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PubMed code 16380256

Compile data set for download or QSAR
Found 35 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM20877
PNG
(3-(1-benzofuran-5-yl)-1-(2-hydroxy-4-methyl-6-{[(2...)
Show SMILES Cc1cc(O)c(C(=O)CCc2ccc3occc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1S/C24H26O9/c1-12-8-16(27)20(15(26)4-2-13-3-5-17-14(10-13)6-7-31-17)18(9-12)32-24-23(30)22(29)21(28)19(11-25)33-24/h3,5-10,19,21-25,27-30H,2,4,11H2,1H3/t19-,21-,22+,23-,24-/m1/s1
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n/an/a 11n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity aginst SGLT2 expressed in CHO-K1 cells

Bioorg Med Chem Lett 16: 1696-701 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.006
BindingDB Entry DOI: 10.7270/Q22J6BDJ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50174677
PNG
((2S,3R,4S,5S,6R)-2-(3-(2-(2,3-dihydrobenzofuran-5-...)
Show SMILES OC[C@H]1O[C@@H](Oc2cccc3[nH]cc(CCc4ccc5OCCc5c4)c23)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C24H27NO7/c26-12-19-21(27)22(28)23(29)24(32-19)31-18-3-1-2-16-20(18)15(11-25-16)6-4-13-5-7-17-14(10-13)8-9-30-17/h1-3,5,7,10-11,19,21-29H,4,6,8-9,12H2/t19-,21-,22+,23-,24-/m1/s1
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n/an/a 24n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity aginst SGLT2 expressed in CHO-K1 cells

Bioorg Med Chem Lett 16: 1696-701 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.006
BindingDB Entry DOI: 10.7270/Q22J6BDJ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50179675
PNG
((2S,3R,4S,5S,6R)-2-(3-(4-ethylbenzyl)-1H-indol-4-y...)
Show SMILES CCc1ccc(Cc2c[nH]c3cccc(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c23)cc1
Show InChI InChI=1S/C23H27NO6/c1-2-13-6-8-14(9-7-13)10-15-11-24-16-4-3-5-17(19(15)16)29-23-22(28)21(27)20(26)18(12-25)30-23/h3-9,11,18,20-28H,2,10,12H2,1H3/t18-,20-,21+,22-,23-/m1/s1
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n/an/a 28n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity aginst SGLT2 expressed in CHO-K1 cells

Bioorg Med Chem Lett 16: 1696-701 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.006
BindingDB Entry DOI: 10.7270/Q22J6BDJ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50179679
PNG
((2S,3R,4S,5S,6R)-2-(3-(4-(thiophen-3-yl)benzyl)-1H...)
Show SMILES OC[C@H]1O[C@@H](Oc2cccc3[nH]cc(Cc4ccc(cc4)-c4ccsc4)c23)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C25H25NO6S/c27-12-20-22(28)23(29)24(30)25(32-20)31-19-3-1-2-18-21(19)17(11-26-18)10-14-4-6-15(7-5-14)16-8-9-33-13-16/h1-9,11,13,20,22-30H,10,12H2/t20-,22-,23+,24-,25-/m1/s1
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n/an/a 50n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity aginst SGLT2 expressed in CHO-K1 cells

Bioorg Med Chem Lett 16: 1696-701 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.006
BindingDB Entry DOI: 10.7270/Q22J6BDJ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50179670
PNG
((2S,3R,4S,5S,6R)-2-(3-(4-(methylthio)benzyl)-1H-in...)
Show SMILES CSc1ccc(Cc2c[nH]c3cccc(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c23)cc1
Show InChI InChI=1S/C22H25NO6S/c1-30-14-7-5-12(6-8-14)9-13-10-23-15-3-2-4-16(18(13)15)28-22-21(27)20(26)19(25)17(11-24)29-22/h2-8,10,17,19-27H,9,11H2,1H3/t17-,19-,20+,21-,22-/m1/s1
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n/an/a 52n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity aginst SGLT2 expressed in CHO-K1 cells

Bioorg Med Chem Lett 16: 1696-701 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.006
BindingDB Entry DOI: 10.7270/Q22J6BDJ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50179671
PNG
((2R,3S,4S,5R,6S)-2-Hydroxymethyl-6-[3-(4-methyl-be...)
Show SMILES Cc1ccc(Cc2c[nH]c3cccc(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c23)cc1
Show InChI InChI=1S/C22H25NO6/c1-12-5-7-13(8-6-12)9-14-10-23-15-3-2-4-16(18(14)15)28-22-21(27)20(26)19(25)17(11-24)29-22/h2-8,10,17,19-27H,9,11H2,1H3/t17-,19-,20+,21-,22-/m1/s1
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n/an/a 66n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity aginst SGLT2 expressed in CHO-K1 cells

Bioorg Med Chem Lett 16: 1696-701 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.006
BindingDB Entry DOI: 10.7270/Q22J6BDJ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50179678
PNG
((2S,3R,4S,5S,6R)-2-(3-Biphenyl-4-ylmethyl-1H-indol...)
Show SMILES OC[C@H]1O[C@@H](Oc2cccc3[nH]cc(Cc4ccc(cc4)-c4ccccc4)c23)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C27H27NO6/c29-15-22-24(30)25(31)26(32)27(34-22)33-21-8-4-7-20-23(21)19(14-28-20)13-16-9-11-18(12-10-16)17-5-2-1-3-6-17/h1-12,14,22,24-32H,13,15H2/t22-,24-,25+,26-,27-/m1/s1
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n/an/a 89n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity aginst SGLT2 expressed in CHO-K1 cells

Bioorg Med Chem Lett 16: 1696-701 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.006
BindingDB Entry DOI: 10.7270/Q22J6BDJ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50179674
PNG
((2S,3R,4S,5S,6R)-2-(3-(4-ethoxybenzyl)-1H-indol-4-...)
Show SMILES CCOc1ccc(Cc2c[nH]c3cccc(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c23)cc1
Show InChI InChI=1S/C23H27NO7/c1-2-29-15-8-6-13(7-9-15)10-14-11-24-16-4-3-5-17(19(14)16)30-23-22(28)21(27)20(26)18(12-25)31-23/h3-9,11,18,20-28H,2,10,12H2,1H3/t18-,20-,21+,22-,23-/m1/s1
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n/an/a 94n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity aginst SGLT2 expressed in CHO-K1 cells

Bioorg Med Chem Lett 16: 1696-701 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.006
BindingDB Entry DOI: 10.7270/Q22J6BDJ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50179684
PNG
((2S,3R,4S,5S,6R)-2-(3-(3-fluoro-4-methylbenzyl)-1H...)
Show SMILES Cc1ccc(Cc2c[nH]c3cccc(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c23)cc1F
Show InChI InChI=1S/C22H24FNO6/c1-11-5-6-12(8-14(11)23)7-13-9-24-15-3-2-4-16(18(13)15)29-22-21(28)20(27)19(26)17(10-25)30-22/h2-6,8-9,17,19-22,24-28H,7,10H2,1H3/t17-,19-,20+,21-,22-/m1/s1
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n/an/a 99n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity aginst SGLT2 expressed in CHO-K1 cells

Bioorg Med Chem Lett 16: 1696-701 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.006
BindingDB Entry DOI: 10.7270/Q22J6BDJ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50179682
PNG
((2S,3R,4S,5S,6R)-2-(3-(4-propylbenzyl)-1H-indol-4-...)
Show SMILES CCCc1ccc(Cc2c[nH]c3cccc(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c23)cc1
Show InChI InChI=1S/C24H29NO6/c1-2-4-14-7-9-15(10-8-14)11-16-12-25-17-5-3-6-18(20(16)17)30-24-23(29)22(28)21(27)19(13-26)31-24/h3,5-10,12,19,21-29H,2,4,11,13H2,1H3/t19-,21-,22+,23-,24-/m1/s1
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n/an/a 119n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity aginst SGLT2 expressed in CHO-K1 cells

Bioorg Med Chem Lett 16: 1696-701 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.006
BindingDB Entry DOI: 10.7270/Q22J6BDJ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50179686
PNG
((2S,3R,4S,5S,6R)-2-(3-(2-(2,3-dihydrobenzo[b][1,4]...)
Show SMILES OC[C@H]1O[C@@H](Oc2cccc3[nH]cc(CCc4ccc5OCCOc5c4)c23)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C24H27NO8/c26-12-19-21(27)22(28)23(29)24(33-19)32-17-3-1-2-15-20(17)14(11-25-15)6-4-13-5-7-16-18(10-13)31-9-8-30-16/h1-3,5,7,10-11,19,21-29H,4,6,8-9,12H2/t19-,21-,22+,23-,24-/m1/s1
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n/an/a 121n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity aginst SGLT2 expressed in CHO-K1 cells

Bioorg Med Chem Lett 16: 1696-701 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.006
BindingDB Entry DOI: 10.7270/Q22J6BDJ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50179673
PNG
((2S,3R,4S,5S,6R)-2-(3-(4-methoxybenzyl)-1H-indol-4...)
Show SMILES COc1ccc(Cc2c[nH]c3cccc(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c23)cc1
Show InChI InChI=1S/C22H25NO7/c1-28-14-7-5-12(6-8-14)9-13-10-23-15-3-2-4-16(18(13)15)29-22-21(27)20(26)19(25)17(11-24)30-22/h2-8,10,17,19-27H,9,11H2,1H3/t17-,19-,20+,21-,22-/m1/s1
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n/an/a 121n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity aginst SGLT2 expressed in CHO-K1 cells

Bioorg Med Chem Lett 16: 1696-701 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.006
BindingDB Entry DOI: 10.7270/Q22J6BDJ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50179685
PNG
((2S,3R,4R,5S,6R)-2-(3-(4-ethylbenzyl)-1H-indol-5-y...)
Show SMILES CCc1ccc(Cc2c[nH]c3ccc(cc23)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C23H27NO5/c1-2-13-3-5-14(6-4-13)9-16-11-24-18-8-7-15(10-17(16)18)23-22(28)21(27)20(26)19(12-25)29-23/h3-8,10-11,19-28H,2,9,12H2,1H3/t19-,20-,21+,22-,23+/m1/s1
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Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity aginst SGLT2 expressed in CHO-K1 cells

Bioorg Med Chem Lett 16: 1696-701 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.006
BindingDB Entry DOI: 10.7270/Q22J6BDJ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM20877
PNG
(3-(1-benzofuran-5-yl)-1-(2-hydroxy-4-methyl-6-{[(2...)
Show SMILES Cc1cc(O)c(C(=O)CCc2ccc3occc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1S/C24H26O9/c1-12-8-16(27)20(15(26)4-2-13-3-5-17-14(10-13)6-7-31-17)18(9-12)32-24-23(30)22(29)21(28)19(11-25)33-24/h3,5-10,19,21-25,27-30H,2,4,11H2,1H3/t19-,21-,22+,23-,24-/m1/s1
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Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity aginst SGLT1 expressed in CHO-K1 cells

Bioorg Med Chem Lett 16: 1696-701 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.006
BindingDB Entry DOI: 10.7270/Q22J6BDJ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50179672
PNG
((2S,3R,4S,5S,6R)-2-(3-(4-(pyridin-3-yl)benzyl)-1H-...)
Show SMILES OC[C@H]1O[C@@H](Oc2cccc3[nH]cc(Cc4ccc(cc4)-c4cccnc4)c23)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C26H26N2O6/c29-14-21-23(30)24(31)25(32)26(34-21)33-20-5-1-4-19-22(20)18(13-28-19)11-15-6-8-16(9-7-15)17-3-2-10-27-12-17/h1-10,12-13,21,23-26,28-32H,11,14H2/t21-,23-,24+,25-,26-/m1/s1
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n/an/a 143n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity aginst SGLT2 expressed in CHO-K1 cells

Bioorg Med Chem Lett 16: 1696-701 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.006
BindingDB Entry DOI: 10.7270/Q22J6BDJ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50179677
PNG
((2S,3R,4S,5S,6R)-2-(3-(3-fluoro-4-methoxybenzyl)-1...)
Show SMILES COc1ccc(Cc2c[nH]c3cccc(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c23)cc1F
Show InChI InChI=1S/C22H24FNO7/c1-29-15-6-5-11(8-13(15)23)7-12-9-24-14-3-2-4-16(18(12)14)30-22-21(28)20(27)19(26)17(10-25)31-22/h2-6,8-9,17,19-22,24-28H,7,10H2,1H3/t17-,19-,20+,21-,22-/m1/s1
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n/an/a 143n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity aginst SGLT2 expressed in CHO-K1 cells

Bioorg Med Chem Lett 16: 1696-701 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.006
BindingDB Entry DOI: 10.7270/Q22J6BDJ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50174677
PNG
((2S,3R,4S,5S,6R)-2-(3-(2-(2,3-dihydrobenzofuran-5-...)
Show SMILES OC[C@H]1O[C@@H](Oc2cccc3[nH]cc(CCc4ccc5OCCc5c4)c23)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C24H27NO7/c26-12-19-21(27)22(28)23(29)24(32-19)31-18-3-1-2-16-20(18)15(11-25-16)6-4-13-5-7-17-14(10-13)8-9-30-17/h1-3,5,7,10-11,19,21-29H,4,6,8-9,12H2/t19-,21-,22+,23-,24-/m1/s1
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n/an/a 145n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity aginst SGLT1 expressed in CHO-K1 cells

Bioorg Med Chem Lett 16: 1696-701 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.006
BindingDB Entry DOI: 10.7270/Q22J6BDJ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50174682
PNG
((2S,3R,4S,5S,6R)-2-(3-(4-methoxyphenethyl)-1H-indo...)
Show SMILES COc1ccc(CCc2c[nH]c3cccc(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c23)cc1
Show InChI InChI=1S/C23H27NO7/c1-29-15-9-6-13(7-10-15)5-8-14-11-24-16-3-2-4-17(19(14)16)30-23-22(28)21(27)20(26)18(12-25)31-23/h2-4,6-7,9-11,18,20-28H,5,8,12H2,1H3/t18-,20-,21+,22-,23-/m1/s1
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n/an/a 163n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity aginst SGLT2 expressed in CHO-K1 cells

Bioorg Med Chem Lett 16: 1696-701 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.006
BindingDB Entry DOI: 10.7270/Q22J6BDJ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50179688
PNG
((2S,3R,4S,5S,6R)-2-[3-(2-Fluoro-biphenyl-4-ylmethy...)
Show SMILES OC[C@H]1O[C@@H](Oc2cccc3[nH]cc(Cc4ccc(c(F)c4)-c4ccccc4)c23)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C27H26FNO6/c28-19-12-15(9-10-18(19)16-5-2-1-3-6-16)11-17-13-29-20-7-4-8-21(23(17)20)34-27-26(33)25(32)24(31)22(14-30)35-27/h1-10,12-13,22,24-27,29-33H,11,14H2/t22-,24-,25+,26-,27-/m1/s1
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n/an/a 182n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity aginst SGLT2 expressed in CHO-K1 cells

Bioorg Med Chem Lett 16: 1696-701 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.006
BindingDB Entry DOI: 10.7270/Q22J6BDJ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50179676
PNG
((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(3-(2-(naphth...)
Show SMILES OC[C@H]1O[C@@H](Oc2cccc3[nH]cc(CCc4ccc5ccccc5c4)c23)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C26H27NO6/c28-14-21-23(29)24(30)25(31)26(33-21)32-20-7-3-6-19-22(20)18(13-27-19)11-9-15-8-10-16-4-1-2-5-17(16)12-15/h1-8,10,12-13,21,23-31H,9,11,14H2/t21-,23-,24+,25-,26-/m1/s1
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n/an/a 201n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity aginst SGLT2 expressed in CHO-K1 cells

Bioorg Med Chem Lett 16: 1696-701 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.006
BindingDB Entry DOI: 10.7270/Q22J6BDJ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50179683
PNG
((2S,3R,4S,5S,6R)-2-(3-(4-ethoxyphenethyl)-1H-indol...)
Show SMILES CCOc1ccc(CCc2c[nH]c3cccc(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c23)cc1
Show InChI InChI=1S/C24H29NO7/c1-2-30-16-10-7-14(8-11-16)6-9-15-12-25-17-4-3-5-18(20(15)17)31-24-23(29)22(28)21(27)19(13-26)32-24/h3-5,7-8,10-12,19,21-29H,2,6,9,13H2,1H3/t19-,21-,22+,23-,24-/m1/s1
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n/an/a 202n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity aginst SGLT2 expressed in CHO-K1 cells

Bioorg Med Chem Lett 16: 1696-701 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.006
BindingDB Entry DOI: 10.7270/Q22J6BDJ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50179680
PNG
((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(3-(naphthale...)
Show SMILES OC[C@H]1O[C@@H](Oc2cccc3[nH]cc(Cc4ccc5ccccc5c4)c23)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C25H25NO6/c27-13-20-22(28)23(29)24(30)25(32-20)31-19-7-3-6-18-21(19)17(12-26-18)11-14-8-9-15-4-1-2-5-16(15)10-14/h1-10,12,20,22-30H,11,13H2/t20-,22-,23+,24-,25-/m1/s1
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n/an/a 293n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity aginst SGLT2 expressed in CHO-K1 cells

Bioorg Med Chem Lett 16: 1696-701 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.006
BindingDB Entry DOI: 10.7270/Q22J6BDJ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50179687
PNG
((2S,3R,4S,5S,6R)-2-(3-(4-chlorobenzyl)-1H-indol-4-...)
Show SMILES OC[C@H]1O[C@@H](Oc2cccc3[nH]cc(Cc4ccc(Cl)cc4)c23)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C21H22ClNO6/c22-13-6-4-11(5-7-13)8-12-9-23-14-2-1-3-15(17(12)14)28-21-20(27)19(26)18(25)16(10-24)29-21/h1-7,9,16,18-21,23-27H,8,10H2/t16-,18-,19+,20-,21-/m1/s1
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n/an/a 296n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity aginst SGLT2 expressed in CHO-K1 cells

Bioorg Med Chem Lett 16: 1696-701 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.006
BindingDB Entry DOI: 10.7270/Q22J6BDJ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50174682
PNG
((2S,3R,4S,5S,6R)-2-(3-(4-methoxyphenethyl)-1H-indo...)
Show SMILES COc1ccc(CCc2c[nH]c3cccc(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c23)cc1
Show InChI InChI=1S/C23H27NO7/c1-29-15-9-6-13(7-10-15)5-8-14-11-24-16-3-2-4-17(19(14)16)30-23-22(28)21(27)20(26)18(12-25)31-23/h2-4,6-7,9-11,18,20-28H,5,8,12H2,1H3/t18-,20-,21+,22-,23-/m1/s1
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n/an/a 611n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity aginst SGLT1 expressed in CHO-K1 cells

Bioorg Med Chem Lett 16: 1696-701 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.006
BindingDB Entry DOI: 10.7270/Q22J6BDJ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50179676
PNG
((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(3-(2-(naphth...)
Show SMILES OC[C@H]1O[C@@H](Oc2cccc3[nH]cc(CCc4ccc5ccccc5c4)c23)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C26H27NO6/c28-14-21-23(29)24(30)25(31)26(33-21)32-20-7-3-6-19-22(20)18(13-27-19)11-9-15-8-10-16-4-1-2-5-17(16)12-15/h1-8,10,12-13,21,23-31H,9,11,14H2/t21-,23-,24+,25-,26-/m1/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity aginst SGLT1 expressed in CHO-K1 cells

Bioorg Med Chem Lett 16: 1696-701 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.006
BindingDB Entry DOI: 10.7270/Q22J6BDJ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50179683
PNG
((2S,3R,4S,5S,6R)-2-(3-(4-ethoxyphenethyl)-1H-indol...)
Show SMILES CCOc1ccc(CCc2c[nH]c3cccc(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c23)cc1
Show InChI InChI=1S/C24H29NO7/c1-2-30-16-10-7-14(8-11-16)6-9-15-12-25-17-4-3-5-18(20(15)17)31-24-23(29)22(28)21(27)19(13-26)32-24/h3-5,7-8,10-12,19,21-29H,2,6,9,13H2,1H3/t19-,21-,22+,23-,24-/m1/s1
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n/an/a 1.19E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity aginst SGLT1 expressed in CHO-K1 cells

Bioorg Med Chem Lett 16: 1696-701 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.006
BindingDB Entry DOI: 10.7270/Q22J6BDJ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50179673
PNG
((2S,3R,4S,5S,6R)-2-(3-(4-methoxybenzyl)-1H-indol-4...)
Show SMILES COc1ccc(Cc2c[nH]c3cccc(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c23)cc1
Show InChI InChI=1S/C22H25NO7/c1-28-14-7-5-12(6-8-14)9-13-10-23-15-3-2-4-16(18(13)15)29-22-21(27)20(26)19(25)17(11-24)30-22/h2-8,10,17,19-27H,9,11H2,1H3/t17-,19-,20+,21-,22-/m1/s1
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n/an/a 1.51E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity aginst SGLT1 expressed in CHO-K1 cells

Bioorg Med Chem Lett 16: 1696-701 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.006
BindingDB Entry DOI: 10.7270/Q22J6BDJ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50179681
PNG
((2S,3R,4S,5S,6R)-2-(3-((2,3-dihydrobenzofuran-6-yl...)
Show SMILES OC[C@H]1O[C@@H](Oc2cccc3[nH]cc(Cc4ccc5CCOc5c4)c23)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C23H25NO7/c25-11-18-20(26)21(27)22(28)23(31-18)30-16-3-1-2-15-19(16)14(10-24-15)8-12-4-5-13-6-7-29-17(13)9-12/h1-5,9-10,18,20-28H,6-8,11H2/t18-,20-,21+,22-,23-/m1/s1
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n/an/a 1.87E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity aginst SGLT2 expressed in CHO-K1 cells

Bioorg Med Chem Lett 16: 1696-701 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.006
BindingDB Entry DOI: 10.7270/Q22J6BDJ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50179672
PNG
((2S,3R,4S,5S,6R)-2-(3-(4-(pyridin-3-yl)benzyl)-1H-...)
Show SMILES OC[C@H]1O[C@@H](Oc2cccc3[nH]cc(Cc4ccc(cc4)-c4cccnc4)c23)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C26H26N2O6/c29-14-21-23(30)24(31)25(32)26(34-21)33-20-5-1-4-19-22(20)18(13-28-19)11-15-6-8-16(9-7-15)17-3-2-10-27-12-17/h1-10,12-13,21,23-26,28-32H,11,14H2/t21-,23-,24+,25-,26-/m1/s1
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n/an/a 1.97E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity aginst SGLT1 expressed in CHO-K1 cells

Bioorg Med Chem Lett 16: 1696-701 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.006
BindingDB Entry DOI: 10.7270/Q22J6BDJ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50179675
PNG
((2S,3R,4S,5S,6R)-2-(3-(4-ethylbenzyl)-1H-indol-4-y...)
Show SMILES CCc1ccc(Cc2c[nH]c3cccc(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c23)cc1
Show InChI InChI=1S/C23H27NO6/c1-2-13-6-8-14(9-7-13)10-15-11-24-16-4-3-5-17(19(15)16)29-23-22(28)21(27)20(26)18(12-25)30-23/h3-9,11,18,20-28H,2,10,12H2,1H3/t18-,20-,21+,22-,23-/m1/s1
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n/an/a 2.14E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity aginst SGLT1 expressed in CHO-K1 cells

Bioorg Med Chem Lett 16: 1696-701 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.006
BindingDB Entry DOI: 10.7270/Q22J6BDJ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50179679
PNG
((2S,3R,4S,5S,6R)-2-(3-(4-(thiophen-3-yl)benzyl)-1H...)
Show SMILES OC[C@H]1O[C@@H](Oc2cccc3[nH]cc(Cc4ccc(cc4)-c4ccsc4)c23)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C25H25NO6S/c27-12-20-22(28)23(29)24(30)25(32-20)31-19-3-1-2-18-21(19)17(11-26-18)10-14-4-6-15(7-5-14)16-8-9-33-13-16/h1-9,11,13,20,22-30H,10,12H2/t20-,22-,23+,24-,25-/m1/s1
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n/an/a 2.24E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity aginst SGLT1 expressed in CHO-K1 cells

Bioorg Med Chem Lett 16: 1696-701 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.006
BindingDB Entry DOI: 10.7270/Q22J6BDJ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50179670
PNG
((2S,3R,4S,5S,6R)-2-(3-(4-(methylthio)benzyl)-1H-in...)
Show SMILES CSc1ccc(Cc2c[nH]c3cccc(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c23)cc1
Show InChI InChI=1S/C22H25NO6S/c1-30-14-7-5-12(6-8-14)9-13-10-23-15-3-2-4-16(18(13)15)28-22-21(27)20(26)19(25)17(11-24)29-22/h2-8,10,17,19-27H,9,11H2,1H3/t17-,19-,20+,21-,22-/m1/s1
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n/an/a 2.89E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity aginst SGLT1 expressed in CHO-K1 cells

Bioorg Med Chem Lett 16: 1696-701 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.006
BindingDB Entry DOI: 10.7270/Q22J6BDJ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50179682
PNG
((2S,3R,4S,5S,6R)-2-(3-(4-propylbenzyl)-1H-indol-4-...)
Show SMILES CCCc1ccc(Cc2c[nH]c3cccc(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c23)cc1
Show InChI InChI=1S/C24H29NO6/c1-2-4-14-7-9-15(10-8-14)11-16-12-25-17-5-3-6-18(20(16)17)30-24-23(29)22(28)21(27)19(13-26)31-24/h3,5-10,12,19,21-29H,2,4,11,13H2,1H3/t19-,21-,22+,23-,24-/m1/s1
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n/an/a 3.20E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity aginst SGLT1 expressed in CHO-K1 cells

Bioorg Med Chem Lett 16: 1696-701 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.006
BindingDB Entry DOI: 10.7270/Q22J6BDJ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50179686
PNG
((2S,3R,4S,5S,6R)-2-(3-(2-(2,3-dihydrobenzo[b][1,4]...)
Show SMILES OC[C@H]1O[C@@H](Oc2cccc3[nH]cc(CCc4ccc5OCCOc5c4)c23)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C24H27NO8/c26-12-19-21(27)22(28)23(29)24(33-19)32-17-3-1-2-15-20(17)14(11-25-15)6-4-13-5-7-16-18(10-13)31-9-8-30-16/h1-3,5,7,10-11,19,21-29H,4,6,8-9,12H2/t19-,21-,22+,23-,24-/m1/s1
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n/an/a 3.61E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity aginst SGLT1 expressed in CHO-K1 cells

Bioorg Med Chem Lett 16: 1696-701 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.006
BindingDB Entry DOI: 10.7270/Q22J6BDJ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM50179671
PNG
((2R,3S,4S,5R,6S)-2-Hydroxymethyl-6-[3-(4-methyl-be...)
Show SMILES Cc1ccc(Cc2c[nH]c3cccc(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c23)cc1
Show InChI InChI=1S/C22H25NO6/c1-12-5-7-13(8-6-12)9-14-10-23-15-3-2-4-16(18(14)15)28-22-21(27)20(26)19(25)17(11-24)29-22/h2-8,10,17,19-27H,9,11H2,1H3/t17-,19-,20+,21-,22-/m1/s1
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n/an/a 4.39E+3n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity aginst SGLT1 expressed in CHO-K1 cells

Bioorg Med Chem Lett 16: 1696-701 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.006
BindingDB Entry DOI: 10.7270/Q22J6BDJ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%