Found 12 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50051832
(CHEMBL440280 | [((2E,6E,10E)-3,7,11,15-Tetramethyl...)Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#8]-[#7]-[#6](=O)-[#6]P([#8])([#8])=O Show InChI InChI=1S/C22H38NO5P/c1-18(2)9-6-10-19(3)11-7-12-20(4)13-8-14-21(5)15-16-28-23-22(24)17-29(25,26)27/h9,11,13,15H,6-8,10,12,14,16-17H2,1-5H3,(H,23,24)(H2,25,26,27)/b19-11+,20-13+,21-15+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 66 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Pisa
Curated by ChEMBL
| Assay Description
In vitro inhibition of Geranylgeranyl protein transferase I |
Bioorg Med Chem Lett 13: 4405-8 (2003)
BindingDB Entry DOI: 10.7270/Q2NG4Q10 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50136457
(CHEMBL136472 | [1-((2E,6E,10E)-3,7,11,15-Tetrameth...)Show SMILES [#6]-[#6](-[#6](=O)-[#7]-[#6]-[#6]=[#6](-[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6])P([#8])([#8])=O |w:6.5| Show InChI InChI=1S/C23H40NO4P/c1-18(2)10-7-11-19(3)12-8-13-20(4)14-9-15-21(5)16-17-24-23(25)22(6)29(26,27)28/h10,12,14,16,22H,7-9,11,13,15,17H2,1-6H3,(H,24,25)(H2,26,27,28)/b19-12+,20-14+,21-16? | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 111 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Pisa
Curated by ChEMBL
| Assay Description
In vitro inhibition of Geranylgeranyl protein transferase I |
Bioorg Med Chem Lett 13: 4405-8 (2003)
BindingDB Entry DOI: 10.7270/Q2NG4Q10 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50136461
(CHEMBL139238 | [1-((2E,6E,10E)-3,7,11,15-Tetrameth...)Show SMILES [#6]-[#6]-[#6](-[#6](=O)-[#7]-[#8]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6])P([#8])([#8])=O Show InChI InChI=1S/C24H42NO5P/c1-7-23(31(27,28)29)24(26)25-30-18-17-22(6)16-10-15-21(5)14-9-13-20(4)12-8-11-19(2)3/h11,13,15,17,23H,7-10,12,14,16,18H2,1-6H3,(H,25,26)(H2,27,28,29)/b20-13+,21-15+,22-17+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 146 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Pisa
Curated by ChEMBL
| Assay Description
In vitro inhibition of Geranylgeranyl protein transferase I |
Bioorg Med Chem Lett 13: 4405-8 (2003)
BindingDB Entry DOI: 10.7270/Q2NG4Q10 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50136459
(CHEMBL139377 | [1-((2E,6E,10E)-3,7,11,15-Tetrameth...)Show SMILES [#6]-[#6](-[#6](=O)-[#7]-[#8]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6])P([#8])([#8])=O Show InChI InChI=1S/C23H40NO5P/c1-18(2)10-7-11-19(3)12-8-13-20(4)14-9-15-21(5)16-17-29-24-23(25)22(6)30(26,27)28/h10,12,14,16,22H,7-9,11,13,15,17H2,1-6H3,(H,24,25)(H2,26,27,28)/b19-12+,20-14+,21-16+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 151 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Pisa
Curated by ChEMBL
| Assay Description
In vitro inhibition of Geranylgeranyl protein transferase I |
Bioorg Med Chem Lett 13: 4405-8 (2003)
BindingDB Entry DOI: 10.7270/Q2NG4Q10 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50136460
(CHEMBL138033 | [((2E,6E,10E)-3,7,11,15-Tetramethyl...)Show SMILES [#6]\[#6](-[#6])=[#6]/[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]-[#6](-[#6])=[#6]-[#6]-[#7]-[#6](=O)-[#6]P([#8])([#8])=O |w:18.18| Show InChI InChI=1S/C22H38NO4P/c1-18(2)9-6-10-19(3)11-7-12-20(4)13-8-14-21(5)15-16-23-22(24)17-28(25,26)27/h9,11,13,15H,6-8,10,12,14,16-17H2,1-5H3,(H,23,24)(H2,25,26,27)/b19-11+,20-13+,21-15? | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 275 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Pisa
Curated by ChEMBL
| Assay Description
In vitro inhibition of Geranylgeranyl protein transferase I |
Bioorg Med Chem Lett 13: 4405-8 (2003)
BindingDB Entry DOI: 10.7270/Q2NG4Q10 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50136458
(CHEMBL134682 | [1-((2E,6E,10E)-3,7,11,15-Tetrameth...)Show SMILES [#6]-[#6]-[#6](-[#6](=O)-[#7]-[#6]-[#6]=[#6](-[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6])P([#8])([#8])=O |w:7.6| Show InChI InChI=1S/C24H42NO4P/c1-7-23(30(27,28)29)24(26)25-18-17-22(6)16-10-15-21(5)14-9-13-20(4)12-8-11-19(2)3/h11,13,15,17,23H,7-10,12,14,16,18H2,1-6H3,(H,25,26)(H2,27,28,29)/b20-13+,21-15+,22-17? | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 566 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Pisa
Curated by ChEMBL
| Assay Description
In vitro inhibition of Geranylgeranyl protein transferase I |
Bioorg Med Chem Lett 13: 4405-8 (2003)
BindingDB Entry DOI: 10.7270/Q2NG4Q10 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50051832
(CHEMBL440280 | [((2E,6E,10E)-3,7,11,15-Tetramethyl...)Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#8]-[#7]-[#6](=O)-[#6]P([#8])([#8])=O Show InChI InChI=1S/C22H38NO5P/c1-18(2)9-6-10-19(3)11-7-12-20(4)13-8-14-21(5)15-16-28-23-22(24)17-29(25,26)27/h9,11,13,15H,6-8,10,12,14,16-17H2,1-5H3,(H,23,24)(H2,25,26,27)/b19-11+,20-13+,21-15+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Pisa
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyl protein transferase |
Bioorg Med Chem Lett 13: 4405-8 (2003)
BindingDB Entry DOI: 10.7270/Q2NG4Q10 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50136460
(CHEMBL138033 | [((2E,6E,10E)-3,7,11,15-Tetramethyl...)Show SMILES [#6]\[#6](-[#6])=[#6]/[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]-[#6](-[#6])=[#6]-[#6]-[#7]-[#6](=O)-[#6]P([#8])([#8])=O |w:18.18| Show InChI InChI=1S/C22H38NO4P/c1-18(2)9-6-10-19(3)11-7-12-20(4)13-8-14-21(5)15-16-23-22(24)17-28(25,26)27/h9,11,13,15H,6-8,10,12,14,16-17H2,1-5H3,(H,23,24)(H2,25,26,27)/b19-11+,20-13+,21-15? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Pisa
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyl protein transferase |
Bioorg Med Chem Lett 13: 4405-8 (2003)
BindingDB Entry DOI: 10.7270/Q2NG4Q10 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50136459
(CHEMBL139377 | [1-((2E,6E,10E)-3,7,11,15-Tetrameth...)Show SMILES [#6]-[#6](-[#6](=O)-[#7]-[#8]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6])P([#8])([#8])=O Show InChI InChI=1S/C23H40NO5P/c1-18(2)10-7-11-19(3)12-8-13-20(4)14-9-15-21(5)16-17-29-24-23(25)22(6)30(26,27)28/h10,12,14,16,22H,7-9,11,13,15,17H2,1-6H3,(H,24,25)(H2,26,27,28)/b19-12+,20-14+,21-16+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Pisa
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyl protein transferase |
Bioorg Med Chem Lett 13: 4405-8 (2003)
BindingDB Entry DOI: 10.7270/Q2NG4Q10 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50136457
(CHEMBL136472 | [1-((2E,6E,10E)-3,7,11,15-Tetrameth...)Show SMILES [#6]-[#6](-[#6](=O)-[#7]-[#6]-[#6]=[#6](-[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6])P([#8])([#8])=O |w:6.5| Show InChI InChI=1S/C23H40NO4P/c1-18(2)10-7-11-19(3)12-8-13-20(4)14-9-15-21(5)16-17-24-23(25)22(6)29(26,27)28/h10,12,14,16,22H,7-9,11,13,15,17H2,1-6H3,(H,24,25)(H2,26,27,28)/b19-12+,20-14+,21-16? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Pisa
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyl protein transferase |
Bioorg Med Chem Lett 13: 4405-8 (2003)
BindingDB Entry DOI: 10.7270/Q2NG4Q10 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50136458
(CHEMBL134682 | [1-((2E,6E,10E)-3,7,11,15-Tetrameth...)Show SMILES [#6]-[#6]-[#6](-[#6](=O)-[#7]-[#6]-[#6]=[#6](-[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6])P([#8])([#8])=O |w:7.6| Show InChI InChI=1S/C24H42NO4P/c1-7-23(30(27,28)29)24(26)25-18-17-22(6)16-10-15-21(5)14-9-13-20(4)12-8-11-19(2)3/h11,13,15,17,23H,7-10,12,14,16,18H2,1-6H3,(H,25,26)(H2,27,28,29)/b20-13+,21-15+,22-17? | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Pisa
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyl protein transferase |
Bioorg Med Chem Lett 13: 4405-8 (2003)
BindingDB Entry DOI: 10.7270/Q2NG4Q10 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50136461
(CHEMBL139238 | [1-((2E,6E,10E)-3,7,11,15-Tetrameth...)Show SMILES [#6]-[#6]-[#6](-[#6](=O)-[#7]-[#8]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6])P([#8])([#8])=O Show InChI InChI=1S/C24H42NO5P/c1-7-23(31(27,28)29)24(26)25-30-18-17-22(6)16-10-15-21(5)14-9-13-20(4)12-8-11-19(2)3/h11,13,15,17,23H,7-10,12,14,16,18H2,1-6H3,(H,25,26)(H2,27,28,29)/b20-13+,21-15+,22-17+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Pisa
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyl protein transferase |
Bioorg Med Chem Lett 13: 4405-8 (2003)
BindingDB Entry DOI: 10.7270/Q2NG4Q10 |
More data for this
Ligand-Target Pair | |
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