Found 51 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM3532
(CHEMBL540068 | CHEMBL7917 | N-(3-chlorophenyl)-6,7...)Show InChI InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| Purchase
CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against Epidermal growth factor receptor tyrosine kinase activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50153858
(CHEMBL185328 | N-[3-(2-Chloro-pyrimidin-4-ylamino)...)Show SMILES Cc1ccc(NC(=O)c2ccnc(c2)N2CCOCC2)cc1Nc1ccnc(Cl)n1 Show InChI InChI=1S/C21H21ClN6O2/c1-14-2-3-16(13-17(14)26-18-5-7-24-21(22)27-18)25-20(29)15-4-6-23-19(12-15)28-8-10-30-11-9-28/h2-7,12-13H,8-11H2,1H3,(H,25,29)(H,24,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against alpha mitogen activated protein kinase p38 activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM13336
(4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...)Show SMILES CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against alpha mitogen activated protein kinase p38 activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50153861
(3-Fluoro-N-[4-methyl-3-(2-methylsulfanyl-pyrimidin...)Show SMILES CSc1nccc(Nc2cc(NC(=O)c3cc(F)cc(c3)N3CCOCC3)ccc2C)n1 Show InChI InChI=1S/C23H24FN5O2S/c1-15-3-4-18(14-20(15)27-21-5-6-25-23(28-21)32-2)26-22(30)16-11-17(24)13-19(12-16)29-7-9-31-10-8-29/h3-6,11-14H,7-10H2,1-2H3,(H,26,30)(H,25,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against alpha mitogen activated protein kinase p38 activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50153870
(CHEMBL184052 | N-[3-(6,7-Dimethoxy-quinazolin-4-yl...)Show SMILES COc1cc2ncnc(Nc3cc(NC(=O)c4cccc(c4)N4CCOCC4)ccc3C)c2cc1OC Show InChI InChI=1S/C28H29N5O4/c1-18-7-8-20(31-28(34)19-5-4-6-21(13-19)33-9-11-37-12-10-33)14-23(18)32-27-22-15-25(35-2)26(36-3)16-24(22)29-17-30-27/h4-8,13-17H,9-12H2,1-3H3,(H,31,34)(H,29,30,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against alpha mitogen activated protein kinase p38 activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50153865
(CHEMBL184271 | N-{3-[7-Methoxy-6-(2-morpholin-4-yl...)Show SMILES COc1cc2ncnc(Nc3cc(NC(=O)c4ccnc(c4)N4CCOCC4)ccc3C)c2cc1OCCN1CCOCC1 Show InChI InChI=1S/C32H37N7O5/c1-22-3-4-24(36-32(40)23-5-6-33-30(17-23)39-10-14-43-15-11-39)18-26(22)37-31-25-19-29(28(41-2)20-27(25)34-21-35-31)44-16-9-38-7-12-42-13-8-38/h3-6,17-21H,7-16H2,1-2H3,(H,36,40)(H,34,35,37) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against alpha mitogen activated protein kinase p38 activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50153880
(CHEMBL364576 | N-[3-(6,7-Dimethoxy-quinazolin-4-yl...)Show SMILES COc1cc2ncnc(Nc3cc(NC(=O)c4cccc(c4)N(C)C)ccc3C)c2cc1OC Show InChI InChI=1S/C26H27N5O3/c1-16-9-10-18(29-26(32)17-7-6-8-19(11-17)31(2)3)12-21(16)30-25-20-13-23(33-4)24(34-5)14-22(20)27-15-28-25/h6-15H,1-5H3,(H,29,32)(H,27,28,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against alpha mitogen activated protein kinase p38 activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50153857
(CHEMBL186665 | N-{3-[2-(3-Dimethylamino-propoxy)-p...)Show SMILES CN(C)CCCOc1nccc(Nc2cc(NC(=O)c3ccnc(c3)N3CCOCC3)ccc2C)n1 Show InChI InChI=1S/C26H33N7O3/c1-19-5-6-21(29-25(34)20-7-9-27-24(17-20)33-12-15-35-16-13-33)18-22(19)30-23-8-10-28-26(31-23)36-14-4-11-32(2)3/h5-10,17-18H,4,11-16H2,1-3H3,(H,29,34)(H,28,30,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against alpha mitogen activated protein kinase p38 activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50153871
(CHEMBL365614 | N-{4-Methyl-3-[2-(1-methyl-piperidi...)Show SMILES CN1CCCC(COc2nccc(Nc3cc(NC(=O)c4ccnc(c4)N4CCOCC4)ccc3C)n2)C1 Show InChI InChI=1S/C28H35N7O3/c1-20-5-6-23(31-27(36)22-7-9-29-26(16-22)35-12-14-37-15-13-35)17-24(20)32-25-8-10-30-28(33-25)38-19-21-4-3-11-34(2)18-21/h5-10,16-17,21H,3-4,11-15,18-19H2,1-2H3,(H,31,36)(H,30,32,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against alpha mitogen activated protein kinase p38 activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50153859
(CHEMBL184659 | N-(3-{[7-METHOXY-6-(2-PYRROLIDIN-1-...)Show SMILES COc1cc2ncnc(Nc3cc(NC(=O)c4ccnc(c4)N4CCOCC4)ccc3C)c2cc1OCCN1CCCC1 Show InChI InChI=1S/C32H37N7O4/c1-22-5-6-24(36-32(40)23-7-8-33-30(17-23)39-12-14-42-15-13-39)18-26(22)37-31-25-19-29(43-16-11-38-9-3-4-10-38)28(41-2)20-27(25)34-21-35-31/h5-8,17-21H,3-4,9-16H2,1-2H3,(H,36,40)(H,34,35,37) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against alpha mitogen activated protein kinase p38 activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50153876
(CHEMBL188114 | N-{3-[6-(2-Dimethylamino-ethoxy)-7-...)Show SMILES COc1cc2ncnc(Nc3cc(NC(=O)c4ccnc(c4)N4CCOCC4)ccc3C)c2cc1OCCN(C)C Show InChI InChI=1S/C30H35N7O4/c1-20-5-6-22(34-30(38)21-7-8-31-28(15-21)37-10-12-40-13-11-37)16-24(20)35-29-23-17-27(41-14-9-36(2)3)26(39-4)18-25(23)32-19-33-29/h5-8,15-19H,9-14H2,1-4H3,(H,34,38)(H,32,33,35) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against alpha mitogen activated protein kinase p38 activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50153852
(CHEMBL185315 | N-(4-methyl-3-(2-(1-methylpiperidin...)Show SMILES CN1CCC(CC1)Oc1nccc(Nc2cc(NC(=O)c3ccnc(c3)N3CCOCC3)ccc2C)n1 Show InChI InChI=1S/C27H33N7O3/c1-19-3-4-21(30-26(35)20-5-9-28-25(17-20)34-13-15-36-16-14-34)18-23(19)31-24-6-10-29-27(32-24)37-22-7-11-33(2)12-8-22/h3-6,9-10,17-18,22H,7-8,11-16H2,1-2H3,(H,30,35)(H,29,31,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against alpha mitogen activated protein kinase p38 activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50153875
(CHEMBL361431 | N-{4-Methyl-3-[2-(1-propyl-piperidi...)Show SMILES CCCN1CCC(CC1)Oc1nccc(Nc2cc(NC(=O)c3cccc(c3)N3CCOCC3)ccc2C)n1 Show InChI InChI=1S/C30H38N6O3/c1-3-13-35-14-10-26(11-15-35)39-30-31-12-9-28(34-30)33-27-21-24(8-7-22(27)2)32-29(37)23-5-4-6-25(20-23)36-16-18-38-19-17-36/h4-9,12,20-21,26H,3,10-11,13-19H2,1-2H3,(H,32,37)(H,31,33,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against alpha mitogen activated protein kinase p38 activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50153874
(CHEMBL187007 | N-[4-Chloro-3-(6,7-dimethoxy-quinaz...)Show SMILES COc1cc2ncnc(Nc3cc(NC(=O)c4cccc(c4)N(C)C)ccc3Cl)c2cc1OC Show InChI InChI=1S/C25H24ClN5O3/c1-31(2)17-7-5-6-15(10-17)25(32)29-16-8-9-19(26)21(11-16)30-24-18-12-22(33-3)23(34-4)13-20(18)27-14-28-24/h5-14H,1-4H3,(H,29,32)(H,27,28,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against alpha mitogen activated protein kinase p38 activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50153867
(CHEMBL184725 | N-{4-Methyl-3-[2-(1-propyl-piperidi...)Show SMILES CCCN1CCC(CC1)Oc1nccc(Nc2cc(NC(=O)c3ccnc(c3)N3CCOCC3)ccc2C)n1 Show InChI InChI=1S/C29H37N7O3/c1-3-12-35-13-8-24(9-14-35)39-29-31-11-7-26(34-29)33-25-20-23(5-4-21(25)2)32-28(37)22-6-10-30-27(19-22)36-15-17-38-18-16-36/h4-7,10-11,19-20,24H,3,8-9,12-18H2,1-2H3,(H,32,37)(H,31,33,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against alpha mitogen activated protein kinase p38 activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50153884
(CHEMBL363462 | N-{3-[6-(2-Diisopropylamino-ethoxy)...)Show SMILES COc1cc2ncnc(Nc3cc(NC(=O)c4ccnc(c4)N4CCOCC4)ccc3C)c2cc1OCCN(C(C)C)C(C)C Show InChI InChI=1S/C34H43N7O4/c1-22(2)41(23(3)4)13-16-45-31-19-27-29(20-30(31)43-6)36-21-37-33(27)39-28-18-26(8-7-24(28)5)38-34(42)25-9-10-35-32(17-25)40-11-14-44-15-12-40/h7-10,17-23H,11-16H2,1-6H3,(H,38,42)(H,36,37,39) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against alpha mitogen activated protein kinase p38 activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50153878
(CHEMBL186580 | N-[5-(6,7-Dimethoxy-quinazolin-4-yl...)Show SMILES COc1cc2ncnc(Nc3cc(NC(=O)c4ccccc4)c(F)cc3F)c2cc1OC Show InChI InChI=1S/C23H18F2N4O3/c1-31-20-8-14-17(11-21(20)32-2)26-12-27-22(14)28-18-10-19(16(25)9-15(18)24)29-23(30)13-6-4-3-5-7-13/h3-12H,1-2H3,(H,29,30)(H,26,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against alpha mitogen activated protein kinase p38 activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50153879
(CHEMBL426969 | N-{4-Methyl-3-[2-(3-pyrrolidin-1-yl...)Show SMILES Cc1ccc(NC(=O)c2ccnc(c2)N2CCOCC2)cc1Nc1ccnc(NCCCN2CCCC2)n1 Show InChI InChI=1S/C28H36N8O2/c1-21-5-6-23(32-27(37)22-7-10-29-26(19-22)36-15-17-38-18-16-36)20-24(21)33-25-8-11-31-28(34-25)30-9-4-14-35-12-2-3-13-35/h5-8,10-11,19-20H,2-4,9,12-18H2,1H3,(H,32,37)(H2,30,31,33,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against alpha mitogen activated protein kinase p38 activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50153853
(CHEMBL188167 | N-{3-[7-Methoxy-6-(2-piperidin-1-yl...)Show SMILES COc1cc2ncnc(Nc3cc(NC(=O)c4ccnc(c4)N4CCOCC4)ccc3C)c2cc1OCCN1CCCCC1 Show InChI InChI=1S/C33H39N7O4/c1-23-6-7-25(37-33(41)24-8-9-34-31(18-24)40-13-15-43-16-14-40)19-27(23)38-32-26-20-30(29(42-2)21-28(26)35-22-36-32)44-17-12-39-10-4-3-5-11-39/h6-9,18-22H,3-5,10-17H2,1-2H3,(H,37,41)(H,35,36,38) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against alpha mitogen activated protein kinase p38 activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50153881
(CHEMBL362902 | N-{3-[2-(3-Dimethylamino-2,2-dimeth...)Show SMILES CN(C)CC(C)(C)COc1nccc(Nc2cc(NC(=O)c3ccnc(c3)N3CCOCC3)ccc2C)n1 Show InChI InChI=1S/C28H37N7O3/c1-20-6-7-22(31-26(36)21-8-10-29-25(16-21)35-12-14-37-15-13-35)17-23(20)32-24-9-11-30-27(33-24)38-19-28(2,3)18-34(4)5/h6-11,16-17H,12-15,18-19H2,1-5H3,(H,31,36)(H,30,32,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against alpha mitogen activated protein kinase p38 activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50153854
(CHEMBL184555 | N-[3-(6,7-Dimethoxy-quinazolin-4-yl...)Show SMILES COc1cc2ncnc(Nc3cc(NC(=O)c4ccccc4)ccc3C)c2cc1OC Show InChI InChI=1S/C24H22N4O3/c1-15-9-10-17(27-24(29)16-7-5-4-6-8-16)11-19(15)28-23-18-12-21(30-2)22(31-3)13-20(18)25-14-26-23/h4-14H,1-3H3,(H,27,29)(H,25,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against alpha mitogen activated protein kinase p38 activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50153860
(CHEMBL366080 | N-(4-Methyl-3-{2-[methyl-(1-methyl-...)Show SMILES CN(C1CCN(C)CC1)c1nccc(Nc2cc(NC(=O)c3ccnc(c3)N3CCOCC3)ccc2C)n1 Show InChI InChI=1S/C28H36N8O2/c1-20-4-5-22(31-27(37)21-6-10-29-26(18-21)36-14-16-38-17-15-36)19-24(20)32-25-7-11-30-28(33-25)35(3)23-8-12-34(2)13-9-23/h4-7,10-11,18-19,23H,8-9,12-17H2,1-3H3,(H,31,37)(H,30,32,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against alpha mitogen activated protein kinase p38 activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50153872
(CHEMBL185327 | N-[4-Chloro-3-(6,7-dimethoxy-quinaz...)Show SMILES COc1cc2ncnc(Nc3cc(NC(=O)c4ccccc4)ccc3Cl)c2cc1OC Show InChI InChI=1S/C23H19ClN4O3/c1-30-20-11-16-18(12-21(20)31-2)25-13-26-22(16)28-19-10-15(8-9-17(19)24)27-23(29)14-6-4-3-5-7-14/h3-13H,1-2H3,(H,27,29)(H,25,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against alpha mitogen activated protein kinase p38 activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50153850
(CHEMBL359797 | N-{4-Methyl-3-[2-(3-morpholin-4-yl-...)Show SMILES Cc1ccc(NC(=O)c2ccnc(c2)N2CCOCC2)cc1Nc1ccnc(NCCCN2CCOCC2)n1 Show InChI InChI=1S/C28H36N8O3/c1-21-3-4-23(32-27(37)22-5-8-29-26(19-22)36-13-17-39-18-14-36)20-24(21)33-25-6-9-31-28(34-25)30-7-2-10-35-11-15-38-16-12-35/h3-6,8-9,19-20H,2,7,10-18H2,1H3,(H,32,37)(H2,30,31,33,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against alpha mitogen activated protein kinase p38 activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50153882
(CHEMBL182772 | N-{3-[2-(Allyl-methyl-amino)-pyrimi...)Show SMILES CN(CC=C)c1nccc(Nc2cc(NC(=O)c3ccnc(c3)N3CCOCC3)ccc2C)n1 Show InChI InChI=1S/C25H29N7O2/c1-4-11-31(3)25-27-10-8-22(30-25)29-21-17-20(6-5-18(21)2)28-24(33)19-7-9-26-23(16-19)32-12-14-34-15-13-32/h4-10,16-17H,1,11-15H2,2-3H3,(H,28,33)(H,27,29,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against alpha mitogen activated protein kinase p38 activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50153864
(CHEMBL186802 | N-[3-(6,7-Dimethoxy-quinazolin-4-yl...)Show SMILES COc1cc2ncnc(Nc3cccc(NC(=O)c4ccccc4)c3)c2cc1OC Show InChI InChI=1S/C23H20N4O3/c1-29-20-12-18-19(13-21(20)30-2)24-14-25-22(18)26-16-9-6-10-17(11-16)27-23(28)15-7-4-3-5-8-15/h3-14H,1-2H3,(H,27,28)(H,24,25,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against alpha mitogen activated protein kinase p38 activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50153856
(CHEMBL185162 | N-[4-Methyl-3-(pyrimidin-4-ylamino)...)Show SMILES Cc1ccc(NC(=O)c2ccnc(c2)N2CCOCC2)cc1Nc1ccncn1 Show InChI InChI=1S/C21H22N6O2/c1-15-2-3-17(13-18(15)26-19-5-6-22-14-24-19)25-21(28)16-4-7-23-20(12-16)27-8-10-29-11-9-27/h2-7,12-14H,8-11H2,1H3,(H,25,28)(H,22,24,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against alpha mitogen activated protein kinase p38 activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50153869
(CHEMBL365830 | N-[3-(6,7-Dimethoxy-quinazolin-4-yl...)Show SMILES COc1cc2ncnc(Nc3cccc(NC(=O)c4cccc(c4)N(C)C)c3)c2cc1OC Show InChI InChI=1S/C25H25N5O3/c1-30(2)19-10-5-7-16(11-19)25(31)29-18-9-6-8-17(12-18)28-24-20-13-22(32-3)23(33-4)14-21(20)26-15-27-24/h5-15H,1-4H3,(H,29,31)(H,26,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against alpha mitogen activated protein kinase p38 activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50153851
(CHEMBL185567 | N-[3-(6-Chloro-pyrimidin-4-ylamino)...)Show SMILES Cc1ccc(NC(=O)c2ccnc(c2)N2CCOCC2)cc1Nc1cc(Cl)ncn1 Show InChI InChI=1S/C21H21ClN6O2/c1-14-2-3-16(11-17(14)27-19-12-18(22)24-13-25-19)26-21(29)15-4-5-23-20(10-15)28-6-8-30-9-7-28/h2-5,10-13H,6-9H2,1H3,(H,26,29)(H,24,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against alpha mitogen activated protein kinase p38 activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50153877
(CHEMBL188126 | N-{3-[6-(3-Diethylamino-propylamino...)Show SMILES CCN(CC)CCCNc1cc(Nc2cc(NC(=O)c3ccnc(c3)N3CCOCC3)ccc2C)ncn1 Show InChI InChI=1S/C28H38N8O2/c1-4-35(5-2)12-6-10-29-25-19-26(32-20-31-25)34-24-18-23(8-7-21(24)3)33-28(37)22-9-11-30-27(17-22)36-13-15-38-16-14-36/h7-9,11,17-20H,4-6,10,12-16H2,1-3H3,(H,33,37)(H2,29,31,32,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 280 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against alpha mitogen activated protein kinase p38 activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50153873
(CHEMBL186852 | N-{4-Methyl-3-[6-(3-pyrrolidin-1-yl...)Show SMILES Cc1ccc(NC(=O)c2ccnc(c2)N2CCOCC2)cc1Nc1cc(NCCCN2CCCC2)ncn1 Show InChI InChI=1S/C28H36N8O2/c1-21-5-6-23(33-28(37)22-7-9-30-27(17-22)36-13-15-38-16-14-36)18-24(21)34-26-19-25(31-20-32-26)29-8-4-12-35-10-2-3-11-35/h5-7,9,17-20H,2-4,8,10-16H2,1H3,(H,33,37)(H2,29,31,32,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against alpha mitogen activated protein kinase p38 activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50153878
(CHEMBL186580 | N-[5-(6,7-Dimethoxy-quinazolin-4-yl...)Show SMILES COc1cc2ncnc(Nc3cc(NC(=O)c4ccccc4)c(F)cc3F)c2cc1OC Show InChI InChI=1S/C23H18F2N4O3/c1-31-20-8-14-17(11-21(20)32-2)26-12-27-22(14)28-18-10-19(16(25)9-15(18)24)29-23(30)13-6-4-3-5-7-13/h3-12H,1-2H3,(H,29,30)(H,26,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 490 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against Epidermal growth factor receptor tyrosine kinase activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50153862
(CHEMBL184685 | N-[2-Chloro-5-(6,7-dimethoxy-quinaz...)Show SMILES COc1cc2ncnc(Nc3cc(NC(=O)c4ccccc4)c(Cl)cc3F)c2cc1OC Show InChI InChI=1S/C23H18ClFN4O3/c1-31-20-8-14-17(11-21(20)32-2)26-12-27-22(14)28-19-10-18(15(24)9-16(19)25)29-23(30)13-6-4-3-5-7-13/h3-12H,1-2H3,(H,29,30)(H,26,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 510 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against alpha mitogen activated protein kinase p38 activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM3532
(CHEMBL540068 | CHEMBL7917 | N-(3-chlorophenyl)-6,7...)Show InChI InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 560 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against alpha mitogen activated protein kinase p38 activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50153863
(CHEMBL360209 | N-[2-Chloro-5-(6,7-dimethoxy-quinaz...)Show SMILES COc1cc2ncnc(Nc3ccc(Cl)c(NC(=O)c4ccccc4)c3)c2cc1OC Show InChI InChI=1S/C23H19ClN4O3/c1-30-20-11-16-18(12-21(20)31-2)25-13-26-22(16)27-15-8-9-17(24)19(10-15)28-23(29)14-6-4-3-5-7-14/h3-13H,1-2H3,(H,28,29)(H,25,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 610 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against alpha mitogen activated protein kinase p38 activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50153866
(CHEMBL182397 | N-[3-(6,7-Dimethoxy-quinazolin-4-yl...)Show SMILES COc1cc2ncnc(Nc3cccc(NC(=O)c4ccccc4)c3F)c2cc1OC Show InChI InChI=1S/C23H19FN4O3/c1-30-19-11-15-18(12-20(19)31-2)25-13-26-22(15)27-16-9-6-10-17(21(16)24)28-23(29)14-7-4-3-5-8-14/h3-13H,1-2H3,(H,28,29)(H,25,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 690 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against alpha mitogen activated protein kinase p38 activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50153868
(CHEMBL184682 | N-[2-Chloro-5-(6,7-dimethoxy-quinaz...)Show SMILES COc1cc2ncnc(Nc3ccc(Cl)c(NC(=O)c4cccc(c4)N(C)C)c3)c2cc1OC Show InChI InChI=1S/C25H24ClN5O3/c1-31(2)17-7-5-6-15(10-17)25(32)30-21-11-16(8-9-19(21)26)29-24-18-12-22(33-3)23(34-4)13-20(18)27-14-28-24/h5-14H,1-4H3,(H,30,32)(H,27,28,29) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against Epidermal growth factor receptor tyrosine kinase activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50153883
(CHEMBL184257 | N-{4-Methyl-3-[6-(4-methyl-[1,4]dia...)Show SMILES CN1CCCN(CC1)c1cc(Nc2cc(NC(=O)c3ccnc(c3)N3CCOCC3)ccc2C)ncn1 Show InChI InChI=1S/C27H34N8O2/c1-20-4-5-22(31-27(36)21-6-7-28-25(16-21)35-12-14-37-15-13-35)17-23(20)32-24-18-26(30-19-29-24)34-9-3-8-33(2)10-11-34/h4-7,16-19H,3,8-15H2,1-2H3,(H,31,36)(H,29,30,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.22E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against alpha mitogen activated protein kinase p38 activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50153868
(CHEMBL184682 | N-[2-Chloro-5-(6,7-dimethoxy-quinaz...)Show SMILES COc1cc2ncnc(Nc3ccc(Cl)c(NC(=O)c4cccc(c4)N(C)C)c3)c2cc1OC Show InChI InChI=1S/C25H24ClN5O3/c1-31(2)17-7-5-6-15(10-17)25(32)30-21-11-16(8-9-19(21)26)29-24-18-12-22(33-3)23(34-4)13-20(18)27-14-28-24/h5-14H,1-4H3,(H,30,32)(H,27,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.69E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against alpha mitogen activated protein kinase p38 activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50153855
(CHEMBL186747 | N-[5-(6,7-Dimethoxy-quinazolin-4-yl...)Show SMILES COc1cc2ncnc(Nc3ccc(C)c(NC(=O)c4ccccc4)c3)c2cc1OC Show InChI InChI=1S/C24H22N4O3/c1-15-9-10-17(11-19(15)28-24(29)16-7-5-4-6-8-16)27-23-18-12-21(30-2)22(31-3)13-20(18)25-14-26-23/h4-14H,1-3H3,(H,28,29)(H,25,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.09E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against alpha mitogen activated protein kinase p38 activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50153863
(CHEMBL360209 | N-[2-Chloro-5-(6,7-dimethoxy-quinaz...)Show SMILES COc1cc2ncnc(Nc3ccc(Cl)c(NC(=O)c4ccccc4)c3)c2cc1OC Show InChI InChI=1S/C23H19ClN4O3/c1-30-20-11-16-18(12-21(20)31-2)25-13-26-22(16)27-15-8-9-17(24)19(10-15)28-23(29)14-6-4-3-5-7-14/h3-13H,1-2H3,(H,28,29)(H,25,26,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against Epidermal growth factor receptor tyrosine kinase activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50153866
(CHEMBL182397 | N-[3-(6,7-Dimethoxy-quinazolin-4-yl...)Show SMILES COc1cc2ncnc(Nc3cccc(NC(=O)c4ccccc4)c3F)c2cc1OC Show InChI InChI=1S/C23H19FN4O3/c1-30-19-11-15-18(12-20(19)31-2)25-13-26-22(15)27-16-9-6-10-17(21(16)24)28-23(29)14-7-4-3-5-8-14/h3-13H,1-2H3,(H,28,29)(H,25,26,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against Epidermal growth factor receptor tyrosine kinase activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50153855
(CHEMBL186747 | N-[5-(6,7-Dimethoxy-quinazolin-4-yl...)Show SMILES COc1cc2ncnc(Nc3ccc(C)c(NC(=O)c4ccccc4)c3)c2cc1OC Show InChI InChI=1S/C24H22N4O3/c1-15-9-10-17(11-19(15)28-24(29)16-7-5-4-6-8-16)27-23-18-12-21(30-2)22(31-3)13-20(18)25-14-26-23/h4-14H,1-3H3,(H,28,29)(H,25,26,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against Epidermal growth factor receptor tyrosine kinase activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50153864
(CHEMBL186802 | N-[3-(6,7-Dimethoxy-quinazolin-4-yl...)Show SMILES COc1cc2ncnc(Nc3cccc(NC(=O)c4ccccc4)c3)c2cc1OC Show InChI InChI=1S/C23H20N4O3/c1-29-20-12-18-19(13-21(20)30-2)24-14-25-22(18)26-16-9-6-10-17(11-16)27-23(28)15-7-4-3-5-8-15/h3-14H,1-2H3,(H,27,28)(H,24,25,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against Epidermal growth factor receptor tyrosine kinase activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50153872
(CHEMBL185327 | N-[4-Chloro-3-(6,7-dimethoxy-quinaz...)Show SMILES COc1cc2ncnc(Nc3cc(NC(=O)c4ccccc4)ccc3Cl)c2cc1OC Show InChI InChI=1S/C23H19ClN4O3/c1-30-20-11-16-18(12-21(20)31-2)25-13-26-22(16)28-19-10-15(8-9-17(19)24)27-23(29)14-6-4-3-5-7-14/h3-13H,1-2H3,(H,27,29)(H,25,26,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against Epidermal growth factor receptor tyrosine kinase activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50153874
(CHEMBL187007 | N-[4-Chloro-3-(6,7-dimethoxy-quinaz...)Show SMILES COc1cc2ncnc(Nc3cc(NC(=O)c4cccc(c4)N(C)C)ccc3Cl)c2cc1OC Show InChI InChI=1S/C25H24ClN5O3/c1-31(2)17-7-5-6-15(10-17)25(32)29-16-8-9-19(26)21(11-16)30-24-18-12-22(33-3)23(34-4)13-20(18)27-14-28-24/h5-14H,1-4H3,(H,29,32)(H,27,28,30) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against Epidermal growth factor receptor tyrosine kinase activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50153880
(CHEMBL364576 | N-[3-(6,7-Dimethoxy-quinazolin-4-yl...)Show SMILES COc1cc2ncnc(Nc3cc(NC(=O)c4cccc(c4)N(C)C)ccc3C)c2cc1OC Show InChI InChI=1S/C26H27N5O3/c1-16-9-10-18(29-26(32)17-7-6-8-19(11-17)31(2)3)12-21(16)30-25-20-13-23(33-4)24(34-5)14-22(20)27-15-28-25/h6-15H,1-5H3,(H,29,32)(H,27,28,30) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against Epidermal growth factor receptor tyrosine kinase activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50153870
(CHEMBL184052 | N-[3-(6,7-Dimethoxy-quinazolin-4-yl...)Show SMILES COc1cc2ncnc(Nc3cc(NC(=O)c4cccc(c4)N4CCOCC4)ccc3C)c2cc1OC Show InChI InChI=1S/C28H29N5O4/c1-18-7-8-20(31-28(34)19-5-4-6-21(13-19)33-9-11-37-12-10-33)14-23(18)32-27-22-15-25(35-2)26(36-3)16-24(22)29-17-30-27/h4-8,13-17H,9-12H2,1-3H3,(H,31,34)(H,29,30,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against Epidermal growth factor receptor tyrosine kinase activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM13336
(4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...)Show SMILES CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >3.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against Epidermal growth factor receptor tyrosine kinase activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50153869
(CHEMBL365830 | N-[3-(6,7-Dimethoxy-quinazolin-4-yl...)Show SMILES COc1cc2ncnc(Nc3cccc(NC(=O)c4cccc(c4)N(C)C)c3)c2cc1OC Show InChI InChI=1S/C25H25N5O3/c1-30(2)19-10-5-7-16(11-19)25(31)29-18-9-6-8-17(12-18)28-24-20-13-22(32-3)23(33-4)14-21(20)26-15-27-24/h5-15H,1-4H3,(H,29,31)(H,26,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against Epidermal growth factor receptor tyrosine kinase activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50153854
(CHEMBL184555 | N-[3-(6,7-Dimethoxy-quinazolin-4-yl...)Show SMILES COc1cc2ncnc(Nc3cc(NC(=O)c4ccccc4)ccc3C)c2cc1OC Show InChI InChI=1S/C24H22N4O3/c1-15-9-10-17(27-24(29)16-7-5-4-6-8-16)11-19(15)28-23-18-12-21(30-2)22(31-3)13-20(18)25-14-26-23/h4-14H,1-3H3,(H,27,29)(H,25,26,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibitory concentration against Epidermal growth factor receptor tyrosine kinase activity |
Bioorg Med Chem Lett 14: 5389-94 (2004)
Article DOI: 10.1016/j.bmcl.2004.08.007
BindingDB Entry DOI: 10.7270/Q24Q7TGZ |
More data for this
Ligand-Target Pair | |
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