Found 26 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179415
(2-(6-(4-(2-methoxyethyl)piperazin-1-yl)pyrimidin-4...)Show InChI InChI=1S/C15H19N7OS/c1-23-7-6-21-2-4-22(5-3-21)14-8-13(18-11-19-14)20-15-17-10-12(9-16)24-15/h8,10-11H,2-7H2,1H3,(H,17,18,19,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of KDR |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089
BindingDB Entry DOI: 10.7270/Q279448N |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179418
(2-(6-(4-aminoazepan-1-yl)pyrimidin-4-ylamino)thiaz...)Show InChI InChI=1S/C14H17N7S/c15-7-11-8-17-14(22-11)20-12-6-13(19-9-18-12)21-4-1-2-10(16)3-5-21/h6,8-10H,1-5,16H2,(H,17,18,19,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of KDR |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089
BindingDB Entry DOI: 10.7270/Q279448N |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179427
(2-(6-(4-(2-(pyrrolidin-1-yl)ethyl)piperazin-1-yl)p...)Show InChI InChI=1S/C18H24N8S/c19-12-15-13-20-18(27-15)23-16-11-17(22-14-21-16)26-9-7-25(8-10-26)6-5-24-3-1-2-4-24/h11,13-14H,1-10H2,(H,20,21,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of KDR |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089
BindingDB Entry DOI: 10.7270/Q279448N |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179413
(2-(6-(4-aminopiperidin-1-yl)pyrimidin-4-ylamino)th...)Show InChI InChI=1S/C13H15N7S/c14-6-10-7-16-13(21-10)19-11-5-12(18-8-17-11)20-3-1-9(15)2-4-20/h5,7-9H,1-4,15H2,(H,16,17,18,19) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of KDR |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089
BindingDB Entry DOI: 10.7270/Q279448N |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179420
(2-(6-(4-(3-morpholinopropyl)piperazin-1-yl)pyrimid...)Show SMILES N#Cc1cnc(Nc2cc(ncn2)N2CCN(CCCN3CCOCC3)CC2)s1 Show InChI InChI=1S/C19H26N8OS/c20-13-16-14-21-19(29-16)24-17-12-18(23-15-22-17)27-6-4-25(5-7-27)2-1-3-26-8-10-28-11-9-26/h12,14-15H,1-11H2,(H,21,22,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of KDR |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089
BindingDB Entry DOI: 10.7270/Q279448N |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179417
(2-(6-(4-methylpiperazin-1-yl)pyrimidin-4-ylamino)t...)Show InChI InChI=1S/C13H15N7S/c1-19-2-4-20(5-3-19)12-6-11(16-9-17-12)18-13-15-8-10(7-14)21-13/h6,8-9H,2-5H2,1H3,(H,15,16,17,18) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of KDR |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089
BindingDB Entry DOI: 10.7270/Q279448N |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179427
(2-(6-(4-(2-(pyrrolidin-1-yl)ethyl)piperazin-1-yl)p...)Show InChI InChI=1S/C18H24N8S/c19-12-15-13-20-18(27-15)23-16-11-17(22-14-21-16)26-9-7-25(8-10-26)6-5-24-3-1-2-4-24/h11,13-14H,1-10H2,(H,20,21,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089
BindingDB Entry DOI: 10.7270/Q279448N |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179414
(2-(6-(4-(2-morpholinoethyl)piperazin-1-yl)pyrimidi...)Show SMILES N#Cc1cnc(Nc2cc(ncn2)N2CCN(CCN3CCOCC3)CC2)s1 Show InChI InChI=1S/C18H24N8OS/c19-12-15-13-20-18(28-15)23-16-11-17(22-14-21-16)26-5-3-24(4-6-26)1-2-25-7-9-27-10-8-25/h11,13-14H,1-10H2,(H,20,21,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of KDR |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089
BindingDB Entry DOI: 10.7270/Q279448N |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179416
(2-(6-(4-acetylpiperazin-1-yl)pyrimidin-4-ylamino)t...)Show InChI InChI=1S/C14H15N7OS/c1-10(22)20-2-4-21(5-3-20)13-6-12(17-9-18-13)19-14-16-8-11(7-15)23-14/h6,8-9H,2-5H2,1H3,(H,16,17,18,19) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of KDR |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089
BindingDB Entry DOI: 10.7270/Q279448N |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179418
(2-(6-(4-aminoazepan-1-yl)pyrimidin-4-ylamino)thiaz...)Show InChI InChI=1S/C14H17N7S/c15-7-11-8-17-14(22-11)20-12-6-13(19-9-18-12)21-4-1-2-10(16)3-5-21/h6,8-10H,1-5,16H2,(H,17,18,19,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089
BindingDB Entry DOI: 10.7270/Q279448N |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179422
(2-(6-(piperazin-1-yl)pyrimidin-4-ylamino)thiazole-...)Show InChI InChI=1S/C12H13N7S/c13-6-9-7-15-12(20-9)18-10-5-11(17-8-16-10)19-3-1-14-2-4-19/h5,7-8,14H,1-4H2,(H,15,16,17,18) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of KDR |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089
BindingDB Entry DOI: 10.7270/Q279448N |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179421
((rac)-2-(6-(3-aminopyrrolidin-1-yl)pyrimidin-4-yla...)Show InChI InChI=1S/C12H13N7S/c13-4-9-5-15-12(20-9)18-10-3-11(17-7-16-10)19-2-1-8(14)6-19/h3,5,7-8H,1-2,6,14H2,(H,15,16,17,18) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of KDR |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089
BindingDB Entry DOI: 10.7270/Q279448N |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179414
(2-(6-(4-(2-morpholinoethyl)piperazin-1-yl)pyrimidi...)Show SMILES N#Cc1cnc(Nc2cc(ncn2)N2CCN(CCN3CCOCC3)CC2)s1 Show InChI InChI=1S/C18H24N8OS/c19-12-15-13-20-18(28-15)23-16-11-17(22-14-21-16)26-5-3-24(4-6-26)1-2-25-7-9-27-10-8-25/h11,13-14H,1-10H2,(H,20,21,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089
BindingDB Entry DOI: 10.7270/Q279448N |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179421
((rac)-2-(6-(3-aminopyrrolidin-1-yl)pyrimidin-4-yla...)Show InChI InChI=1S/C12H13N7S/c13-4-9-5-15-12(20-9)18-10-3-11(17-7-16-10)19-2-1-8(14)6-19/h3,5,7-8H,1-2,6,14H2,(H,15,16,17,18) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089
BindingDB Entry DOI: 10.7270/Q279448N |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179415
(2-(6-(4-(2-methoxyethyl)piperazin-1-yl)pyrimidin-4...)Show InChI InChI=1S/C15H19N7OS/c1-23-7-6-21-2-4-22(5-3-21)14-8-13(18-11-19-14)20-15-17-10-12(9-16)24-15/h8,10-11H,2-7H2,1H3,(H,17,18,19,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089
BindingDB Entry DOI: 10.7270/Q279448N |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179417
(2-(6-(4-methylpiperazin-1-yl)pyrimidin-4-ylamino)t...)Show InChI InChI=1S/C13H15N7S/c1-19-2-4-20(5-3-19)12-6-11(16-9-17-12)18-13-15-8-10(7-14)21-13/h6,8-9H,2-5H2,1H3,(H,15,16,17,18) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089
BindingDB Entry DOI: 10.7270/Q279448N |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179420
(2-(6-(4-(3-morpholinopropyl)piperazin-1-yl)pyrimid...)Show SMILES N#Cc1cnc(Nc2cc(ncn2)N2CCN(CCCN3CCOCC3)CC2)s1 Show InChI InChI=1S/C19H26N8OS/c20-13-16-14-21-19(29-16)24-17-12-18(23-15-22-17)27-6-4-25(5-7-27)2-1-3-26-8-10-28-11-9-26/h12,14-15H,1-11H2,(H,21,22,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089
BindingDB Entry DOI: 10.7270/Q279448N |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179423
(2-(6-(1,4-diazepan-1-yl)pyrimidin-4-ylamino)thiazo...)Show InChI InChI=1S/C13H15N7S/c14-7-10-8-16-13(21-10)19-11-6-12(18-9-17-11)20-4-1-2-15-3-5-20/h6,8-9,15H,1-5H2,(H,16,17,18,19) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of KDR |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089
BindingDB Entry DOI: 10.7270/Q279448N |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179423
(2-(6-(1,4-diazepan-1-yl)pyrimidin-4-ylamino)thiazo...)Show InChI InChI=1S/C13H15N7S/c14-7-10-8-16-13(21-10)19-11-6-12(18-9-17-11)20-4-1-2-15-3-5-20/h6,8-9,15H,1-5H2,(H,16,17,18,19) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089
BindingDB Entry DOI: 10.7270/Q279448N |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179422
(2-(6-(piperazin-1-yl)pyrimidin-4-ylamino)thiazole-...)Show InChI InChI=1S/C12H13N7S/c13-6-9-7-15-12(20-9)18-10-5-11(17-8-16-10)19-3-1-14-2-4-19/h5,7-8,14H,1-4H2,(H,15,16,17,18) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089
BindingDB Entry DOI: 10.7270/Q279448N |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179425
(2-(6-aminopyrimidin-4-ylamino)thiazole-5-carbonitr...)Show InChI InChI=1S/C8H6N6S/c9-2-5-3-11-8(15-5)14-7-1-6(10)12-4-13-7/h1,3-4H,(H3,10,11,12,13,14) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of KDR |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089
BindingDB Entry DOI: 10.7270/Q279448N |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179416
(2-(6-(4-acetylpiperazin-1-yl)pyrimidin-4-ylamino)t...)Show InChI InChI=1S/C14H15N7OS/c1-10(22)20-2-4-21(5-3-20)13-6-12(17-9-18-13)19-14-16-8-11(7-15)23-14/h6,8-9H,2-5H2,1H3,(H,16,17,18,19) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089
BindingDB Entry DOI: 10.7270/Q279448N |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179413
(2-(6-(4-aminopiperidin-1-yl)pyrimidin-4-ylamino)th...)Show InChI InChI=1S/C13H15N7S/c14-6-10-7-16-13(21-10)19-11-5-12(18-8-17-11)20-3-1-9(15)2-4-20/h5,7-9H,1-4,15H2,(H,16,17,18,19) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089
BindingDB Entry DOI: 10.7270/Q279448N |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179419
(2-(2-(4-acetylpiperazin-1-yl)pyrimidin-4-ylamino)t...)Show InChI InChI=1S/C14H15N7OS/c1-10(22)20-4-6-21(7-5-20)13-16-3-2-12(18-13)19-14-17-9-11(8-15)23-14/h2-3,9H,4-7H2,1H3,(H,16,17,18,19) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 153 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of KDR |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089
BindingDB Entry DOI: 10.7270/Q279448N |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179424
(2-(2-aminopyrimidin-4-ylamino)thiazole-5-carbonitr...)Show InChI InChI=1S/C8H6N6S/c9-3-5-4-12-8(15-5)14-6-1-2-11-7(10)13-6/h1-2,4H,(H3,10,11,12,13,14) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 557 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of KDR |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089
BindingDB Entry DOI: 10.7270/Q279448N |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179426
(2-(pyrimidin-4-ylamino)thiazole-5-carbonitrile | C...)Show InChI InChI=1S/C8H5N5S/c9-3-6-4-11-8(14-6)13-7-1-2-10-5-12-7/h1-2,4-5H,(H,10,11,12,13) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 990 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of KDR |
Bioorg Med Chem Lett 16: 1146-50 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.089
BindingDB Entry DOI: 10.7270/Q279448N |
More data for this
Ligand-Target Pair | |
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