1-[3-methoxyspiro[3,4-dihydro-1H-isochromene-1,4'-...)
Show SMILES COC1Cc2ccccc2C2(CCN(CCCc3ccccc3)CC2)O1
Show InChI InChI=1S/C23H29NO2/c1-25-22-18-20-11-5-6-12-21(20)23(26-22)13-16-24(17-14-23)15-7-10-19-8-3-2-4-9-19/h2-6,8-9,11-12,22H,7,10,13-18H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Inhibition of MDL 105519 binding to NMDA, glycine receptor

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))		BDBM50108653
PNG
(1'-benzyl-3-methoxyspiro[3,4-dihydro-1H-isochromen...)
Show SMILES COC1Cc2ccccc2C2(CCN(Cc3ccccc3)CC2)O1
Show InChI InChI=1S/C21H25NO2/c1-23-20-15-18-9-5-6-10-19(18)21(24-20)11-13-22(14-12-21)16-17-7-3-2-4-8-17/h2-10,20H,11-16H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Inhibition of GR-65630 binding to 5-hydroxytryptamine 3 receptor

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2C


(Rattus norvegicus (Rat))		BDBM50108654
PNG
(1-[3-methoxyspiro[3,4-dihydro-1H-isochromene-1,4'-...)
Show SMILES COC1Cc2ccccc2C2(CCN(CCCc3ccccc3)CC2)O1
Show InChI InChI=1S/C23H29NO2/c1-25-22-18-20-11-5-6-12-21(20)23(26-22)13-16-24(17-14-23)15-7-10-19-8-3-2-4-9-19/h2-6,8-9,11-12,22H,7,10,13-18H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pharmazeutisches Institut der Universität Freiburg

Curated by ChEMBL


Assay Description
Inhibition of MK 801 binding to NMDA, PCP receptor

J Med Chem 45: 438-48 (2002)


BindingDB Entry DOI: 10.7270/Q2VT1RDH
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%