Found 12 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
ATP-binding cassette sub-family C member 8/ATP-sensitive inward rectifier potassium channel 11
(Homo sapiens (Human)) | BDBM50190500
(6-chloro-3-(1-methyl-1-phenylethyl)amino-4H-thieno...)Show SMILES CC(C)(NC1=Nc2cc(Cl)sc2S(=O)(=O)N1)c1ccccc1 |t:4| Show InChI InChI=1S/C14H14ClN3O2S2/c1-14(2,9-6-4-3-5-7-9)17-13-16-10-8-11(15)21-12(10)22(19,20)18-13/h3-8H,1-2H3,(H2,16,17,18) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 81 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk Research and Development
Curated by ChEMBL
| Assay Description Displacement of [3H]glibenclamide from human Kir6.2/SUR1 expressed in HEK293 cells in presence of 2 mM ATP |
J Med Chem 49: 4127-39 (2006)
Article DOI: 10.1021/jm060042j BindingDB Entry DOI: 10.7270/Q2B27TWN |
More data for this Ligand-Target Pair | |
ATP-binding cassette sub-family C member 8/ATP-sensitive inward rectifier potassium channel 11
(Homo sapiens (Human)) | BDBM50118359
((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)Show InChI InChI=1S/C9H10ClN3O2S2/c1-9(2-3-9)12-8-11-5-4-6(10)16-7(5)17(14,15)13-8/h4H,2-3H2,1H3,(H2,11,12,13) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 286 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk Research and Development
Curated by ChEMBL
| Assay Description Displacement of [3H]glibenclamide from human Kir6.2/SUR1 expressed in HEK293 cells in presence of 2 mM ATP |
J Med Chem 49: 4127-39 (2006)
Article DOI: 10.1021/jm060042j BindingDB Entry DOI: 10.7270/Q2B27TWN |
More data for this Ligand-Target Pair | |
ATP-binding cassette sub-family C member 8/ATP-sensitive inward rectifier potassium channel 11
(Homo sapiens (Human)) | BDBM86248
(CAS_364-98-7 | NSC_3019 | diazoxide)Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
KEGG PC cid PC sid PDB UniChem
Patents
| Article PubMed
| n/a | n/a | 1.94E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk Research and Development
Curated by ChEMBL
| Assay Description Displacement of [3H]glibenclamide from human Kir6.2/SUR1 expressed in HEK293 cells in presence of 2 mM ATP |
J Med Chem 49: 4127-39 (2006)
Article DOI: 10.1021/jm060042j BindingDB Entry DOI: 10.7270/Q2B27TWN |
More data for this Ligand-Target Pair | |
ATP-binding cassette sub-family C member 8/ATP-sensitive inward rectifier potassium channel 11
(Homo sapiens (Human)) | BDBM50190500
(6-chloro-3-(1-methyl-1-phenylethyl)amino-4H-thieno...)Show SMILES CC(C)(NC1=Nc2cc(Cl)sc2S(=O)(=O)N1)c1ccccc1 |t:4| Show InChI InChI=1S/C14H14ClN3O2S2/c1-14(2,9-6-4-3-5-7-9)17-13-16-10-8-11(15)21-12(10)22(19,20)18-13/h3-8H,1-2H3,(H2,16,17,18) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.60E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk Research and Development
Curated by ChEMBL
| Assay Description Displacement of [3H]glibenclamide from human Kir6.2/SUR1 expressed in HEK293 cells |
J Med Chem 49: 4127-39 (2006)
Article DOI: 10.1021/jm060042j BindingDB Entry DOI: 10.7270/Q2B27TWN |
More data for this Ligand-Target Pair | |
ATP-binding cassette sub-family C member 8/ATP-sensitive inward rectifier potassium channel 11
(Homo sapiens (Human)) | BDBM50118359
((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)Show InChI InChI=1S/C9H10ClN3O2S2/c1-9(2-3-9)12-8-11-5-4-6(10)16-7(5)17(14,15)13-8/h4H,2-3H2,1H3,(H2,11,12,13) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 6.96E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk Research and Development
Curated by ChEMBL
| Assay Description Displacement of [3H]glibenclamide from human Kir6.2/SUR1 expressed in HEK293 cells |
J Med Chem 49: 4127-39 (2006)
Article DOI: 10.1021/jm060042j BindingDB Entry DOI: 10.7270/Q2B27TWN |
More data for this Ligand-Target Pair | |
ATP-binding cassette sub-family C member 8/ATP-sensitive inward rectifier potassium channel 11
(Homo sapiens (Human)) | BDBM86248
(CAS_364-98-7 | NSC_3019 | diazoxide)Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
KEGG PC cid PC sid PDB UniChem
Patents
| Article PubMed
| n/a | n/a | 7.40E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk Research and Development
Curated by ChEMBL
| Assay Description Displacement of [3H]glibenclamide from human Kir6.2/SUR1 expressed in HEK293 cells |
J Med Chem 49: 4127-39 (2006)
Article DOI: 10.1021/jm060042j BindingDB Entry DOI: 10.7270/Q2B27TWN |
More data for this Ligand-Target Pair | |
ATP-binding cassette sub-family C member 8/ATP-sensitive inward rectifier potassium channel 11
(Homo sapiens (Human)) | BDBM50118359
((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)Show InChI InChI=1S/C9H10ClN3O2S2/c1-9(2-3-9)12-8-11-5-4-6(10)16-7(5)17(14,15)13-8/h4H,2-3H2,1H3,(H2,11,12,13) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 190 | n/a | n/a | n/a | n/a |
Novo Nordisk Research and Development
Curated by ChEMBL
| Assay Description Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channels |
J Med Chem 49: 4127-39 (2006)
Article DOI: 10.1021/jm060042j BindingDB Entry DOI: 10.7270/Q2B27TWN |
More data for this Ligand-Target Pair | |
ATP-binding cassette sub-family C member 8/ATP-sensitive inward rectifier potassium channel 11
(Homo sapiens (Human)) | BDBM50190502
(6-bromo-3-(1-methylcyclopropyl)amino-4H-thieno[3,2...)Show InChI InChI=1S/C9H10BrN3O2S2/c1-9(2-3-9)12-8-11-5-4-6(10)16-7(5)17(14,15)13-8/h4H,2-3H2,1H3,(H2,11,12,13) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 160 | n/a | n/a | n/a | n/a |
Novo Nordisk Research and Development
Curated by ChEMBL
| Assay Description Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channels |
J Med Chem 49: 4127-39 (2006)
Article DOI: 10.1021/jm060042j BindingDB Entry DOI: 10.7270/Q2B27TWN |
More data for this Ligand-Target Pair | |
ATP-binding cassette sub-family C member 8/ATP-sensitive inward rectifier potassium channel 11
(Homo sapiens (Human)) | BDBM50190501
(6-chloro-3-{[1-(trifluoromethyl)cyclopropyl]-amino...)Show SMILES FC(F)(F)C1(CC1)NC1=Nc2cc(Cl)sc2S(=O)(=O)N1 |t:9| Show InChI InChI=1S/C9H7ClF3N3O2S2/c10-5-3-4-6(19-5)20(17,18)16-7(14-4)15-8(1-2-8)9(11,12)13/h3H,1-2H2,(H2,14,15,16) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 530 | n/a | n/a | n/a | n/a |
Novo Nordisk Research and Development
Curated by ChEMBL
| Assay Description Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channels |
J Med Chem 49: 4127-39 (2006)
Article DOI: 10.1021/jm060042j BindingDB Entry DOI: 10.7270/Q2B27TWN |
More data for this Ligand-Target Pair | |
ATP-binding cassette sub-family C member 8/ATP-sensitive inward rectifier potassium channel 11
(Homo sapiens (Human)) | BDBM86248
(CAS_364-98-7 | NSC_3019 | diazoxide)Show InChI InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
KEGG PC cid PC sid PDB UniChem
Patents
| Article PubMed
| n/a | n/a | n/a | n/a | 3.30E+4 | n/a | n/a | n/a | n/a |
Novo Nordisk Research and Development
Curated by ChEMBL
| Assay Description Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channels |
J Med Chem 49: 4127-39 (2006)
Article DOI: 10.1021/jm060042j BindingDB Entry DOI: 10.7270/Q2B27TWN |
More data for this Ligand-Target Pair | |
ATP-binding cassette sub-family C member 8/ATP-sensitive inward rectifier potassium channel 11
(Homo sapiens (Human)) | BDBM50190500
(6-chloro-3-(1-methyl-1-phenylethyl)amino-4H-thieno...)Show SMILES CC(C)(NC1=Nc2cc(Cl)sc2S(=O)(=O)N1)c1ccccc1 |t:4| Show InChI InChI=1S/C14H14ClN3O2S2/c1-14(2,9-6-4-3-5-7-9)17-13-16-10-8-11(15)21-12(10)22(19,20)18-13/h3-8H,1-2H3,(H2,16,17,18) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 180 | n/a | n/a | n/a | n/a |
Novo Nordisk Research and Development
Curated by ChEMBL
| Assay Description Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channels |
J Med Chem 49: 4127-39 (2006)
Article DOI: 10.1021/jm060042j BindingDB Entry DOI: 10.7270/Q2B27TWN |
More data for this Ligand-Target Pair | |
ATP-binding cassette sub-family C member 8/ATP-sensitive inward rectifier potassium channel 11
(Homo sapiens (Human)) | BDBM50190496
(6-chloro-3-(1-phenylcyclopropyl)amino-4H-thieno[3,...)Show SMILES Clc1cc2N=C(NC3(CC3)c3ccccc3)NS(=O)(=O)c2s1 |t:4| Show InChI InChI=1S/C14H12ClN3O2S2/c15-11-8-10-12(21-11)22(19,20)18-13(16-10)17-14(6-7-14)9-4-2-1-3-5-9/h1-5,8H,6-7H2,(H2,16,17,18) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 810 | n/a | n/a | n/a | n/a |
Novo Nordisk Research and Development
Curated by ChEMBL
| Assay Description Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channels |
J Med Chem 49: 4127-39 (2006)
Article DOI: 10.1021/jm060042j BindingDB Entry DOI: 10.7270/Q2B27TWN |
More data for this Ligand-Target Pair | |