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PubMed code 12502354

Compile data set for download or QSAR
Found 30 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50122512
PNG
(3-{4-[2-(4-Fluoro-phenyl)-2-(4-methyl-piperazin-1-...)
Show SMILES CC(CN1CCN(CC(N2CCN(C)CC2)c2ccc(F)cc2)CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C27H37FN4O/c1-22(27(33)24-6-4-3-5-7-24)20-30-14-16-31(17-15-30)21-26(23-8-10-25(28)11-9-23)32-18-12-29(2)13-19-32/h3-11,22,26H,12-21H2,1-2H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of [125I]-AGRP to the human Melanocortin 4 receptor

J Med Chem 46: 9-11 (2002)


Article DOI: 10.1021/jm0255522
BindingDB Entry DOI: 10.7270/Q2SQ8ZQ1
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50122513
PNG
(1-(4-Chloro-phenyl)-3-{4-[2-(4-chloro-phenyl)-2-(4...)
Show SMILES CC(CN1CCN(CC(N2CCN(C)CC2)c2ccc(Cl)cc2)CC1)C(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H36Cl2N4O/c1-21(27(34)23-5-9-25(29)10-6-23)19-31-13-15-32(16-14-31)20-26(22-3-7-24(28)8-4-22)33-17-11-30(2)12-18-33/h3-10,21,26H,11-20H2,1-2H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of [125I]-AGRP to the human Melanocortin 4 receptor

J Med Chem 46: 9-11 (2002)


Article DOI: 10.1021/jm0255522
BindingDB Entry DOI: 10.7270/Q2SQ8ZQ1
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50122513
PNG
(1-(4-Chloro-phenyl)-3-{4-[2-(4-chloro-phenyl)-2-(4...)
Show SMILES CC(CN1CCN(CC(N2CCN(C)CC2)c2ccc(Cl)cc2)CC1)C(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H36Cl2N4O/c1-21(27(34)23-5-9-25(29)10-6-23)19-31-13-15-32(16-14-31)20-26(22-3-7-24(28)8-4-22)33-17-11-30(2)12-18-33/h3-10,21,26H,11-20H2,1-2H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of alpha [125I]-NDP-MSH to the human Melanocortin 4 receptor

J Med Chem 46: 9-11 (2002)


Article DOI: 10.1021/jm0255522
BindingDB Entry DOI: 10.7270/Q2SQ8ZQ1
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50122508
PNG
(3-{4-[2-(4-Cyclohexyl-piperazin-1-yl)-2-(4-fluoro-...)
Show SMILES CC(CN1CCN(CC(N2CCN(CC2)C2CCCCC2)c2ccc(F)cc2)CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C32H45FN4O/c1-26(32(38)28-8-4-2-5-9-28)24-34-16-18-35(19-17-34)25-31(27-12-14-29(33)15-13-27)37-22-20-36(21-23-37)30-10-6-3-7-11-30/h2,4-5,8-9,12-15,26,30-31H,3,6-7,10-11,16-25H2,1H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of [125I]-AGRP to the human Melanocortin 4 receptor

J Med Chem 46: 9-11 (2002)


Article DOI: 10.1021/jm0255522
BindingDB Entry DOI: 10.7270/Q2SQ8ZQ1
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50122508
PNG
(3-{4-[2-(4-Cyclohexyl-piperazin-1-yl)-2-(4-fluoro-...)
Show SMILES CC(CN1CCN(CC(N2CCN(CC2)C2CCCCC2)c2ccc(F)cc2)CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C32H45FN4O/c1-26(32(38)28-8-4-2-5-9-28)24-34-16-18-35(19-17-34)25-31(27-12-14-29(33)15-13-27)37-22-20-36(21-23-37)30-10-6-3-7-11-30/h2,4-5,8-9,12-15,26,30-31H,3,6-7,10-11,16-25H2,1H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of alpha [125I]-NDP-MSH to the human Melanocortin 4 receptor

J Med Chem 46: 9-11 (2002)


Article DOI: 10.1021/jm0255522
BindingDB Entry DOI: 10.7270/Q2SQ8ZQ1
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50122515
PNG
(1-(4-Chloro-phenyl)-3-{4-[2-(4-fluoro-phenyl)-2-(4...)
Show SMILES CC(CN1CCN(CC(N2CCN(C)CC2)c2ccc(F)cc2)CC1)C(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H36ClFN4O/c1-21(27(34)23-3-7-24(28)8-4-23)19-31-13-15-32(16-14-31)20-26(22-5-9-25(29)10-6-22)33-17-11-30(2)12-18-33/h3-10,21,26H,11-20H2,1-2H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of alpha [125I]-NDP-MSH to the human Melanocortin 4 receptor

J Med Chem 46: 9-11 (2002)


Article DOI: 10.1021/jm0255522
BindingDB Entry DOI: 10.7270/Q2SQ8ZQ1
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50122516
PNG
(1-(3,4-Dichloro-phenyl)-3-{4-[2-(4-fluoro-phenyl)-...)
Show SMILES CC(CN1CCN(CC(N2CCN(C)CC2)c2ccc(F)cc2)CC1)C(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C27H35Cl2FN4O/c1-20(27(35)22-5-8-24(28)25(29)17-22)18-32-11-13-33(14-12-32)19-26(21-3-6-23(30)7-4-21)34-15-9-31(2)10-16-34/h3-8,17,20,26H,9-16,18-19H2,1-2H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of alpha [125I]-NDP-MSH to the human Melanocortin 4 receptor

J Med Chem 46: 9-11 (2002)


Article DOI: 10.1021/jm0255522
BindingDB Entry DOI: 10.7270/Q2SQ8ZQ1
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50122502
PNG
(3-{4-[2-(4-Ethyl-piperazin-1-yl)-2-(4-fluoro-pheny...)
Show SMILES CCN1CCN(CC1)C(CN1CCN(CC(C)C(=O)c2ccccc2)CC1)c1ccc(F)cc1
Show InChI InChI=1S/C28H39FN4O/c1-3-30-17-19-33(20-18-30)27(24-9-11-26(29)12-10-24)22-32-15-13-31(14-16-32)21-23(2)28(34)25-7-5-4-6-8-25/h4-12,23,27H,3,13-22H2,1-2H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of alpha [125I]-NDP-MSH to the human Melanocortin 4 receptor

J Med Chem 46: 9-11 (2002)


Article DOI: 10.1021/jm0255522
BindingDB Entry DOI: 10.7270/Q2SQ8ZQ1
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50122512
PNG
(3-{4-[2-(4-Fluoro-phenyl)-2-(4-methyl-piperazin-1-...)
Show SMILES CC(CN1CCN(CC(N2CCN(C)CC2)c2ccc(F)cc2)CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C27H37FN4O/c1-22(27(33)24-6-4-3-5-7-24)20-30-14-16-31(17-15-30)21-26(23-8-10-25(28)11-9-23)32-18-12-29(2)13-19-32/h3-11,22,26H,12-21H2,1-2H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of alpha [125I]-NDP-MSH to the human Melanocortin 4 receptor

J Med Chem 46: 9-11 (2002)


Article DOI: 10.1021/jm0255522
BindingDB Entry DOI: 10.7270/Q2SQ8ZQ1
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50122507
PNG
(3-{4-[2-(4-Fluoro-phenyl)-2-(4-phenyl-piperazin-1-...)
Show SMILES CC(CN1CCN(CC(N2CCN(CC2)c2ccccc2)c2ccc(F)cc2)CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C32H39FN4O/c1-26(32(38)28-8-4-2-5-9-28)24-34-16-18-35(19-17-34)25-31(27-12-14-29(33)15-13-27)37-22-20-36(21-23-37)30-10-6-3-7-11-30/h2-15,26,31H,16-25H2,1H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of alpha [125I]-NDP-MSH to the human Melanocortin 4 receptor

J Med Chem 46: 9-11 (2002)


Article DOI: 10.1021/jm0255522
BindingDB Entry DOI: 10.7270/Q2SQ8ZQ1
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50122515
PNG
(1-(4-Chloro-phenyl)-3-{4-[2-(4-fluoro-phenyl)-2-(4...)
Show SMILES CC(CN1CCN(CC(N2CCN(C)CC2)c2ccc(F)cc2)CC1)C(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H36ClFN4O/c1-21(27(34)23-3-7-24(28)8-4-23)19-31-13-15-32(16-14-31)20-26(22-5-9-25(29)10-6-22)33-17-11-30(2)12-18-33/h3-10,21,26H,11-20H2,1-2H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of [125I]-AGRP to the human Melanocortin 4 receptor

J Med Chem 46: 9-11 (2002)


Article DOI: 10.1021/jm0255522
BindingDB Entry DOI: 10.7270/Q2SQ8ZQ1
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50122502
PNG
(3-{4-[2-(4-Ethyl-piperazin-1-yl)-2-(4-fluoro-pheny...)
Show SMILES CCN1CCN(CC1)C(CN1CCN(CC(C)C(=O)c2ccccc2)CC1)c1ccc(F)cc1
Show InChI InChI=1S/C28H39FN4O/c1-3-30-17-19-33(20-18-30)27(24-9-11-26(29)12-10-24)22-32-15-13-31(14-16-32)21-23(2)28(34)25-7-5-4-6-8-25/h4-12,23,27H,3,13-22H2,1-2H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of [125I]-AGRP to the human Melanocortin 4 receptor

J Med Chem 46: 9-11 (2002)


Article DOI: 10.1021/jm0255522
BindingDB Entry DOI: 10.7270/Q2SQ8ZQ1
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50122510
PNG
(3-{4-[2-(3-Chloro-phenyl)-2-(4-methyl-piperazin-1-...)
Show SMILES CC(CN1CCN(CC(N2CCN(C)CC2)c2cccc(Cl)c2)CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C27H37ClN4O/c1-22(27(33)23-7-4-3-5-8-23)20-30-13-15-31(16-14-30)21-26(24-9-6-10-25(28)19-24)32-17-11-29(2)12-18-32/h3-10,19,22,26H,11-18,20-21H2,1-2H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of [125I]-AGRP to the human Melanocortin 4 receptor

J Med Chem 46: 9-11 (2002)


Article DOI: 10.1021/jm0255522
BindingDB Entry DOI: 10.7270/Q2SQ8ZQ1
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50122516
PNG
(1-(3,4-Dichloro-phenyl)-3-{4-[2-(4-fluoro-phenyl)-...)
Show SMILES CC(CN1CCN(CC(N2CCN(C)CC2)c2ccc(F)cc2)CC1)C(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C27H35Cl2FN4O/c1-20(27(35)22-5-8-24(28)25(29)17-22)18-32-11-13-33(14-12-32)19-26(21-3-6-23(30)7-4-21)34-15-9-31(2)10-16-34/h3-8,17,20,26H,9-16,18-19H2,1-2H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of [125I]-AGRP to the human Melanocortin 4 receptor

J Med Chem 46: 9-11 (2002)


Article DOI: 10.1021/jm0255522
BindingDB Entry DOI: 10.7270/Q2SQ8ZQ1
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50122509
PNG
(3-{4-[2-(4-Fluoro-phenyl)-2-(4-methyl-piperazin-1-...)
Show SMILES CC(CN1CCN(CC(N2CCN(C)CC2)c2ccc(F)cc2)CC1)C(=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C28H36F4N4O/c1-21(27(37)23-3-7-24(8-4-23)28(30,31)32)19-34-13-15-35(16-14-34)20-26(22-5-9-25(29)10-6-22)36-17-11-33(2)12-18-36/h3-10,21,26H,11-20H2,1-2H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of alpha [125I]-NDP-MSH to the human Melanocortin 4 receptor

J Med Chem 46: 9-11 (2002)


Article DOI: 10.1021/jm0255522
BindingDB Entry DOI: 10.7270/Q2SQ8ZQ1
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50122505
PNG
(3-{4-[2-(4-Fluoro-phenyl)-2-(4-methyl-piperazin-1-...)
Show SMILES CC(CN1CCN(CC(N2CCN(C)CC2)c2ccc(F)cc2)CC1)C(=O)c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C27H36FN5O3/c1-21(27(34)23-5-9-25(10-6-23)33(35)36)19-30-13-15-31(16-14-30)20-26(22-3-7-24(28)8-4-22)32-17-11-29(2)12-18-32/h3-10,21,26H,11-20H2,1-2H3
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n/an/a 588n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of [125I]-AGRP to the human Melanocortin 4 receptor

J Med Chem 46: 9-11 (2002)


Article DOI: 10.1021/jm0255522
BindingDB Entry DOI: 10.7270/Q2SQ8ZQ1
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50122506
PNG
(3-{4-[2-(4-Fluoro-phenyl)-2-(4-methyl-piperazin-1-...)
Show SMILES COc1ccc(cc1)C(=O)C(C)CN1CCN(CC(N2CCN(C)CC2)c2ccc(F)cc2)CC1
Show InChI InChI=1S/C28H39FN4O2/c1-22(28(34)24-6-10-26(35-3)11-7-24)20-31-14-16-32(17-15-31)21-27(23-4-8-25(29)9-5-23)33-18-12-30(2)13-19-33/h4-11,22,27H,12-21H2,1-3H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of alpha [125I]-NDP-MSH to the human Melanocortin 4 receptor

J Med Chem 46: 9-11 (2002)


Article DOI: 10.1021/jm0255522
BindingDB Entry DOI: 10.7270/Q2SQ8ZQ1
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50122510
PNG
(3-{4-[2-(3-Chloro-phenyl)-2-(4-methyl-piperazin-1-...)
Show SMILES CC(CN1CCN(CC(N2CCN(C)CC2)c2cccc(Cl)c2)CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C27H37ClN4O/c1-22(27(33)23-7-4-3-5-8-23)20-30-13-15-31(16-14-30)21-26(24-9-6-10-25(28)19-24)32-17-11-29(2)12-18-32/h3-10,19,22,26H,11-18,20-21H2,1-2H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of alpha [125I]-NDP-MSH to the human Melanocortin 4 receptor

J Med Chem 46: 9-11 (2002)


Article DOI: 10.1021/jm0255522
BindingDB Entry DOI: 10.7270/Q2SQ8ZQ1
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50122509
PNG
(3-{4-[2-(4-Fluoro-phenyl)-2-(4-methyl-piperazin-1-...)
Show SMILES CC(CN1CCN(CC(N2CCN(C)CC2)c2ccc(F)cc2)CC1)C(=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C28H36F4N4O/c1-21(27(37)23-3-7-24(8-4-23)28(30,31)32)19-34-13-15-35(16-14-34)20-26(22-5-9-25(29)10-6-22)36-17-11-33(2)12-18-36/h3-10,21,26H,11-20H2,1-2H3
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n/an/a 820n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of [125I]-AGRP to the human Melanocortin 4 receptor

J Med Chem 46: 9-11 (2002)


Article DOI: 10.1021/jm0255522
BindingDB Entry DOI: 10.7270/Q2SQ8ZQ1
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50122505
PNG
(3-{4-[2-(4-Fluoro-phenyl)-2-(4-methyl-piperazin-1-...)
Show SMILES CC(CN1CCN(CC(N2CCN(C)CC2)c2ccc(F)cc2)CC1)C(=O)c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C27H36FN5O3/c1-21(27(34)23-5-9-25(10-6-23)33(35)36)19-30-13-15-31(16-14-30)20-26(22-3-7-24(28)8-4-22)32-17-11-29(2)12-18-32/h3-10,21,26H,11-20H2,1-2H3
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n/an/a 1.50E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of alpha [125I]-NDP-MSH to the human Melanocortin 4 receptor

J Med Chem 46: 9-11 (2002)


Article DOI: 10.1021/jm0255522
BindingDB Entry DOI: 10.7270/Q2SQ8ZQ1
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50122506
PNG
(3-{4-[2-(4-Fluoro-phenyl)-2-(4-methyl-piperazin-1-...)
Show SMILES COc1ccc(cc1)C(=O)C(C)CN1CCN(CC(N2CCN(C)CC2)c2ccc(F)cc2)CC1
Show InChI InChI=1S/C28H39FN4O2/c1-22(28(34)24-6-10-26(35-3)11-7-24)20-31-14-16-32(17-15-31)21-27(23-4-8-25(29)9-5-23)33-18-12-30(2)13-19-33/h4-11,22,27H,12-21H2,1-3H3
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n/an/a 2.15E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of [125I]-AGRP to the human Melanocortin 4 receptor

J Med Chem 46: 9-11 (2002)


Article DOI: 10.1021/jm0255522
BindingDB Entry DOI: 10.7270/Q2SQ8ZQ1
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50122507
PNG
(3-{4-[2-(4-Fluoro-phenyl)-2-(4-phenyl-piperazin-1-...)
Show SMILES CC(CN1CCN(CC(N2CCN(CC2)c2ccccc2)c2ccc(F)cc2)CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C32H39FN4O/c1-26(32(38)28-8-4-2-5-9-28)24-34-16-18-35(19-17-34)25-31(27-12-14-29(33)15-13-27)37-22-20-36(21-23-37)30-10-6-3-7-11-30/h2-15,26,31H,16-25H2,1H3
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n/an/a 2.86E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of [125I]-AGRP to the human Melanocortin 4 receptor

J Med Chem 46: 9-11 (2002)


Article DOI: 10.1021/jm0255522
BindingDB Entry DOI: 10.7270/Q2SQ8ZQ1
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50122511
PNG
(2-{4-[2-(4-Chloro-phenyl)-2-(4-methyl-piperazin-1-...)
Show SMILES CN1CCN(CC1)C(CN1CCN(CC2CCc3ccccc3C2=O)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C28H37ClN4O/c1-30-12-18-33(19-13-30)27(23-8-10-25(29)11-9-23)21-32-16-14-31(15-17-32)20-24-7-6-22-4-2-3-5-26(22)28(24)34/h2-5,8-11,24,27H,6-7,12-21H2,1H3
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n/an/a 3.23E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of alpha [125I]-NDP-MSH to the human Melanocortin 4 receptor

J Med Chem 46: 9-11 (2002)


Article DOI: 10.1021/jm0255522
BindingDB Entry DOI: 10.7270/Q2SQ8ZQ1
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50122503
PNG
(1-{1-(4-fluorophenyl)-2-[4-(3-phenylpropyl)hexahyd...)
Show SMILES CN1CCN(CC1)C(CN1CCN(CCCc2ccccc2)CC1)c1ccc(F)cc1
Show InChI InChI=1S/C26H37FN4/c1-28-14-20-31(21-15-28)26(24-9-11-25(27)12-10-24)22-30-18-16-29(17-19-30)13-5-8-23-6-3-2-4-7-23/h2-4,6-7,9-12,26H,5,8,13-22H2,1H3
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n/an/a 3.83E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of alpha [125I]-NDP-MSH to the human Melanocortin 4 receptor

J Med Chem 46: 9-11 (2002)


Article DOI: 10.1021/jm0255522
BindingDB Entry DOI: 10.7270/Q2SQ8ZQ1
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50122514
PNG
(2-Methyl-3-{4-[2-(4-methyl-piperazin-1-yl)-2-pheny...)
Show SMILES CC(CN1CCN(CC(N2CCN(C)CC2)c2ccccc2)CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C27H38N4O/c1-23(27(32)25-11-7-4-8-12-25)21-29-15-17-30(18-16-29)22-26(24-9-5-3-6-10-24)31-19-13-28(2)14-20-31/h3-12,23,26H,13-22H2,1-2H3
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n/an/a>5.00E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of [125I]-AGRP to the human Melanocortin 4 receptor

J Med Chem 46: 9-11 (2002)


Article DOI: 10.1021/jm0255522
BindingDB Entry DOI: 10.7270/Q2SQ8ZQ1
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50122504
PNG
(3-{4-[2-(4-Fluoro-phenyl)-2-(4-methyl-piperazin-1-...)
Show SMILES CN1CCN(CC1)C(CN1CCN(CCC(=O)c2ccccc2)CC1)c1ccc(F)cc1
Show InChI InChI=1S/C26H35FN4O/c1-28-13-19-31(20-14-28)25(22-7-9-24(27)10-8-22)21-30-17-15-29(16-18-30)12-11-26(32)23-5-3-2-4-6-23/h2-10,25H,11-21H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of alpha [125I]-NDP-MSH to the human Melanocortin 4 receptor

J Med Chem 46: 9-11 (2002)


Article DOI: 10.1021/jm0255522
BindingDB Entry DOI: 10.7270/Q2SQ8ZQ1
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50122504
PNG
(3-{4-[2-(4-Fluoro-phenyl)-2-(4-methyl-piperazin-1-...)
Show SMILES CN1CCN(CC1)C(CN1CCN(CCC(=O)c2ccccc2)CC1)c1ccc(F)cc1
Show InChI InChI=1S/C26H35FN4O/c1-28-13-19-31(20-14-28)25(22-7-9-24(27)10-8-22)21-30-17-15-29(16-18-30)12-11-26(32)23-5-3-2-4-6-23/h2-10,25H,11-21H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of [125I]-AGRP to the human Melanocortin 4 receptor

J Med Chem 46: 9-11 (2002)


Article DOI: 10.1021/jm0255522
BindingDB Entry DOI: 10.7270/Q2SQ8ZQ1
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50122511
PNG
(2-{4-[2-(4-Chloro-phenyl)-2-(4-methyl-piperazin-1-...)
Show SMILES CN1CCN(CC1)C(CN1CCN(CC2CCc3ccccc3C2=O)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C28H37ClN4O/c1-30-12-18-33(19-13-30)27(23-8-10-25(29)11-9-23)21-32-16-14-31(15-17-32)20-24-7-6-22-4-2-3-5-26(22)28(24)34/h2-5,8-11,24,27H,6-7,12-21H2,1H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of [125I]-AGRP to the human Melanocortin 4 receptor

J Med Chem 46: 9-11 (2002)


Article DOI: 10.1021/jm0255522
BindingDB Entry DOI: 10.7270/Q2SQ8ZQ1
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50122514
PNG
(2-Methyl-3-{4-[2-(4-methyl-piperazin-1-yl)-2-pheny...)
Show SMILES CC(CN1CCN(CC(N2CCN(C)CC2)c2ccccc2)CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C27H38N4O/c1-23(27(32)25-11-7-4-8-12-25)21-29-15-17-30(18-16-29)22-26(24-9-5-3-6-10-24)31-19-13-28(2)14-20-31/h3-12,23,26H,13-22H2,1-2H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of alpha [125I]-NDP-MSH to the human Melanocortin 4 receptor

J Med Chem 46: 9-11 (2002)


Article DOI: 10.1021/jm0255522
BindingDB Entry DOI: 10.7270/Q2SQ8ZQ1
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50122503
PNG
(1-{1-(4-fluorophenyl)-2-[4-(3-phenylpropyl)hexahyd...)
Show SMILES CN1CCN(CC1)C(CN1CCN(CCCc2ccccc2)CC1)c1ccc(F)cc1
Show InChI InChI=1S/C26H37FN4/c1-28-14-20-31(21-15-28)26(24-9-11-25(27)12-10-24)22-30-18-16-29(17-19-30)13-5-8-23-6-3-2-4-7-23/h2-4,6-7,9-12,26H,5,8,13-22H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
In vitro ability to inhibit the binding of [125I]-AGRP to the human Melanocortin 4 receptor

J Med Chem 46: 9-11 (2002)


Article DOI: 10.1021/jm0255522
BindingDB Entry DOI: 10.7270/Q2SQ8ZQ1
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%