Found 56 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50177189
(6-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)C(=O)NC(C)C(C)(C)C)c1F Show InChI InChI=1S/C32H39F2N5O5/c1-16(2)39(17(3)4)26-24(33)29(43-21-11-9-10-19(14-21)27(35)36)38-30(25(26)34)44-23-13-12-20(15-22(23)31(41)42)28(40)37-18(5)32(6,7)8/h9-18H,1-8H3,(H3,35,36)(H,37,40)(H,41,42) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant FVIIa/TF complex |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50177187
(6-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)C(=O)NCc2ccc(Cl)cc2)c1F Show InChI InChI=1S/C33H32ClF2N5O5/c1-17(2)41(18(3)4)28-26(35)31(45-23-7-5-6-20(14-23)29(37)38)40-32(27(28)36)46-25-13-10-21(15-24(25)33(43)44)30(42)39-16-19-8-11-22(34)12-9-19/h5-15,17-18H,16H2,1-4H3,(H3,37,38)(H,39,42)(H,43,44) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant FVIIa/TF complex |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50177200
(6-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES COc1cccc(CNC(=O)c2ccc(Oc3nc(Oc4cccc(c4)C(N)=N)c(F)c(N(C(C)C)C(C)C)c3F)c(c2)C(O)=O)c1 Show InChI InChI=1S/C34H35F2N5O6/c1-18(2)41(19(3)4)29-27(35)32(46-24-11-7-9-21(15-24)30(37)38)40-33(28(29)36)47-26-13-12-22(16-25(26)34(43)44)31(42)39-17-20-8-6-10-23(14-20)45-5/h6-16,18-19H,17H2,1-5H3,(H3,37,38)(H,39,42)(H,43,44) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant FVIIa/TF complex |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50177185
(6-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)CNC(=O)c1ccc(Oc2nc(Oc3cccc(c3)C(N)=N)c(F)c(N(C(C)C)C(C)C)c2F)c(c1)C(O)=O Show InChI InChI=1S/C30H35F2N5O5/c1-15(2)14-35-27(38)19-10-11-22(21(13-19)30(39)40)42-29-24(32)25(37(16(3)4)17(5)6)23(31)28(36-29)41-20-9-7-8-18(12-20)26(33)34/h7-13,15-17H,14H2,1-6H3,(H3,33,34)(H,35,38)(H,39,40) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant FVIIa/TF complex |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50177192
(6-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)C(=O)NCc2ccc(C)cc2C)c1F Show InChI InChI=1S/C35H37F2N5O5/c1-18(2)42(19(3)4)30-28(36)33(46-25-9-7-8-22(15-25)31(38)39)41-34(29(30)37)47-27-13-12-23(16-26(27)35(44)45)32(43)40-17-24-11-10-20(5)14-21(24)6/h7-16,18-19H,17H2,1-6H3,(H3,38,39)(H,40,43)(H,44,45) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant FVIIa/TF complex |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50177209
(6-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)C(=O)NCc2c(C)cccc2C)c1F Show InChI InChI=1S/C35H37F2N5O5/c1-18(2)42(19(3)4)30-28(36)33(46-24-12-8-11-22(15-24)31(38)39)41-34(29(30)37)47-27-14-13-23(16-25(27)35(44)45)32(43)40-17-26-20(5)9-7-10-21(26)6/h7-16,18-19H,17H2,1-6H3,(H3,38,39)(H,40,43)(H,44,45) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant FVIIa/TF complex |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50177190
(4-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)-c2ccccc2)c1F Show InChI InChI=1S/C31H30F2N4O4/c1-17(2)37(18(3)4)27-25(32)29(40-22-12-8-11-21(15-22)28(34)35)36-30(26(27)33)41-24-14-13-20(16-23(24)31(38)39)19-9-6-5-7-10-19/h5-18H,1-4H3,(H3,34,35)(H,38,39) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant FVIIa/TF complex |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50177196
(6-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)C(=O)NC2CCCC2)c1F Show InChI InChI=1S/C31H35F2N5O5/c1-16(2)38(17(3)4)26-24(32)29(42-21-11-7-8-18(14-21)27(34)35)37-30(25(26)33)43-23-13-12-19(15-22(23)31(40)41)28(39)36-20-9-5-6-10-20/h7-8,11-17,20H,5-6,9-10H2,1-4H3,(H3,34,35)(H,36,39)(H,40,41) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant FVIIa/TF complex |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50177201
(CHEMBL382807 | N-benzyl-6-[6-(3-carbamimidoyl-phen...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)C(=O)NCc2ccccc2)c1F Show InChI InChI=1S/C33H33F2N5O5/c1-18(2)40(19(3)4)28-26(34)31(44-23-12-8-11-21(15-23)29(36)37)39-32(27(28)35)45-25-14-13-22(16-24(25)33(42)43)30(41)38-17-20-9-6-5-7-10-20/h5-16,18-19H,17H2,1-4H3,(H3,36,37)(H,38,41)(H,42,43) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant FVIIa/TF complex |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50177213
(4-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)-c2cccc(C)c2)c1F Show InChI InChI=1S/C32H32F2N4O4/c1-17(2)38(18(3)4)28-26(33)30(41-23-11-7-10-22(15-23)29(35)36)37-31(27(28)34)42-25-13-12-21(16-24(25)32(39)40)20-9-6-8-19(5)14-20/h6-18H,1-5H3,(H3,35,36)(H,39,40) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant FVIIa/TF complex |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50177212
(6-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)C(=O)NC2CCCCC2)c1F Show InChI InChI=1S/C32H37F2N5O5/c1-17(2)39(18(3)4)27-25(33)30(43-22-12-8-9-19(15-22)28(35)36)38-31(26(27)34)44-24-14-13-20(16-23(24)32(41)42)29(40)37-21-10-6-5-7-11-21/h8-9,12-18,21H,5-7,10-11H2,1-4H3,(H3,35,36)(H,37,40)(H,41,42) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant FVIIa/TF complex |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50177193
(2-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)-c2ccsc2)c1F Show InChI InChI=1S/C29H28F2N4O4S/c1-15(2)35(16(3)4)25-23(30)27(38-20-7-5-6-18(12-20)26(32)33)34-28(24(25)31)39-22-9-8-17(13-21(22)29(36)37)19-10-11-40-14-19/h5-16H,1-4H3,(H3,32,33)(H,36,37) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 67 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant FVIIa/TF complex |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50177214
(5-benzyl-2-[6-(3-carbamimidoyl-phenoxy)-4-diisopro...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(Cc3ccccc3)cc2C(O)=O)c1F Show InChI InChI=1S/C32H32F2N4O4/c1-18(2)38(19(3)4)28-26(33)30(41-23-12-8-11-22(17-23)29(35)36)37-31(27(28)34)42-25-14-13-21(16-24(25)32(39)40)15-20-9-6-5-7-10-20/h5-14,16-19H,15H2,1-4H3,(H3,35,36)(H,39,40) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 73 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant FVIIa/TF complex |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50177215
(6-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CCCNC(=O)c1ccc(Oc2nc(Oc3cccc(c3)C(N)=N)c(F)c(N(C(C)C)C(C)C)c2F)c(c1)C(O)=O Show InChI InChI=1S/C29H33F2N5O5/c1-6-12-34-26(37)18-10-11-21(20(14-18)29(38)39)41-28-23(31)24(36(15(2)3)16(4)5)22(30)27(35-28)40-19-9-7-8-17(13-19)25(32)33/h7-11,13-16H,6,12H2,1-5H3,(H3,32,33)(H,34,37)(H,38,39) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 92 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant FVIIa/TF complex |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50177203
(2-[6-(3-Carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)-c2ccccn2)c1F Show InChI InChI=1S/C30H29F2N5O4/c1-16(2)37(17(3)4)26-24(31)28(40-20-9-7-8-19(14-20)27(33)34)36-29(25(26)32)41-23-12-11-18(15-21(23)30(38)39)22-10-5-6-13-35-22/h5-17H,1-4H3,(H3,33,34)(H,38,39) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 97 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant FVIIa/TF complex |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50177194
(6-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CCCCCNC(=O)c1ccc(Oc2nc(Oc3cccc(c3)C(N)=N)c(F)c(N(C(C)C)C(C)C)c2F)c(c1)C(O)=O Show InChI InChI=1S/C31H37F2N5O5/c1-6-7-8-14-36-28(39)20-12-13-23(22(16-20)31(40)41)43-30-25(33)26(38(17(2)3)18(4)5)24(32)29(37-30)42-21-11-9-10-19(15-21)27(34)35/h9-13,15-18H,6-8,14H2,1-5H3,(H3,34,35)(H,36,39)(H,40,41) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant FVIIa/TF complex |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50177205
(4-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)-c2cccc(CO)c2)c1F Show InChI InChI=1S/C32H32F2N4O5/c1-17(2)38(18(3)4)28-26(33)30(42-23-10-6-9-22(14-23)29(35)36)37-31(27(28)34)43-25-12-11-21(15-24(25)32(40)41)20-8-5-7-19(13-20)16-39/h5-15,17-18,39H,16H2,1-4H3,(H3,35,36)(H,40,41) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant FVIIa/TF complex |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50177210
(4-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)-c2cccc(c2)C(C)C)c1F Show InChI InChI=1S/C34H36F2N4O4/c1-18(2)21-9-7-10-22(15-21)23-13-14-27(26(17-23)34(41)42)44-33-29(36)30(40(19(3)4)20(5)6)28(35)32(39-33)43-25-12-8-11-24(16-25)31(37)38/h7-20H,1-6H3,(H3,37,38)(H,41,42) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant FVIIa/TF complex |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50177197
(2-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)N(C)C)c1F Show InChI InChI=1S/C27H31F2N5O4/c1-14(2)34(15(3)4)23-21(28)25(37-18-9-7-8-16(12-18)24(30)31)32-26(22(23)29)38-20-11-10-17(33(5)6)13-19(20)27(35)36/h7-15H,1-6H3,(H3,30,31)(H,35,36) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant FVIIa/TF complex |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50177199
(6-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)C(=O)NCc2cccs2)c1F Show InChI InChI=1S/C31H31F2N5O5S/c1-16(2)38(17(3)4)26-24(32)29(42-20-8-5-7-18(13-20)27(34)35)37-30(25(26)33)43-23-11-10-19(14-22(23)31(40)41)28(39)36-15-21-9-6-12-44-21/h5-14,16-17H,15H2,1-4H3,(H3,34,35)(H,36,39)(H,40,41) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant FVIIa/TF complex |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50177193
(2-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)-c2ccsc2)c1F Show InChI InChI=1S/C29H28F2N4O4S/c1-15(2)35(16(3)4)25-23(30)27(38-20-7-5-6-18(12-20)26(32)33)34-28(24(25)31)39-22-9-8-17(13-21(22)29(36)37)19-10-11-40-14-19/h5-16H,1-4H3,(H3,32,33)(H,36,37) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FIIa |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50177204
(6-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)C(=O)NC2CC2)c1F Show InChI InChI=1S/C29H31F2N5O5/c1-14(2)36(15(3)4)24-22(30)27(40-19-7-5-6-16(12-19)25(32)33)35-28(23(24)31)41-21-11-8-17(13-20(21)29(38)39)26(37)34-18-9-10-18/h5-8,11-15,18H,9-10H2,1-4H3,(H3,32,33)(H,34,37)(H,38,39) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant FVIIa/TF complex |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50177208
(6-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)C(=O)NCc2ccccc2Cl)c1F Show InChI InChI=1S/C33H32ClF2N5O5/c1-17(2)41(18(3)4)28-26(35)31(45-22-10-7-9-19(14-22)29(37)38)40-32(27(28)36)46-25-13-12-20(15-23(25)33(43)44)30(42)39-16-21-8-5-6-11-24(21)34/h5-15,17-18H,16H2,1-4H3,(H3,37,38)(H,39,42)(H,43,44) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant FVIIa/TF complex |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50177198
(6-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)C(=O)NCc2ccco2)c1F Show InChI InChI=1S/C31H31F2N5O6/c1-16(2)38(17(3)4)26-24(32)29(43-20-8-5-7-18(13-20)27(34)35)37-30(25(26)33)44-23-11-10-19(14-22(23)31(40)41)28(39)36-15-21-9-6-12-42-21/h5-14,16-17H,15H2,1-4H3,(H3,34,35)(H,36,39)(H,40,41) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant FVIIa/TF complex |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50177211
(2-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)-c2ccncc2)c1F Show InChI InChI=1S/C30H29F2N5O4/c1-16(2)37(17(3)4)26-24(31)28(40-21-7-5-6-20(14-21)27(33)34)36-29(25(26)32)41-23-9-8-19(15-22(23)30(38)39)18-10-12-35-13-11-18/h5-17H,1-4H3,(H3,33,34)(H,38,39) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant FVIIa/TF complex |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50177191
(4-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)-c2ccccc2C)c1F Show InChI InChI=1S/C32H32F2N4O4/c1-17(2)38(18(3)4)28-26(33)30(41-22-11-8-10-21(15-22)29(35)36)37-31(27(28)34)42-25-14-13-20(16-24(25)32(39)40)23-12-7-6-9-19(23)5/h6-18H,1-5H3,(H3,35,36)(H,39,40) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant FVIIa/TF complex |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50177186
(2-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES COc1ccc(Oc2nc(Oc3cccc(c3)C(N)=N)c(F)c(N(C(C)C)C(C)C)c2F)c(c1)C(O)=O Show InChI InChI=1S/C26H28F2N4O5/c1-13(2)32(14(3)4)22-20(27)24(36-17-8-6-7-15(11-17)23(29)30)31-25(21(22)28)37-19-10-9-16(35-5)12-18(19)26(33)34/h6-14H,1-5H3,(H3,29,30)(H,33,34) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant FVIIa/TF complex |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50177207
(2-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)-c2ncccn2)c1F Show InChI InChI=1S/C29H28F2N6O4/c1-15(2)37(16(3)4)24-22(30)27(40-19-8-5-7-17(13-19)25(32)33)36-28(23(24)31)41-21-10-9-18(14-20(21)29(38)39)26-34-11-6-12-35-26/h5-16H,1-4H3,(H3,32,33)(H,38,39) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant FVIIa/TF complex |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50177186
(2-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES COc1ccc(Oc2nc(Oc3cccc(c3)C(N)=N)c(F)c(N(C(C)C)C(C)C)c2F)c(c1)C(O)=O Show InChI InChI=1S/C26H28F2N4O5/c1-13(2)32(14(3)4)22-20(27)24(36-17-8-6-7-15(11-17)23(29)30)31-25(21(22)28)37-19-10-9-16(35-5)12-18(19)26(33)34/h6-14H,1-5H3,(H3,29,30)(H,33,34) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 330 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FIIa |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50177197
(2-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)N(C)C)c1F Show InChI InChI=1S/C27H31F2N5O4/c1-14(2)34(15(3)4)23-21(28)25(37-18-9-7-8-16(12-18)24(30)31)32-26(22(23)29)38-20-11-10-17(33(5)6)13-19(20)27(35)36/h7-15H,1-6H3,(H3,30,31)(H,35,36) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FIIa |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50370705
(CHEMBL1162921)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)C(=O)NCCc2ccccc2)c1F Show InChI InChI=1S/C34H35F2N5O5/c1-19(2)41(20(3)4)29-27(35)32(45-24-12-8-11-22(17-24)30(37)38)40-33(28(29)36)46-26-14-13-23(18-25(26)34(43)44)31(42)39-16-15-21-9-6-5-7-10-21/h5-14,17-20H,15-16H2,1-4H3,(H3,37,38)(H,39,42)(H,43,44) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant FVIIa/TF complex |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50177190
(4-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)-c2ccccc2)c1F Show InChI InChI=1S/C31H30F2N4O4/c1-17(2)37(18(3)4)27-25(32)29(40-22-12-8-11-21(15-22)28(34)35)36-30(26(27)33)41-24-14-13-20(16-23(24)31(38)39)19-9-6-5-7-10-19/h5-18H,1-4H3,(H3,34,35)(H,38,39) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FIIa |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50177188
(2-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)-c2ccc3ccccc3c2)c1F Show InChI InChI=1S/C35H32F2N4O4/c1-19(2)41(20(3)4)31-29(36)33(44-26-11-7-10-25(17-26)32(38)39)40-34(30(31)37)45-28-15-14-24(18-27(28)35(42)43)23-13-12-21-8-5-6-9-22(21)16-23/h5-20H,1-4H3,(H3,38,39)(H,42,43) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 570 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant FVIIa/TF complex |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50177202
(6-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES COc1ccccc1CNC(=O)c1ccc(Oc2nc(Oc3cccc(c3)C(N)=N)c(F)c(N(C(C)C)C(C)C)c2F)c(c1)C(O)=O Show InChI InChI=1S/C34H35F2N5O6/c1-18(2)41(19(3)4)29-27(35)32(46-23-11-8-10-20(15-23)30(37)38)40-33(28(29)36)47-26-14-13-21(16-24(26)34(43)44)31(42)39-17-22-9-6-7-12-25(22)45-5/h6-16,18-19H,17H2,1-5H3,(H3,37,38)(H,39,42)(H,43,44) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 590 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant FVIIa/TF complex |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50177216
(6-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)C(=O)NCC2CCCCC2)c1F Show InChI InChI=1S/C33H39F2N5O5/c1-18(2)40(19(3)4)28-26(34)31(44-23-12-8-11-21(15-23)29(36)37)39-32(27(28)35)45-25-14-13-22(16-24(25)33(42)43)30(41)38-17-20-9-6-5-7-10-20/h8,11-16,18-20H,5-7,9-10,17H2,1-4H3,(H3,36,37)(H,38,41)(H,42,43) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant FVIIa/TF complex |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50177201
(CHEMBL382807 | N-benzyl-6-[6-(3-carbamimidoyl-phen...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)C(=O)NCc2ccccc2)c1F Show InChI InChI=1S/C33H33F2N5O5/c1-18(2)40(19(3)4)28-26(34)31(44-23-12-8-11-21(15-23)29(36)37)39-32(27(28)35)45-25-14-13-22(16-24(25)33(42)43)30(41)38-17-20-9-6-5-7-10-20/h5-16,18-19H,17H2,1-4H3,(H3,36,37)(H,38,41)(H,42,43) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 670 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FIIa |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50177203
(2-[6-(3-Carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)-c2ccccn2)c1F Show InChI InChI=1S/C30H29F2N5O4/c1-16(2)37(17(3)4)26-24(31)28(40-20-9-7-8-19(14-20)27(33)34)36-29(25(26)32)41-23-12-11-18(15-21(23)30(38)39)22-10-5-6-13-35-22/h5-17H,1-4H3,(H3,33,34)(H,38,39) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 810 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FIIa |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50177187
(6-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)C(=O)NCc2ccc(Cl)cc2)c1F Show InChI InChI=1S/C33H32ClF2N5O5/c1-17(2)41(18(3)4)28-26(35)31(45-23-7-5-6-20(14-23)29(37)38)40-32(27(28)36)46-25-13-10-21(15-24(25)33(43)44)30(42)39-16-19-8-11-22(34)12-9-19/h5-15,17-18H,16H2,1-4H3,(H3,37,38)(H,39,42)(H,43,44) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 970 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FIIa |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50177205
(4-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)-c2cccc(CO)c2)c1F Show InChI InChI=1S/C32H32F2N4O5/c1-17(2)38(18(3)4)28-26(33)30(42-23-10-6-9-22(14-23)29(35)36)37-31(27(28)34)43-25-12-11-21(15-24(25)32(40)41)20-8-5-7-19(13-20)16-39/h5-15,17-18,39H,16H2,1-4H3,(H3,35,36)(H,40,41) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FIIa |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50177185
(6-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)CNC(=O)c1ccc(Oc2nc(Oc3cccc(c3)C(N)=N)c(F)c(N(C(C)C)C(C)C)c2F)c(c1)C(O)=O Show InChI InChI=1S/C30H35F2N5O5/c1-15(2)14-35-27(38)19-10-11-22(21(13-19)30(39)40)42-29-24(32)25(37(16(3)4)17(5)6)23(31)28(36-29)41-20-9-7-8-18(12-20)26(33)34/h7-13,15-17H,14H2,1-6H3,(H3,33,34)(H,35,38)(H,39,40) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FIIa |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50177215
(6-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CCCNC(=O)c1ccc(Oc2nc(Oc3cccc(c3)C(N)=N)c(F)c(N(C(C)C)C(C)C)c2F)c(c1)C(O)=O Show InChI InChI=1S/C29H33F2N5O5/c1-6-12-34-26(37)18-10-11-21(20(14-18)29(38)39)41-28-23(31)24(36(15(2)3)16(4)5)22(30)27(35-28)40-19-9-7-8-17(13-19)25(32)33/h7-11,13-16H,6,12H2,1-5H3,(H3,32,33)(H,34,37)(H,38,39) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FIIa |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50177191
(4-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)-c2ccccc2C)c1F Show InChI InChI=1S/C32H32F2N4O4/c1-17(2)38(18(3)4)28-26(33)30(41-22-11-8-10-21(15-22)29(35)36)37-31(27(28)34)42-25-14-13-20(16-24(25)32(39)40)23-12-7-6-9-19(23)5/h6-18H,1-5H3,(H3,35,36)(H,39,40) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FIIa |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50177204
(6-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)C(=O)NC2CC2)c1F Show InChI InChI=1S/C29H31F2N5O5/c1-14(2)36(15(3)4)24-22(30)27(40-19-7-5-6-16(12-19)25(32)33)35-28(23(24)31)41-21-11-8-17(13-20(21)29(38)39)26(37)34-18-9-10-18/h5-8,11-15,18H,9-10H2,1-4H3,(H3,32,33)(H,34,37)(H,38,39) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FIIa |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50177194
(6-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CCCCCNC(=O)c1ccc(Oc2nc(Oc3cccc(c3)C(N)=N)c(F)c(N(C(C)C)C(C)C)c2F)c(c1)C(O)=O Show InChI InChI=1S/C31H37F2N5O5/c1-6-7-8-14-36-28(39)20-12-13-23(22(16-20)31(40)41)43-30-25(33)26(38(17(2)3)18(4)5)24(32)29(37-30)42-21-11-9-10-19(15-21)27(34)35/h9-13,15-18H,6-8,14H2,1-5H3,(H3,34,35)(H,36,39)(H,40,41) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FIIa |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50177206
(6-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)C(=O)NCC2CCCCO2)c1F Show InChI InChI=1S/C32H37F2N5O6/c1-17(2)39(18(3)4)27-25(33)30(44-21-10-7-8-19(14-21)28(35)36)38-31(26(27)34)45-24-12-11-20(15-23(24)32(41)42)29(40)37-16-22-9-5-6-13-43-22/h7-8,10-12,14-15,17-18,22H,5-6,9,13,16H2,1-4H3,(H3,35,36)(H,37,40)(H,41,42) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant FVIIa/TF complex |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50177209
(6-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)C(=O)NCc2c(C)cccc2C)c1F Show InChI InChI=1S/C35H37F2N5O5/c1-18(2)42(19(3)4)30-28(36)33(46-24-12-8-11-22(15-24)31(38)39)41-34(29(30)37)47-27-14-13-23(16-25(27)35(44)45)32(43)40-17-26-20(5)9-7-10-21(26)6/h7-16,18-19H,17H2,1-6H3,(H3,38,39)(H,40,43)(H,44,45) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FIIa |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50177189
(6-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)C(=O)NC(C)C(C)(C)C)c1F Show InChI InChI=1S/C32H39F2N5O5/c1-16(2)39(17(3)4)26-24(33)29(43-21-11-9-10-19(14-21)27(35)36)38-30(25(26)34)44-23-13-12-20(15-22(23)31(41)42)28(40)37-18(5)32(6,7)8/h9-18H,1-8H3,(H3,35,36)(H,37,40)(H,41,42) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FIIa |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50177195
(2-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(CN(C)C)cc2C(O)=O)c1F Show InChI InChI=1S/C28H33F2N5O4/c1-15(2)35(16(3)4)24-22(29)26(38-19-9-7-8-18(13-19)25(31)32)33-27(23(24)30)39-21-11-10-17(14-34(5)6)12-20(21)28(36)37/h7-13,15-16H,14H2,1-6H3,(H3,31,32)(H,36,37) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant FVIIa/TF complex |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50177192
(6-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)C(=O)NCc2ccc(C)cc2C)c1F Show InChI InChI=1S/C35H37F2N5O5/c1-18(2)42(19(3)4)30-28(36)33(46-25-9-7-8-22(15-25)31(38)39)41-34(29(30)37)47-27-13-12-23(16-26(27)35(44)45)32(43)40-17-24-11-10-20(5)14-21(24)6/h7-16,18-19H,17H2,1-6H3,(H3,38,39)(H,40,43)(H,44,45) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FIIa |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50177196
(6-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)C(=O)NC2CCCC2)c1F Show InChI InChI=1S/C31H35F2N5O5/c1-16(2)38(17(3)4)26-24(32)29(42-21-11-7-8-18(14-21)27(34)35)37-30(25(26)33)43-23-13-12-19(15-22(23)31(40)41)28(39)36-20-9-5-6-10-20/h7-8,11-17,20H,5-6,9-10H2,1-4H3,(H3,34,35)(H,36,39)(H,40,41) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FIIa |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50177214
(5-benzyl-2-[6-(3-carbamimidoyl-phenoxy)-4-diisopro...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(Cc3ccccc3)cc2C(O)=O)c1F Show InChI InChI=1S/C32H32F2N4O4/c1-18(2)38(19(3)4)28-26(33)30(41-23-12-8-11-22(17-23)29(35)36)37-31(27(28)34)42-25-14-13-21(16-24(25)32(39)40)15-20-9-6-5-7-10-20/h5-14,16-19H,15H2,1-4H3,(H3,35,36)(H,39,40) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FIIa |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50177213
(4-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)-c2cccc(C)c2)c1F Show InChI InChI=1S/C32H32F2N4O4/c1-17(2)38(18(3)4)28-26(33)30(41-23-11-7-10-22(15-23)29(35)36)37-31(27(28)34)42-25-13-12-21(16-24(25)32(39)40)20-9-6-8-19(5)14-20/h6-18H,1-5H3,(H3,35,36)(H,39,40) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FIIa |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50177206
(6-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)C(=O)NCC2CCCCO2)c1F Show InChI InChI=1S/C32H37F2N5O6/c1-17(2)39(18(3)4)27-25(33)30(44-21-10-7-8-19(14-21)28(35)36)38-31(26(27)34)45-24-12-11-20(15-23(24)32(41)42)29(40)37-16-22-9-5-6-13-43-22/h7-8,10-12,14-15,17-18,22H,5-6,9,13,16H2,1-4H3,(H3,35,36)(H,37,40)(H,41,42) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FIIa |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50177212
(6-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)C(=O)NC2CCCCC2)c1F Show InChI InChI=1S/C32H37F2N5O5/c1-17(2)39(18(3)4)27-25(33)30(43-22-12-8-9-19(15-22)28(35)36)38-31(26(27)34)44-24-14-13-20(16-23(24)32(41)42)29(40)37-21-10-6-5-7-11-21/h8-9,12-18,21H,5-7,10-11H2,1-4H3,(H3,35,36)(H,37,40)(H,41,42) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FIIa |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50177210
(4-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES CC(C)N(C(C)C)c1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2ccc(cc2C(O)=O)-c2cccc(c2)C(C)C)c1F Show InChI InChI=1S/C34H36F2N4O4/c1-18(2)21-9-7-10-22(15-21)23-13-14-27(26(17-23)34(41)42)44-33-29(36)30(40(19(3)4)20(5)6)28(35)32(39-33)43-25-12-8-11-24(16-25)31(37)38/h7-20H,1-6H3,(H3,37,38)(H,41,42) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FIIa |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50177200
(6-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)Show SMILES COc1cccc(CNC(=O)c2ccc(Oc3nc(Oc4cccc(c4)C(N)=N)c(F)c(N(C(C)C)C(C)C)c3F)c(c2)C(O)=O)c1 Show InChI InChI=1S/C34H35F2N5O6/c1-18(2)41(19(3)4)29-27(35)32(46-24-11-7-9-21(15-24)30(37)38)40-33(28(29)36)47-26-13-12-22(16-25(26)34(43)44)31(42)39-17-20-8-6-10-23(14-20)45-5/h6-16,18-19H,17H2,1-5H3,(H3,37,38)(H,39,42)(H,43,44) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of FIIa |
Bioorg Med Chem Lett 16: 1060-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.10.076
BindingDB Entry DOI: 10.7270/Q2Q81DWW |
More data for this
Ligand-Target Pair | |
Search and Browse
