Affinity Data by PubMed id=16325402

PubMed code 16325402

Found 15 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50178546 (4-(5-(4-(2-fluoroethylamino)phenyl)thiophen-2-yl)p...) Show SMILES Oc1ccc(cc1)-c1ccc(s1)-c1ccc(NCCF)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Displacement of [125I]IMPY from beta amyloid plaque in brain homogenates				Bioorg Med Chem Lett 16: 1350-2 (2006) Article DOI: 10.1016/j.bmcl.2005.11.055 BindingDB Entry DOI: 10.7270/Q2HX1C83
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM25849 (4-[5-(4-hydroxyphenyl)thiophen-2-yl]phenol \| CHEMB...) Show SMILES Oc1ccc(cc1)-c1ccc(s1)-c1ccc(O)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Displacement of [125I]IMPY from beta amyloid plaque in brain homogenates				Bioorg Med Chem Lett 16: 1350-2 (2006) Article DOI: 10.1016/j.bmcl.2005.11.055 BindingDB Entry DOI: 10.7270/Q2HX1C83
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50178542 (4-(5-(4-methoxyphenyl)thiophen-2-yl)benzenamine \| ...) Show SMILES COc1ccc(cc1)-c1ccc(s1)-c1ccc(N)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	5.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Displacement of [125I]IMPY from beta amyloid plaque in brain homogenates				Bioorg Med Chem Lett 16: 1350-2 (2006) Article DOI: 10.1016/j.bmcl.2005.11.055 BindingDB Entry DOI: 10.7270/Q2HX1C83
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50178547 (4-(5-(4-aminophenyl)thiophen-2-yl)benzenamine \| CH...) Show SMILES Nc1ccc(cc1)-c1ccc(s1)-c1ccc(N)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	6.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Displacement of [125I]IMPY from beta amyloid plaque in brain homogenates				Bioorg Med Chem Lett 16: 1350-2 (2006) Article DOI: 10.1016/j.bmcl.2005.11.055 BindingDB Entry DOI: 10.7270/Q2HX1C83
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50178536 (4-(5-(4-methoxyphenyl)thiophen-2-yl)phenol \| CHEMB...) Show SMILES COc1ccc(cc1)-c1ccc(s1)-c1ccc(O)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Displacement of [125I]IMPY from beta amyloid plaque in brain homogenates				Bioorg Med Chem Lett 16: 1350-2 (2006) Article DOI: 10.1016/j.bmcl.2005.11.055 BindingDB Entry DOI: 10.7270/Q2HX1C83
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50178538 (4-(5-(4-(dimethylamino)phenyl)thiophen-2-yl)phenol...) Show SMILES CN(C)c1ccc(cc1)-c1ccc(s1)-c1ccc(O)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Displacement of [125I]IMPY from beta amyloid plaque in brain homogenates				Bioorg Med Chem Lett 16: 1350-2 (2006) Article DOI: 10.1016/j.bmcl.2005.11.055 BindingDB Entry DOI: 10.7270/Q2HX1C83
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50178537 (4-(5-(4-aminophenyl)thiophen-2-yl)phenol \| CHEMBL2...) Show SMILES Nc1ccc(cc1)-c1ccc(s1)-c1ccc(O)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	9.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Displacement of [125I]IMPY from beta amyloid plaque in brain homogenates				Bioorg Med Chem Lett 16: 1350-2 (2006) Article DOI: 10.1016/j.bmcl.2005.11.055 BindingDB Entry DOI: 10.7270/Q2HX1C83
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50178544 (2-(4-nitrophenyl)-5-(4-methoxyphenyl)thiophene \| C...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	19	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Displacement of [125I]IMPY from beta amyloid plaque in brain homogenates				Bioorg Med Chem Lett 16: 1350-2 (2006) Article DOI: 10.1016/j.bmcl.2005.11.055 BindingDB Entry DOI: 10.7270/Q2HX1C83
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50178539 (CHEMBL202938 \| N-(2-fluoroethyl)-4-(5-(4-methoxyph...) Show SMILES COc1ccc(cc1)-c1ccc(s1)-c1ccc(NCCF)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	22	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Displacement of [125I]IMPY from beta amyloid plaque in brain homogenates				Bioorg Med Chem Lett 16: 1350-2 (2006) Article DOI: 10.1016/j.bmcl.2005.11.055 BindingDB Entry DOI: 10.7270/Q2HX1C83
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50178534 (4-(5-(4-(methylamino)phenyl)thiophen-2-yl)phenol \|...) Show SMILES CNc1ccc(cc1)-c1ccc(s1)-c1ccc(O)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	31	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Displacement of [125I]IMPY from beta amyloid plaque in brain homogenates				Bioorg Med Chem Lett 16: 1350-2 (2006) Article DOI: 10.1016/j.bmcl.2005.11.055 BindingDB Entry DOI: 10.7270/Q2HX1C83
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50178543 (2,5-bis(4-methoxyphenyl)thiophene \| CHEMBL378797) Show SMILES COc1ccc(cc1)-c1ccc(s1)-c1ccc(OC)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	108	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Displacement of [125I]IMPY from beta amyloid plaque in brain homogenates				Bioorg Med Chem Lett 16: 1350-2 (2006) Article DOI: 10.1016/j.bmcl.2005.11.055 BindingDB Entry DOI: 10.7270/Q2HX1C83
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50178545 (2,5-bis(4-nitrophenyl)thiophene \| CHEMBL202898) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	185	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Displacement of [125I]IMPY from beta amyloid plaque in brain homogenates				Bioorg Med Chem Lett 16: 1350-2 (2006) Article DOI: 10.1016/j.bmcl.2005.11.055 BindingDB Entry DOI: 10.7270/Q2HX1C83
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50178535 (4-(5-(4-methoxyphenyl)thiophen-2-yl)-N,N-dimethylb...) Show SMILES COc1ccc(cc1)-c1ccc(s1)-c1ccc(cc1)N(C)C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Displacement of [125I]IMPY from beta amyloid plaque in brain homogenates				Bioorg Med Chem Lett 16: 1350-2 (2006) Article DOI: 10.1016/j.bmcl.2005.11.055 BindingDB Entry DOI: 10.7270/Q2HX1C83
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50178541 (2,5-bis(2-methoxyphenyl)thiophene \| CHEMBL204873) Show SMILES COc1ccccc1-c1ccc(s1)-c1ccccc1OC Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	625	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Displacement of [125I]IMPY from beta amyloid plaque in brain homogenates				Bioorg Med Chem Lett 16: 1350-2 (2006) Article DOI: 10.1016/j.bmcl.2005.11.055 BindingDB Entry DOI: 10.7270/Q2HX1C83
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50178540 (2,5-bis(4-(methylthio)phenyl)thiophene \| CHEMBL424...) Show SMILES CSc1ccc(cc1)-c1ccc(s1)-c1ccc(SC)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Displacement of [125I]IMPY from beta amyloid plaque in brain homogenates				Bioorg Med Chem Lett 16: 1350-2 (2006) Article DOI: 10.1016/j.bmcl.2005.11.055 BindingDB Entry DOI: 10.7270/Q2HX1C83
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%