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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human)) | BDBM26078 (2-(carbamoylamino)-5-{2-[5-(hydroxymethyl)thiophen...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet  | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 195 | n/a | n/a | n/a | n/a | 7.6 | 25 |
Pfizer | Assay Description The inhibitory effect of test compounds on kinase activity was measured using a biotinylated I-Kappa-B-alpha peptide and increasing doses of inhibito... | Bioorg Med Chem Lett 15: 2870-5 (2005) Article DOI: 10.1016/j.bmcl.2005.03.090 BindingDB Entry DOI: 10.7270/Q2T72FRG | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human)) | BDBM26087 (2-(carbamoylamino)-5-(2-cyclopropylethynyl)thiophe...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 273 | n/a | n/a | n/a | n/a | 7.6 | 25 |
Pfizer | Assay Description The inhibitory effect of test compounds on kinase activity was measured using a biotinylated I-Kappa-B-alpha peptide and increasing doses of inhibito... | Bioorg Med Chem Lett 15: 2870-5 (2005) Article DOI: 10.1016/j.bmcl.2005.03.090 BindingDB Entry DOI: 10.7270/Q2T72FRG | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human)) | BDBM26086 (2-(carbamoylamino)-5-[2-(3-hydroxyphenyl)ethynyl]t...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 303 | n/a | n/a | n/a | n/a | 7.6 | 25 |
Pfizer | Assay Description The inhibitory effect of test compounds on kinase activity was measured using a biotinylated I-Kappa-B-alpha peptide and increasing doses of inhibito... | Bioorg Med Chem Lett 15: 2870-5 (2005) Article DOI: 10.1016/j.bmcl.2005.03.090 BindingDB Entry DOI: 10.7270/Q2T72FRG | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human)) | BDBM26082 (2-(carbamoylamino)-5-[2-(3-fluorophenyl)ethynyl]th...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 331 | n/a | n/a | n/a | n/a | 7.6 | 25 |
Pfizer | Assay Description The inhibitory effect of test compounds on kinase activity was measured using a biotinylated I-Kappa-B-alpha peptide and increasing doses of inhibito... | Bioorg Med Chem Lett 15: 2870-5 (2005) Article DOI: 10.1016/j.bmcl.2005.03.090 BindingDB Entry DOI: 10.7270/Q2T72FRG | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human)) | BDBM26081 (2-(carbamoylamino)-5-[2-(5-cyanothiophen-3-yl)ethy...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 333 | n/a | n/a | n/a | n/a | 7.6 | 25 |
Pfizer | Assay Description The inhibitory effect of test compounds on kinase activity was measured using a biotinylated I-Kappa-B-alpha peptide and increasing doses of inhibito... | Bioorg Med Chem Lett 15: 2870-5 (2005) Article DOI: 10.1016/j.bmcl.2005.03.090 BindingDB Entry DOI: 10.7270/Q2T72FRG | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human)) | BDBM26077 (2-(carbamoylamino)-5-[2-(thiophen-3-yl)ethynyl]thi...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 420 | n/a | n/a | n/a | n/a | 7.6 | 25 |
Pfizer | Assay Description The inhibitory effect of test compounds on kinase activity was measured using a biotinylated I-Kappa-B-alpha peptide and increasing doses of inhibito... | Bioorg Med Chem Lett 15: 2870-5 (2005) Article DOI: 10.1016/j.bmcl.2005.03.090 BindingDB Entry DOI: 10.7270/Q2T72FRG | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human)) | BDBM26097 (2-(carbamoylamino)-5-[2-(3-methanesulfonamidopheny...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 454 | n/a | n/a | n/a | n/a | 7.6 | 25 |
Pfizer | Assay Description The inhibitory effect of test compounds on kinase activity was measured using a biotinylated I-Kappa-B-alpha peptide and increasing doses of inhibito... | Bioorg Med Chem Lett 15: 2870-5 (2005) Article DOI: 10.1016/j.bmcl.2005.03.090 BindingDB Entry DOI: 10.7270/Q2T72FRG | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human)) | BDBM26079 (2-(carbamoylamino)-5-{2-[5-(1-hydroxypropyl)thioph...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 465 | n/a | n/a | n/a | n/a | 7.6 | 25 |
Pfizer | Assay Description The inhibitory effect of test compounds on kinase activity was measured using a biotinylated I-Kappa-B-alpha peptide and increasing doses of inhibito... | Bioorg Med Chem Lett 15: 2870-5 (2005) Article DOI: 10.1016/j.bmcl.2005.03.090 BindingDB Entry DOI: 10.7270/Q2T72FRG | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human)) | BDBM26090 (5-acetylenyl-3-thiophenecarboxamide, 1n | N-(3-{2-...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 557 | n/a | n/a | n/a | n/a | 7.6 | 25 |
Pfizer | Assay Description The inhibitory effect of test compounds on kinase activity was measured using a biotinylated I-Kappa-B-alpha peptide and increasing doses of inhibito... | Bioorg Med Chem Lett 15: 2870-5 (2005) Article DOI: 10.1016/j.bmcl.2005.03.090 BindingDB Entry DOI: 10.7270/Q2T72FRG | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human)) | BDBM26080 (2-(carbamoylamino)-5-{2-[5-(1-hydroxy-2-methylprop...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 563 | n/a | n/a | n/a | n/a | 7.6 | 25 |
Pfizer | Assay Description The inhibitory effect of test compounds on kinase activity was measured using a biotinylated I-Kappa-B-alpha peptide and increasing doses of inhibito... | Bioorg Med Chem Lett 15: 2870-5 (2005) Article DOI: 10.1016/j.bmcl.2005.03.090 BindingDB Entry DOI: 10.7270/Q2T72FRG | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human)) | BDBM26083 (2-(carbamoylamino)-5-[2-(2-fluorophenyl)ethynyl]th...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 620 | n/a | n/a | n/a | n/a | 7.6 | 25 |
Pfizer | Assay Description The inhibitory effect of test compounds on kinase activity was measured using a biotinylated I-Kappa-B-alpha peptide and increasing doses of inhibito... | Bioorg Med Chem Lett 15: 2870-5 (2005) Article DOI: 10.1016/j.bmcl.2005.03.090 BindingDB Entry DOI: 10.7270/Q2T72FRG | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human)) | BDBM26092 (5-[2-(3-benzamidophenyl)ethynyl]-2-(carbamoylamino...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 704 | n/a | n/a | n/a | n/a | 7.6 | 25 |
Pfizer | Assay Description The inhibitory effect of test compounds on kinase activity was measured using a biotinylated I-Kappa-B-alpha peptide and increasing doses of inhibito... | Bioorg Med Chem Lett 15: 2870-5 (2005) Article DOI: 10.1016/j.bmcl.2005.03.090 BindingDB Entry DOI: 10.7270/Q2T72FRG | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human)) | BDBM26088 (5-[2-(3-aminophenyl)ethynyl]-2-(carbamoylamino)thi...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 709 | n/a | n/a | n/a | n/a | 7.6 | 25 |
Pfizer | Assay Description The inhibitory effect of test compounds on kinase activity was measured using a biotinylated I-Kappa-B-alpha peptide and increasing doses of inhibito... | Bioorg Med Chem Lett 15: 2870-5 (2005) Article DOI: 10.1016/j.bmcl.2005.03.090 BindingDB Entry DOI: 10.7270/Q2T72FRG | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human)) | BDBM26085 (2-(carbamoylamino)-5-[2-(2-methylphenyl)ethynyl]th...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 716 | n/a | n/a | n/a | n/a | 7.6 | 25 |
Pfizer | Assay Description The inhibitory effect of test compounds on kinase activity was measured using a biotinylated I-Kappa-B-alpha peptide and increasing doses of inhibito... | Bioorg Med Chem Lett 15: 2870-5 (2005) Article DOI: 10.1016/j.bmcl.2005.03.090 BindingDB Entry DOI: 10.7270/Q2T72FRG | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human)) | BDBM26093 (2-(carbamoylamino)-5-[2-(3-acetamidophenyl)ethynyl...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 964 | n/a | n/a | n/a | n/a | 7.6 | 25 |
Pfizer | Assay Description The inhibitory effect of test compounds on kinase activity was measured using a biotinylated I-Kappa-B-alpha peptide and increasing doses of inhibito... | Bioorg Med Chem Lett 15: 2870-5 (2005) Article DOI: 10.1016/j.bmcl.2005.03.090 BindingDB Entry DOI: 10.7270/Q2T72FRG | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human)) | BDBM26094 (2-(carbamoylamino)-5-{2-[3-(2,2,2-trifluoroacetami...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 980 | n/a | n/a | n/a | n/a | 7.6 | 25 |
Pfizer | Assay Description The inhibitory effect of test compounds on kinase activity was measured using a biotinylated I-Kappa-B-alpha peptide and increasing doses of inhibito... | Bioorg Med Chem Lett 15: 2870-5 (2005) Article DOI: 10.1016/j.bmcl.2005.03.090 BindingDB Entry DOI: 10.7270/Q2T72FRG | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human)) | BDBM26084 (2-(carbamoylamino)-5-[2-(2-chlorophenyl)ethynyl]th...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.01E+3 | n/a | n/a | n/a | n/a | 7.6 | 25 |
Pfizer | Assay Description The inhibitory effect of test compounds on kinase activity was measured using a biotinylated I-Kappa-B-alpha peptide and increasing doses of inhibito... | Bioorg Med Chem Lett 15: 2870-5 (2005) Article DOI: 10.1016/j.bmcl.2005.03.090 BindingDB Entry DOI: 10.7270/Q2T72FRG | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human)) | BDBM26091 (5-acetylenyl-3-thiophenecarboxamide, 1o | N-(3-{2-...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.85E+3 | n/a | n/a | n/a | n/a | 7.6 | 25 |
Pfizer | Assay Description The inhibitory effect of test compounds on kinase activity was measured using a biotinylated I-Kappa-B-alpha peptide and increasing doses of inhibito... | Bioorg Med Chem Lett 15: 2870-5 (2005) Article DOI: 10.1016/j.bmcl.2005.03.090 BindingDB Entry DOI: 10.7270/Q2T72FRG | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human)) | BDBM26095 (2-(carbamoylamino)-5-(2-{3-[2-(dimethylamino)aceta...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.88E+3 | n/a | n/a | n/a | n/a | 7.6 | 25 |
Pfizer | Assay Description The inhibitory effect of test compounds on kinase activity was measured using a biotinylated I-Kappa-B-alpha peptide and increasing doses of inhibito... | Bioorg Med Chem Lett 15: 2870-5 (2005) Article DOI: 10.1016/j.bmcl.2005.03.090 BindingDB Entry DOI: 10.7270/Q2T72FRG | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human)) | BDBM26096 (5-acetylenyl-3-thiophenecarboxamide, 1t | methyl N...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a | 7.6 | 25 |
Pfizer | Assay Description The inhibitory effect of test compounds on kinase activity was measured using a biotinylated I-Kappa-B-alpha peptide and increasing doses of inhibito... | Bioorg Med Chem Lett 15: 2870-5 (2005) Article DOI: 10.1016/j.bmcl.2005.03.090 BindingDB Entry DOI: 10.7270/Q2T72FRG | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human)) | BDBM26098 (3-amino-5-(thiophen-3-yl)thiophene-2-carboxamide |...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.12E+4 | n/a | n/a | n/a | n/a | 7.6 | 25 |
Pfizer | Assay Description The inhibitory effect of test compounds on kinase activity was measured using a biotinylated I-Kappa-B-alpha peptide and increasing doses of inhibito... | Bioorg Med Chem Lett 15: 2870-5 (2005) Article DOI: 10.1016/j.bmcl.2005.03.090 BindingDB Entry DOI: 10.7270/Q2T72FRG | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human)) | BDBM26089 (5-acetylenyl-3-thiophenecarboxamide, 1m | N-(3-{2-...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | 7.6 | 25 |
Pfizer | Assay Description The inhibitory effect of test compounds on kinase activity was measured using a biotinylated I-Kappa-B-alpha peptide and increasing doses of inhibito... | Bioorg Med Chem Lett 15: 2870-5 (2005) Article DOI: 10.1016/j.bmcl.2005.03.090 BindingDB Entry DOI: 10.7270/Q2T72FRG | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
