Affinity Data by PubMed id=12270187

PubMed code 12270187

Found 12 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
ATP-binding cassette sub-family C member 8/ATP-sensitive inward rectifier potassium channel 11 (Homo sapiens (Human))	BDBM50119269 (CHEMBL102025 \| Cyclobutyl-(7-fluoro-1,1-dioxo-1,4-...) Show SMILES Fc1ccc2N=C(NC3CCC3)NS(=O)(=O)c2c1 \|t:5\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	356	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Inhibition of Beta-cell KATP channel				Bioorg Med Chem Lett 12: 2977-80 (2002) BindingDB Entry DOI: 10.7270/Q20V8C4M
GlaxoSmithKline Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 8/ATP-sensitive inward rectifier potassium channel 11 (Homo sapiens (Human))	BDBM50119270 (CHEMBL319596 \| Cyclobutyl-(1,1-dioxo-1,4-dihydro-1...) Show SMILES O=S1(=O)NC(NC2CCC2)=Nc2ccccc12 \|c:10\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	1.96E+3	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Inhibition of Beta-cell KATP channel				Bioorg Med Chem Lett 12: 2977-80 (2002) BindingDB Entry DOI: 10.7270/Q20V8C4M
GlaxoSmithKline Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 8/ATP-sensitive inward rectifier potassium channel 11 (Homo sapiens (Human))	BDBM50119273 (CHEMBL101736 \| N3-Cyclobutyl-1,1-dioxo-1,4-dihyd...) Show SMILES Nc1ccc2N=C(NC3CCC3)NS(=O)(=O)c2c1 \|t:5\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	3.20E+4	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Negative log EC50 for Beta-cell KATP channel				Bioorg Med Chem Lett 12: 2977-80 (2002) BindingDB Entry DOI: 10.7270/Q20V8C4M
GlaxoSmithKline Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 8/ATP-sensitive inward rectifier potassium channel 11 (Homo sapiens (Human))	BDBM50119270 (CHEMBL319596 \| Cyclobutyl-(1,1-dioxo-1,4-dihydro-1...) Show SMILES O=S1(=O)NC(NC2CCC2)=Nc2ccccc12 \|c:10\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Negative log EC50 for Beta-cell KATP channel				Bioorg Med Chem Lett 12: 2977-80 (2002) BindingDB Entry DOI: 10.7270/Q20V8C4M
GlaxoSmithKline Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 8/ATP-sensitive inward rectifier potassium channel 11 (Homo sapiens (Human))	BDBM50119273 (CHEMBL101736 \| N3-Cyclobutyl-1,1-dioxo-1,4-dihyd...) Show SMILES Nc1ccc2N=C(NC3CCC3)NS(=O)(=O)c2c1 \|t:5\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	3.10E+4	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Inhibition of Beta-cell KATP channel				Bioorg Med Chem Lett 12: 2977-80 (2002) BindingDB Entry DOI: 10.7270/Q20V8C4M
GlaxoSmithKline Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 8/ATP-sensitive inward rectifier potassium channel 11 (Homo sapiens (Human))	BDBM50119274 (CHEMBL100793 \| Cyclobutyl-(7-nitro-1,1-dioxo-1,4-d...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	530	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Inhibition of Beta-cell KATP channel				Bioorg Med Chem Lett 12: 2977-80 (2002) BindingDB Entry DOI: 10.7270/Q20V8C4M
GlaxoSmithKline Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 8/ATP-sensitive inward rectifier potassium channel 11 (Homo sapiens (Human))	BDBM50119271 (CHEMBL319521 \| Cyclobutyl-(7-methoxy-1,1-dioxo-1,4...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	3.87E+3	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Inhibition of Beta-cell KATP channel				Bioorg Med Chem Lett 12: 2977-80 (2002) BindingDB Entry DOI: 10.7270/Q20V8C4M
GlaxoSmithKline Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 8/ATP-sensitive inward rectifier potassium channel 11 (Homo sapiens (Human))	BDBM86248 (CAS_364-98-7 \| NSC_3019 \| diazoxide) Show SMILES CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1 \|t:1\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Patents	PubMed	n/a	n/a	n/a	n/a	8.80E+3	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Inhibition of Beta-cell KATP channel				Bioorg Med Chem Lett 12: 2977-80 (2002) BindingDB Entry DOI: 10.7270/Q20V8C4M
GlaxoSmithKline Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 8/ATP-sensitive inward rectifier potassium channel 11 (Homo sapiens (Human))	BDBM50119272 ((7-Chloro-1,1-dioxo-1,4-dihydro-1lambda6-benzo[1...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	196	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Inhibition of Beta-cell KATP channel				Bioorg Med Chem Lett 12: 2977-80 (2002) BindingDB Entry DOI: 10.7270/Q20V8C4M
GlaxoSmithKline Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 8/ATP-sensitive inward rectifier potassium channel 11 (Homo sapiens (Human))	BDBM50119272 ((7-Chloro-1,1-dioxo-1,4-dihydro-1lambda6-benzo[1...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Negative log EC50 for Beta-cell KATP channel				Bioorg Med Chem Lett 12: 2977-80 (2002) BindingDB Entry DOI: 10.7270/Q20V8C4M
GlaxoSmithKline Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 8/ATP-sensitive inward rectifier potassium channel 11 (Homo sapiens (Human))	BDBM50119271 (CHEMBL319521 \| Cyclobutyl-(7-methoxy-1,1-dioxo-1,4...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Negative log EC50 for Beta-cell KATP channel				Bioorg Med Chem Lett 12: 2977-80 (2002) BindingDB Entry DOI: 10.7270/Q20V8C4M
GlaxoSmithKline Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 8/ATP-sensitive inward rectifier potassium channel 11 (Homo sapiens (Human))	BDBM50119269 (CHEMBL102025 \| Cyclobutyl-(7-fluoro-1,1-dioxo-1,4-...) Show SMILES Fc1ccc2N=C(NC3CCC3)NS(=O)(=O)c2c1 \|t:5\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	400	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Negative log EC50 for Beta-cell KATP channel				Bioorg Med Chem Lett 12: 2977-80 (2002) BindingDB Entry DOI: 10.7270/Q20V8C4M
GlaxoSmithKline Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%