Found 11 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50109937
((R)-2-[(Indane-2-carbonyl)-amino]-3-naphthalen-1-y...)Show SMILES SCCCOC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)C1Cc2ccccc2C1 Show InChI InChI=1S/C26H27NO3S/c28-25(22-15-19-8-1-2-9-20(19)16-22)27-24(26(29)30-13-6-14-31)17-21-11-5-10-18-7-3-4-12-23(18)21/h1-5,7-12,22,24,31H,6,13-17H2,(H,27,28)/t24-/m1/s1 | PDB
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| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 7.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Tested for the inhibition of Candida GGTase I in Candida albicans |
Bioorg Med Chem Lett 12: 629-32 (2002)
BindingDB Entry DOI: 10.7270/Q2251HGT |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50109938
(9H-Xanthene-9-carboxylic acid {(R)-2-(3,4-dichloro...)Show SMILES Clc1ccc(C[C@@H](NC(=O)C2c3ccccc3Oc3ccccc23)C(=O)NCCc2cnc[nH]2)cc1Cl Show InChI InChI=1S/C28H24Cl2N4O3/c29-21-10-9-17(13-22(21)30)14-23(27(35)32-12-11-18-15-31-16-33-18)34-28(36)26-19-5-1-3-7-24(19)37-25-8-4-2-6-20(25)26/h1-10,13,15-16,23,26H,11-12,14H2,(H,31,33)(H,32,35)(H,34,36)/t23-/m1/s1 | PDB
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UniProtKB/SwissProt
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antibodypedia
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Candida geranylgeranyl transferase I at 3 uM |
Bioorg Med Chem Lett 12: 629-32 (2002)
BindingDB Entry DOI: 10.7270/Q2251HGT |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50109933
(2-(2,3-Dihydro-benzo[1,4]dioxin-2-yl)-thiazole-4-c...)Show InChI InChI=1S/C16H17NO5S3/c18-10(6-23)14(7-24)22-16(19)9-8-25-15(17-9)13-5-20-11-3-1-2-4-12(11)21-13/h1-4,8,10,13-14,18,23-24H,5-7H2 | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Tested for the inhibition of Candida GGTase I in Candida albicans |
Bioorg Med Chem Lett 12: 629-32 (2002)
BindingDB Entry DOI: 10.7270/Q2251HGT |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50109933
(2-(2,3-Dihydro-benzo[1,4]dioxin-2-yl)-thiazole-4-c...)Show InChI InChI=1S/C16H17NO5S3/c18-10(6-23)14(7-24)22-16(19)9-8-25-15(17-9)13-5-20-11-3-1-2-4-12(11)21-13/h1-4,8,10,13-14,18,23-24H,5-7H2 | PDB
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antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Tested for the inhibition of Candida GGTase I in Candida albicans |
Bioorg Med Chem Lett 12: 629-32 (2002)
BindingDB Entry DOI: 10.7270/Q2251HGT |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50109940
(2-(2,3-Dihydro-benzo[1,4]dioxin-2-yl)-thiazole-4-c...)Show InChI InChI=1S/C15H15NO5S2/c17-9(7-22)5-20-15(18)10-8-23-14(16-10)13-6-19-11-3-1-2-4-12(11)21-13/h1-4,8-9,13,17,22H,5-7H2 | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Tested for the inhibition of Candida GGTase I in Candida albicans |
Bioorg Med Chem Lett 12: 629-32 (2002)
BindingDB Entry DOI: 10.7270/Q2251HGT |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50109935
(2-(2,3-Dihydro-benzo[1,4]dioxin-2-yl)-thiazole-4-c...)Show InChI InChI=1S/C15H15NO4S2/c17-15(18-6-3-7-21)10-9-22-14(16-10)13-8-19-11-4-1-2-5-12(11)20-13/h1-2,4-5,9,13,21H,3,6-8H2 | PDB
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PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Candida geranylgeranyl transferase I at 3 uM |
Bioorg Med Chem Lett 12: 629-32 (2002)
BindingDB Entry DOI: 10.7270/Q2251HGT |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50109934
(CHEMBL347650 | Indan-2-carboxylic acid {(R)-1-[2-(...)Show SMILES O=C(NCCc1cnc[nH]1)[C@@H](Cc1cccc2ccccc12)NC(=O)C1Cc2ccccc2C1 Show InChI InChI=1S/C28H28N4O2/c33-27(23-14-20-7-1-2-8-21(20)15-23)32-26(28(34)30-13-12-24-17-29-18-31-24)16-22-10-5-9-19-6-3-4-11-25(19)22/h1-11,17-18,23,26H,12-16H2,(H,29,31)(H,30,34)(H,32,33)/t26-/m1/s1 | PDB
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| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Candida geranylgeranyl transferase I |
Bioorg Med Chem Lett 12: 629-32 (2002)
BindingDB Entry DOI: 10.7270/Q2251HGT |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50109936
(2-(2,3-Dihydro-benzo[1,4]dioxin-2-yl)-thiazole-4-c...)Show InChI InChI=1S/C15H16N2O3S2/c18-14(16-6-3-7-21)10-9-22-15(17-10)13-8-19-11-4-1-2-5-12(11)20-13/h1-2,4-5,9,13,21H,3,6-8H2,(H,16,18) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
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| PubMed
| n/a | n/a | 780 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Tested for the inhibition of Candida GGTase I in Candida albicans |
Bioorg Med Chem Lett 12: 629-32 (2002)
BindingDB Entry DOI: 10.7270/Q2251HGT |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50109939
(2-(2,3-Dihydro-benzo[1,4]dioxin-2-yl)-thiazole-4-c...)Show InChI InChI=1S/C14H13NO4S2/c16-14(17-5-6-20)9-8-21-13(15-9)12-7-18-10-3-1-2-4-11(10)19-12/h1-4,8,12,20H,5-7H2 | PDB
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PC cid
PC sid
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| PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Candida geranylgeranyl transferase I at 3 uM |
Bioorg Med Chem Lett 12: 629-32 (2002)
BindingDB Entry DOI: 10.7270/Q2251HGT |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50109933
(2-(2,3-Dihydro-benzo[1,4]dioxin-2-yl)-thiazole-4-c...)Show InChI InChI=1S/C16H17NO5S3/c18-10(6-23)14(7-24)22-16(19)9-8-25-15(17-9)13-5-20-11-3-1-2-4-12(11)21-13/h1-4,8,10,13-14,18,23-24H,5-7H2 | PDB
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PC cid
PC sid
UniChem
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| n/a | n/a | 4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human geranylgeranyl transferase I |
Bioorg Med Chem Lett 12: 629-32 (2002)
BindingDB Entry DOI: 10.7270/Q2251HGT |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50109933
(2-(2,3-Dihydro-benzo[1,4]dioxin-2-yl)-thiazole-4-c...)Show InChI InChI=1S/C16H17NO5S3/c18-10(6-23)14(7-24)22-16(19)9-8-25-15(17-9)13-5-20-11-3-1-2-4-12(11)21-13/h1-4,8,10,13-14,18,23-24H,5-7H2 | PDB
MMDB
Reactome pathway
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PC cid
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| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of human farnesyl transferase |
Bioorg Med Chem Lett 12: 629-32 (2002)
BindingDB Entry DOI: 10.7270/Q2251HGT |
More data for this
Ligand-Target Pair | |
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