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PubMed code 15341489

Compile data set for download or QSAR
Found 34 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50152049
PNG
(3-(2,4-Dichloro-phenyl)-7-dicyclopropylmethyl-8-et...)
Show SMILES CCc1nc2N(CN(C)C(=O)c2n1C(C1CC1)C1CC1)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C21H24Cl2N4O/c1-3-17-24-20-19(27(17)18(12-4-5-12)13-6-7-13)21(28)25(2)11-26(20)16-9-8-14(22)10-15(16)23/h8-10,12-13,18H,3-7,11H2,1-2H3
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n/an/a 6n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- Ovine CRF binding to rat frontal cortex corticotropin releasing factor 1 receptor

J Med Chem 47: 4741-54 (2004)


Article DOI: 10.1021/jm049787k
BindingDB Entry DOI: 10.7270/Q21C1WBB
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50152033
PNG
(7-(1-Cyclopropyl-butyl)-3-(2,4-dichloro-phenyl)-8-...)
Show SMILES CCCC(C1CC1)n1c(CC)nc2N(CN(C)C(=O)c12)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C21H26Cl2N4O/c1-4-6-16(13-7-8-13)27-18(5-2)24-20-19(27)21(28)25(3)12-26(20)17-10-9-14(22)11-15(17)23/h9-11,13,16H,4-8,12H2,1-3H3
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n/an/a 10n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- Ovine CRF binding to rat frontal cortex corticotropin releasing factor 1 receptor

J Med Chem 47: 4741-54 (2004)


Article DOI: 10.1021/jm049787k
BindingDB Entry DOI: 10.7270/Q21C1WBB
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50152054
PNG
(7-(1-Cyclopropyl-propyl)-3-(2,4-dichloro-phenyl)-8...)
Show SMILES CCC(C1CC1)n1c(CC)nc2N(CN(C)C(=O)c12)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C20H24Cl2N4O/c1-4-15(12-6-7-12)26-17(5-2)23-19-18(26)20(27)24(3)11-25(19)16-9-8-13(21)10-14(16)22/h8-10,12,15H,4-7,11H2,1-3H3
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n/an/a 14n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- Ovine CRF binding to rat frontal cortex corticotropin releasing factor 1 receptor

J Med Chem 47: 4741-54 (2004)


Article DOI: 10.1021/jm049787k
BindingDB Entry DOI: 10.7270/Q21C1WBB
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50152059
PNG
(3-(2,4-Dichloro-phenyl)-8-ethyl-7-(1-ethyl-pentyl)...)
Show SMILES CCCCC(CC)n1c(CC)nc2N(CN(C)C(=O)c12)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C21H28Cl2N4O/c1-5-8-9-15(6-2)27-18(7-3)24-20-19(27)21(28)25(4)13-26(20)17-11-10-14(22)12-16(17)23/h10-12,15H,5-9,13H2,1-4H3
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n/an/a 18n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- Ovine CRF binding to rat frontal cortex corticotropin releasing factor 1 receptor

J Med Chem 47: 4741-54 (2004)


Article DOI: 10.1021/jm049787k
BindingDB Entry DOI: 10.7270/Q21C1WBB
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50152043
PNG
(8-Ethyl-1-methyl-7-(1-propyl-butyl)-3-(2,4,6-trime...)
Show SMILES CCCC(CCC)n1c(CC)nc2N(CN(C)C(=O)c12)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C24H36N4O/c1-8-11-19(12-9-2)28-20(10-3)25-23-22(28)24(29)26(7)15-27(23)21-17(5)13-16(4)14-18(21)6/h13-14,19H,8-12,15H2,1-7H3
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n/an/a 22n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- Ovine CRF binding to rat frontal cortex corticotropin releasing factor 1 receptor

J Med Chem 47: 4741-54 (2004)


Article DOI: 10.1021/jm049787k
BindingDB Entry DOI: 10.7270/Q21C1WBB
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50152031
PNG
(7-(1-Cyclobutyl-ethyl)-3-(2,4-dichloro-phenyl)-8-e...)
Show SMILES CCc1nc2N(CN(C)C(=O)c2n1C(C)C1CCC1)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C20H24Cl2N4O/c1-4-17-23-19-18(26(17)12(2)13-6-5-7-13)20(27)24(3)11-25(19)16-9-8-14(21)10-15(16)22/h8-10,12-13H,4-7,11H2,1-3H3
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n/an/a 26n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- Ovine CRF binding to rat frontal cortex corticotropin releasing factor 1 receptor

J Med Chem 47: 4741-54 (2004)


Article DOI: 10.1021/jm049787k
BindingDB Entry DOI: 10.7270/Q21C1WBB
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50152055
PNG
(3-(2-Chloro-4-methoxy-phenyl)-8-ethyl-1-methyl-7-(...)
Show SMILES CCCC(CCC)n1c(CC)nc2N(CN(C)C(=O)c12)c1ccc(OC)cc1Cl
Show InChI InChI=1S/C22H31ClN4O2/c1-6-9-15(10-7-2)27-19(8-3)24-21-20(27)22(28)25(4)14-26(21)18-12-11-16(29-5)13-17(18)23/h11-13,15H,6-10,14H2,1-5H3
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n/an/a 27n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- Ovine CRF binding to rat frontal cortex corticotropin releasing factor 1 receptor

J Med Chem 47: 4741-54 (2004)


Article DOI: 10.1021/jm049787k
BindingDB Entry DOI: 10.7270/Q21C1WBB
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50152044
PNG
(3-(2,4-Dichloro-phenyl)-8-ethyl-7-(1-methoxymethyl...)
Show SMILES CCCC(COC)n1c(CC)nc2N(CN(C)C(=O)c12)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C20H26Cl2N4O2/c1-5-7-14(11-28-4)26-17(6-2)23-19-18(26)20(27)24(3)12-25(19)16-9-8-13(21)10-15(16)22/h8-10,14H,5-7,11-12H2,1-4H3
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n/an/a 43n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- Ovine CRF binding to rat frontal cortex corticotropin releasing factor 1 receptor

J Med Chem 47: 4741-54 (2004)


Article DOI: 10.1021/jm049787k
BindingDB Entry DOI: 10.7270/Q21C1WBB
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50152030
PNG
(3-(2-Chloro-4-isopropyl-phenyl)-8-ethyl-1-methyl-7...)
Show SMILES CCCC(CCC)n1c(CC)nc2N(CN(C)C(=O)c12)c1ccc(cc1Cl)C(C)C
Show InChI InChI=1S/C24H35ClN4O/c1-7-10-18(11-8-2)29-21(9-3)26-23-22(29)24(30)27(6)15-28(23)20-13-12-17(16(4)5)14-19(20)25/h12-14,16,18H,7-11,15H2,1-6H3
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n/an/a 50n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- Ovine CRF binding to rat frontal cortex corticotropin releasing factor 1 receptor

J Med Chem 47: 4741-54 (2004)


Article DOI: 10.1021/jm049787k
BindingDB Entry DOI: 10.7270/Q21C1WBB
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50152035
PNG
(3-(2,4-Dichloro-phenyl)-8-ethyl-7-(1-ethyl-2-methy...)
Show SMILES CCC(C(C)C)n1c(CC)nc2N(CN(C)C(=O)c12)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C20H26Cl2N4O/c1-6-15(12(3)4)26-17(7-2)23-19-18(26)20(27)24(5)11-25(19)16-9-8-13(21)10-14(16)22/h8-10,12,15H,6-7,11H2,1-5H3
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n/an/a 51n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- Ovine CRF binding to rat frontal cortex corticotropin releasing factor 1 receptor

J Med Chem 47: 4741-54 (2004)


Article DOI: 10.1021/jm049787k
BindingDB Entry DOI: 10.7270/Q21C1WBB
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50152037
PNG
(3-(2,4-Dichloro-phenyl)-8-ethyl-1-methyl-7-(1-meth...)
Show SMILES CCCC(C)n1c(CC)nc2N(CN(C)C(=O)c12)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C19H24Cl2N4O/c1-5-7-12(3)25-16(6-2)22-18-17(25)19(26)23(4)11-24(18)15-9-8-13(20)10-14(15)21/h8-10,12H,5-7,11H2,1-4H3
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n/an/a 52n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- Ovine CRF binding to rat frontal cortex corticotropin releasing factor 1 receptor

J Med Chem 47: 4741-54 (2004)


Article DOI: 10.1021/jm049787k
BindingDB Entry DOI: 10.7270/Q21C1WBB
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50152038
PNG
(3-(2,4-Dichloro-phenyl)-8-ethyl-1-methyl-7-(1-prop...)
Show SMILES CCCC(CCC)n1c(CC)nc2N(CN(C)C(=O)c12)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C21H28Cl2N4O/c1-5-8-15(9-6-2)27-18(7-3)24-20-19(27)21(28)25(4)13-26(20)17-11-10-14(22)12-16(17)23/h10-12,15H,5-9,13H2,1-4H3
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n/an/a 54n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- Ovine CRF binding to rat frontal cortex corticotropin releasing factor 1 receptor

J Med Chem 47: 4741-54 (2004)


Article DOI: 10.1021/jm049787k
BindingDB Entry DOI: 10.7270/Q21C1WBB
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50152056
PNG
(7-(1-Cyclopropyl-ethyl)-3-(2,4-dichloro-phenyl)-8-...)
Show SMILES CCc1nc2N(CN(C)C(=O)c2n1C(C)C1CC1)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C19H22Cl2N4O/c1-4-16-22-18-17(25(16)11(2)12-5-6-12)19(26)23(3)10-24(18)15-8-7-13(20)9-14(15)21/h7-9,11-12H,4-6,10H2,1-3H3
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n/an/a 55n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- Ovine CRF binding to rat frontal cortex corticotropin releasing factor 1 receptor

J Med Chem 47: 4741-54 (2004)


Article DOI: 10.1021/jm049787k
BindingDB Entry DOI: 10.7270/Q21C1WBB
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50152053
PNG
(3-(2,4-Dichloro-phenyl)-8-ethyl-1-methyl-7-(1-prop...)
Show SMILES CCCC(CCC)n1c(CC)nc2n(-c3ccc(Cl)cc3Cl)c(=O)n(C)c(=O)c12 |(-.14,6.58,;-1.18,5.43,;-.7,3.98,;-1.74,2.83,;-3.25,3.14,;-3.7,4.6,;-5.22,4.93,;-1.26,1.37,;-2.17,.12,;-3.7,.13,;-4.47,1.46,;-1.26,-1.13,;.19,-.66,;1.52,-1.42,;1.52,-2.96,;2.87,-3.71,;2.87,-5.25,;1.52,-6.03,;1.54,-7.57,;.19,-5.25,;.19,-3.71,;-1.13,-2.94,;2.87,-.66,;4.19,-1.42,;2.87,.9,;4.19,1.67,;1.52,1.67,;1.51,3.21,;.19,.89,)|
Show InChI InChI=1S/C21H26Cl2N4O2/c1-5-8-14(9-6-2)26-17(7-3)24-19-18(26)20(28)25(4)21(29)27(19)16-11-10-13(22)12-15(16)23/h10-12,14H,5-9H2,1-4H3
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n/an/a 75n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- Ovine CRF binding to rat frontal cortex corticotropin releasing factor 1 receptor

J Med Chem 47: 4741-54 (2004)


Article DOI: 10.1021/jm049787k
BindingDB Entry DOI: 10.7270/Q21C1WBB
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50152034
PNG
(3-(2,4-Dichloro-phenyl)-8-ethyl-7-(1-ethyl-propyl)...)
Show SMILES CCC(CC)n1c(CC)nc2N(CN(C)C(=O)c12)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C19H24Cl2N4O/c1-5-13(6-2)25-16(7-3)22-18-17(25)19(26)23(4)11-24(18)15-9-8-12(20)10-14(15)21/h8-10,13H,5-7,11H2,1-4H3
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n/an/a 112n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- Ovine CRF binding to rat frontal cortex corticotropin releasing factor 1 receptor

J Med Chem 47: 4741-54 (2004)


Article DOI: 10.1021/jm049787k
BindingDB Entry DOI: 10.7270/Q21C1WBB
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50152040
PNG
(3-(2-Chloro-4-methoxy-phenyl)-7-(1-cyclopropyl-pro...)
Show SMILES CCC(C1CC1)n1c(CC)nc2N(CN(C)C(=O)c12)c1ccc(OC)cc1Cl
Show InChI InChI=1S/C21H27ClN4O2/c1-5-16(13-7-8-13)26-18(6-2)23-20-19(26)21(27)24(3)12-25(20)17-10-9-14(28-4)11-15(17)22/h9-11,13,16H,5-8,12H2,1-4H3
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n/an/a 113n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- Ovine CRF binding to rat frontal cortex corticotropin releasing factor 1 receptor

J Med Chem 47: 4741-54 (2004)


Article DOI: 10.1021/jm049787k
BindingDB Entry DOI: 10.7270/Q21C1WBB
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50152051
PNG
(8-Ethyl-3-(4-methoxy-2-pyridin-3-ylmethyl-phenyl)-...)
Show SMILES CCCC(CCC)n1c(CC)nc2N(CN(C)C(=O)c12)c1ccc(OC)cc1Cc1cccnc1
Show InChI InChI=1S/C28H37N5O2/c1-6-10-22(11-7-2)33-25(8-3)30-27-26(33)28(34)31(4)19-32(27)24-14-13-23(35-5)17-21(24)16-20-12-9-15-29-18-20/h9,12-15,17-18,22H,6-8,10-11,16,19H2,1-5H3
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n/an/a 161n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- Ovine CRF binding to rat frontal cortex corticotropin releasing factor 1 receptor

J Med Chem 47: 4741-54 (2004)


Article DOI: 10.1021/jm049787k
BindingDB Entry DOI: 10.7270/Q21C1WBB
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50152061
PNG
(3-(4-Chloro-phenyl)-8-ethyl-1-methyl-7-(1-propyl-b...)
Show SMILES CCCC(CCC)n1c(CC)nc2N(CN(C)C(=O)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H29ClN4O/c1-5-8-17(9-6-2)26-18(7-3)23-20-19(26)21(27)24(4)14-25(20)16-12-10-15(22)11-13-16/h10-13,17H,5-9,14H2,1-4H3
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n/an/a 173n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- Ovine CRF binding to rat frontal cortex corticotropin releasing factor 1 receptor

J Med Chem 47: 4741-54 (2004)


Article DOI: 10.1021/jm049787k
BindingDB Entry DOI: 10.7270/Q21C1WBB
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50152048
PNG
(8-Ethyl-1-methyl-7-(1-propyl-butyl)-3-(2,4,6-trime...)
Show SMILES CCCC(CCC)n1c(CC)nc2n(-c3c(C)cc(C)cc3C)c(=O)n(C)c(=O)c12 |(-5.37,5.03,;-3.85,4.71,;-3.38,3.26,;-1.88,2.93,;-.84,4.08,;-1.32,5.53,;-.28,6.69,;-1.4,1.46,;-2.33,.21,;-3.85,.23,;-4.62,1.56,;-1.4,-1.03,;.05,-.56,;1.38,-1.33,;1.38,-2.87,;2.71,-3.62,;4.06,-2.85,;2.71,-5.16,;1.38,-5.95,;1.4,-7.47,;.05,-5.16,;.05,-3.62,;-1.28,-2.85,;2.71,-.56,;4.06,-1.33,;2.71,1,;4.06,1.77,;1.38,1.77,;1.38,3.31,;.05,.98,)|
Show InChI InChI=1S/C24H34N4O2/c1-8-11-18(12-9-2)27-19(10-3)25-22-21(27)23(29)26(7)24(30)28(22)20-16(5)13-15(4)14-17(20)6/h13-14,18H,8-12H2,1-7H3
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n/an/a 191n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- Ovine CRF binding to rat frontal cortex corticotropin releasing factor 1 receptor

J Med Chem 47: 4741-54 (2004)


Article DOI: 10.1021/jm049787k
BindingDB Entry DOI: 10.7270/Q21C1WBB
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50152042
PNG
(7-Biphenyl-4-ylmethyl-3-(2,4-dichloro-phenyl)-8-et...)
Show SMILES CCc1nc2N(CN(C)C(=O)c2n1Cc1ccc(cc1)-c1ccccc1)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C27H24Cl2N4O/c1-3-24-30-26-25(27(34)31(2)17-33(26)23-14-13-21(28)15-22(23)29)32(24)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19/h4-15H,3,16-17H2,1-2H3
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n/an/a 324n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- Ovine CRF binding to rat frontal cortex corticotropin releasing factor 1 receptor

J Med Chem 47: 4741-54 (2004)


Article DOI: 10.1021/jm049787k
BindingDB Entry DOI: 10.7270/Q21C1WBB
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50152039
PNG
(3-(2,4-Dichloro-phenyl)-8-ethyl-1,2-dimethyl-7-(1-...)
Show SMILES CCCC(CCC)n1c(CC)nc2N(C(C)N(C)C(=O)c12)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C22H30Cl2N4O/c1-6-9-16(10-7-2)28-19(8-3)25-21-20(28)22(29)26(5)14(4)27(21)18-12-11-15(23)13-17(18)24/h11-14,16H,6-10H2,1-5H3
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n/an/a 383n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- Ovine CRF binding to rat frontal cortex corticotropin releasing factor 1 receptor

J Med Chem 47: 4741-54 (2004)


Article DOI: 10.1021/jm049787k
BindingDB Entry DOI: 10.7270/Q21C1WBB
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50152045
PNG
(3-(2,4-Dichloro-phenyl)-8-ethyl-7-(4-methoxy-benzy...)
Show SMILES CCc1nc2N(CN(C)C(=O)c2n1Cc1ccc(OC)cc1)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C22H22Cl2N4O2/c1-4-19-25-21-20(27(19)12-14-5-8-16(30-3)9-6-14)22(29)26(2)13-28(21)18-10-7-15(23)11-17(18)24/h5-11H,4,12-13H2,1-3H3
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n/an/a 456n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- Ovine CRF binding to rat frontal cortex corticotropin releasing factor 1 receptor

J Med Chem 47: 4741-54 (2004)


Article DOI: 10.1021/jm049787k
BindingDB Entry DOI: 10.7270/Q21C1WBB
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50152036
PNG
(3-(2,4-Dichloro-phenyl)-8-ethyl-1-methyl-7-(2-meth...)
Show SMILES CCc1nc2N(CN(C)C(=O)c2n1Cc1ccccc1C)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C22H22Cl2N4O/c1-4-19-25-21-20(27(19)12-15-8-6-5-7-14(15)2)22(29)26(3)13-28(21)18-10-9-16(23)11-17(18)24/h5-11H,4,12-13H2,1-3H3
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n/an/a 458n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- Ovine CRF binding to rat frontal cortex corticotropin releasing factor 1 receptor

J Med Chem 47: 4741-54 (2004)


Article DOI: 10.1021/jm049787k
BindingDB Entry DOI: 10.7270/Q21C1WBB
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50152057
PNG
(3-(2-Chloro-4-isopropyl-phenyl)-8-ethyl-7-(1-ethyl...)
Show SMILES CCC(C(C)C)n1c(CC)nc2N(CN(C)C(=O)c12)c1ccc(cc1Cl)C(C)C
Show InChI InChI=1S/C23H33ClN4O/c1-8-18(15(5)6)28-20(9-2)25-22-21(28)23(29)26(7)13-27(22)19-11-10-16(14(3)4)12-17(19)24/h10-12,14-15,18H,8-9,13H2,1-7H3
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n/an/a 555n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- Ovine CRF binding to rat frontal cortex corticotropin releasing factor 1 receptor

J Med Chem 47: 4741-54 (2004)


Article DOI: 10.1021/jm049787k
BindingDB Entry DOI: 10.7270/Q21C1WBB
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50152032
PNG
(3-(2,4-Dichloro-phenyl)-2,8-diethyl-1-methyl-7-(1-...)
Show SMILES CCCC(CCC)n1c(CC)nc2N(C(CC)N(C)C(=O)c12)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C23H32Cl2N4O/c1-6-10-16(11-7-2)28-19(8-3)26-22-21(28)23(30)27(5)20(9-4)29(22)18-13-12-15(24)14-17(18)25/h12-14,16,20H,6-11H2,1-5H3
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n/an/a 626n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- Ovine CRF binding to rat frontal cortex corticotropin releasing factor 1 receptor

J Med Chem 47: 4741-54 (2004)


Article DOI: 10.1021/jm049787k
BindingDB Entry DOI: 10.7270/Q21C1WBB
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50152060
PNG
(7-Benzyloxymethyl-3-(2,4-dichloro-phenyl)-8-ethyl-...)
Show SMILES CCc1nc2N(CN(C)C(=O)c2n1COCc1ccccc1)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C22H22Cl2N4O2/c1-3-19-25-21-20(28(19)14-30-12-15-7-5-4-6-8-15)22(29)26(2)13-27(21)18-10-9-16(23)11-17(18)24/h4-11H,3,12-14H2,1-2H3
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n/an/a 860n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- Ovine CRF binding to rat frontal cortex corticotropin releasing factor 1 receptor

J Med Chem 47: 4741-54 (2004)


Article DOI: 10.1021/jm049787k
BindingDB Entry DOI: 10.7270/Q21C1WBB
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50152058
PNG
(3-(2-Chloro-4-methoxy-phenyl)-8-ethyl-1-methyl-7-(...)
Show SMILES CCc1nc2N(CN(C)C(=O)c2n1Cc1ccccc1C)c1ccc(OC)cc1Cl
Show InChI InChI=1S/C23H25ClN4O2/c1-5-20-25-22-21(27(20)13-16-9-7-6-8-15(16)2)23(29)26(3)14-28(22)19-11-10-17(30-4)12-18(19)24/h6-12H,5,13-14H2,1-4H3
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n/an/a 875n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- Ovine CRF binding to rat frontal cortex corticotropin releasing factor 1 receptor

J Med Chem 47: 4741-54 (2004)


Article DOI: 10.1021/jm049787k
BindingDB Entry DOI: 10.7270/Q21C1WBB
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50152041
PNG
(3-(2,4-Dichloro-phenyl)-1-methyl-7-(1-propyl-butyl...)
Show SMILES CCCC(CCC)n1cnc2N(CN(C)C(=O)c12)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C19H24Cl2N4O/c1-4-6-14(7-5-2)24-11-22-18-17(24)19(26)23(3)12-25(18)16-9-8-13(20)10-15(16)21/h8-11,14H,4-7,12H2,1-3H3
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n/an/a 898n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- Ovine CRF binding to rat frontal cortex corticotropin releasing factor 1 receptor

J Med Chem 47: 4741-54 (2004)


Article DOI: 10.1021/jm049787k
BindingDB Entry DOI: 10.7270/Q21C1WBB
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50152052
PNG
(8-Ethyl-3-(4-methoxy-2-methyl-5-pyridin-3-yl-pheny...)
Show SMILES CCCC(CCC)n1c(CC)nc2n(-c3cc(c(OC)cc3C)-c3cccnc3)c(=O)n(C)c(=O)c12 |(-6.16,6.3,;-4.64,5.99,;-4.18,4.52,;-2.66,4.2,;-1.63,5.34,;-2.1,6.81,;-1.07,7.94,;-2.19,2.73,;-3.1,1.49,;-4.64,1.49,;-5.41,2.82,;-2.19,.23,;-.74,.72,;.59,-.05,;.59,-1.59,;1.94,-2.36,;1.94,-3.9,;.59,-4.67,;.61,-6.21,;-.74,-6.98,;-.74,-3.9,;-.74,-2.36,;-2.05,-1.59,;3.27,-4.65,;3.27,-6.21,;4.62,-6.96,;5.93,-6.19,;5.93,-4.64,;4.6,-3.88,;1.94,.72,;3.27,-.05,;1.94,2.26,;3.27,3.03,;.59,3.03,;.59,4.59,;-.74,2.26,)|
Show InChI InChI=1S/C28H35N5O3/c1-7-11-20(12-8-2)32-24(9-3)30-26-25(32)27(34)31(5)28(35)33(26)22-16-21(19-13-10-14-29-17-19)23(36-6)15-18(22)4/h10,13-17,20H,7-9,11-12H2,1-6H3
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n/an/a 1.08E+3n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- Ovine CRF binding to rat frontal cortex corticotropin releasing factor 1 receptor

J Med Chem 47: 4741-54 (2004)


Article DOI: 10.1021/jm049787k
BindingDB Entry DOI: 10.7270/Q21C1WBB
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50152047
PNG
(3-(2,4-Dichloro-phenyl)-8-ethyl-7-(1-ethyl-propyl)...)
Show SMILES CCC(CC)n1c(CC)nc2n(-c3ccc(Cl)cc3Cl)c(=O)n(C)c(=O)c12 |(-1.38,5.87,;-.9,4.4,;-1.93,3.26,;-3.44,3.58,;-3.91,5.05,;-1.46,1.79,;-2.37,.55,;-3.91,.55,;-4.68,1.88,;-1.46,-.7,;,-.22,;1.34,-1,;1.34,-2.52,;2.66,-3.29,;2.66,-4.81,;1.34,-5.6,;1.34,-7.14,;,-4.83,;,-3.29,;-1.33,-2.52,;2.66,-.22,;3.99,-1,;2.66,1.32,;3.99,2.1,;1.34,2.09,;1.31,3.63,;,1.31,)|
Show InChI InChI=1S/C19H22Cl2N4O2/c1-5-12(6-2)24-15(7-3)22-17-16(24)18(26)23(4)19(27)25(17)14-9-8-11(20)10-13(14)21/h8-10,12H,5-7H2,1-4H3
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n/an/a 2.99E+3n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- Ovine CRF binding to rat frontal cortex corticotropin releasing factor 1 receptor

J Med Chem 47: 4741-54 (2004)


Article DOI: 10.1021/jm049787k
BindingDB Entry DOI: 10.7270/Q21C1WBB
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50152046
PNG
(3-(2,4-Dichloro-phenyl)-8-ethyl-1-methyl-7-naphtha...)
Show SMILES CCc1nc2N(CN(C)C(=O)c2n1Cc1cccc2ccccc12)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C25H22Cl2N4O/c1-3-22-28-24-23(30(22)14-17-9-6-8-16-7-4-5-10-19(16)17)25(32)29(2)15-31(24)21-12-11-18(26)13-20(21)27/h4-13H,3,14-15H2,1-2H3
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n/an/a 9.00E+3n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- Ovine CRF binding to rat frontal cortex corticotropin releasing factor 1 receptor

J Med Chem 47: 4741-54 (2004)


Article DOI: 10.1021/jm049787k
BindingDB Entry DOI: 10.7270/Q21C1WBB
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM50152050
PNG
(5-(2,4-Dichloro-phenylamino)-2-ethyl-3-(1-ethyl-pr...)
Show SMILES CCC(CC)n1c(CC)nc(Nc2ccc(Cl)cc2Cl)c1C(N)=O
Show InChI InChI=1S/C17H22Cl2N4O/c1-4-11(5-2)23-14(6-3)22-17(15(23)16(20)24)21-13-8-7-10(18)9-12(13)19/h7-9,11,21H,4-6H2,1-3H3,(H2,20,24)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- Ovine CRF binding to rat frontal cortex corticotropin releasing factor 1 receptor

J Med Chem 47: 4741-54 (2004)


Article DOI: 10.1021/jm049787k
BindingDB Entry DOI: 10.7270/Q21C1WBB
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 2


(Homo sapiens (Human))		BDBM50152049
PNG
(3-(2,4-Dichloro-phenyl)-7-dicyclopropylmethyl-8-et...)
Show SMILES CCc1nc2N(CN(C)C(=O)c2n1C(C1CC1)C1CC1)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C21H24Cl2N4O/c1-3-17-24-20-19(27(17)18(12-4-5-12)13-6-7-13)21(28)25(2)11-26(20)16-9-8-14(22)10-15(16)23/h8-10,12-13,18H,3-7,11H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- sauvagine binding to corticotropin releasing factor receptor 2 of porcine choroid plexus

J Med Chem 47: 4741-54 (2004)


Article DOI: 10.1021/jm049787k
BindingDB Entry DOI: 10.7270/Q21C1WBB
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 2


(Homo sapiens (Human))		BDBM50152038
PNG
(3-(2,4-Dichloro-phenyl)-8-ethyl-1-methyl-7-(1-prop...)
Show SMILES CCCC(CCC)n1c(CC)nc2N(CN(C)C(=O)c12)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C21H28Cl2N4O/c1-5-8-15(9-6-2)27-18(7-3)24-20-19(27)21(28)25(4)13-26(20)17-11-10-14(22)12-16(17)23/h10-12,15H,5-9,13H2,1-4H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of [125I]- sauvagine binding to corticotropin releasing factor receptor 2 of porcine choroid plexus

J Med Chem 47: 4741-54 (2004)


Article DOI: 10.1021/jm049787k
BindingDB Entry DOI: 10.7270/Q21C1WBB
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%