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PubMed code 16621571

Compile data set for download or QSAR
Found 29 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20441
PNG
(3-1H-indol-4-yl-1-{[4-(trifluoromethoxy)phenyl]met...)
Show SMILES FC(F)(F)Oc1ccc(CNC(=O)Nc2cccc3[nH]ccc23)cc1
Show InChI InChI=1S/C17H14F3N3O2/c18-17(19,20)25-12-6-4-11(5-7-12)10-22-16(24)23-15-3-1-2-14-13(15)8-9-21-14/h1-9,21H,10H2,(H2,22,23,24)
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n/an/an/an/a 80n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem 14: 4740-9 (2006)


Article DOI: 10.1016/j.bmc.2006.03.027
BindingDB Entry DOI: 10.7270/Q2DB8035
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20457
PNG
([4-(trifluoromethyl)phenyl]methyl N-(1H-indol-4-yl...)
Show SMILES FC(F)(F)c1ccc(COC(=O)Nc2cccc3[nH]ccc23)cc1
Show InChI InChI=1S/C17H13F3N2O2/c18-17(19,20)12-6-4-11(5-7-12)10-24-16(23)22-15-3-1-2-14-13(15)8-9-21-14/h1-9,21H,10H2,(H,22,23)
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n/an/an/an/a 940n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem 14: 4740-9 (2006)


Article DOI: 10.1016/j.bmc.2006.03.027
BindingDB Entry DOI: 10.7270/Q2DB8035
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20447
PNG
(1-[(3,4-dichlorophenyl)methyl]-3-1H-indazol-4-ylur...)
Show SMILES Clc1ccc(CNC(=O)Nc2cccc3[nH]ncc23)cc1Cl
Show InChI InChI=1S/C15H12Cl2N4O/c16-11-5-4-9(6-12(11)17)7-18-15(22)20-13-2-1-3-14-10(13)8-19-21-14/h1-6,8H,7H2,(H,19,21)(H2,18,20,22)
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n/an/an/an/a 21n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem 14: 4740-9 (2006)


Article DOI: 10.1016/j.bmc.2006.03.027
BindingDB Entry DOI: 10.7270/Q2DB8035
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20449
PNG
(3-1H-indazol-4-yl-1-{[4-(trifluoromethoxy)phenyl]m...)
Show SMILES FC(F)(F)Oc1ccc(CNC(=O)Nc2cccc3[nH]ncc23)cc1
Show InChI InChI=1S/C16H13F3N4O2/c17-16(18,19)25-11-6-4-10(5-7-11)8-20-15(24)22-13-2-1-3-14-12(13)9-21-23-14/h1-7,9H,8H2,(H,21,23)(H2,20,22,24)
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n/an/an/an/a 11n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem 14: 4740-9 (2006)


Article DOI: 10.1016/j.bmc.2006.03.027
BindingDB Entry DOI: 10.7270/Q2DB8035
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20451
PNG
(3-(1-methyl-1H-indazol-4-yl)-1-{[4-(trifluorometho...)
Show SMILES Cn1ncc2c(NC(=O)NCc3ccc(OC(F)(F)F)cc3)cccc12
Show InChI InChI=1S/C17H15F3N4O2/c1-24-15-4-2-3-14(13(15)10-22-24)23-16(25)21-9-11-5-7-12(8-6-11)26-17(18,19)20/h2-8,10H,9H2,1H3,(H2,21,23,25)
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n/an/an/an/a 35n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem 14: 4740-9 (2006)


Article DOI: 10.1016/j.bmc.2006.03.027
BindingDB Entry DOI: 10.7270/Q2DB8035
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20439
PNG
(1-[(3,4-dichlorophenyl)methyl]-3-1H-indol-4-ylurea...)
Show SMILES Clc1ccc(CNC(=O)Nc2cccc3[nH]ccc23)cc1Cl
Show InChI InChI=1S/C16H13Cl2N3O/c17-12-5-4-10(8-13(12)18)9-20-16(22)21-15-3-1-2-14-11(15)6-7-19-14/h1-8,19H,9H2,(H2,20,21,22)
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n/an/an/an/a 220n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem 14: 4740-9 (2006)


Article DOI: 10.1016/j.bmc.2006.03.027
BindingDB Entry DOI: 10.7270/Q2DB8035
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20450
PNG
(3-1H-indazol-4-yl-1-{[3-(trifluoromethyl)phenyl]me...)
Show SMILES FC(F)(F)c1cccc(CNC(=O)Nc2cccc3[nH]ncc23)c1
Show InChI InChI=1S/C16H13F3N4O/c17-16(18,19)11-4-1-3-10(7-11)8-20-15(24)22-13-5-2-6-14-12(13)9-21-23-14/h1-7,9H,8H2,(H,21,23)(H2,20,22,24)
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n/an/an/an/a 44n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem 14: 4740-9 (2006)


Article DOI: 10.1016/j.bmc.2006.03.027
BindingDB Entry DOI: 10.7270/Q2DB8035
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20430
PNG
(1-[(4-bromophenyl)methyl]-3-1H-indol-5-ylurea | he...)
Show SMILES Brc1ccc(CNC(=O)Nc2ccc3[nH]ccc3c2)cc1
Show InChI InChI=1S/C16H14BrN3O/c17-13-3-1-11(2-4-13)10-19-16(21)20-14-5-6-15-12(9-14)7-8-18-15/h1-9,18H,10H2,(H2,19,20,21)
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n/an/an/an/a 5.85E+3n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem 14: 4740-9 (2006)


Article DOI: 10.1016/j.bmc.2006.03.027
BindingDB Entry DOI: 10.7270/Q2DB8035
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20435
PNG
(1-[(4-bromophenyl)methyl]-3-(2,3-dimethyl-1H-indol...)
Show SMILES Cc1[nH]c2cccc(NC(=O)NCc3ccc(Br)cc3)c2c1C
Show InChI InChI=1S/C18H18BrN3O/c1-11-12(2)21-15-4-3-5-16(17(11)15)22-18(23)20-10-13-6-8-14(19)9-7-13/h3-9,21H,10H2,1-2H3,(H2,20,22,23)
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n/an/an/an/a 1.47E+3n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem 14: 4740-9 (2006)


Article DOI: 10.1016/j.bmc.2006.03.027
BindingDB Entry DOI: 10.7270/Q2DB8035
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20446
PNG
(1-[(4-fluorophenyl)methyl]-3-1H-indol-4-ylurea | h...)
Show SMILES Fc1ccc(CNC(=O)Nc2cccc3[nH]ccc23)cc1
Show InChI InChI=1S/C16H14FN3O/c17-12-6-4-11(5-7-12)10-19-16(21)20-15-3-1-2-14-13(15)8-9-18-14/h1-9,18H,10H2,(H2,19,20,21)
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n/an/an/an/a 2.71E+3n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem 14: 4740-9 (2006)


Article DOI: 10.1016/j.bmc.2006.03.027
BindingDB Entry DOI: 10.7270/Q2DB8035
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20429
PNG
(1-[(4-bromophenyl)methyl]-3-1H-indol-4-ylurea | he...)
Show SMILES Brc1ccc(CNC(=O)Nc2cccc3[nH]ccc23)cc1
Show InChI InChI=1S/C16H14BrN3O/c17-12-6-4-11(5-7-12)10-19-16(21)20-15-3-1-2-14-13(15)8-9-18-14/h1-9,18H,10H2,(H2,19,20,21)
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n/an/an/an/a 110n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem 14: 4740-9 (2006)


Article DOI: 10.1016/j.bmc.2006.03.027
BindingDB Entry DOI: 10.7270/Q2DB8035
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20433
PNG
(1-[(4-bromophenyl)methyl]-3-1H-indazol-4-ylurea | ...)
Show SMILES Brc1ccc(CNC(=O)Nc2cccc3[nH]ncc23)cc1
Show InChI InChI=1S/C15H13BrN4O/c16-11-6-4-10(5-7-11)8-17-15(21)19-13-2-1-3-14-12(13)9-18-20-14/h1-7,9H,8H2,(H,18,20)(H2,17,19,21)
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n/an/an/an/a 13n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem 14: 4740-9 (2006)


Article DOI: 10.1016/j.bmc.2006.03.027
BindingDB Entry DOI: 10.7270/Q2DB8035
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20440
PNG
(3-1H-indol-4-yl-1-{[4-(trifluoromethyl)phenyl]meth...)
Show SMILES FC(F)(F)c1ccc(CNC(=O)Nc2cccc3[nH]ccc23)cc1
Show InChI InChI=1S/C17H14F3N3O/c18-17(19,20)12-6-4-11(5-7-12)10-22-16(24)23-15-3-1-2-14-13(15)8-9-21-14/h1-9,21H,10H2,(H2,22,23,24)
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n/an/an/an/a 60n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem 14: 4740-9 (2006)


Article DOI: 10.1016/j.bmc.2006.03.027
BindingDB Entry DOI: 10.7270/Q2DB8035
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20445
PNG
(1-[(3-fluorophenyl)methyl]-3-1H-indol-4-ylurea | h...)
Show SMILES Fc1cccc(CNC(=O)Nc2cccc3[nH]ccc23)c1
Show InChI InChI=1S/C16H14FN3O/c17-12-4-1-3-11(9-12)10-19-16(21)20-15-6-2-5-14-13(15)7-8-18-14/h1-9,18H,10H2,(H2,19,20,21)
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n/an/an/an/a 2.70E+3n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem 14: 4740-9 (2006)


Article DOI: 10.1016/j.bmc.2006.03.027
BindingDB Entry DOI: 10.7270/Q2DB8035
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20434
PNG
(1-[(4-bromophenyl)methyl]-3-1H-indazol-5-ylurea | ...)
Show SMILES Brc1ccc(CNC(=O)Nc2ccc3[nH]ncc3c2)cc1
Show InChI InChI=1S/C15H13BrN4O/c16-12-3-1-10(2-4-12)8-17-15(21)19-13-5-6-14-11(7-13)9-18-20-14/h1-7,9H,8H2,(H,18,20)(H2,17,19,21)
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n/an/an/an/a 3.54E+3n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem 14: 4740-9 (2006)


Article DOI: 10.1016/j.bmc.2006.03.027
BindingDB Entry DOI: 10.7270/Q2DB8035
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20437
PNG
(1-[(4-bromophenyl)methyl]-3-(2-methyl-2H-indazol-4...)
Show SMILES Cn1cc2c(NC(=O)NCc3ccc(Br)cc3)cccc2n1
Show InChI InChI=1S/C16H15BrN4O/c1-21-10-13-14(3-2-4-15(13)20-21)19-16(22)18-9-11-5-7-12(17)8-6-11/h2-8,10H,9H2,1H3,(H2,18,19,22)
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n/an/an/an/a 1.39E+3n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem 14: 4740-9 (2006)


Article DOI: 10.1016/j.bmc.2006.03.027
BindingDB Entry DOI: 10.7270/Q2DB8035
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20432
PNG
(1-[(4-bromophenyl)methyl]-3-1H-indol-7-ylurea | he...)
Show SMILES Brc1ccc(CNC(=O)Nc2cccc3cc[nH]c23)cc1
Show InChI InChI=1S/C16H14BrN3O/c17-13-6-4-11(5-7-13)10-19-16(21)20-14-3-1-2-12-8-9-18-15(12)14/h1-9,18H,10H2,(H2,19,20,21)
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n/an/an/an/a 180n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem 14: 4740-9 (2006)


Article DOI: 10.1016/j.bmc.2006.03.027
BindingDB Entry DOI: 10.7270/Q2DB8035
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20443
PNG
(1-{[4-chloro-3-(trifluoromethyl)phenyl]methyl}-3-1...)
Show SMILES FC(F)(F)c1cc(CNC(=O)Nc2cccc3[nH]ccc23)ccc1Cl
Show InChI InChI=1S/C17H13ClF3N3O/c18-13-5-4-10(8-12(13)17(19,20)21)9-23-16(25)24-15-3-1-2-14-11(15)6-7-22-14/h1-8,22H,9H2,(H2,23,24,25)
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n/an/an/an/a 70n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem 14: 4740-9 (2006)


Article DOI: 10.1016/j.bmc.2006.03.027
BindingDB Entry DOI: 10.7270/Q2DB8035
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20455
PNG
(2-(1H-indazol-4-yl)-N-{[4-(trifluoromethyl)phenyl]...)
Show SMILES FC(F)(F)c1ccc(CNC(=O)Cc2cccc3[nH]ncc23)cc1
Show InChI InChI=1S/C17H14F3N3O/c18-17(19,20)13-6-4-11(5-7-13)9-21-16(24)8-12-2-1-3-15-14(12)10-22-23-15/h1-7,10H,8-9H2,(H,21,24)(H,22,23)
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n/an/an/an/a 1.02E+4n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem 14: 4740-9 (2006)


Article DOI: 10.1016/j.bmc.2006.03.027
BindingDB Entry DOI: 10.7270/Q2DB8035
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20431
PNG
(1-[(4-bromophenyl)methyl]-3-1H-indol-6-ylurea | he...)
Show SMILES Brc1ccc(CNC(=O)Nc2ccc3cc[nH]c3c2)cc1
Show InChI InChI=1S/C16H14BrN3O/c17-13-4-1-11(2-5-13)10-19-16(21)20-14-6-3-12-7-8-18-15(12)9-14/h1-9,18H,10H2,(H2,19,20,21)
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n/an/an/an/a 3.01E+3n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem 14: 4740-9 (2006)


Article DOI: 10.1016/j.bmc.2006.03.027
BindingDB Entry DOI: 10.7270/Q2DB8035
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20436
PNG
(1-[(4-bromophenyl)methyl]-3-(1-methyl-1H-indazol-4...)
Show SMILES Cn1ncc2c(NC(=O)NCc3ccc(Br)cc3)cccc12
Show InChI InChI=1S/C16H15BrN4O/c1-21-15-4-2-3-14(13(15)10-19-21)20-16(22)18-9-11-5-7-12(17)8-6-11/h2-8,10H,9H2,1H3,(H2,18,20,22)
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n/an/an/an/a 76n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem 14: 4740-9 (2006)


Article DOI: 10.1016/j.bmc.2006.03.027
BindingDB Entry DOI: 10.7270/Q2DB8035
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20438
PNG
(3-1H-1,3-benzodiazol-4-yl-1-[(4-bromophenyl)methyl...)
Show SMILES Brc1ccc(CNC(=O)Nc2cccc3nc[nH]c23)cc1
Show InChI InChI=1S/C15H13BrN4O/c16-11-6-4-10(5-7-11)8-17-15(21)20-13-3-1-2-12-14(13)19-9-18-12/h1-7,9H,8H2,(H,18,19)(H2,17,20,21)
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n/an/an/an/a 2.47E+3n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem 14: 4740-9 (2006)


Article DOI: 10.1016/j.bmc.2006.03.027
BindingDB Entry DOI: 10.7270/Q2DB8035
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20452
PNG
(1-[(4-chlorophenyl)methyl]-3-(1-methyl-1H-indazol-...)
Show SMILES Cn1ncc2c(NC(=O)NCc3ccc(Cl)cc3)cccc12
Show InChI InChI=1S/C16H15ClN4O/c1-21-15-4-2-3-14(13(15)10-19-21)20-16(22)18-9-11-5-7-12(17)8-6-11/h2-8,10H,9H2,1H3,(H2,18,20,22)
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n/an/an/an/a 60n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem 14: 4740-9 (2006)


Article DOI: 10.1016/j.bmc.2006.03.027
BindingDB Entry DOI: 10.7270/Q2DB8035
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20453
PNG
(1-[(4-fluorophenyl)methyl]-3-(1-methyl-1H-indazol-...)
Show SMILES Cn1ncc2c(NC(=O)NCc3ccc(F)cc3)cccc12
Show InChI InChI=1S/C16H15FN4O/c1-21-15-4-2-3-14(13(15)10-19-21)20-16(22)18-9-11-5-7-12(17)8-6-11/h2-8,10H,9H2,1H3,(H2,18,20,22)
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n/an/an/an/a 720n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem 14: 4740-9 (2006)


Article DOI: 10.1016/j.bmc.2006.03.027
BindingDB Entry DOI: 10.7270/Q2DB8035
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20456
PNG
(2-(1H-indol-4-yl)-N-{[4-(trifluoromethyl)phenyl]me...)
Show SMILES FC(F)(F)c1ccc(CNC(=O)Cc2cccc3[nH]ccc23)cc1
Show InChI InChI=1S/C18H15F3N2O/c19-18(20,21)14-6-4-12(5-7-14)11-23-17(24)10-13-2-1-3-16-15(13)8-9-22-16/h1-9,22H,10-11H2,(H,23,24)
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n/an/an/an/a 520n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem 14: 4740-9 (2006)


Article DOI: 10.1016/j.bmc.2006.03.027
BindingDB Entry DOI: 10.7270/Q2DB8035
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20442
PNG
(1-{[3-fluoro-4-(trifluoromethyl)phenyl]methyl}-3-1...)
Show SMILES Fc1cc(CNC(=O)Nc2cccc3[nH]ccc23)ccc1C(F)(F)F
Show InChI InChI=1S/C17H13F4N3O/c18-13-8-10(4-5-12(13)17(19,20)21)9-23-16(25)24-15-3-1-2-14-11(15)6-7-22-14/h1-8,22H,9H2,(H2,23,24,25)
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n/an/an/an/a 40n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem 14: 4740-9 (2006)


Article DOI: 10.1016/j.bmc.2006.03.027
BindingDB Entry DOI: 10.7270/Q2DB8035
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20448
PNG
(3-1H-indazol-4-yl-1-{[4-(trifluoromethyl)phenyl]me...)
Show SMILES FC(F)(F)c1ccc(CNC(=O)Nc2cccc3[nH]ncc23)cc1
Show InChI InChI=1S/C16H13F3N4O/c17-16(18,19)11-6-4-10(5-7-11)8-20-15(24)22-13-2-1-3-14-12(13)9-21-23-14/h1-7,9H,8H2,(H,21,23)(H2,20,22,24)
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n/an/an/an/a 9n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem 14: 4740-9 (2006)


Article DOI: 10.1016/j.bmc.2006.03.027
BindingDB Entry DOI: 10.7270/Q2DB8035
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20454
PNG
(1-[(3,4-dichlorophenyl)methyl]-3-(1-methyl-1H-inda...)
Show SMILES Cn1ncc2c(NC(=O)NCc3ccc(Cl)c(Cl)c3)cccc12
Show InChI InChI=1S/C16H14Cl2N4O/c1-22-15-4-2-3-14(11(15)9-20-22)21-16(23)19-8-10-5-6-12(17)13(18)7-10/h2-7,9H,8H2,1H3,(H2,19,21,23)
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n/an/an/an/a 120n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem 14: 4740-9 (2006)


Article DOI: 10.1016/j.bmc.2006.03.027
BindingDB Entry DOI: 10.7270/Q2DB8035
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20444
PNG
(1-[(4-chlorophenyl)methyl]-3-1H-indol-4-ylurea | h...)
Show SMILES Clc1ccc(CNC(=O)Nc2cccc3[nH]ccc23)cc1
Show InChI InChI=1S/C16H14ClN3O/c17-12-6-4-11(5-7-12)10-19-16(21)20-15-3-1-2-14-13(15)8-9-18-14/h1-9,18H,10H2,(H2,19,20,21)
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n/an/an/an/a 150n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem 14: 4740-9 (2006)


Article DOI: 10.1016/j.bmc.2006.03.027
BindingDB Entry DOI: 10.7270/Q2DB8035
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%