BindingDB logo
myBDB logout

PubMed code 15634008

Compile data set for download or QSAR
Found 32 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11162
PNG
((1R)-3-oxo-3-[3-(trifluoroethyl)-5,6-dihydro[1,2,4...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C16H15F6N5O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4,6,9H,1-3,5,7,23H2/t9-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MCE
PC cid
PC sid
PDB
UniChem

Similars

DrugBank
PDB
Article
PubMed
n/an/a 18n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11160
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1cc(F)ccc1F |r|
Show InChI InChI=1S/C16H16F5N5O/c17-10-1-2-12(18)9(5-10)6-11(22)7-14(27)25-3-4-26-13(8-25)23-24-15(26)16(19,20)21/h1-2,5,11H,3-4,6-8,22H2/t11-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 27n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11161
PNG
((1R)-3-(5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7...)
Show SMILES N[C@@H](CC(=O)N1CCn2cnnc2C1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C15H16F3N5O/c16-11-6-13(18)12(17)4-9(11)3-10(19)5-15(24)22-1-2-23-8-20-21-14(23)7-22/h4,6,8,10H,1-3,5,7,19H2/t10-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 68n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11163
PNG
((1R)-1-(2,5-difluorobenzyl)-3-oxo-3-[3-(2,2,2-trif...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)C(F)(F)F)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C17H15F8N5O/c18-10-6-12(20)11(19)4-8(10)3-9(26)5-14(31)29-1-2-30-13(7-29)27-28-15(30)16(21,22)17(23,24)25/h4,6,9H,1-3,5,7,26H2/t9-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 71n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11164
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(2,2,2-tr...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(CC(F)(F)F)nnc2C1)Cc1cc(F)ccc1F |r|
Show InChI InChI=1S/C17H18F5N5O/c18-11-1-2-13(19)10(5-11)6-12(23)7-16(28)26-3-4-27-14(8-17(20,21)22)24-25-15(27)9-26/h1-2,5,12H,3-4,6-9,23H2/t12-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 103n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11159
PNG
((1R)-1-(3,4-difluorobenzyl)-3-oxo-3-[3-(trifluorom...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1ccc(F)c(F)c1 |r|
Show InChI InChI=1S/C16H16F5N5O/c17-11-2-1-9(6-12(11)18)5-10(22)7-14(27)25-3-4-26-13(8-25)23-24-15(26)16(19,20)21/h1-2,6,10H,3-5,7-8,22H2/t10-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 128n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11158
PNG
((1R)-1-(3,4-difluorobenzyl)-3-(3-ethyl-5,6-dihydro...)
Show SMILES CCc1nnc2CN(CCn12)C(=O)C[C@H](N)Cc1ccc(F)c(F)c1 |r|
Show InChI InChI=1S/C17H21F2N5O/c1-2-15-21-22-16-10-23(5-6-24(15)16)17(25)9-12(20)7-11-3-4-13(18)14(19)8-11/h3-4,8,12H,2,5-7,9-10,20H2,1H3/t12-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 231n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM11157
PNG
((1R)-1-(3,4-difluorobenzyl)-3-(5,6-dihydro[1,2,4]t...)
Show SMILES N[C@@H](CC(=O)N1CCn2cnnc2C1)Cc1ccc(F)c(F)c1 |r|
Show InChI InChI=1S/C15H17F2N5O/c16-12-2-1-10(6-13(12)17)5-11(18)7-15(23)21-3-4-22-9-19-20-14(22)8-21/h1-2,6,9,11H,3-5,7-8,18H2/t11-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 455n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM11157
PNG
((1R)-1-(3,4-difluorobenzyl)-3-(5,6-dihydro[1,2,4]t...)
Show SMILES N[C@@H](CC(=O)N1CCn2cnnc2C1)Cc1ccc(F)c(F)c1 |r|
Show InChI InChI=1S/C15H17F2N5O/c16-12-2-1-10(6-13(12)17)5-11(18)7-15(23)21-3-4-22-9-19-20-14(22)8-21/h1-2,6,9,11H,3-5,7-8,18H2/t11-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM11161
PNG
((1R)-3-(5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7...)
Show SMILES N[C@@H](CC(=O)N1CCn2cnnc2C1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C15H16F3N5O/c16-11-6-13(18)12(17)4-9(11)3-10(19)5-15(24)22-1-2-23-8-20-21-14(23)7-22/h4,6,8,10H,1-3,5,7,19H2/t10-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM11164
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(2,2,2-tr...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(CC(F)(F)F)nnc2C1)Cc1cc(F)ccc1F |r|
Show InChI InChI=1S/C17H18F5N5O/c18-11-1-2-13(19)10(5-11)6-12(23)7-16(28)26-3-4-27-14(8-17(20,21)22)24-25-15(27)9-26/h1-2,5,12H,3-4,6-9,23H2/t12-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.50E+4n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM11157
PNG
((1R)-1-(3,4-difluorobenzyl)-3-(5,6-dihydro[1,2,4]t...)
Show SMILES N[C@@H](CC(=O)N1CCn2cnnc2C1)Cc1ccc(F)c(F)c1 |r|
Show InChI InChI=1S/C15H17F2N5O/c16-12-2-1-10(6-13(12)17)5-11(18)7-15(23)21-3-4-22-9-19-20-14(22)8-21/h1-2,6,9,11H,3-5,7-8,18H2/t11-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.80E+4n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM11158
PNG
((1R)-1-(3,4-difluorobenzyl)-3-(3-ethyl-5,6-dihydro...)
Show SMILES CCc1nnc2CN(CCn12)C(=O)C[C@H](N)Cc1ccc(F)c(F)c1 |r|
Show InChI InChI=1S/C17H21F2N5O/c1-2-15-21-22-16-10-23(5-6-24(15)16)17(25)9-12(20)7-11-3-4-13(18)14(19)8-11/h3-4,8,12H,2,5-7,9-10,20H2,1H3/t12-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.50E+4n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM11159
PNG
((1R)-1-(3,4-difluorobenzyl)-3-oxo-3-[3-(trifluorom...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1ccc(F)c(F)c1 |r|
Show InChI InChI=1S/C16H16F5N5O/c17-11-2-1-9(6-12(11)18)5-10(22)7-14(27)25-3-4-26-13(8-25)23-24-15(26)16(19,20)21/h1-2,6,10H,3-5,7-8,22H2/t10-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.60E+4n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM11162
PNG
((1R)-3-oxo-3-[3-(trifluoroethyl)-5,6-dihydro[1,2,4...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C16H15F6N5O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4,6,9H,1-3,5,7,23H2/t9-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MCE
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a 4.80E+4n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM11158
PNG
((1R)-1-(3,4-difluorobenzyl)-3-(3-ethyl-5,6-dihydro...)
Show SMILES CCc1nnc2CN(CCn12)C(=O)C[C@H](N)Cc1ccc(F)c(F)c1 |r|
Show InChI InChI=1S/C17H21F2N5O/c1-2-15-21-22-16-10-23(5-6-24(15)16)17(25)9-12(20)7-11-3-4-13(18)14(19)8-11/h3-4,8,12H,2,5-7,9-10,20H2,1H3/t12-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.40E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM11160
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1cc(F)ccc1F |r|
Show InChI InChI=1S/C16H16F5N5O/c17-10-1-2-12(18)9(5-10)6-11(22)7-14(27)25-3-4-26-13(8-25)23-24-15(26)16(19,20)21/h1-2,5,11H,3-4,6-8,22H2/t11-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.90E+4n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM11161
PNG
((1R)-3-(5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7...)
Show SMILES N[C@@H](CC(=O)N1CCn2cnnc2C1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C15H16F3N5O/c16-11-6-13(18)12(17)4-9(11)3-10(19)5-15(24)22-1-2-23-8-20-21-14(23)7-22/h4,6,8,10H,1-3,5,7,19H2/t10-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.20E+4n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM11163
PNG
((1R)-1-(2,5-difluorobenzyl)-3-oxo-3-[3-(2,2,2-trif...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)C(F)(F)F)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C17H15F8N5O/c18-10-6-12(20)11(19)4-8(10)3-9(26)5-14(31)29-1-2-30-13(7-29)27-28-15(30)16(21,22)17(23,24)25/h4,6,9H,1-3,5,7,26H2/t9-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.80E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))
BDBM11163
PNG
((1R)-1-(2,5-difluorobenzyl)-3-oxo-3-[3-(2,2,2-trif...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)C(F)(F)F)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C17H15F8N5O/c18-10-6-12(20)11(19)4-8(10)3-9(26)5-14(31)29-1-2-30-13(7-29)27-28-15(30)16(21,22)17(23,24)25/h4,6,9H,1-3,5,7,26H2/t9-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.00E+4n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM11159
PNG
((1R)-1-(3,4-difluorobenzyl)-3-oxo-3-[3-(trifluorom...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1ccc(F)c(F)c1 |r|
Show InChI InChI=1S/C16H16F5N5O/c17-11-2-1-9(6-12(11)18)5-10(22)7-14(27)25-3-4-26-13(8-25)23-24-15(26)16(19,20)21/h1-2,6,10H,3-5,7-8,22H2/t10-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 9.80E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11164
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(2,2,2-tr...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(CC(F)(F)F)nnc2C1)Cc1cc(F)ccc1F |r|
Show InChI InChI=1S/C17H18F5N5O/c18-11-1-2-13(19)10(5-11)6-12(23)7-16(28)26-3-4-27-14(8-17(20,21)22)24-25-15(27)9-26/h1-2,5,12H,3-4,6-9,23H2/t12-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11157
PNG
((1R)-1-(3,4-difluorobenzyl)-3-(5,6-dihydro[1,2,4]t...)
Show SMILES N[C@@H](CC(=O)N1CCn2cnnc2C1)Cc1ccc(F)c(F)c1 |r|
Show InChI InChI=1S/C15H17F2N5O/c16-12-2-1-10(6-13(12)17)5-11(18)7-15(23)21-3-4-22-9-19-20-14(22)8-21/h1-2,6,9,11H,3-5,7-8,18H2/t11-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM11164
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(2,2,2-tr...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(CC(F)(F)F)nnc2C1)Cc1cc(F)ccc1F |r|
Show InChI InChI=1S/C17H18F5N5O/c18-11-1-2-13(19)10(5-11)6-12(23)7-16(28)26-3-4-27-14(8-17(20,21)22)24-25-15(27)9-26/h1-2,5,12H,3-4,6-9,23H2/t12-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM11160
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1cc(F)ccc1F |r|
Show InChI InChI=1S/C16H16F5N5O/c17-10-1-2-12(18)9(5-10)6-11(22)7-14(27)25-3-4-26-13(8-25)23-24-15(26)16(19,20)21/h1-2,5,11H,3-4,6-8,22H2/t11-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11163
PNG
((1R)-1-(2,5-difluorobenzyl)-3-oxo-3-[3-(2,2,2-trif...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)C(F)(F)F)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C17H15F8N5O/c18-10-6-12(20)11(19)4-8(10)3-9(26)5-14(31)29-1-2-30-13(7-29)27-28-15(30)16(21,22)17(23,24)25/h4,6,9H,1-3,5,7,26H2/t9-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11161
PNG
((1R)-3-(5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7...)
Show SMILES N[C@@H](CC(=O)N1CCn2cnnc2C1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C15H16F3N5O/c16-11-6-13(18)12(17)4-9(11)3-10(19)5-15(24)22-1-2-23-8-20-21-14(23)7-22/h4,6,8,10H,1-3,5,7,19H2/t10-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))
BDBM11162
PNG
((1R)-3-oxo-3-[3-(trifluoroethyl)-5,6-dihydro[1,2,4...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C16H15F6N5O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4,6,9H,1-3,5,7,23H2/t9-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MCE
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11160
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1cc(F)ccc1F |r|
Show InChI InChI=1S/C16H16F5N5O/c17-10-1-2-12(18)9(5-10)6-11(22)7-14(27)25-3-4-26-13(8-25)23-24-15(26)16(19,20)21/h1-2,5,11H,3-4,6-8,22H2/t11-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11159
PNG
((1R)-1-(3,4-difluorobenzyl)-3-oxo-3-[3-(trifluorom...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1ccc(F)c(F)c1 |r|
Show InChI InChI=1S/C16H16F5N5O/c17-11-2-1-9(6-12(11)18)5-10(22)7-14(27)25-3-4-26-13(8-25)23-24-15(26)16(19,20)21/h1-2,6,10H,3-5,7-8,22H2/t10-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11162
PNG
((1R)-3-oxo-3-[3-(trifluoroethyl)-5,6-dihydro[1,2,4...)
Show SMILES N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C16H15F6N5O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4,6,9H,1-3,5,7,23H2/t9-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MCE
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))
BDBM11158
PNG
((1R)-1-(3,4-difluorobenzyl)-3-(3-ethyl-5,6-dihydro...)
Show SMILES CCc1nnc2CN(CCn12)C(=O)C[C@H](N)Cc1ccc(F)c(F)c1 |r|
Show InChI InChI=1S/C17H21F2N5O/c1-2-15-21-22-16-10-23(5-6-24(15)16)17(25)9-12(20)7-11-3-4-13(18)14(19)8-11/h3-4,8,12H,2,5-7,9-10,20H2,1H3/t12-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/a7.537



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 48: 141-51 (2005)


Article DOI: 10.1021/jm0493156
BindingDB Entry DOI: 10.7270/Q2HH6H8H
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%