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PubMed code 12570387

Compile data set for download or QSAR
Found 60 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM21392
PNG
(3-(2-aminoethyl)-1H-indole-5-carboxamide | 5-CT | ...)
Show SMILES NCCc1c[nH]c2ccc(cc12)C(N)=O
Show InChI InChI=1S/C11H13N3O/c12-4-3-8-6-14-10-2-1-7(11(13)15)5-9(8)10/h1-2,5-6,14H,3-4,12H2,(H2,13,15)
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 0.510n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 7 receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50068364
PNG
(1-(3-Methoxy-phenyl)-4-[4-(2-methoxy-phenyl)-piper...)
Show SMILES COc1cccc(c1)C(=O)CCCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C22H28N2O3/c1-26-19-8-5-7-18(17-19)21(25)10-6-12-23-13-15-24(16-14-23)20-9-3-4-11-22(20)27-2/h3-5,7-9,11,17H,6,10,12-16H2,1-2H3
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 0.780n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 1A receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM50123695
PNG
(6-(4-Benzo[d]isoxazol-3-yl-piperazin-1-yl)-1-(2-me...)
Show SMILES COc1ccccc1C(=O)CCCCCN1CCN(CC1)c1noc2ccccc12
Show InChI InChI=1S/C24H29N3O3/c1-29-22-12-6-4-9-19(22)21(28)11-3-2-8-14-26-15-17-27(18-16-26)24-20-10-5-7-13-23(20)30-25-24/h4-7,9-10,12-13H,2-3,8,11,14-18H2,1H3
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 0.900n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 7 receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM21393
PNG
(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Show SMILES CCCN(CCC)C1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
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 1.20n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 1A receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM50123697
PNG
(6-(4-Benzo[d]isoxazol-3-yl-piperazin-1-yl)-1-(2-hy...)
Show SMILES Oc1ccccc1C(=O)CCCCCN1CCN(CC1)c1noc2ccccc12
Show InChI InChI=1S/C23H27N3O3/c27-20(18-8-3-5-11-21(18)28)10-2-1-7-13-25-14-16-26(17-15-25)23-19-9-4-6-12-22(19)29-24-23/h3-6,8-9,11-12,28H,1-2,7,10,13-17H2
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 2.93n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 7 receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50123710
PNG
(1-(3-Methoxy-phenyl)-6-[4-(2-methoxy-phenyl)-piper...)
Show SMILES COc1cccc(c1)C(=O)CCCCCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C24H32N2O3/c1-28-21-10-8-9-20(19-21)23(27)12-4-3-7-14-25-15-17-26(18-16-25)22-11-5-6-13-24(22)29-2/h5-6,8-11,13,19H,3-4,7,12,14-18H2,1-2H3
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 3.40n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 1A receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50123716
PNG
(1-(3-Methoxy-phenyl)-5-[4-(2-methoxy-phenyl)-piper...)
Show SMILES COc1cccc(c1)C(=O)CCCCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C23H30N2O3/c1-27-20-9-7-8-19(18-20)22(26)11-5-6-13-24-14-16-25(17-15-24)21-10-3-4-12-23(21)28-2/h3-4,7-10,12,18H,5-6,11,13-17H2,1-2H3
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 3.40n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 1A receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50123698
PNG
(1-(3-Hydroxy-phenyl)-5-[4-(2-methoxy-phenyl)-piper...)
Show SMILES COc1ccccc1N1CCN(CCCCC(=O)c2cccc(O)c2)CC1
Show InChI InChI=1S/C22H28N2O3/c1-27-22-11-3-2-9-20(22)24-15-13-23(14-16-24)12-5-4-10-21(26)18-7-6-8-19(25)17-18/h2-3,6-9,11,17,25H,4-5,10,12-16H2,1H3
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 3.70n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 1A receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50123695
PNG
(6-(4-Benzo[d]isoxazol-3-yl-piperazin-1-yl)-1-(2-me...)
Show SMILES COc1ccccc1C(=O)CCCCCN1CCN(CC1)c1noc2ccccc12
Show InChI InChI=1S/C24H29N3O3/c1-29-22-12-6-4-9-19(22)21(28)11-3-2-8-14-26-15-17-27(18-16-26)24-20-10-5-7-13-23(20)30-25-24/h4-7,9-10,12-13H,2-3,8,11,14-18H2,1H3
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 3.94n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity of compound was tested for Dopamine receptor D4

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50123701
PNG
(1-(2-Hydroxy-phenyl)-5-[4-(2-methoxy-phenyl)-piper...)
Show SMILES COc1ccccc1N1CCN(CCCCC(=O)c2ccccc2O)CC1
Show InChI InChI=1S/C22H28N2O3/c1-27-22-12-5-3-9-19(22)24-16-14-23(15-17-24)13-7-6-11-21(26)18-8-2-4-10-20(18)25/h2-5,8-10,12,25H,6-7,11,13-17H2,1H3
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 4.10n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 1A receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM50123713
PNG
(1-(2-Hydroxy-phenyl)-6-[4-(2-methoxy-phenyl)-piper...)
Show SMILES COc1ccccc1N1CCN(CCCCCC(=O)c2ccccc2O)CC1
Show InChI InChI=1S/C23H30N2O3/c1-28-23-13-7-5-10-20(23)25-17-15-24(16-18-25)14-8-2-3-11-21(26)19-9-4-6-12-22(19)27/h4-7,9-10,12-13,27H,2-3,8,11,14-18H2,1H3
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 5.80n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 7 receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50123713
PNG
(1-(2-Hydroxy-phenyl)-6-[4-(2-methoxy-phenyl)-piper...)
Show SMILES COc1ccccc1N1CCN(CCCCCC(=O)c2ccccc2O)CC1
Show InChI InChI=1S/C23H30N2O3/c1-28-23-13-7-5-10-20(23)25-17-15-24(16-18-25)14-8-2-3-11-21(26)19-9-4-6-12-22(19)27/h4-7,9-10,12-13,27H,2-3,8,11,14-18H2,1H3
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 5.80n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 1A receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50123705
PNG
(6-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-1-phenyl-h...)
Show SMILES COc1ccccc1N1CCN(CCCCCC(=O)c2ccccc2)CC1
Show InChI InChI=1S/C23H30N2O2/c1-27-23-14-8-7-12-21(23)25-18-16-24(17-19-25)15-9-3-6-13-22(26)20-10-4-2-5-11-20/h2,4-5,7-8,10-12,14H,3,6,9,13,15-19H2,1H3
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 6.40n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 1A receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50123704
PNG
(5-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-1-phenyl-p...)
Show SMILES COc1ccccc1N1CCN(CCCCC(=O)c2ccccc2)CC1
Show InChI InChI=1S/C22H28N2O2/c1-26-22-13-6-5-11-20(22)24-17-15-23(16-18-24)14-8-7-12-21(25)19-9-3-2-4-10-19/h2-6,9-11,13H,7-8,12,14-18H2,1H3
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 7n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 1A receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50123697
PNG
(6-(4-Benzo[d]isoxazol-3-yl-piperazin-1-yl)-1-(2-hy...)
Show SMILES Oc1ccccc1C(=O)CCCCCN1CCN(CC1)c1noc2ccccc12
Show InChI InChI=1S/C23H27N3O3/c27-20(18-8-3-5-11-21(18)28)10-2-1-7-13-25-14-16-26(17-15-25)23-19-9-4-6-12-22(19)29-24-23/h3-6,8-9,11-12,28H,1-2,7,10,13-17H2
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 7.97n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity of compound was tested for 5-hydroxytryptamine 2A receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50123695
PNG
(6-(4-Benzo[d]isoxazol-3-yl-piperazin-1-yl)-1-(2-me...)
Show SMILES COc1ccccc1C(=O)CCCCCN1CCN(CC1)c1noc2ccccc12
Show InChI InChI=1S/C24H29N3O3/c1-29-22-12-6-4-9-19(22)21(28)11-3-2-8-14-26-15-17-27(18-16-26)24-20-10-5-7-13-23(20)30-25-24/h4-7,9-10,12-13H,2-3,8,11,14-18H2,1H3
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 9.03n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity of compound was tested for 5-hydroxytryptamine 2A receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50123706
PNG
(1-(4-Hydroxy-phenyl)-6-[4-(2-methoxy-phenyl)-piper...)
Show SMILES COc1ccccc1N1CCN(CCCCCC(=O)c2ccc(O)cc2)CC1
Show InChI InChI=1S/C23H30N2O3/c1-28-23-9-5-4-7-21(23)25-17-15-24(16-18-25)14-6-2-3-8-22(27)19-10-12-20(26)13-11-19/h4-5,7,9-13,26H,2-3,6,8,14-18H2,1H3
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 14n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 1A receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM50123698
PNG
(1-(3-Hydroxy-phenyl)-5-[4-(2-methoxy-phenyl)-piper...)
Show SMILES COc1ccccc1N1CCN(CCCCC(=O)c2cccc(O)c2)CC1
Show InChI InChI=1S/C22H28N2O3/c1-27-22-11-3-2-9-20(22)24-15-13-23(14-16-24)12-5-4-10-21(26)18-7-6-8-19(25)17-18/h2-3,6-9,11,17,25H,4-5,10,12-16H2,1H3
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 15n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 7 receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM50123701
PNG
(1-(2-Hydroxy-phenyl)-5-[4-(2-methoxy-phenyl)-piper...)
Show SMILES COc1ccccc1N1CCN(CCCCC(=O)c2ccccc2O)CC1
Show InChI InChI=1S/C22H28N2O3/c1-27-22-12-5-3-9-19(22)24-16-14-23(15-17-24)13-7-6-11-21(26)18-8-2-4-10-20(18)25/h2-5,8-10,12,25H,6-7,11,13-17H2,1H3
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 16.4n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 7 receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM50123702
PNG
(4-(4-Benzo[d]isoxazol-3-yl-piperazin-1-yl)-1-(2-hy...)
Show SMILES Oc1ccccc1C(=O)CCCN1CCN(CC1)c1noc2ccccc12
Show InChI InChI=1S/C21H23N3O3/c25-18-8-3-1-6-16(18)19(26)9-5-11-23-12-14-24(15-13-23)21-17-7-2-4-10-20(17)27-22-21/h1-4,6-8,10,25H,5,9,11-15H2
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 19.5n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 7 receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50123699
PNG
(1-(4-Hydroxy-phenyl)-5-[4-(2-methoxy-phenyl)-piper...)
Show SMILES COc1ccccc1N1CCN(CCCCC(=O)c2ccc(O)cc2)CC1
Show InChI InChI=1S/C22H28N2O3/c1-27-22-8-3-2-6-20(22)24-16-14-23(15-17-24)13-5-4-7-21(26)18-9-11-19(25)12-10-18/h2-3,6,8-12,25H,4-5,7,13-17H2,1H3
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 20n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 1A receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM50123706
PNG
(1-(4-Hydroxy-phenyl)-6-[4-(2-methoxy-phenyl)-piper...)
Show SMILES COc1ccccc1N1CCN(CCCCCC(=O)c2ccc(O)cc2)CC1
Show InChI InChI=1S/C23H30N2O3/c1-28-23-9-5-4-7-21(23)25-17-15-24(16-18-25)14-6-2-3-8-22(27)19-10-12-20(26)13-11-19/h4-5,7,9-13,26H,2-3,6,8,14-18H2,1H3
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 23.7n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 7 receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50123707
PNG
(1-(3-Hydroxy-phenyl)-6-[4-(2-methoxy-phenyl)-piper...)
Show SMILES COc1ccccc1N1CCN(CCCCCC(=O)c2cccc(O)c2)CC1
Show InChI InChI=1S/C23H30N2O3/c1-28-23-12-5-4-10-21(23)25-16-14-24(15-17-25)13-6-2-3-11-22(27)19-8-7-9-20(26)18-19/h4-5,7-10,12,18,26H,2-3,6,11,13-17H2,1H3
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 24n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 1A receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM50123707
PNG
(1-(3-Hydroxy-phenyl)-6-[4-(2-methoxy-phenyl)-piper...)
Show SMILES COc1ccccc1N1CCN(CCCCCC(=O)c2cccc(O)c2)CC1
Show InChI InChI=1S/C23H30N2O3/c1-28-23-12-5-4-10-21(23)25-16-14-24(15-17-25)13-6-2-3-11-22(27)19-8-7-9-20(26)18-19/h4-5,7-10,12,18,26H,2-3,6,11,13-17H2,1H3
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 26.8n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 7 receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM50123705
PNG
(6-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-1-phenyl-h...)
Show SMILES COc1ccccc1N1CCN(CCCCCC(=O)c2ccccc2)CC1
Show InChI InChI=1S/C23H30N2O2/c1-27-23-14-8-7-12-21(23)25-18-16-24(17-19-25)15-9-3-6-13-22(26)20-10-4-2-5-11-20/h2,4-5,7-8,10-12,14H,3,6,9,13,15-19H2,1H3
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 28.4n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 7 receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM50123714
PNG
(1-(2-Hydroxy-phenyl)-6-(4-phenyl-piperazin-1-yl)-h...)
Show SMILES Oc1ccccc1C(=O)CCCCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C22H28N2O2/c25-21(20-11-6-7-13-22(20)26)12-5-2-8-14-23-15-17-24(18-16-23)19-9-3-1-4-10-19/h1,3-4,6-7,9-11,13,26H,2,5,8,12,14-18H2
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 43n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 7 receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM50123704
PNG
(5-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-1-phenyl-p...)
Show SMILES COc1ccccc1N1CCN(CCCCC(=O)c2ccccc2)CC1
Show InChI InChI=1S/C22H28N2O2/c1-26-22-13-6-5-11-20(22)24-17-15-23(16-18-24)14-8-7-12-21(25)19-9-3-2-4-10-19/h2-6,9-11,13H,7-8,12,14-18H2,1H3
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 43.5n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 7 receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM50123710
PNG
(1-(3-Methoxy-phenyl)-6-[4-(2-methoxy-phenyl)-piper...)
Show SMILES COc1cccc(c1)C(=O)CCCCCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C24H32N2O3/c1-28-21-10-8-9-20(19-21)23(27)12-4-3-7-14-25-15-17-26(18-16-25)22-11-5-6-13-24(22)29-2/h5-6,8-11,13,19H,3-4,7,12,14-18H2,1-2H3
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 46n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 7 receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM50123709
PNG
(5-(4-Benzo[d]isoxazol-3-yl-piperazin-1-yl)-1-(2-hy...)
Show SMILES Oc1ccccc1C(=O)CCCCN1CCN(CC1)c1noc2ccccc12
Show InChI InChI=1S/C22H25N3O3/c26-19-9-3-1-7-17(19)20(27)10-5-6-12-24-13-15-25(16-14-24)22-18-8-2-4-11-21(18)28-23-22/h1-4,7-9,11,26H,5-6,10,12-16H2
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 52n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 7 receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Rattus norvegicus (Rat))		BDBM50123695
PNG
(6-(4-Benzo[d]isoxazol-3-yl-piperazin-1-yl)-1-(2-me...)
Show SMILES COc1ccccc1C(=O)CCCCCN1CCN(CC1)c1noc2ccccc12
Show InChI InChI=1S/C24H29N3O3/c1-29-22-12-6-4-9-19(22)21(28)11-3-2-8-14-26-15-17-27(18-16-26)24-20-10-5-7-13-23(20)30-25-24/h4-7,9-10,12-13H,2-3,8,11,14-18H2,1H3
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 54.9n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity of compound was tested for Dopamine receptor D3

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50123711
PNG
(1-(2-Hydroxy-phenyl)-6-(4-pyridin-2-yl-piperazin-1...)
Show SMILES Oc1ccccc1C(=O)CCCCCN1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C21H27N3O2/c25-19(18-8-3-4-10-20(18)26)9-2-1-7-13-23-14-16-24(17-15-23)21-11-5-6-12-22-21/h3-6,8,10-12,26H,1-2,7,9,13-17H2
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 56n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 1A receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM50123699
PNG
(1-(4-Hydroxy-phenyl)-5-[4-(2-methoxy-phenyl)-piper...)
Show SMILES COc1ccccc1N1CCN(CCCCC(=O)c2ccc(O)cc2)CC1
Show InChI InChI=1S/C22H28N2O3/c1-27-22-8-3-2-6-20(22)24-16-14-23(15-17-24)13-5-4-7-21(26)18-9-11-19(25)12-10-18/h2-3,6,8-12,25H,4-5,7,13-17H2,1H3
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 59.1n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 7 receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50123697
PNG
(6-(4-Benzo[d]isoxazol-3-yl-piperazin-1-yl)-1-(2-hy...)
Show SMILES Oc1ccccc1C(=O)CCCCCN1CCN(CC1)c1noc2ccccc12
Show InChI InChI=1S/C23H27N3O3/c27-20(18-8-3-5-11-21(18)28)10-2-1-7-13-25-14-16-26(17-15-25)23-19-9-4-6-12-22(19)29-24-23/h3-6,8-9,11-12,28H,1-2,7,10,13-17H2
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 61n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity of compound was tested for Sigma receptor type 1

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50123695
PNG
(6-(4-Benzo[d]isoxazol-3-yl-piperazin-1-yl)-1-(2-me...)
Show SMILES COc1ccccc1C(=O)CCCCCN1CCN(CC1)c1noc2ccccc12
Show InChI InChI=1S/C24H29N3O3/c1-29-22-12-6-4-9-19(22)21(28)11-3-2-8-14-26-15-17-27(18-16-26)24-20-10-5-7-13-23(20)30-25-24/h4-7,9-10,12-13H,2-3,8,11,14-18H2,1H3
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 78.1n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity of compound was tested for Dopamine receptor D2L

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM50123716
PNG
(1-(3-Methoxy-phenyl)-5-[4-(2-methoxy-phenyl)-piper...)
Show SMILES COc1cccc(c1)C(=O)CCCCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C23H30N2O3/c1-27-20-9-7-8-19(18-20)22(26)11-5-6-13-24-14-16-25(17-15-24)21-10-3-4-12-23(21)28-2/h3-4,7-10,12,18H,5-6,11,13-17H2,1-2H3
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 85n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 7 receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM50123711
PNG
(1-(2-Hydroxy-phenyl)-6-(4-pyridin-2-yl-piperazin-1...)
Show SMILES Oc1ccccc1C(=O)CCCCCN1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C21H27N3O2/c25-19(18-8-3-4-10-20(18)26)9-2-1-7-13-23-14-16-24(17-15-23)21-11-5-6-12-22-21/h3-6,8,10-12,26H,1-2,7,9,13-17H2
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 105n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 7 receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM50068364
PNG
(1-(3-Methoxy-phenyl)-4-[4-(2-methoxy-phenyl)-piper...)
Show SMILES COc1cccc(c1)C(=O)CCCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C22H28N2O3/c1-26-19-8-5-7-18(17-19)21(25)10-6-12-23-13-15-24(16-14-23)20-9-3-4-11-22(20)27-2/h3-5,7-9,11,17H,6,10,12-16H2,1-2H3
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 109n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 7 receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50123714
PNG
(1-(2-Hydroxy-phenyl)-6-(4-phenyl-piperazin-1-yl)-h...)
Show SMILES Oc1ccccc1C(=O)CCCCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C22H28N2O2/c25-21(20-11-6-7-13-22(20)26)12-5-2-8-14-23-15-17-24(18-16-23)19-9-3-1-4-10-19/h1,3-4,6-7,9-11,13,26H,2,5,8,12,14-18H2
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 137n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 1A receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)		BDBM50123695
PNG
(6-(4-Benzo[d]isoxazol-3-yl-piperazin-1-yl)-1-(2-me...)
Show SMILES COc1ccccc1C(=O)CCCCCN1CCN(CC1)c1noc2ccccc12
Show InChI InChI=1S/C24H29N3O3/c1-29-22-12-6-4-9-19(22)21(28)11-3-2-8-14-26-15-17-27(18-16-26)24-20-10-5-7-13-23(20)30-25-24/h4-7,9-10,12-13H,2-3,8,11,14-18H2,1H3
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 147n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity of compound was tested for Sigma receptor type 2

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM50123708
PNG
(6-(4-Benzooxazol-2-yl-piperazin-1-yl)-1-(2-hydroxy...)
Show SMILES Oc1ccccc1C(=O)CCCCCN1CCN(CC1)c1nc2ccccc2o1
Show InChI InChI=1S/C23H27N3O3/c27-20(18-8-3-5-11-21(18)28)10-2-1-7-13-25-14-16-26(17-15-25)23-24-19-9-4-6-12-22(19)29-23/h3-6,8-9,11-12,28H,1-2,7,10,13-17H2
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 148n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 7 receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50123695
PNG
(6-(4-Benzo[d]isoxazol-3-yl-piperazin-1-yl)-1-(2-me...)
Show SMILES COc1ccccc1C(=O)CCCCCN1CCN(CC1)c1noc2ccccc12
Show InChI InChI=1S/C24H29N3O3/c1-29-22-12-6-4-9-19(22)21(28)11-3-2-8-14-26-15-17-27(18-16-26)24-20-10-5-7-13-23(20)30-25-24/h4-7,9-10,12-13H,2-3,8,11,14-18H2,1H3
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 175n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 1A receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)		BDBM50123697
PNG
(6-(4-Benzo[d]isoxazol-3-yl-piperazin-1-yl)-1-(2-hy...)
Show SMILES Oc1ccccc1C(=O)CCCCCN1CCN(CC1)c1noc2ccccc12
Show InChI InChI=1S/C23H27N3O3/c27-20(18-8-3-5-11-21(18)28)10-2-1-7-13-25-14-16-26(17-15-25)23-19-9-4-6-12-22(19)29-24-23/h3-6,8-9,11-12,28H,1-2,7,10,13-17H2
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 182n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity of compound was tested for Sigma receptor type 2

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50123697
PNG
(6-(4-Benzo[d]isoxazol-3-yl-piperazin-1-yl)-1-(2-hy...)
Show SMILES Oc1ccccc1C(=O)CCCCCN1CCN(CC1)c1noc2ccccc12
Show InChI InChI=1S/C23H27N3O3/c27-20(18-8-3-5-11-21(18)28)10-2-1-7-13-25-14-16-26(17-15-25)23-19-9-4-6-12-22(19)29-24-23/h3-6,8-9,11-12,28H,1-2,7,10,13-17H2
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 189n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 1A receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50123697
PNG
(6-(4-Benzo[d]isoxazol-3-yl-piperazin-1-yl)-1-(2-hy...)
Show SMILES Oc1ccccc1C(=O)CCCCCN1CCN(CC1)c1noc2ccccc12
Show InChI InChI=1S/C23H27N3O3/c27-20(18-8-3-5-11-21(18)28)10-2-1-7-13-25-14-16-26(17-15-25)23-19-9-4-6-12-22(19)29-24-23/h3-6,8-9,11-12,28H,1-2,7,10,13-17H2
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 246n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity of compound was tested for Dopamine receptor D2L

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50123703
PNG
(1-(2-Hydroxy-phenyl)-6-[4-(3-trifluoromethyl-pheny...)
Show SMILES Oc1ccccc1C(=O)CCCCCN1CCN(CC1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H27F3N2O2/c24-23(25,26)18-7-6-8-19(17-18)28-15-13-27(14-16-28)12-5-1-2-10-21(29)20-9-3-4-11-22(20)30/h3-4,6-9,11,17,30H,1-2,5,10,12-16H2
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 282n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 1A receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50123697
PNG
(6-(4-Benzo[d]isoxazol-3-yl-piperazin-1-yl)-1-(2-hy...)
Show SMILES Oc1ccccc1C(=O)CCCCCN1CCN(CC1)c1noc2ccccc12
Show InChI InChI=1S/C23H27N3O3/c27-20(18-8-3-5-11-21(18)28)10-2-1-7-13-25-14-16-26(17-15-25)23-19-9-4-6-12-22(19)29-24-23/h3-6,8-9,11-12,28H,1-2,7,10,13-17H2
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 318n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity of compound was tested for Dopamine receptor D4

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Rattus norvegicus (Rat))		BDBM50123697
PNG
(6-(4-Benzo[d]isoxazol-3-yl-piperazin-1-yl)-1-(2-hy...)
Show SMILES Oc1ccccc1C(=O)CCCCCN1CCN(CC1)c1noc2ccccc12
Show InChI InChI=1S/C23H27N3O3/c27-20(18-8-3-5-11-21(18)28)10-2-1-7-13-25-14-16-26(17-15-25)23-19-9-4-6-12-22(19)29-24-23/h3-6,8-9,11-12,28H,1-2,7,10,13-17H2
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 361n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity of compound was tested for Dopamine receptor D3

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM50123703
PNG
(1-(2-Hydroxy-phenyl)-6-[4-(3-trifluoromethyl-pheny...)
Show SMILES Oc1ccccc1C(=O)CCCCCN1CCN(CC1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H27F3N2O2/c24-23(25,26)18-7-6-8-19(17-18)28-15-13-27(14-16-28)12-5-1-2-10-21(29)20-9-3-4-11-22(20)30/h3-4,6-9,11,17,30H,1-2,5,10,12-16H2
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 384n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 7 receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50123700
PNG
(1-(2-Hydroxy-phenyl)-6-[4-(5-methoxy-benzo[d]isoxa...)
Show SMILES COc1ccc2onc(N3CCN(CCCCCC(=O)c4ccccc4O)CC3)c2c1
Show InChI InChI=1S/C24H29N3O4/c1-30-18-10-11-23-20(17-18)24(25-31-23)27-15-13-26(14-16-27)12-6-2-3-8-21(28)19-7-4-5-9-22(19)29/h4-5,7,9-11,17,29H,2-3,6,8,12-16H2,1H3
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 389n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 1A receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM50123700
PNG
(1-(2-Hydroxy-phenyl)-6-[4-(5-methoxy-benzo[d]isoxa...)
Show SMILES COc1ccc2onc(N3CCN(CCCCCC(=O)c4ccccc4O)CC3)c2c1
Show InChI InChI=1S/C24H29N3O4/c1-30-18-10-11-23-20(17-18)24(25-31-23)27-15-13-26(14-16-27)12-6-2-3-8-21(28)19-7-4-5-9-22(19)29/h4-5,7,9-11,17,29H,2-3,6,8,12-16H2,1H3
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 462n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 7 receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM50123715
PNG
(6-[4-(1H-Benzoimidazol-2-yl)-piperazin-1-yl]-1-(2-...)
Show SMILES Oc1ccccc1C(=O)CCCCCN1CCN(CC1)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C23H28N4O2/c28-21(18-8-3-6-12-22(18)29)11-2-1-7-13-26-14-16-27(17-15-26)23-24-19-9-4-5-10-20(19)25-23/h3-6,8-10,12,29H,1-2,7,11,13-17H2,(H,24,25)
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 682n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 7 receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM50123696
PNG
(6-(4-Cyclohexyl-piperazin-1-yl)-1-(2-hydroxy-pheny...)
Show SMILES Oc1ccccc1C(=O)CCCCCN1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C22H34N2O2/c25-21(20-11-6-7-13-22(20)26)12-5-2-8-14-23-15-17-24(18-16-23)19-9-3-1-4-10-19/h6-7,11,13,19,26H,1-5,8-10,12,14-18H2
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>800n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 7 receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50123696
PNG
(6-(4-Cyclohexyl-piperazin-1-yl)-1-(2-hydroxy-pheny...)
Show SMILES Oc1ccccc1C(=O)CCCCCN1CCN(CC1)C1CCCCC1
Show InChI InChI=1S/C22H34N2O2/c25-21(20-11-6-7-13-22(20)26)12-5-2-8-14-23-15-17-24(18-16-23)19-9-3-1-4-10-19/h6-7,11,13,19,26H,1-5,8-10,12,14-18H2
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>850n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 1A receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50123712
PNG
(1-(2-Hydroxy-phenyl)-6-(4-methyl-piperazin-1-yl)-h...)
Show SMILES CN1CCN(CCCCCC(=O)c2ccccc2O)CC1
Show InChI InChI=1S/C17H26N2O2/c1-18-11-13-19(14-12-18)10-6-2-3-8-16(20)15-7-4-5-9-17(15)21/h4-5,7,9,21H,2-3,6,8,10-14H2,1H3
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>850n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 1A receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50123715
PNG
(6-[4-(1H-Benzoimidazol-2-yl)-piperazin-1-yl]-1-(2-...)
Show SMILES Oc1ccccc1C(=O)CCCCCN1CCN(CC1)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C23H28N4O2/c28-21(18-8-3-6-12-22(18)29)11-2-1-7-13-26-14-16-27(17-15-26)23-24-19-9-4-5-10-20(19)25-23/h3-6,8-10,12,29H,1-2,7,11,13-17H2,(H,24,25)
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>850n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 1A receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50123709
PNG
(5-(4-Benzo[d]isoxazol-3-yl-piperazin-1-yl)-1-(2-hy...)
Show SMILES Oc1ccccc1C(=O)CCCCN1CCN(CC1)c1noc2ccccc12
Show InChI InChI=1S/C22H25N3O3/c26-19-9-3-1-7-17(19)20(27)10-5-6-12-24-13-15-25(16-14-24)22-18-8-2-4-11-21(18)28-23-22/h1-4,7-9,11,26H,5-6,10,12-16H2
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 919n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 1A receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Rattus norvegicus (rat))		BDBM50123712
PNG
(1-(2-Hydroxy-phenyl)-6-(4-methyl-piperazin-1-yl)-h...)
Show SMILES CN1CCN(CCCCCC(=O)c2ccccc2O)CC1
Show InChI InChI=1S/C17H26N2O2/c1-18-11-13-19(14-12-18)10-6-2-3-8-16(20)15-7-4-5-9-17(15)21/h4-5,7,9,21H,2-3,6,8,10-14H2,1H3
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>1.00E+3n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 7 receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50123702
PNG
(4-(4-Benzo[d]isoxazol-3-yl-piperazin-1-yl)-1-(2-hy...)
Show SMILES Oc1ccccc1C(=O)CCCN1CCN(CC1)c1noc2ccccc12
Show InChI InChI=1S/C21H23N3O3/c25-18-8-3-1-6-16(18)19(26)9-5-11-23-12-14-24(15-13-23)21-17-7-2-4-10-20(17)27-22-21/h1-4,6-8,10,25H,5,9,11-15H2
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 1.06E+3n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 1A receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50123708
PNG
(6-(4-Benzooxazol-2-yl-piperazin-1-yl)-1-(2-hydroxy...)
Show SMILES Oc1ccccc1C(=O)CCCCCN1CCN(CC1)c1nc2ccccc2o1
Show InChI InChI=1S/C23H27N3O3/c27-20(18-8-3-5-11-21(18)28)10-2-1-7-13-25-14-16-26(17-15-25)23-24-19-9-4-6-12-22(19)29-23/h3-6,8-9,11-12,28H,1-2,7,10,13-17H2
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 1.46E+3n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity to the rat 5-hydroxytryptamine 1A receptor

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50123695
PNG
(6-(4-Benzo[d]isoxazol-3-yl-piperazin-1-yl)-1-(2-me...)
Show SMILES COc1ccccc1C(=O)CCCCCN1CCN(CC1)c1noc2ccccc12
Show InChI InChI=1S/C24H29N3O3/c1-29-22-12-6-4-9-19(22)21(28)11-3-2-8-14-26-15-17-27(18-16-26)24-20-10-5-7-13-23(20)30-25-24/h4-7,9-10,12-13H,2-3,8,11,14-18H2,1H3
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 4.30E+3n/an/an/an/an/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Binding affinity of compound was tested for Sigma receptor type 1

J Med Chem 46: 646-9 (2003)


Article DOI: 10.1021/jm020994z
BindingDB Entry DOI: 10.7270/Q23T9GKN
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%