Affinity Data by PubMed id=12127543

PubMed code 12127543

Found 26 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM22418 (Cocaine \| Cocaine (-) \| methyl (1R,2R,3S,5S)-3-(be...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	130	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Southern Research Institute Curated by ChEMBL					Assay Description Inhibition of [125I]RTI-55 binding to Serotonin transporter of rat caudate membranes				Bioorg Med Chem Lett 12: 2225-8 (2002) BindingDB Entry DOI: 10.7270/Q2DZ08T2
Southern Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM22418 (Cocaine \| Cocaine (-) \| methyl (1R,2R,3S,5S)-3-(be...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	460	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Southern Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]RTI-55 from Dopamine transporter of rat caudate membranes				Bioorg Med Chem Lett 12: 2225-8 (2002) BindingDB Entry DOI: 10.7270/Q2DZ08T2
Southern Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50116317 (Benzhydryl-(2-phenyl-quinazolin-4-yl)-amine \| CHEM...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	530	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Southern Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]RTI-55 from Dopamine transporter of rat caudate membranes				Bioorg Med Chem Lett 12: 2225-8 (2002) BindingDB Entry DOI: 10.7270/Q2DZ08T2
Southern Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50116318 ((1-Phenyl-ethyl)-(2-phenyl-quinazolin-4-yl)-amine ...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Southern Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]RTI-55 from Dopamine transporter of rat caudate membranes				Bioorg Med Chem Lett 12: 2225-8 (2002) BindingDB Entry DOI: 10.7270/Q2DZ08T2
Southern Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50116316 (4-(8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yloxy)-2-phe...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	5.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Southern Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]RTI-55 from Dopamine transporter of rat caudate membranes				Bioorg Med Chem Lett 12: 2225-8 (2002) BindingDB Entry DOI: 10.7270/Q2DZ08T2
Southern Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM50116316 (4-(8-Methyl-8-aza-bicyclo[3.2.1]oct-3-yloxy)-2-phe...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	5.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Southern Research Institute Curated by ChEMBL					Assay Description Inhibition of [125I]RTI-55 binding to Serotonin transporter of rat caudate membranes				Bioorg Med Chem Lett 12: 2225-8 (2002) BindingDB Entry DOI: 10.7270/Q2DZ08T2
Southern Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50116319 ((2,2-Diphenyl-ethyl)-(2-phenyl-quinazolin-4-yl)-am...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	5.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Southern Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]RTI-55 from Dopamine transporter of rat caudate membranes				Bioorg Med Chem Lett 12: 2225-8 (2002) BindingDB Entry DOI: 10.7270/Q2DZ08T2
Southern Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50116320 ((1-Phenyl-ethyl)-(2-phenyl-quinazolin-4-yl)-amine ...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	6.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Southern Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]RTI-55 from Dopamine transporter of rat caudate membranes				Bioorg Med Chem Lett 12: 2225-8 (2002) BindingDB Entry DOI: 10.7270/Q2DZ08T2
Southern Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50116315 (CHEMBL70336 \| Dimethyl-[3-(2-phenyl-quinazolin-4-y...) Show SMILES CN(C)CCCSc1nc(nc2ccccc12)-c1ccccc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	6.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Southern Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]RTI-55 from Dopamine transporter of rat caudate membranes				Bioorg Med Chem Lett 12: 2225-8 (2002) BindingDB Entry DOI: 10.7270/Q2DZ08T2
Southern Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50033296 (Benzyl-(2-phenyl-quinazolin-4-yl)-amine \| CHEMBL72...) Show SMILES C(Nc1nc(nc2ccccc12)-c1ccccc1)c1ccccc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	7.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Southern Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]RTI-55 from Dopamine transporter of rat caudate membranes				Bioorg Med Chem Lett 12: 2225-8 (2002) BindingDB Entry DOI: 10.7270/Q2DZ08T2
Southern Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50116314 (4-(1-Methyl-piperidin-4-yloxy)-2-phenyl-quinazolin...) Show SMILES CN1CCC(CC1)Oc1nc(nc2ccccc12)-c1ccccc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	9.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Southern Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]RTI-55 from Dopamine transporter of rat caudate membranes				Bioorg Med Chem Lett 12: 2225-8 (2002) BindingDB Entry DOI: 10.7270/Q2DZ08T2
Southern Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM50116315 (CHEMBL70336 \| Dimethyl-[3-(2-phenyl-quinazolin-4-y...) Show SMILES CN(C)CCCSc1nc(nc2ccccc12)-c1ccccc1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	9.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Southern Research Institute Curated by ChEMBL					Assay Description Inhibition of [125I]RTI-55 binding to Serotonin transporter of rat caudate membranes				Bioorg Med Chem Lett 12: 2225-8 (2002) BindingDB Entry DOI: 10.7270/Q2DZ08T2
Southern Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50116324 (CHEMBL70265 \| Dimethyl-[3-(2-phenyl-quinazolin-4-y...) Show SMILES CN(C)CCCOc1nc(nc2ccccc12)-c1ccccc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	9.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Southern Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]RTI-55 from Dopamine transporter of rat caudate membranes				Bioorg Med Chem Lett 12: 2225-8 (2002) BindingDB Entry DOI: 10.7270/Q2DZ08T2
Southern Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50116323 (4-Benzhydrylsulfanyl-2-phenyl-quinazoline \| CHEMBL...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Southern Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]RTI-55 from Dopamine transporter of rat caudate membranes				Bioorg Med Chem Lett 12: 2225-8 (2002) BindingDB Entry DOI: 10.7270/Q2DZ08T2
Southern Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM50116318 ((1-Phenyl-ethyl)-(2-phenyl-quinazolin-4-yl)-amine ...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Southern Research Institute Curated by ChEMBL					Assay Description Inhibition of [125I]RTI-55 binding to Serotonin transporter of rat caudate membranes				Bioorg Med Chem Lett 12: 2225-8 (2002) BindingDB Entry DOI: 10.7270/Q2DZ08T2
Southern Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM50116322 (CHEMBL304567 \| N,N-Dimethyl-N'-(2-phenyl-quinazoli...) Show SMILES CN(C)CCCNc1nc(nc2ccccc12)-c1ccccc1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Southern Research Institute Curated by ChEMBL					Assay Description Inhibition of [125I]RTI-55 binding to Serotonin transporter of rat caudate membranes				Bioorg Med Chem Lett 12: 2225-8 (2002) BindingDB Entry DOI: 10.7270/Q2DZ08T2
Southern Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM50116314 (4-(1-Methyl-piperidin-4-yloxy)-2-phenyl-quinazolin...) Show SMILES CN1CCC(CC1)Oc1nc(nc2ccccc12)-c1ccccc1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Southern Research Institute Curated by ChEMBL					Assay Description Inhibition of [125I]RTI-55 binding to Serotonin transporter of rat caudate membranes				Bioorg Med Chem Lett 12: 2225-8 (2002) BindingDB Entry DOI: 10.7270/Q2DZ08T2
Southern Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM50116321 ((3,3-Diphenyl-propyl)-(2-phenyl-quinazolin-4-yl)-a...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Southern Research Institute Curated by ChEMBL					Assay Description Inhibition of [125I]RTI-55 binding to Serotonin transporter of rat caudate membranes				Bioorg Med Chem Lett 12: 2225-8 (2002) BindingDB Entry DOI: 10.7270/Q2DZ08T2
Southern Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM50116323 (4-Benzhydrylsulfanyl-2-phenyl-quinazoline \| CHEMBL...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Southern Research Institute Curated by ChEMBL					Assay Description Inhibition of [125I]RTI-55 binding to Serotonin transporter of rat caudate membranes				Bioorg Med Chem Lett 12: 2225-8 (2002) BindingDB Entry DOI: 10.7270/Q2DZ08T2
Southern Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50116321 ((3,3-Diphenyl-propyl)-(2-phenyl-quinazolin-4-yl)-a...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Southern Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]RTI-55 from Dopamine transporter of rat caudate membranes				Bioorg Med Chem Lett 12: 2225-8 (2002) BindingDB Entry DOI: 10.7270/Q2DZ08T2
Southern Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM50116317 (Benzhydryl-(2-phenyl-quinazolin-4-yl)-amine \| CHEM...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Southern Research Institute Curated by ChEMBL					Assay Description Inhibition of [125I]RTI-55 binding to Serotonin transporter of rat caudate membranes				Bioorg Med Chem Lett 12: 2225-8 (2002) BindingDB Entry DOI: 10.7270/Q2DZ08T2
Southern Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM50116324 (CHEMBL70265 \| Dimethyl-[3-(2-phenyl-quinazolin-4-y...) Show SMILES CN(C)CCCOc1nc(nc2ccccc12)-c1ccccc1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Southern Research Institute Curated by ChEMBL					Assay Description Inhibition of [125I]RTI-55 binding to Serotonin transporter of rat caudate membranes				Bioorg Med Chem Lett 12: 2225-8 (2002) BindingDB Entry DOI: 10.7270/Q2DZ08T2
Southern Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50116322 (CHEMBL304567 \| N,N-Dimethyl-N'-(2-phenyl-quinazoli...) Show SMILES CN(C)CCCNc1nc(nc2ccccc12)-c1ccccc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Southern Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]RTI-55 from Dopamine transporter of rat caudate membranes				Bioorg Med Chem Lett 12: 2225-8 (2002) BindingDB Entry DOI: 10.7270/Q2DZ08T2
Southern Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM50033296 (Benzyl-(2-phenyl-quinazolin-4-yl)-amine \| CHEMBL72...) Show SMILES C(Nc1nc(nc2ccccc12)-c1ccccc1)c1ccccc1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Southern Research Institute Curated by ChEMBL					Assay Description Inhibition of [125I]RTI-55 binding to Serotonin transporter of rat caudate membranes				Bioorg Med Chem Lett 12: 2225-8 (2002) BindingDB Entry DOI: 10.7270/Q2DZ08T2
Southern Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM50116320 ((1-Phenyl-ethyl)-(2-phenyl-quinazolin-4-yl)-amine ...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Southern Research Institute Curated by ChEMBL					Assay Description Inhibition of [125I]RTI-55 binding to Serotonin transporter of rat caudate membranes				Bioorg Med Chem Lett 12: 2225-8 (2002) BindingDB Entry DOI: 10.7270/Q2DZ08T2
Southern Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM50116319 ((2,2-Diphenyl-ethyl)-(2-phenyl-quinazolin-4-yl)-am...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Southern Research Institute Curated by ChEMBL					Assay Description Inhibition of [125I]RTI-55 binding to Serotonin transporter of rat caudate membranes				Bioorg Med Chem Lett 12: 2225-8 (2002) BindingDB Entry DOI: 10.7270/Q2DZ08T2
Southern Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%