Found 6 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Hexokinase-4
(Homo sapiens (Human)) | BDBM50183222
((S)-6-(3-isopropoxy-5-(1-phenylpropan-2-yloxy)benz...)Show SMILES CC(C)Oc1cc(O[C@@H](C)Cc2ccccc2)cc(c1)C(=O)Nc1ccc(cn1)C(O)=O Show InChI InChI=1S/C25H26N2O5/c1-16(2)31-21-12-20(24(28)27-23-10-9-19(15-26-23)25(29)30)13-22(14-21)32-17(3)11-18-7-5-4-6-8-18/h4-10,12-17H,11H2,1-3H3,(H,29,30)(H,26,27,28)/t17-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Activitation of glucokinase |
Bioorg Med Chem Lett 16: 2705-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.022 BindingDB Entry DOI: 10.7270/Q28G8K91 |
More data for this Ligand-Target Pair | |
Hexokinase-4
(Homo sapiens (Human)) | BDBM50183220
((R)-6-(3-isopropoxy-5-(1-phenylpropan-2-yloxy)benz...)Show SMILES CC(C)Oc1cc(O[C@H](C)Cc2ccccc2)cc(c1)C(=O)Nc1ccc(cn1)C(O)=O Show InChI InChI=1S/C25H26N2O5/c1-16(2)31-21-12-20(24(28)27-23-10-9-19(15-26-23)25(29)30)13-22(14-21)32-17(3)11-18-7-5-4-6-8-18/h4-10,12-17H,11H2,1-3H3,(H,29,30)(H,26,27,28)/t17-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 90 | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Activitation of glucokinase |
Bioorg Med Chem Lett 16: 2705-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.022 BindingDB Entry DOI: 10.7270/Q28G8K91 |
More data for this Ligand-Target Pair | |
Hexokinase-4
(Homo sapiens (Human)) | BDBM50183219
((R)-6-(3-isopropoxy-5-(1-phenylethoxy)benzamido)ni...)Show SMILES CC(C)Oc1cc(O[C@H](C)c2ccccc2)cc(c1)C(=O)Nc1ccc(cn1)C(O)=O Show InChI InChI=1S/C24H24N2O5/c1-15(2)30-20-11-19(23(27)26-22-10-9-18(14-25-22)24(28)29)12-21(13-20)31-16(3)17-7-5-4-6-8-17/h4-16H,1-3H3,(H,28,29)(H,25,26,27)/t16-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 950 | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Activitation of glucokinase |
Bioorg Med Chem Lett 16: 2705-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.022 BindingDB Entry DOI: 10.7270/Q28G8K91 |
More data for this Ligand-Target Pair | |
Hexokinase-4
(Homo sapiens (Human)) | BDBM50183223
((S)-6-(3-isopropoxy-5-(1-methoxypropan-2-yloxy)ben...)Show SMILES COC[C@H](C)Oc1cc(OC(C)C)cc(c1)C(=O)Nc1ccc(cn1)C(O)=O Show InChI InChI=1S/C20H24N2O6/c1-12(2)27-16-7-15(8-17(9-16)28-13(3)11-26-4)19(23)22-18-6-5-14(10-21-18)20(24)25/h5-10,12-13H,11H2,1-4H3,(H,24,25)(H,21,22,23)/t13-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 610 | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Activitation of glucokinase |
Bioorg Med Chem Lett 16: 2705-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.022 BindingDB Entry DOI: 10.7270/Q28G8K91 |
More data for this Ligand-Target Pair | |
Hexokinase-4
(Homo sapiens (Human)) | BDBM50183221
((S)-6-(3-isopropoxy-5-(1-phenylethoxy)benzamido)ni...)Show SMILES CC(C)Oc1cc(O[C@@H](C)c2ccccc2)cc(c1)C(=O)Nc1ccc(cn1)C(O)=O Show InChI InChI=1S/C24H24N2O5/c1-15(2)30-20-11-19(23(27)26-22-10-9-18(14-25-22)24(28)29)12-21(13-20)31-16(3)17-7-5-4-6-8-17/h4-16H,1-3H3,(H,28,29)(H,25,26,27)/t16-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 110 | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Activitation of glucokinase |
Bioorg Med Chem Lett 16: 2705-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.022 BindingDB Entry DOI: 10.7270/Q28G8K91 |
More data for this Ligand-Target Pair | |
Hexokinase-4
(Homo sapiens (Human)) | BDBM50183218
((R)-6-(3-isopropoxy-5-(1-methoxypropan-2-yloxy)ben...)Show SMILES COC[C@@H](C)Oc1cc(OC(C)C)cc(c1)C(=O)Nc1ccc(cn1)C(O)=O Show InChI InChI=1S/C20H24N2O6/c1-12(2)27-16-7-15(8-17(9-16)28-13(3)11-26-4)19(23)22-18-6-5-14(10-21-18)20(24)25/h5-10,12-13H,11H2,1-4H3,(H,24,25)(H,21,22,23)/t13-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 5.51E+3 | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Activitation of glucokinase |
Bioorg Med Chem Lett 16: 2705-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.022 BindingDB Entry DOI: 10.7270/Q28G8K91 |
More data for this Ligand-Target Pair | |