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PubMed code 12270168

Compile data set for download or QSAR
Found 40 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119033
PNG
((E)-3-Furan-2-yl-N-(3-methoxy-4-oxazol-5-yl-phenyl...)
Show SMILES COc1cc(NC(=O)\C=C\c2ccco2)ccc1-c1cnco1
Show InChI InChI=1S/C17H14N2O4/c1-21-15-9-12(4-6-14(15)16-10-18-11-23-16)19-17(20)7-5-13-3-2-8-22-13/h2-11H,1H3,(H,19,20)/b7-5+
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n/an/a 28n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119042
PNG
((E)-N-(3-Methoxy-4-oxazol-5-yl-phenyl)-3-o-tolyl-a...)
Show SMILES COc1cc(NC(=O)\C=C\c2ccccc2C)ccc1-c1cnco1
Show InChI InChI=1S/C20H18N2O3/c1-14-5-3-4-6-15(14)7-10-20(23)22-16-8-9-17(18(11-16)24-2)19-12-21-13-25-19/h3-13H,1-2H3,(H,22,23)/b10-7+
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n/an/a 35n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119044
PNG
((E)-N-(3-Methoxy-4-oxazol-5-yl-phenyl)-3-quinolin-...)
Show SMILES COc1cc(NC(=O)\C=C\c2ccc3ccccc3n2)ccc1-c1cnco1
Show InChI InChI=1S/C22H17N3O3/c1-27-20-12-17(8-10-18(20)21-13-23-14-28-21)25-22(26)11-9-16-7-6-15-4-2-3-5-19(15)24-16/h2-14H,1H3,(H,25,26)/b11-9+
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n/an/a 57n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119017
PNG
((E)-N-(3-Methoxy-4-oxazol-5-yl-phenyl)-3-pyridin-4...)
Show SMILES COc1cc(NC(=O)\C=C\c2ccncc2)ccc1-c1cnco1
Show InChI InChI=1S/C18H15N3O3/c1-23-16-10-14(3-4-15(16)17-11-20-12-24-17)21-18(22)5-2-13-6-8-19-9-7-13/h2-12H,1H3,(H,21,22)/b5-2+
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n/an/a 57n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119013
PNG
((E)-3-(2-Chloro-phenyl)-N-(3-methoxy-4-oxazol-5-yl...)
Show SMILES COc1cc(NC(=O)\C=C\c2ccccc2Cl)ccc1-c1cnco1
Show InChI InChI=1S/C19H15ClN2O3/c1-24-17-10-14(7-8-15(17)18-11-21-12-25-18)22-19(23)9-6-13-4-2-3-5-16(13)20/h2-12H,1H3,(H,22,23)/b9-6+
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n/an/a 60n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119022
PNG
((E)-N-(3-Methoxy-4-oxazol-5-yl-phenyl)-3-thiophen-...)
Show SMILES COc1cc(NC(=O)\C=C\c2cccs2)ccc1-c1cnco1
Show InChI InChI=1S/C17H14N2O3S/c1-21-15-9-12(4-6-14(15)16-10-18-11-22-16)19-17(20)7-5-13-3-2-8-23-13/h2-11H,1H3,(H,19,20)/b7-5+
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n/an/a 66n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119009
PNG
((E)-N-(3-Methoxy-4-oxazol-5-yl-phenyl)-3-phenyl-ac...)
Show SMILES COc1cc(NC(=O)\C=C\c2ccccc2)ccc1-c1cnco1
Show InChI InChI=1S/C19H16N2O3/c1-23-17-11-15(8-9-16(17)18-12-20-13-24-18)21-19(22)10-7-14-5-3-2-4-6-14/h2-13H,1H3,(H,21,22)/b10-7+
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n/an/a 73n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119027
PNG
((E)-3-(4-Fluoro-2,6-dimethyl-phenyl)-N-(3-methoxy-...)
Show SMILES COc1cc(NC(=O)\C=C\c2c(C)cc(F)cc2C)ccc1-c1cnco1
Show InChI InChI=1S/C21H19FN2O3/c1-13-8-15(22)9-14(2)17(13)6-7-21(25)24-16-4-5-18(19(10-16)26-3)20-11-23-12-27-20/h4-12H,1-3H3,(H,24,25)/b7-6+
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n/an/a 75n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119012
PNG
(1H-Indole-2-carboxylic acid (3-methoxy-4-oxazol-5-...)
Show SMILES COc1cc(NC(=O)c2cc3ccccc3[nH]2)ccc1-c1cnco1
Show InChI InChI=1S/C19H15N3O3/c1-24-17-9-13(6-7-14(17)18-10-20-11-25-18)21-19(23)16-8-12-4-2-3-5-15(12)22-16/h2-11,22H,1H3,(H,21,23)
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n/an/a 110n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119018
PNG
(5-Methyl-thiophene-2-carboxylic acid (3-methoxy-4-...)
Show SMILES COc1cc(NC(=O)c2ccc(C)s2)ccc1-c1cnco1
Show InChI InChI=1S/C16H14N2O3S/c1-10-3-6-15(22-10)16(19)18-11-4-5-12(13(7-11)20-2)14-8-17-9-21-14/h3-9H,1-2H3,(H,18,19)
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n/an/a 110n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119034
PNG
((E)-N-(3-Methoxy-4-oxazol-5-yl-phenyl)-3-(2-methox...)
Show SMILES COc1ccccc1\C=C\C(=O)Nc1ccc(-c2cnco2)c(OC)c1
Show InChI InChI=1S/C20H18N2O4/c1-24-17-6-4-3-5-14(17)7-10-20(23)22-15-8-9-16(18(11-15)25-2)19-12-21-13-26-19/h3-13H,1-2H3,(H,22,23)/b10-7+
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n/an/a 110n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119008
PNG
((E)-3-(4-Fluoro-phenyl)-N-(3-methoxy-4-oxazol-5-yl...)
Show SMILES COc1cc(NC(=O)\C=C\c2ccc(F)cc2)ccc1-c1cnco1
Show InChI InChI=1S/C19H15FN2O3/c1-24-17-10-15(7-8-16(17)18-11-21-12-25-18)22-19(23)9-4-13-2-5-14(20)6-3-13/h2-12H,1H3,(H,22,23)/b9-4+
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n/an/a 120n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119025
PNG
(5-tert-Butyl-furan-2-carboxylic acid (3-methoxy-4-...)
Show SMILES COc1cc(NC(=O)c2ccc(o2)C(C)(C)C)ccc1-c1cnco1
Show InChI InChI=1S/C19H20N2O4/c1-19(2,3)17-8-7-14(25-17)18(22)21-12-5-6-13(15(9-12)23-4)16-10-20-11-24-16/h5-11H,1-4H3,(H,21,22)
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n/an/a 130n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119046
PNG
(1-Methyl-1H-indole-2-carboxylic acid (3-methoxy-4-...)
Show SMILES COc1cc(NC(=O)c2cc3ccccc3n2C)ccc1-c1cnco1
Show InChI InChI=1S/C20H17N3O3/c1-23-16-6-4-3-5-13(16)9-17(23)20(24)22-14-7-8-15(18(10-14)25-2)19-11-21-12-26-19/h3-12H,1-2H3,(H,22,24)
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n/an/a 130n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119020
PNG
(CHEMBL95622 | Indolizine-2-carboxylic acid (3-meth...)
Show SMILES COc1cc(NC(=O)c2cc3ccccn3c2)ccc1-c1cnco1
Show InChI InChI=1S/C19H15N3O3/c1-24-17-9-14(5-6-16(17)18-10-20-12-25-18)21-19(23)13-8-15-4-2-3-7-22(15)11-13/h2-12H,1H3,(H,21,23)
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n/an/a 140n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119016
PNG
(Benzo[b]thiophene-2-carboxylic acid (3-methoxy-4-o...)
Show SMILES COc1cc(NC(=O)c2cc3ccccc3s2)ccc1-c1cnco1
Show InChI InChI=1S/C19H14N2O3S/c1-23-15-9-13(6-7-14(15)16-10-20-11-24-16)21-19(22)18-8-12-4-2-3-5-17(12)25-18/h2-11H,1H3,(H,21,22)
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n/an/a 170n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119043
PNG
((E)-3-(3-Fluoro-phenyl)-N-(3-methoxy-4-oxazol-5-yl...)
Show SMILES COc1cc(NC(=O)\C=C\c2cccc(F)c2)ccc1-c1cnco1
Show InChI InChI=1S/C19H15FN2O3/c1-24-17-10-15(6-7-16(17)18-11-21-12-25-18)22-19(23)8-5-13-3-2-4-14(20)9-13/h2-12H,1H3,(H,22,23)/b8-5+
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n/an/a 200n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119029
PNG
((E)-N-(3-Methoxy-4-oxazol-5-yl-phenyl)-3-pyridin-3...)
Show SMILES COc1cc(NC(=O)\C=C\c2cccnc2)ccc1-c1cnco1
Show InChI InChI=1S/C18H15N3O3/c1-23-16-9-14(5-6-15(16)17-11-20-12-24-17)21-18(22)7-4-13-3-2-8-19-10-13/h2-12H,1H3,(H,21,22)/b7-4+
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n/an/a 210n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119030
PNG
(Benzofuran-2-carboxylic acid (3-methoxy-4-oxazol-5...)
Show SMILES COc1cc(NC(=O)c2cc3ccccc3o2)ccc1-c1cnco1
Show InChI InChI=1S/C19H14N2O4/c1-23-16-9-13(6-7-14(16)18-10-20-11-24-18)21-19(22)17-8-12-4-2-3-5-15(12)25-17/h2-11H,1H3,(H,21,22)
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n/an/a 210n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119031
PNG
((E)-N-(3-Methoxy-4-oxazol-5-yl-phenyl)-3-p-tolyl-a...)
Show SMILES COc1cc(NC(=O)\C=C\c2ccc(C)cc2)ccc1-c1cnco1
Show InChI InChI=1S/C20H18N2O3/c1-14-3-5-15(6-4-14)7-10-20(23)22-16-8-9-17(18(11-16)24-2)19-12-21-13-25-19/h3-13H,1-2H3,(H,22,23)/b10-7+
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n/an/a 210n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119015
PNG
((E)-3-(4-Chloro-phenyl)-N-(3-methoxy-4-oxazol-5-yl...)
Show SMILES COc1cc(NC(=O)\C=C\c2ccc(Cl)cc2)ccc1-c1cnco1
Show InChI InChI=1S/C19H15ClN2O3/c1-24-17-10-15(7-8-16(17)18-11-21-12-25-18)22-19(23)9-4-13-2-5-14(20)6-3-13/h2-12H,1H3,(H,22,23)/b9-4+
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n/an/a 230n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119011
PNG
(CHEMBL414224 | N-(3-Methoxy-4-oxazol-5-yl-phenyl)-...)
Show SMILES COc1cc(NC(=O)c2ccc(C)c(C)c2)ccc1-c1cnco1
Show InChI InChI=1S/C19H18N2O3/c1-12-4-5-14(8-13(12)2)19(22)21-15-6-7-16(17(9-15)23-3)18-10-20-11-24-18/h4-11H,1-3H3,(H,21,22)
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n/an/a 260n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119040
PNG
((E)-3-(3-Chloro-phenyl)-N-(3-methoxy-4-oxazol-5-yl...)
Show SMILES COc1cc(NC(=O)\C=C\c2cccc(Cl)c2)ccc1-c1cnco1
Show InChI InChI=1S/C19H15ClN2O3/c1-24-17-10-15(6-7-16(17)18-11-21-12-25-18)22-19(23)8-5-13-3-2-4-14(20)9-13/h2-12H,1H3,(H,22,23)/b8-5+
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n/an/a 300n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119010
PNG
(Benzo[1,3]dioxole-5-carboxylic acid (3-methoxy-4-o...)
Show SMILES COc1cc(NC(=O)c2ccc3OCOc3c2)ccc1-c1cnco1
Show InChI InChI=1S/C18H14N2O5/c1-22-15-7-12(3-4-13(15)17-8-19-9-23-17)20-18(21)11-2-5-14-16(6-11)25-10-24-14/h2-9H,10H2,1H3,(H,20,21)
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n/an/a 330n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119019
PNG
((E)-3-(2-Fluoro-phenyl)-N-(3-methoxy-4-oxazol-5-yl...)
Show SMILES COc1cc(NC(=O)\C=C\c2ccccc2F)ccc1-c1cnco1
Show InChI InChI=1S/C19H15FN2O3/c1-24-17-10-14(7-8-15(17)18-11-21-12-25-18)22-19(23)9-6-13-4-2-3-5-16(13)20/h2-12H,1H3,(H,22,23)/b9-6+
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n/an/a 410n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119036
PNG
(4,5-Dimethyl-furan-2-carboxylic acid (3-methoxy-4-...)
Show SMILES COc1cc(NC(=O)c2cc(C)c(C)o2)ccc1-c1cnco1
Show InChI InChI=1S/C17H16N2O4/c1-10-6-15(23-11(10)2)17(20)19-12-4-5-13(14(7-12)21-3)16-8-18-9-22-16/h4-9H,1-3H3,(H,19,20)
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n/an/a 540n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119038
PNG
((E)-N-(3-Methoxy-4-oxazol-5-yl-phenyl)-3-m-tolyl-a...)
Show SMILES COc1cc(NC(=O)\C=C\c2cccc(C)c2)ccc1-c1cnco1
Show InChI InChI=1S/C20H18N2O3/c1-14-4-3-5-15(10-14)6-9-20(23)22-16-7-8-17(18(11-16)24-2)19-12-21-13-25-19/h3-13H,1-2H3,(H,22,23)/b9-6+
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n/an/a 590n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119035
PNG
(1H-Indole-5-carboxylic acid (3-methoxy-4-oxazol-5-...)
Show SMILES COc1cc(NC(=O)c2ccc3[nH]ccc3c2)ccc1-c1cnco1
Show InChI InChI=1S/C19H15N3O3/c1-24-17-9-14(3-4-15(17)18-10-20-11-25-18)22-19(23)13-2-5-16-12(8-13)6-7-21-16/h2-11,21H,1H3,(H,22,23)
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n/an/a 630n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119032
PNG
((E)-3-(1H-Indol-3-yl)-N-(3-methoxy-4-oxazol-5-yl-p...)
Show SMILES COc1cc(NC(=O)\C=C\c2c[nH]c3ccccc23)ccc1-c1cnco1
Show InChI InChI=1S/C21H17N3O3/c1-26-19-10-15(7-8-17(19)20-12-22-13-27-20)24-21(25)9-6-14-11-23-18-5-3-2-4-16(14)18/h2-13,23H,1H3,(H,24,25)/b9-6+
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n/an/a 630n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119028
PNG
(CHEMBL99571 | N-(3-Methoxy-4-oxazol-5-yl-phenyl)-b...)
Show SMILES COc1cc(NC(=O)c2ccccc2)ccc1-c1cnco1
Show InChI InChI=1S/C17H14N2O3/c1-21-15-9-13(7-8-14(15)16-10-18-11-22-16)19-17(20)12-5-3-2-4-6-12/h2-11H,1H3,(H,19,20)
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n/an/a 630n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the inosine monophosphate dehydrogenase -II (IMPDH-II) enzyme

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119007
PNG
(CHEMBL97096 | Thiophene-2-carboxylic acid (3-metho...)
Show SMILES COc1cc(NC(=O)c2cccs2)ccc1-c1cnco1
Show InChI InChI=1S/C15H12N2O3S/c1-19-12-7-10(17-15(18)14-3-2-6-21-14)4-5-11(12)13-8-16-9-20-13/h2-9H,1H3,(H,17,18)
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n/an/a 810n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119023
PNG
(5-Pyridin-2-yl-thiophene-2-carboxylic acid (3-meth...)
Show SMILES COc1cc(NC(=O)c2ccc(s2)-c2ccccn2)ccc1-c1cnco1
Show InChI InChI=1S/C20H15N3O3S/c1-25-16-10-13(5-6-14(16)17-11-21-12-26-17)23-20(24)19-8-7-18(27-19)15-4-2-3-9-22-15/h2-12H,1H3,(H,23,24)
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n/an/a 870n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119014
PNG
(1-Methyl-1H-pyrrole-2-carboxylic acid (3-methoxy-4...)
Show SMILES COc1cc(NC(=O)c2cccn2C)ccc1-c1cnco1
Show InChI InChI=1S/C16H15N3O3/c1-19-7-3-4-13(19)16(20)18-11-5-6-12(14(8-11)21-2)15-9-17-10-22-15/h3-10H,1-2H3,(H,18,20)
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n/an/a 890n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119037
PNG
((Z)-N-(3-Methoxy-4-oxazol-5-yl-phenyl)-3-(2-methox...)
Show SMILES COc1ccccc1\C=C/C(=O)Nc1ccc(-c2cnco2)c(OC)c1
Show InChI InChI=1S/C20H18N2O4/c1-24-17-6-4-3-5-14(17)7-10-20(23)22-15-8-9-16(18(11-15)25-2)19-12-21-13-26-19/h3-13H,1-2H3,(H,22,23)/b10-7-
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n/an/a 960n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119026
PNG
(CHEMBL419143 | N-(3-Methoxy-4-oxazol-5-yl-phenyl)-...)
Show SMILES COc1cc(NC(=O)Cc2ccccc2)ccc1-c1cnco1
Show InChI InChI=1S/C18H16N2O3/c1-22-16-10-14(7-8-15(16)17-11-19-12-23-17)20-18(21)9-13-5-3-2-4-6-13/h2-8,10-12H,9H2,1H3,(H,20,21)
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n/an/a 970n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119024
PNG
(3-Methyl-furan-2-carboxylic acid (3-methoxy-4-oxaz...)
Show SMILES COc1cc(NC(=O)c2occc2C)ccc1-c1cnco1
Show InChI InChI=1S/C16H14N2O4/c1-10-5-6-21-15(10)16(19)18-11-3-4-12(13(7-11)20-2)14-8-17-9-22-14/h3-9H,1-2H3,(H,18,19)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119041
PNG
(1H-Indazole-3-carboxylic acid (3-methoxy-4-oxazol-...)
Show SMILES COc1cc(NC(=O)c2[nH]nc3ccccc23)ccc1-c1cnco1
Show InChI InChI=1S/C18H14N4O3/c1-24-15-8-11(6-7-13(15)16-9-19-10-25-16)20-18(23)17-12-4-2-3-5-14(12)21-22-17/h2-10H,1H3,(H,20,23)(H,21,22)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 1


(Homo sapiens (Human))		BDBM50119012
PNG
(1H-Indole-2-carboxylic acid (3-methoxy-4-oxazol-5-...)
Show SMILES COc1cc(NC(=O)c2cc3ccccc3[nH]2)ccc1-c1cnco1
Show InChI InChI=1S/C19H15N3O3/c1-24-17-9-13(6-7-14(17)18-10-20-11-25-18)21-19(23)16-8-12-4-2-3-5-15(12)22-16/h2-11,22H,1H3,(H,21,23)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 1

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119039
PNG
(CHEMBL98488 | Furan-2-carboxylic acid (3-methoxy-4...)
Show SMILES COc1cc(NC(=O)c2ccco2)ccc1-c1cnco1
Show InChI InChI=1S/C15H12N2O4/c1-19-13-7-10(17-15(18)12-3-2-6-20-12)4-5-11(13)14-8-16-9-21-14/h2-9H,1H3,(H,17,18)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
Inosine-5'-monophosphate dehydrogenase 2


(Homo sapiens (Human))		BDBM50119021
PNG
(1H-Indole-3-carboxylic acid (3-methoxy-4-oxazol-5-...)
Show SMILES COc1cc(NC(=O)c2c[nH]c3ccccc23)ccc1-c1cnco1
Show InChI InChI=1S/C19H15N3O3/c1-24-17-8-12(6-7-14(17)18-10-20-11-25-18)22-19(23)15-9-21-16-5-3-2-4-13(15)16/h2-11,21H,1H3,(H,22,23)
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n/an/a>3.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb PRI

Curated by ChEMBL


Assay Description
Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2

Bioorg Med Chem Lett 12: 2879-82 (2002)


BindingDB Entry DOI: 10.7270/Q29886B5
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%