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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM15393 (3-(5-chloro-2,4-dihydroxyphenyl)-N-(4-acetylphenyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet  | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 258 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Vernalis (R&D) Ltd | Assay Description The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90... | Bioorg Med Chem Lett 15: 5197-201 (2005) Article DOI: 10.1016/j.bmcl.2005.08.091 BindingDB Entry DOI: 10.7270/Q2N58JND | |||||||||||
| More data for this Ligand-Target Pair |  3D Structure (crystal) | ||||||||||||
| Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM15399 (3-(5-chloro-2,4-dihydroxyphenyl)-N-[(4-sulfamoylph...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 461 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Vernalis (R&D) Ltd | Assay Description The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90... | Bioorg Med Chem Lett 15: 5197-201 (2005) Article DOI: 10.1016/j.bmcl.2005.08.091 BindingDB Entry DOI: 10.7270/Q2N58JND | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM15397 (3-(5-chloro-2,4-dihydroxyphenyl)-N-[(4-fluoropheny...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.35E+3 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Vernalis (R&D) Ltd | Assay Description The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90... | Bioorg Med Chem Lett 15: 5197-201 (2005) Article DOI: 10.1016/j.bmcl.2005.08.091 BindingDB Entry DOI: 10.7270/Q2N58JND | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM15398 (3-(5-chloro-2,4-dihydroxyphenyl)-N-{[3-(trifluorom...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.40E+3 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Vernalis (R&D) Ltd | Assay Description The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90... | Bioorg Med Chem Lett 15: 5197-201 (2005) Article DOI: 10.1016/j.bmcl.2005.08.091 BindingDB Entry DOI: 10.7270/Q2N58JND | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM15395 (3-(5-chloro-2,4-dihydroxyphenyl)-N-[(4-methoxyphen...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Vernalis (R&D) Ltd | Assay Description The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90... | Bioorg Med Chem Lett 15: 5197-201 (2005) Article DOI: 10.1016/j.bmcl.2005.08.091 BindingDB Entry DOI: 10.7270/Q2N58JND | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM15389 (3-(5-chloro-2,4-dihydroxyphenyl)-N-(4-methoxypheny...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Vernalis (R&D) Ltd | Assay Description The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90... | Bioorg Med Chem Lett 15: 5197-201 (2005) Article DOI: 10.1016/j.bmcl.2005.08.091 BindingDB Entry DOI: 10.7270/Q2N58JND | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM15390 (3-(5-chloro-2,4-dihydroxyphenyl)-N-(4-chlorophenyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 6.90E+3 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Vernalis (R&D) Ltd | Assay Description The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90... | Bioorg Med Chem Lett 15: 5197-201 (2005) Article DOI: 10.1016/j.bmcl.2005.08.091 BindingDB Entry DOI: 10.7270/Q2N58JND | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM15386 (3-(5-chloro-2,4-dihydroxyphenyl)-N-phenyl-1H-pyraz...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 7.10E+3 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Vernalis (R&D) Ltd | Assay Description The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90... | Bioorg Med Chem Lett 15: 5197-201 (2005) Article DOI: 10.1016/j.bmcl.2005.08.091 BindingDB Entry DOI: 10.7270/Q2N58JND | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM15396 (3-(5-chloro-2,4-dihydroxyphenyl)-N-[(3-methoxyphen...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.07E+4 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Vernalis (R&D) Ltd | Assay Description The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90... | Bioorg Med Chem Lett 15: 5197-201 (2005) Article DOI: 10.1016/j.bmcl.2005.08.091 BindingDB Entry DOI: 10.7270/Q2N58JND | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM15388 (3-(5-chloro-2,4-dihydroxyphenyl)-N-(3-methoxypheny...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.17E+4 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Vernalis (R&D) Ltd | Assay Description The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90... | Bioorg Med Chem Lett 15: 5197-201 (2005) Article DOI: 10.1016/j.bmcl.2005.08.091 BindingDB Entry DOI: 10.7270/Q2N58JND | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM15394 (3-(5-chloro-2,4-dihydroxyphenyl)-pyrazole-4-carbox...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.28E+4 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Vernalis (R&D) Ltd | Assay Description The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90... | Bioorg Med Chem Lett 15: 5197-201 (2005) Article DOI: 10.1016/j.bmcl.2005.08.091 BindingDB Entry DOI: 10.7270/Q2N58JND | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM15387 (3-(5-chloro-2,4-dihydroxyphenyl)-N-(4-hydroxypheny...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.47E+4 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Vernalis (R&D) Ltd | Assay Description The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90... | Bioorg Med Chem Lett 15: 5197-201 (2005) Article DOI: 10.1016/j.bmcl.2005.08.091 BindingDB Entry DOI: 10.7270/Q2N58JND | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM15392 (3-(5-chloro-2,4-dihydroxyphenyl)-N-(4-acetamidophe...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.15E+4 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Vernalis (R&D) Ltd | Assay Description The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90... | Bioorg Med Chem Lett 15: 5197-201 (2005) Article DOI: 10.1016/j.bmcl.2005.08.091 BindingDB Entry DOI: 10.7270/Q2N58JND | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM15400 (3-(5-chloro-2,4-dihydroxyphenyl)-N-(furan-2-ylmeth...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.56E+4 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Vernalis (R&D) Ltd | Assay Description The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90... | Bioorg Med Chem Lett 15: 5197-201 (2005) Article DOI: 10.1016/j.bmcl.2005.08.091 BindingDB Entry DOI: 10.7270/Q2N58JND | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM15391 (3-(5-chloro-2,4-dihydroxyphenyl)-N-(4-methoxypheny...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Vernalis (R&D) Ltd | Assay Description The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90... | Bioorg Med Chem Lett 15: 5197-201 (2005) Article DOI: 10.1016/j.bmcl.2005.08.091 BindingDB Entry DOI: 10.7270/Q2N58JND | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM15401 (3-(5-chloro-2,4-dihydroxyphenyl)-N-(pyridin-2-yl)-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Vernalis (R&D) Ltd | Assay Description The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90... | Bioorg Med Chem Lett 15: 5197-201 (2005) Article DOI: 10.1016/j.bmcl.2005.08.091 BindingDB Entry DOI: 10.7270/Q2N58JND | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
