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PubMed code 17234422

Compile data set for download or QSAR
Found 118 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50166529
PNG
((+/-)-1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazi...)
Show SMILES COc1ccc2ccccc2c1CCCCN1CCN(CC(N2CCN(CC2)C(C)C)c2ccc(F)cc2)CC1
Show InChI InChI=1S/C34H47FN4O/c1-27(2)38-22-24-39(25-23-38)33(29-11-14-30(35)15-12-29)26-37-20-18-36(19-21-37)17-7-6-10-32-31-9-5-4-8-28(31)13-16-34(32)40-3/h4-5,8-9,11-16,27,33H,6-7,10,17-26H2,1-3H3
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n/an/a 8.13n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50166529
PNG
((+/-)-1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazi...)
Show SMILES COc1ccc2ccccc2c1CCCCN1CCN(CC(N2CCN(CC2)C(C)C)c2ccc(F)cc2)CC1
Show InChI InChI=1S/C34H47FN4O/c1-27(2)38-22-24-39(25-23-38)33(29-11-14-30(35)15-12-29)26-37-20-18-36(19-21-37)17-7-6-10-32-31-9-5-4-8-28(31)13-16-34(32)40-3/h4-5,8-9,11-16,27,33H,6-7,10,17-26H2,1-3H3
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n/an/a 8.13n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202924
PNG
((+/-)-1-[3-(4'-fluorobiphenyl-2-yl)propyl]-4-[2-(4...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2ccccc2-c2ccc(F)cc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-22-24-40(25-23-39)34(30-11-15-32(36)16-12-30)26-38-20-18-37(19-21-38)17-5-7-28-6-3-4-8-33(28)29-9-13-31(35)14-10-29/h3-4,6,8-16,27,34H,5,7,17-26H2,1-2H3
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n/an/a 10.5n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202930
PNG
((+/-)-1-(3-biphenyl-2-ylpropyl)-4-[2-(4-fluorophen...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H45FN4/c1-28(2)38-23-25-39(26-24-38)34(31-14-16-32(35)17-15-31)27-37-21-19-36(20-22-37)18-8-12-30-11-6-7-13-33(30)29-9-4-3-5-10-29/h3-7,9-11,13-17,28,34H,8,12,18-27H2,1-2H3
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n/an/a 11.2n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202947
PNG
((+/-)-1-[3-(3-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2c(F)cccc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-22-24-40(25-23-39)34(29-13-15-30(35)16-14-29)26-38-20-18-37(19-21-38)17-7-11-32-31(10-6-12-33(32)36)28-8-4-3-5-9-28/h3-6,8-10,12-16,27,34H,7,11,17-26H2,1-2H3
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n/an/a 11.7n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202942
PNG
((+/-)-1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazi...)
Show SMILES COc1cccc(-c2ccccc2)c1CCCN1CCN(CC(N2CCN(CC2)C(C)C)c2ccc(F)cc2)CC1 |w:22.23|
Show InChI InChI=1S/C35H47FN4O/c1-28(2)39-23-25-40(26-24-39)34(30-14-16-31(36)17-15-30)27-38-21-19-37(20-22-38)18-8-12-33-32(11-7-13-35(33)41-3)29-9-5-4-6-10-29/h4-7,9-11,13-17,28,34H,8,12,18-27H2,1-3H3
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n/an/a 15.2n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202981
PNG
((+/-)-1-tert-butyl-4-(1-(4-fluorophenyl)-2-{4-[4-(...)
Show SMILES COc1ccc2ccccc2c1CCCCN1CCN(CC(N2CCN(CC2)C(C)(C)C)c2ccc(F)cc2)CC1 |w:21.22|
Show InChI InChI=1S/C35H49FN4O/c1-35(2,3)40-25-23-39(24-26-40)33(29-12-15-30(36)16-13-29)27-38-21-19-37(20-22-38)18-8-7-11-32-31-10-6-5-9-28(31)14-17-34(32)41-4/h5-6,9-10,12-17,33H,7-8,11,18-27H2,1-4H3
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n/an/a 18n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50166529
PNG
((+/-)-1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazi...)
Show SMILES COc1ccc2ccccc2c1CCCCN1CCN(CC(N2CCN(CC2)C(C)C)c2ccc(F)cc2)CC1
Show InChI InChI=1S/C34H47FN4O/c1-27(2)38-22-24-39(25-23-38)33(29-11-14-30(35)15-12-29)26-37-20-18-36(19-21-37)17-7-6-10-32-31-9-5-4-8-28(31)13-16-34(32)40-3/h4-5,8-9,11-16,27,33H,6-7,10,17-26H2,1-3H3
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n/an/a 22n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202925
PNG
(1-(1-(4-fluorophenyl)-2-{4-[4-(2-isopropoxy-1-naph...)
Show SMILES CC(C)Oc1ccc2ccccc2c1CCCCN1CCN(CC(N2CCN(CC2)C(C)C)c2ccc(F)cc2)CC1 |w:23.24|
Show InChI InChI=1S/C36H51FN4O/c1-28(2)40-23-25-41(26-24-40)35(31-12-15-32(37)16-13-31)27-39-21-19-38(20-22-39)18-8-7-11-34-33-10-6-5-9-30(33)14-17-36(34)42-29(3)4/h5-6,9-10,12-17,28-29,35H,7-8,11,18-27H2,1-4H3
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n/an/a 22n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202941
PNG
((+/-)-1-[3-(6-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2cccc(F)c2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-22-24-40(25-23-39)33(28-13-15-31(35)16-14-28)26-38-20-18-37(19-21-38)17-7-11-30-10-6-12-32(36)34(30)29-8-4-3-5-9-29/h3-6,8-10,12-16,27,33H,7,11,17-26H2,1-2H3
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n/an/a 23n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202938
PNG
((+/-)-1-[3-(3'-fluorobiphenyl-2-yl)propyl]-4-[2-(4...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2ccccc2-c2cccc(F)c2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-21-23-40(24-22-39)34(29-12-14-31(35)15-13-29)26-38-19-17-37(18-20-38)16-6-9-28-7-3-4-11-33(28)30-8-5-10-32(36)25-30/h3-5,7-8,10-15,25,27,34H,6,9,16-24,26H2,1-2H3
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n/an/a 23.6n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202933
PNG
((+/-)-1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazi...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2c(C)cccc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C35H47FN4/c1-28(2)39-23-25-40(26-24-39)35(31-14-16-32(36)17-15-31)27-38-21-19-37(20-22-38)18-8-13-33-29(3)9-7-12-34(33)30-10-5-4-6-11-30/h4-7,9-12,14-17,28,35H,8,13,18-27H2,1-3H3
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n/an/a 24.3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202961
PNG
((+/-)-1-[4-(2-ethoxy-1-naphthyl)butyl]-4-[2-(4-flu...)
Show SMILES CCOc1ccc2ccccc2c1CCCCN1CCN(CC(N2CCN(CC2)C(C)C)c2ccc(F)cc2)CC1 |w:22.23|
Show InChI InChI=1S/C35H49FN4O/c1-4-41-35-17-14-29-9-5-6-10-32(29)33(35)11-7-8-18-37-19-21-38(22-20-37)27-34(30-12-15-31(36)16-13-30)40-25-23-39(24-26-40)28(2)3/h5-6,9-10,12-17,28,34H,4,7-8,11,18-27H2,1-3H3
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n/an/a 26n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202929
PNG
((+/-)-1-[3-(3-chlorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2c(Cl)cccc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44ClFN4/c1-27(2)39-22-24-40(25-23-39)34(29-13-15-30(36)16-14-29)26-38-20-18-37(19-21-38)17-7-11-32-31(10-6-12-33(32)35)28-8-4-3-5-9-28/h3-6,8-10,12-16,27,34H,7,11,17-26H2,1-2H3
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n/an/a 27.1n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202926
PNG
((+/-)-1-[3-(4-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2cc(F)ccc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-21-23-40(24-22-39)34(29-10-12-31(35)13-11-29)26-38-19-17-37(18-20-38)16-6-9-30-25-32(36)14-15-33(30)28-7-4-3-5-8-28/h3-5,7-8,10-15,25,27,34H,6,9,16-24,26H2,1-2H3
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n/an/a 27.1n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202934
PNG
((+/-)-1-[3-(5-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2ccc(F)cc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-21-23-40(24-22-39)34(30-11-13-31(35)14-12-30)26-38-19-17-37(18-20-38)16-6-9-29-10-15-32(36)25-33(29)28-7-4-3-5-8-28/h3-5,7-8,10-15,25,27,34H,6,9,16-24,26H2,1-2H3
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n/an/a 33n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202956
PNG
((+/-)-1-[4-(2-bromo-1-naphthyl)butyl]-4-[2-(4-fluo...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCCc2c(Br)ccc3ccccc23)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C33H44BrFN4/c1-26(2)38-21-23-39(24-22-38)33(28-10-13-29(35)14-11-28)25-37-19-17-36(18-20-37)16-6-5-9-31-30-8-4-3-7-27(30)12-15-32(31)34/h3-4,7-8,10-15,26,33H,5-6,9,16-25H2,1-2H3
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n/an/a 36.8n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202937
PNG
((+/-)-1-[3-(2'-fluorobiphenyl-2-yl)propyl]-4-[2-(4...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2ccccc2-c2ccccc2F)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-22-24-40(25-23-39)34(29-13-15-30(35)16-14-29)26-38-20-18-37(19-21-38)17-7-9-28-8-3-4-10-31(28)32-11-5-6-12-33(32)36/h3-6,8,10-16,27,34H,7,9,17-26H2,1-2H3
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n/an/a 36.8n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202969
PNG
((+/-)-1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazi...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2ccccc2-c2ccc(C)cc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C35H47FN4/c1-28(2)39-23-25-40(26-24-39)35(32-14-16-33(36)17-15-32)27-38-21-19-37(20-22-38)18-6-8-30-7-4-5-9-34(30)31-12-10-29(3)11-13-31/h4-5,7,9-17,28,35H,6,8,18-27H2,1-3H3
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n/an/a 41.8n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202946
PNG
((+/-)-1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazi...)
Show SMILES COc1ccc(cc1)-c1ccccc1CCCN1CCN(CC(N2CCN(CC2)C(C)C)c2ccc(F)cc2)CC1 |w:22.23|
Show InChI InChI=1S/C35H47FN4O/c1-28(2)39-23-25-40(26-24-39)35(31-10-14-32(36)15-11-31)27-38-21-19-37(20-22-38)18-6-8-29-7-4-5-9-34(29)30-12-16-33(41-3)17-13-30/h4-5,7,9-17,28,35H,6,8,18-27H2,1-3H3
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n/an/a 42.6n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202958
PNG
((+/-)-1-cyclopentyl-4-(1-(4-fluorophenyl)-2-{4-[4-...)
Show SMILES COc1ccc2ccccc2c1CCCCN1CCN(CC(N2CCN(CC2)C2CCCC2)c2ccc(F)cc2)CC1 |w:21.22|
Show InChI InChI=1S/C36H49FN4O/c1-42-36-18-15-29-8-2-5-11-33(29)34(36)12-6-7-19-38-20-22-39(23-21-38)28-35(30-13-16-31(37)17-14-30)41-26-24-40(25-27-41)32-9-3-4-10-32/h2,5,8,11,13-18,32,35H,3-4,6-7,9-10,12,19-28H2,1H3
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n/an/a 47.2n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202923
PNG
((+/-)-1-[3-(4'-chlorobiphenyl-2-yl)propyl]-4-[2-(4...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2ccccc2-c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44ClFN4/c1-27(2)39-22-24-40(25-23-39)34(30-11-15-32(36)16-12-30)26-38-20-18-37(19-21-38)17-5-7-28-6-3-4-8-33(28)29-9-13-31(35)14-10-29/h3-4,6,8-16,27,34H,5,7,17-26H2,1-2H3
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n/an/a 53.2n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50155378
PNG
((+/-)-1-(1-(4-fluorophenyl)-2-{4-[4-(2-methoxy-1-n...)
Show SMILES COc1ccc2ccccc2c1CCCCN1CCN(CC(N2CCN(C)CC2)c2ccc(F)cc2)CC1
Show InChI InChI=1S/C32H43FN4O/c1-34-17-23-37(24-18-34)31(27-10-13-28(33)14-11-27)25-36-21-19-35(20-22-36)16-6-5-9-30-29-8-4-3-7-26(29)12-15-32(30)38-2/h3-4,7-8,10-15,31H,5-6,9,16-25H2,1-2H3
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n/an/a 57.3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202940
PNG
((+/-)-1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazi...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2ccccc2-c2ccc(cc2)C(F)(F)F)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C35H44F4N4/c1-27(2)42-22-24-43(25-23-42)34(30-11-15-32(36)16-12-30)26-41-20-18-40(19-21-41)17-5-7-28-6-3-4-8-33(28)29-9-13-31(14-10-29)35(37,38)39/h3-4,6,8-16,27,34H,5,7,17-26H2,1-2H3
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n/an/a 62.8n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202957
PNG
((+/-)-1-(4-biphenyl-2-ylbutyl)-4-[2-(4-fluoropheny...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCCc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C35H47FN4/c1-29(2)39-24-26-40(27-25-39)35(32-15-17-33(36)18-16-32)28-38-22-20-37(21-23-38)19-9-8-13-31-12-6-7-14-34(31)30-10-4-3-5-11-30/h3-7,10-12,14-18,29,35H,8-9,13,19-28H2,1-2H3
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n/an/a 65.1n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202951
PNG
((+/-)-1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazi...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCCc2cccc3ccccc23)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C33H45FN4/c1-27(2)37-22-24-38(25-23-37)33(30-13-15-31(34)16-14-30)26-36-20-18-35(19-21-36)17-6-5-9-29-11-7-10-28-8-3-4-12-32(28)29/h3-4,7-8,10-16,27,33H,5-6,9,17-26H2,1-2H3
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n/an/a 72.3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202949
PNG
((+/-)-1-(1-ethylpropyl)-4-(1-(4-fluorophenyl)-2-{4...)
Show SMILES CCC(CC)N1CCN(CC1)C(CN1CCN(CCCCc2c(OC)ccc3ccccc23)CC1)c1ccc(F)cc1 |w:11.12|
Show InChI InChI=1S/C36H51FN4O/c1-4-32(5-2)40-24-26-41(27-25-40)35(30-13-16-31(37)17-14-30)28-39-22-20-38(21-23-39)19-9-8-12-34-33-11-7-6-10-29(33)15-18-36(34)42-3/h6-7,10-11,13-18,32,35H,4-5,8-9,12,19-28H2,1-3H3
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n/an/a 82.8n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202935
PNG
((+/-)-1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazi...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2ccccc2-c2ccc(OC(F)(F)F)cc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C35H44F4N4O/c1-27(2)42-22-24-43(25-23-42)34(30-9-13-31(36)14-10-30)26-41-20-18-40(19-21-41)17-5-7-28-6-3-4-8-33(28)29-11-15-32(16-12-29)44-35(37,38)39/h3-4,6,8-16,27,34H,5,7,17-26H2,1-2H3
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n/an/a 85.9n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202975
PNG
((+/-)-2'-(3-{4-[2-(4-fluorophenyl)-2-(4-isopropylp...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2ccccc2-c2ccc(cc2)N(C)C)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C36H50FN5/c1-29(2)41-24-26-42(27-25-41)36(32-11-15-33(37)16-12-32)28-40-22-20-39(21-23-40)19-7-9-30-8-5-6-10-35(30)31-13-17-34(18-14-31)38(3)4/h5-6,8,10-18,29,36H,7,9,19-28H2,1-4H3
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n/an/a 92.5n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202963
PNG
((+/-)-1-[3-(4'-tert-Butylbiphenyl-2-yl)propyl]-4-[...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2ccccc2-c2ccc(cc2)C(C)(C)C)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C38H53FN4/c1-30(2)42-25-27-43(28-26-42)37(33-14-18-35(39)19-15-33)29-41-23-21-40(22-24-41)20-8-10-31-9-6-7-11-36(31)32-12-16-34(17-13-32)38(3,4)5/h6-7,9,11-19,30,37H,8,10,20-29H2,1-5H3
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n/an/a 100n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202974
PNG
((+/-)-1-ethyl-4-(1-(4-fluorophenyl)-2-{4-[4-(1-nap...)
Show SMILES CCN1CCN(CC1)C(CN1CCN(CCCCc2cccc3ccccc23)CC1)c1ccc(F)cc1 |w:8.9|
Show InChI InChI=1S/C32H43FN4/c1-2-34-22-24-37(25-23-34)32(29-13-15-30(33)16-14-29)26-36-20-18-35(19-21-36)17-6-5-9-28-11-7-10-27-8-3-4-12-31(27)28/h3-4,7-8,10-16,32H,2,5-6,9,17-26H2,1H3
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n/an/a 105n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202955
PNG
((+/-)-1-[2-(4-fluorophenyl)-2-(4-methylpiperazin-1...)
Show SMILES CN1CCN(CC1)C(CN1CCN(CCCCc2cccc3ccccc23)CC1)c1ccc(F)cc1 |w:7.8|
Show InChI InChI=1S/C31H41FN4/c1-33-17-23-36(24-18-33)31(28-12-14-29(32)15-13-28)25-35-21-19-34(20-22-35)16-5-4-8-27-10-6-9-26-7-2-3-11-30(26)27/h2-3,6-7,9-15,31H,4-5,8,16-25H2,1H3
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n/an/a 118n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202953
PNG
((+/-)-1-(4-{4-[2-(4-fluorophenyl)-2-(4-isopropylpi...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCCc2c(O)ccc3ccccc23)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C33H45FN4O/c1-26(2)37-21-23-38(24-22-37)32(28-10-13-29(34)14-11-28)25-36-19-17-35(18-20-36)16-6-5-9-31-30-8-4-3-7-27(30)12-15-33(31)39/h3-4,7-8,10-15,26,32,39H,5-6,9,16-25H2,1-2H3
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n/an/a 131n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202982
PNG
((+/-)-1-[2-(4-chlorophenyl)-2-(4-methylpiperazin-1...)
Show SMILES CN1CCN(CC1)C(CN1CCN(CCCCc2cccc3ccccc23)CC1)c1ccc(Cl)cc1 |w:7.8|
Show InChI InChI=1S/C31H41ClN4/c1-33-17-23-36(24-18-33)31(28-12-14-29(32)15-13-28)25-35-21-19-34(20-22-35)16-5-4-8-27-10-6-9-26-7-2-3-11-30(26)27/h2-3,6-7,9-15,31H,4-5,8,16-25H2,1H3
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n/an/a 132n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202928
PNG
((+/-)-1-cyclopropyl-4-(1-(4-fluorophenyl)-2-{4-[4-...)
Show SMILES Fc1ccc(cc1)C(CN1CCN(CCCCc2cccc3ccccc23)CC1)N1CCN(CC1)C1CC1 |w:7.8|
Show InChI InChI=1S/C33H43FN4/c34-30-13-11-29(12-14-30)33(38-24-22-37(23-25-38)31-15-16-31)26-36-20-18-35(19-21-36)17-4-3-7-28-9-5-8-27-6-1-2-10-32(27)28/h1-2,5-6,8-14,31,33H,3-4,7,15-26H2
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n/an/a 147n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202950
PNG
((+/-)-1-(3-biphenyl-3-ylpropyl)-4-[2-(4-fluorophen...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2cccc(c2)-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H45FN4/c1-28(2)38-22-24-39(25-23-38)34(31-13-15-33(35)16-14-31)27-37-20-18-36(19-21-37)17-7-9-29-8-6-12-32(26-29)30-10-4-3-5-11-30/h3-6,8,10-16,26,28,34H,7,9,17-25,27H2,1-2H3
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n/an/a 156n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202927
PNG
((+/-)-1-[2-(4-bromophenyl)-2-(4-methylpiperazin-1-...)
Show SMILES CN1CCN(CC1)C(CN1CCN(CCCCc2cccc3ccccc23)CC1)c1ccc(Br)cc1 |w:7.8|
Show InChI InChI=1S/C31H41BrN4/c1-33-17-23-36(24-18-33)31(28-12-14-29(32)15-13-28)25-35-21-19-34(20-22-35)16-5-4-8-27-10-6-9-26-7-2-3-11-30(26)27/h2-3,6-7,9-15,31H,4-5,8,16-25H2,1H3
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n/an/a 159n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202943
PNG
((+/-)-1-(1-(4-fluorophenyl)-2-{4-[4-(1-naphthyl)bu...)
Show SMILES CCCN1CCN(CC1)C(CN1CCN(CCCCc2cccc3ccccc23)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C33H45FN4/c1-2-17-35-23-25-38(26-24-35)33(30-13-15-31(34)16-14-30)27-37-21-19-36(20-22-37)18-6-5-9-29-11-7-10-28-8-3-4-12-32(28)29/h3-4,7-8,10-16,33H,2,5-6,9,17-27H2,1H3
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n/an/a 177n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202939
PNG
((+/-)-1-(2-biphenyl-2-ylethyl)-4-[2-(4-fluoropheny...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C33H43FN4/c1-27(2)37-22-24-38(25-23-37)33(30-12-14-31(34)15-13-30)26-36-20-18-35(19-21-36)17-16-29-10-6-7-11-32(29)28-8-4-3-5-9-28/h3-15,27,33H,16-26H2,1-2H3
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n/an/a 186n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM50202947
PNG
((+/-)-1-[3-(3-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2c(F)cccc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-22-24-40(25-23-39)34(29-13-15-30(35)16-14-29)26-38-20-18-37(19-21-38)17-7-11-32-31(10-6-12-33(32)36)28-8-4-3-5-9-28/h3-6,8-10,12-16,27,34H,7,11,17-26H2,1-2H3
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n/an/a 206n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]nisoxetine from NET in rat cortical membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202948
PNG
(1-[2-(4-fluorophenyl)-2-(4-methylpiperazin-1-yl)et...)
Show SMILES CN1CCN(CC1)C(CN1CCN(CCCc2cccc3ccccc23)CC1)c1ccc(F)cc1 |w:7.8|
Show InChI InChI=1S/C30H39FN4/c1-32-16-22-35(23-17-32)30(27-11-13-28(31)14-12-27)24-34-20-18-33(19-21-34)15-5-9-26-8-4-7-25-6-2-3-10-29(25)26/h2-4,6-8,10-14,30H,5,9,15-24H2,1H3
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n/an/a 208n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202959
PNG
((+/-)-1-[2-(4-fluorophenyl)-2-(4-methylpiperazin-1...)
Show SMILES CN1CCN(CC1)C(CN1CCN(CCCCCc2cccc3ccccc23)CC1)c1ccc(F)cc1 |w:7.8|
Show InChI InChI=1S/C32H43FN4/c1-34-18-24-37(25-19-34)32(29-13-15-30(33)16-14-29)26-36-22-20-35(21-23-36)17-6-2-3-8-27-10-7-11-28-9-4-5-12-31(27)28/h4-5,7,9-16,32H,2-3,6,8,17-26H2,1H3
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n/an/a 218n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM50202938
PNG
((+/-)-1-[3-(3'-fluorobiphenyl-2-yl)propyl]-4-[2-(4...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2ccccc2-c2cccc(F)c2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-21-23-40(24-22-39)34(29-12-14-31(35)15-13-29)26-38-19-17-37(18-20-38)16-6-9-28-7-3-4-11-33(28)30-8-5-10-32(36)25-30/h3-5,7-8,10-15,25,27,34H,6,9,16-24,26H2,1-2H3
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n/an/a 226n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]nisoxetine from NET in rat cortical membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202944
PNG
((+/-)-1-methyl-4-{2-{4-[4-(1-naphthyl)butyl]pipera...)
Show SMILES CN1CCN(CC1)C(CN1CCN(CCCCc2cccc3ccccc23)CC1)c1ccc(cc1)C(F)(F)F |w:7.8|
Show InChI InChI=1S/C32H41F3N4/c1-36-17-23-39(24-18-36)31(28-12-14-29(15-13-28)32(33,34)35)25-38-21-19-37(20-22-38)16-5-4-8-27-10-6-9-26-7-2-3-11-30(26)27/h2-3,6-7,9-15,31H,4-5,8,16-25H2,1H3
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n/an/a 226n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202979
PNG
((+/-)-1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazi...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2ccccc2-c2ccc(cc2)-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C40H49FN4/c1-32(2)44-27-29-45(30-28-44)40(37-18-20-38(41)21-19-37)31-43-25-23-42(24-26-43)22-8-12-35-11-6-7-13-39(35)36-16-14-34(15-17-36)33-9-4-3-5-10-33/h3-7,9-11,13-21,32,40H,8,12,22-31H2,1-2H3
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n/an/a 228n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202965
PNG
((+/-)-1-(1-(4-fluorophenyl)-2-{4-[4-(4-methoxy-1-n...)
Show SMILES COc1ccc(CCCCN2CCN(CC(N3CCN(C)CC3)c3ccc(F)cc3)CC2)c2ccccc12 |w:15.14|
Show InChI InChI=1S/C32H43FN4O/c1-34-17-23-37(24-18-34)31(27-10-13-28(33)14-11-27)25-36-21-19-35(20-22-36)16-6-5-7-26-12-15-32(38-2)30-9-4-3-8-29(26)30/h3-4,8-15,31H,5-7,16-25H2,1-2H3
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n/an/a 228n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202978
PNG
((+/-)-1-cyclohexyl-4-(1-(4-fluorophenyl)-2-{4-[4-(...)
Show SMILES Fc1ccc(cc1)C(CN1CCN(CCCCc2cccc3ccccc23)CC1)N1CCN(CC1)C1CCCCC1 |w:7.8|
Show InChI InChI=1S/C36H49FN4/c37-33-18-16-32(17-19-33)36(41-27-25-40(26-28-41)34-13-2-1-3-14-34)29-39-23-21-38(22-24-39)20-7-6-10-31-12-8-11-30-9-4-5-15-35(30)31/h4-5,8-9,11-12,15-19,34,36H,1-3,6-7,10,13-14,20-29H2
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n/an/a 241n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202932
PNG
((+/-)-1-(3-biphenyl-4-ylpropyl)-4-[2-(4-fluorophen...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2ccc(cc2)-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H45FN4/c1-28(2)38-23-25-39(26-24-38)34(32-14-16-33(35)17-15-32)27-37-21-19-36(20-22-37)18-6-7-29-10-12-31(13-11-29)30-8-4-3-5-9-30/h3-5,8-17,28,34H,6-7,18-27H2,1-2H3
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n/an/a 243n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202970
PNG
((+/-)-1-methyl-4-[2-{4-[4-(1-naphthyl)butyl]pipera...)
Show SMILES CN1CCN(CC1)C(CN1CCN(CCCCc2cccc3ccccc23)CC1)c1ccc(cc1)[N+]([O-])=O |w:7.8|
Show InChI InChI=1S/C31H41N5O2/c1-32-17-23-35(24-18-32)31(28-12-14-29(15-13-28)36(37)38)25-34-21-19-33(20-22-34)16-5-4-8-27-10-6-9-26-7-2-3-11-30(26)27/h2-3,6-7,9-15,31H,4-5,8,16-25H2,1H3
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n/an/a 263n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM50202924
PNG
((+/-)-1-[3-(4'-fluorobiphenyl-2-yl)propyl]-4-[2-(4...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2ccccc2-c2ccc(F)cc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-22-24-40(25-23-39)34(30-11-15-32(36)16-12-30)26-38-20-18-37(19-21-38)17-5-7-28-6-3-4-8-33(28)29-9-13-31(35)14-10-29/h3-4,6,8-16,27,34H,5,7,17-26H2,1-2H3
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n/an/a 290n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]nisoxetine from NET in rat cortical membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202936
PNG
((+/-)-1-methyl-4-(1-(4-methylphenyl)-2-{4-[4-(1-na...)
Show SMILES CN1CCN(CC1)C(CN1CCN(CCCCc2cccc3ccccc23)CC1)c1ccc(C)cc1 |w:7.8|
Show InChI InChI=1S/C32H44N4/c1-27-13-15-30(16-14-27)32(36-24-18-33(2)19-25-36)26-35-22-20-34(21-23-35)17-6-5-9-29-11-7-10-28-8-3-4-12-31(28)29/h3-4,7-8,10-16,32H,5-6,9,17-26H2,1-2H3
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n/an/a 296n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202945
PNG
((+/-)-1-[2-(4-fluorophenyl)-2-piperazin-1-ylethyl]...)
Show SMILES Fc1ccc(cc1)C(CN1CCN(CCCCc2cccc3ccccc23)CC1)N1CCNCC1 |w:7.8|
Show InChI InChI=1S/C30H39FN4/c31-28-13-11-27(12-14-28)30(35-18-15-32-16-19-35)24-34-22-20-33(21-23-34)17-4-3-7-26-9-5-8-25-6-1-2-10-29(25)26/h1-2,5-6,8-14,30,32H,3-4,7,15-24H2
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n/an/a 303n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202980
PNG
((+/-)-1-[2-(4-fluorophenyl)-2-(4-methylpiperazin-1...)
Show SMILES CN1CCN(CC1)C(CN1CCN(CCCCc2ccc3ccccc3c2)CC1)c1ccc(F)cc1 |w:7.8|
Show InChI InChI=1S/C31H41FN4/c1-33-16-22-36(23-17-33)31(28-11-13-30(32)14-12-28)25-35-20-18-34(19-21-35)15-5-4-6-26-9-10-27-7-2-3-8-29(27)24-26/h2-3,7-14,24,31H,4-6,15-23,25H2,1H3
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n/an/a 336n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202976
PNG
((+/-)-1-[2-(4-fluorophenyl)-2-(4-methylpiperazin-1...)
Show SMILES CN1CCN(CC1)C(CN1CCN(CCCCCCc2cccc3ccccc23)CC1)c1ccc(F)cc1 |w:7.8|
Show InChI InChI=1S/C33H45FN4/c1-35-19-25-38(26-20-35)33(30-14-16-31(34)17-15-30)27-37-23-21-36(22-24-37)18-7-3-2-4-9-28-11-8-12-29-10-5-6-13-32(28)29/h5-6,8,10-17,33H,2-4,7,9,18-27H2,1H3
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n/an/a 341n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM50202926
PNG
((+/-)-1-[3-(4-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2cc(F)ccc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-21-23-40(24-22-39)34(29-10-12-31(35)13-11-29)26-38-19-17-37(18-20-38)16-6-9-30-25-32(36)14-15-33(30)28-7-4-3-5-8-28/h3-5,7-8,10-15,25,27,34H,6,9,16-24,26H2,1-2H3
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n/an/a 369n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]nisoxetine from NET in rat cortical membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202968
PNG
((+-)-1-[2-(3-bromophenyl)-2-(4-methylpiperazin-1-y...)
Show SMILES CN1CCN(CC1)C(CN1CCN(CCCCc2cccc3ccccc23)CC1)c1cccc(Br)c1 |w:7.8|
Show InChI InChI=1S/C31H41BrN4/c1-33-16-22-36(23-17-33)31(28-12-7-13-29(32)24-28)25-35-20-18-34(19-21-35)15-5-4-9-27-11-6-10-26-8-2-3-14-30(26)27/h2-3,6-8,10-14,24,31H,4-5,9,15-23,25H2,1H3
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n/an/a 565n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202971
PNG
((+/-)-1-[2-(4-fluorophenyl)-2-(4-methylpiperazin-1...)
Show SMILES CN1CCN(CC1)C(CN1CCN(CCc2cccc3ccccc23)CC1)c1ccc(F)cc1 |w:7.8|
Show InChI InChI=1S/C29H37FN4/c1-31-15-21-34(22-16-31)29(26-9-11-27(30)12-10-26)23-33-19-17-32(18-20-33)14-13-25-7-4-6-24-5-2-3-8-28(24)25/h2-12,29H,13-23H2,1H3
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n/an/a 567n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202931
PNG
((+/-)-1-[2-(4-fluorophenyl)-2-(4-methylpiperazin-1...)
Show SMILES CN1CCN(CC1)C(CN1CCN(Cc2cccc3ccccc23)CC1)c1ccc(F)cc1 |w:7.8|
Show InChI InChI=1S/C28H35FN4/c1-30-13-19-33(20-14-30)28(24-9-11-26(29)12-10-24)22-32-17-15-31(16-18-32)21-25-7-4-6-23-5-2-3-8-27(23)25/h2-12,28H,13-22H2,1H3
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n/an/a 594n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50202930
PNG
((+/-)-1-(3-biphenyl-2-ylpropyl)-4-[2-(4-fluorophen...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H45FN4/c1-28(2)38-23-25-39(26-24-38)34(31-14-16-32(35)17-15-31)27-37-21-19-36(20-22-37)18-8-12-30-11-6-7-13-33(30)29-9-4-3-5-10-29/h3-7,9-11,13-17,28,34H,8,12,18-27H2,1-2H3
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n/an/a 645n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]raclopride from dopamine D2 receptor in rat striatal membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202967
PNG
((+/-)-1-[2-(3-fluorophenyl)-2-(4-methylpiperazin-1...)
Show SMILES CN1CCN(CC1)C(CN1CCN(CCCCc2cccc3ccccc23)CC1)c1cccc(F)c1 |w:7.8|
Show InChI InChI=1S/C31H41FN4/c1-33-16-22-36(23-17-33)31(28-12-7-13-29(32)24-28)25-35-20-18-34(19-21-35)15-5-4-9-27-11-6-10-26-8-2-3-14-30(26)27/h2-3,6-8,10-14,24,31H,4-5,9,15-23,25H2,1H3
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n/an/a 653n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM50202930
PNG
((+/-)-1-(3-biphenyl-2-ylpropyl)-4-[2-(4-fluorophen...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H45FN4/c1-28(2)38-23-25-39(26-24-38)34(31-14-16-32(35)17-15-31)27-37-21-19-36(20-22-37)18-8-12-30-11-6-7-13-33(30)29-9-4-3-5-10-29/h3-7,9-11,13-17,28,34H,8,12,18-27H2,1-2H3
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n/an/a 671n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]nisoxetine from NET in rat cortical membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50202924
PNG
((+/-)-1-[3-(4'-fluorobiphenyl-2-yl)propyl]-4-[2-(4...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2ccccc2-c2ccc(F)cc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-22-24-40(25-23-39)34(30-11-15-32(36)16-12-30)26-38-20-18-37(19-21-38)17-5-7-28-6-3-4-8-33(28)29-9-13-31(35)14-10-29/h3-4,6,8-16,27,34H,5,7,17-26H2,1-2H3
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n/an/a 721n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]raclopride from dopamine D2 receptor in rat striatal membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50202926
PNG
((+/-)-1-[3-(4-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2cc(F)ccc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-21-23-40(24-22-39)34(29-10-12-31(35)13-11-29)26-38-19-17-37(18-20-38)16-6-9-30-25-32(36)14-15-33(30)28-7-4-3-5-8-28/h3-5,7-8,10-15,25,27,34H,6,9,16-24,26H2,1-2H3
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n/an/a 721n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]raclopride from dopamine D2 receptor in rat striatal membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202952
PNG
((+/-)-1-methyl-4-(2-{4-[4-(1-naphthyl)butyl]pipera...)
Show SMILES CN1CCN(CC1)C(CN1CCN(CCCCc2cccc3ccccc23)CC1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C31H42N4/c1-32-18-24-35(25-19-32)31(29-12-3-2-4-13-29)26-34-22-20-33(21-23-34)17-8-7-11-28-15-9-14-27-10-5-6-16-30(27)28/h2-6,9-10,12-16,31H,7-8,11,17-26H2,1H3
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n/an/a 745n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202966
PNG
((+/-)-1-[2-biphenyl-4-yl-2-(4-methylpiperazin-1-yl...)
Show SMILES CN1CCN(CC1)C(CN1CCN(CCCCc2cccc3ccccc23)CC1)c1ccc(cc1)-c1ccccc1 |w:7.8|
Show InChI InChI=1S/C37H46N4/c1-38-22-28-41(29-23-38)37(35-19-17-32(18-20-35)31-10-3-2-4-11-31)30-40-26-24-39(25-27-40)21-8-7-13-34-15-9-14-33-12-5-6-16-36(33)34/h2-6,9-12,14-20,37H,7-8,13,21-30H2,1H3
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n/an/a 756n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202973
PNG
((+/-)-1-[2-(4-methoxyphenyl)-2-(4-methylpiperazin-...)
Show SMILES COc1ccc(cc1)C(CN1CCN(CCCCc2cccc3ccccc23)CC1)N1CCN(C)CC1 |w:8.9|
Show InChI InChI=1S/C32H44N4O/c1-33-18-24-36(25-19-33)32(29-13-15-30(37-2)16-14-29)26-35-22-20-34(21-23-35)17-6-5-9-28-11-7-10-27-8-3-4-12-31(27)28/h3-4,7-8,10-16,32H,5-6,9,17-26H2,1-2H3
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n/an/a 871n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Histamine H1 receptor


(RAT)		BDBM50202924
PNG
((+/-)-1-[3-(4'-fluorobiphenyl-2-yl)propyl]-4-[2-(4...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2ccccc2-c2ccc(F)cc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-22-24-40(25-23-39)34(30-11-15-32(36)16-12-30)26-38-20-18-37(19-21-38)17-5-7-28-6-3-4-8-33(28)29-9-13-31(35)14-10-29/h3-4,6,8-16,27,34H,5,7,17-26H2,1-2H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]pyrilamine from histamine H1 receptor in rat brain membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50202934
PNG
((+/-)-1-[3-(5-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2ccc(F)cc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-21-23-40(24-22-39)34(30-11-13-31(35)14-12-30)26-38-19-17-37(18-20-38)16-6-9-29-10-15-32(36)25-33(29)28-7-4-3-5-8-28/h3-5,7-8,10-15,25,27,34H,6,9,16-24,26H2,1-2H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]raclopride from dopamine D2 receptor in rat striatal membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Histamine H1 receptor


(RAT)		BDBM50202933
PNG
((+/-)-1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazi...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2c(C)cccc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C35H47FN4/c1-28(2)39-23-25-40(26-24-39)35(31-14-16-32(36)17-15-31)27-38-21-19-37(20-22-38)18-8-13-33-29(3)9-7-12-34(33)30-10-5-4-6-11-30/h4-7,9-12,14-17,28,35H,8,13,18-27H2,1-3H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]pyrilamine from histamine H1 receptor in rat brain membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50202941
PNG
((+/-)-1-[3-(6-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2cccc(F)c2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-22-24-40(25-23-39)33(28-13-15-31(35)16-14-28)26-38-20-18-37(19-21-38)17-7-11-30-10-6-12-32(36)34(30)29-8-4-3-5-9-29/h3-6,8-10,12-16,27,33H,7,11,17-26H2,1-2H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]raclopride from dopamine D2 receptor in rat striatal membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50202929
PNG
((+/-)-1-[3-(3-chlorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2c(Cl)cccc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44ClFN4/c1-27(2)39-22-24-40(25-23-39)34(29-13-15-30(36)16-14-29)26-38-20-18-37(19-21-38)17-7-11-32-31(10-6-12-33(32)35)28-8-4-3-5-9-28/h3-6,8-10,12-16,27,34H,7,11,17-26H2,1-2H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]raclopride from dopamine D2 receptor in rat striatal membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Histamine H1 receptor


(RAT)		BDBM50202947
PNG
((+/-)-1-[3-(3-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2c(F)cccc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-22-24-40(25-23-39)34(29-13-15-30(35)16-14-29)26-38-20-18-37(19-21-38)17-7-11-32-31(10-6-12-33(32)36)28-8-4-3-5-9-28/h3-6,8-10,12-16,27,34H,7,11,17-26H2,1-2H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]pyrilamine from histamine H1 receptor in rat brain membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Histamine H1 receptor


(RAT)		BDBM50202941
PNG
((+/-)-1-[3-(6-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2cccc(F)c2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-22-24-40(25-23-39)33(28-13-15-31(35)16-14-28)26-38-20-18-37(19-21-38)17-7-11-30-10-6-12-32(36)34(30)29-8-4-3-5-9-29/h3-6,8-10,12-16,27,33H,7,11,17-26H2,1-2H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]pyrilamine from histamine H1 receptor in rat brain membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Histamine H1 receptor


(RAT)		BDBM50202929
PNG
((+/-)-1-[3-(3-chlorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2c(Cl)cccc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44ClFN4/c1-27(2)39-22-24-40(25-23-39)34(29-13-15-30(36)16-14-29)26-38-20-18-37(19-21-38)17-7-11-32-31(10-6-12-33(32)35)28-8-4-3-5-9-28/h3-6,8-10,12-16,27,34H,7,11,17-26H2,1-2H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]pyrilamine from histamine H1 receptor in rat brain membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Histamine H1 receptor


(RAT)		BDBM50202930
PNG
((+/-)-1-(3-biphenyl-2-ylpropyl)-4-[2-(4-fluorophen...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H45FN4/c1-28(2)38-23-25-39(26-24-38)34(31-14-16-32(35)17-15-31)27-37-21-19-36(20-22-37)18-8-12-30-11-6-7-13-33(30)29-9-4-3-5-10-29/h3-7,9-11,13-17,28,34H,8,12,18-27H2,1-2H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]pyrilamine from histamine H1 receptor in rat brain membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Histamine H1 receptor


(RAT)		BDBM50202934
PNG
((+/-)-1-[3-(5-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2ccc(F)cc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-21-23-40(24-22-39)34(30-11-13-31(35)14-12-30)26-38-19-17-37(18-20-38)16-6-9-29-10-15-32(36)25-33(29)28-7-4-3-5-8-28/h3-5,7-8,10-15,25,27,34H,6,9,16-24,26H2,1-2H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]pyrilamine from histamine H1 receptor in rat brain membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50202938
PNG
((+/-)-1-[3-(3'-fluorobiphenyl-2-yl)propyl]-4-[2-(4...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2ccccc2-c2cccc(F)c2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-21-23-40(24-22-39)34(29-12-14-31(35)15-13-29)26-38-19-17-37(18-20-38)16-6-9-28-7-3-4-11-33(28)30-8-5-10-32(36)25-30/h3-5,7-8,10-15,25,27,34H,6,9,16-24,26H2,1-2H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]raclopride from dopamine D2 receptor in rat striatal membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50202933
PNG
((+/-)-1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazi...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2c(C)cccc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C35H47FN4/c1-28(2)39-23-25-40(26-24-39)35(31-14-16-32(36)17-15-31)27-38-21-19-37(20-22-38)18-8-13-33-29(3)9-7-12-34(33)30-10-5-4-6-11-30/h4-7,9-12,14-17,28,35H,8,13,18-27H2,1-3H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]raclopride from dopamine D2 receptor in rat striatal membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Histamine H1 receptor


(RAT)		BDBM50202926
PNG
((+/-)-1-[3-(4-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2cc(F)ccc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-21-23-40(24-22-39)34(29-10-12-31(35)13-11-29)26-38-19-17-37(18-20-38)16-6-9-30-25-32(36)14-15-33(30)28-7-4-3-5-8-28/h3-5,7-8,10-15,25,27,34H,6,9,16-24,26H2,1-2H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]pyrilamine from histamine H1 receptor in rat brain membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Histamine H1 receptor


(RAT)		BDBM50202938
PNG
((+/-)-1-[3-(3'-fluorobiphenyl-2-yl)propyl]-4-[2-(4...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2ccccc2-c2cccc(F)c2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-21-23-40(24-22-39)34(29-12-14-31(35)15-13-29)26-38-19-17-37(18-20-38)16-6-9-28-7-3-4-11-33(28)30-8-5-10-32(36)25-30/h3-5,7-8,10-15,25,27,34H,6,9,16-24,26H2,1-2H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]pyrilamine from histamine H1 receptor in rat brain membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50202947
PNG
((+/-)-1-[3-(3-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2c(F)cccc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-22-24-40(25-23-39)34(29-13-15-30(35)16-14-29)26-38-20-18-37(19-21-38)17-7-11-32-31(10-6-12-33(32)36)28-8-4-3-5-9-28/h3-6,8-10,12-16,27,34H,7,11,17-26H2,1-2H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]raclopride from dopamine D2 receptor in rat striatal membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50202926
PNG
((+/-)-1-[3-(4-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2cc(F)ccc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-21-23-40(24-22-39)34(29-10-12-31(35)13-11-29)26-38-19-17-37(18-20-38)16-6-9-30-25-32(36)14-15-33(30)28-7-4-3-5-8-28/h3-5,7-8,10-15,25,27,34H,6,9,16-24,26H2,1-2H3
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n/an/a 1.17E+3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]paroxatine from SET in rat cortical membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202977
PNG
((+/-)-1-[2-(4-fluorophenyl)-2-(4-methylpiperazin-1...)
Show SMILES CN1CCN(CC1)C(CN1CCN(CCCc2ccc3ccccc3c2)CC1)c1ccc(F)cc1 |w:7.8|
Show InChI InChI=1S/C30H39FN4/c1-32-15-21-35(22-16-32)30(27-10-12-29(31)13-11-27)24-34-19-17-33(18-20-34)14-4-5-25-8-9-26-6-2-3-7-28(26)23-25/h2-3,6-13,23,30H,4-5,14-22,24H2,1H3
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n/an/a 1.19E+3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202954
PNG
((+/-)-1-[2-(4-fluorophenyl)-2-(4-methylpiperazin-1...)
Show SMILES CN1CCN(CC1)C(CN1CCN(Cc2ccc3ccccc3c2)CC1)c1ccc(F)cc1 |w:7.8|
Show InChI InChI=1S/C28H35FN4/c1-30-12-18-33(19-13-30)28(25-8-10-27(29)11-9-25)22-32-16-14-31(15-17-32)21-23-6-7-24-4-2-3-5-26(24)20-23/h2-11,20,28H,12-19,21-22H2,1H3
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n/an/a 1.25E+3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50202929
PNG
((+/-)-1-[3-(3-chlorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2c(Cl)cccc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44ClFN4/c1-27(2)39-22-24-40(25-23-39)34(29-13-15-30(36)16-14-29)26-38-20-18-37(19-21-38)17-7-11-32-31(10-6-12-33(32)35)28-8-4-3-5-9-28/h3-6,8-10,12-16,27,34H,7,11,17-26H2,1-2H3
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n/an/a 1.29E+3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]paroxatine from SET in rat cortical membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50202924
PNG
((+/-)-1-[3-(4'-fluorobiphenyl-2-yl)propyl]-4-[2-(4...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2ccccc2-c2ccc(F)cc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-22-24-40(25-23-39)34(30-11-15-32(36)16-12-30)26-38-20-18-37(19-21-38)17-5-7-28-6-3-4-8-33(28)29-9-13-31(35)14-10-29/h3-4,6,8-16,27,34H,5,7,17-26H2,1-2H3
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n/an/a 1.34E+3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]paroxatine from SET in rat cortical membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50202934
PNG
((+/-)-1-[3-(5-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2ccc(F)cc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-21-23-40(24-22-39)34(30-11-13-31(35)14-12-30)26-38-19-17-37(18-20-38)16-6-9-29-10-15-32(36)25-33(29)28-7-4-3-5-8-28/h3-5,7-8,10-15,25,27,34H,6,9,16-24,26H2,1-2H3
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n/an/a 1.37E+3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]paroxatine from SET in rat cortical membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50202947
PNG
((+/-)-1-[3-(3-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2c(F)cccc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-22-24-40(25-23-39)34(29-13-15-30(35)16-14-29)26-38-20-18-37(19-21-38)17-7-11-32-31(10-6-12-33(32)36)28-8-4-3-5-9-28/h3-6,8-10,12-16,27,34H,7,11,17-26H2,1-2H3
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n/an/a 1.46E+3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]paroxatine from SET in rat cortical membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM50202929
PNG
((+/-)-1-[3-(3-chlorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2c(Cl)cccc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44ClFN4/c1-27(2)39-22-24-40(25-23-39)34(29-13-15-30(36)16-14-29)26-38-20-18-37(19-21-38)17-7-11-32-31(10-6-12-33(32)35)28-8-4-3-5-9-28/h3-6,8-10,12-16,27,34H,7,11,17-26H2,1-2H3
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n/an/a 1.77E+3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]nisoxetine from NET in rat cortical membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM50202934
PNG
((+/-)-1-[3-(5-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2ccc(F)cc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-21-23-40(24-22-39)34(30-11-13-31(35)14-12-30)26-38-19-17-37(18-20-38)16-6-9-29-10-15-32(36)25-33(29)28-7-4-3-5-8-28/h3-5,7-8,10-15,25,27,34H,6,9,16-24,26H2,1-2H3
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n/an/a 1.85E+3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]nisoxetine from NET in rat cortical membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202962
PNG
((+/-)-1-[2-(4-fluorophenyl)-2-(4-methylpiperazin-1...)
Show SMILES CN1CCN(CC1)C(CN1CCN(CCc2ccc3ccccc3c2)CC1)c1ccc(F)cc1 |w:7.8|
Show InChI InChI=1S/C29H37FN4/c1-31-14-20-34(21-15-31)29(26-8-10-28(30)11-9-26)23-33-18-16-32(17-19-33)13-12-24-6-7-25-4-2-3-5-27(25)22-24/h2-11,22,29H,12-21,23H2,1H3
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n/an/a 1.87E+3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50202938
PNG
((+/-)-1-[3-(3'-fluorobiphenyl-2-yl)propyl]-4-[2-(4...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2ccccc2-c2cccc(F)c2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-21-23-40(24-22-39)34(29-12-14-31(35)15-13-29)26-38-19-17-37(18-20-38)16-6-9-28-7-3-4-11-33(28)30-8-5-10-32(36)25-30/h3-5,7-8,10-15,25,27,34H,6,9,16-24,26H2,1-2H3
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n/an/a 2.11E+3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]paroxatine from SET in rat cortical membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202960
PNG
((+/-)-1-[2-(2-bromophenyl)-2-(4-methylpiperazin-1-...)
Show SMILES CN1CCN(CC1)C(CN1CCN(CCCCc2cccc3ccccc23)CC1)c1ccccc1Br |w:7.8|
Show InChI InChI=1S/C31H41BrN4/c1-33-17-23-36(24-18-33)31(29-14-4-5-15-30(29)32)25-35-21-19-34(20-22-35)16-7-6-10-27-12-8-11-26-9-2-3-13-28(26)27/h2-5,8-9,11-15,31H,6-7,10,16-25H2,1H3
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n/an/a 2.30E+3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM50202933
PNG
((+/-)-1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazi...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2c(C)cccc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C35H47FN4/c1-28(2)39-23-25-40(26-24-39)35(31-14-16-32(36)17-15-31)27-38-21-19-37(20-22-38)18-8-13-33-29(3)9-7-12-34(33)30-10-5-4-6-11-30/h4-7,9-12,14-17,28,35H,8,13,18-27H2,1-3H3
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n/an/a 2.40E+3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]nisoxetine from NET in rat cortical membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Transporter


(Rattus norvegicus)		BDBM50202941
PNG
((+/-)-1-[3-(6-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2cccc(F)c2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-22-24-40(25-23-39)33(28-13-15-31(35)16-14-28)26-38-20-18-37(19-21-38)17-7-11-30-10-6-12-32(36)34(30)29-8-4-3-5-9-29/h3-6,8-10,12-16,27,33H,7,11,17-26H2,1-2H3
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n/an/a 2.83E+3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]nisoxetine from NET in rat cortical membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50202930
PNG
((+/-)-1-(3-biphenyl-2-ylpropyl)-4-[2-(4-fluorophen...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H45FN4/c1-28(2)38-23-25-39(26-24-38)34(31-14-16-32(35)17-15-31)27-37-21-19-36(20-22-37)18-8-12-30-11-6-7-13-33(30)29-9-4-3-5-10-29/h3-7,9-11,13-17,28,34H,8,12,18-27H2,1-2H3
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n/an/a 3.13E+3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]paroxatine from SET in rat cortical membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50202941
PNG
((+/-)-1-[3-(6-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2cccc(F)c2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-22-24-40(25-23-39)33(28-13-15-31(35)16-14-28)26-38-20-18-37(19-21-38)17-7-11-30-10-6-12-32(36)34(30)29-8-4-3-5-9-29/h3-6,8-10,12-16,27,33H,7,11,17-26H2,1-2H3
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n/an/a 3.40E+3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]paroxatine from SET in rat cortical membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202964
PNG
((+/-)-4-(1-(4-methylpiperazin-1-yl)-2-{4-[4-(1-nap...)
Show SMILES CN1CCN(CC1)C(CN1CCN(CCCCc2cccc3ccccc23)CC1)c1ccc(N)cc1 |w:7.8|
Show InChI InChI=1S/C31H43N5/c1-33-17-23-36(24-18-33)31(28-12-14-29(32)15-13-28)25-35-21-19-34(20-22-35)16-5-4-8-27-10-6-9-26-7-2-3-11-30(26)27/h2-3,6-7,9-15,31H,4-5,8,16-25,32H2,1H3
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n/an/a 3.59E+3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))		BDBM50202933
PNG
((+/-)-1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazi...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2c(C)cccc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C35H47FN4/c1-28(2)39-23-25-40(26-24-39)35(31-14-16-32(36)17-15-31)27-38-21-19-37(20-22-38)18-8-13-33-29(3)9-7-12-34(33)30-10-5-4-6-11-30/h4-7,9-12,14-17,28,35H,8,13,18-27H2,1-3H3
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n/an/a 4.96E+3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]paroxatine from SET in rat cortical membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50202934
PNG
((+/-)-1-[3-(5-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2ccc(F)cc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-21-23-40(24-22-39)34(30-11-13-31(35)14-12-30)26-38-19-17-37(18-20-38)16-6-9-29-10-15-32(36)25-33(29)28-7-4-3-5-8-28/h3-5,7-8,10-15,25,27,34H,6,9,16-24,26H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from delta opiate receptor in rat brain membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50202941
PNG
((+/-)-1-[3-(6-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2cccc(F)c2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-22-24-40(25-23-39)33(28-13-15-31(35)16-14-28)26-38-20-18-37(19-21-38)17-7-11-30-10-6-12-32(36)34(30)29-8-4-3-5-9-29/h3-6,8-10,12-16,27,33H,7,11,17-26H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from delta opiate receptor in rat brain membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50202929
PNG
((+/-)-1-[3-(3-chlorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2c(Cl)cccc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44ClFN4/c1-27(2)39-22-24-40(25-23-39)34(29-13-15-30(36)16-14-29)26-38-20-18-37(19-21-38)17-7-11-32-31(10-6-12-33(32)35)28-8-4-3-5-9-28/h3-6,8-10,12-16,27,34H,7,11,17-26H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from delta opiate receptor in rat brain membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50202933
PNG
((+/-)-1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazi...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2c(C)cccc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C35H47FN4/c1-28(2)39-23-25-40(26-24-39)35(31-14-16-32(36)17-15-31)27-38-21-19-37(20-22-38)18-8-13-33-29(3)9-7-12-34(33)30-10-5-4-6-11-30/h4-7,9-12,14-17,28,35H,8,13,18-27H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opiate receptor in rat brain membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50202924
PNG
((+/-)-1-[3-(4'-fluorobiphenyl-2-yl)propyl]-4-[2-(4...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2ccccc2-c2ccc(F)cc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-22-24-40(25-23-39)34(30-11-15-32(36)16-12-30)26-38-20-18-37(19-21-38)17-5-7-28-6-3-4-8-33(28)29-9-13-31(35)14-10-29/h3-4,6,8-16,27,34H,5,7,17-26H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from delta opiate receptor in rat brain membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50202930
PNG
((+/-)-1-(3-biphenyl-2-ylpropyl)-4-[2-(4-fluorophen...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H45FN4/c1-28(2)38-23-25-39(26-24-38)34(31-14-16-32(35)17-15-31)27-37-21-19-36(20-22-37)18-8-12-30-11-6-7-13-33(30)29-9-4-3-5-10-29/h3-7,9-11,13-17,28,34H,8,12,18-27H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from delta opiate receptor in rat brain membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50202926
PNG
((+/-)-1-[3-(4-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2cc(F)ccc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-21-23-40(24-22-39)34(29-10-12-31(35)13-11-29)26-38-19-17-37(18-20-38)16-6-9-30-25-32(36)14-15-33(30)28-7-4-3-5-8-28/h3-5,7-8,10-15,25,27,34H,6,9,16-24,26H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opiate receptor in rat brain membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50202930
PNG
((+/-)-1-(3-biphenyl-2-ylpropyl)-4-[2-(4-fluorophen...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2ccccc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H45FN4/c1-28(2)38-23-25-39(26-24-38)34(31-14-16-32(35)17-15-31)27-37-21-19-36(20-22-37)18-8-12-30-11-6-7-13-33(30)29-9-4-3-5-10-29/h3-7,9-11,13-17,28,34H,8,12,18-27H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opiate receptor in rat brain membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50202934
PNG
((+/-)-1-[3-(5-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2ccc(F)cc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-21-23-40(24-22-39)34(30-11-13-31(35)14-12-30)26-38-19-17-37(18-20-38)16-6-9-29-10-15-32(36)25-33(29)28-7-4-3-5-8-28/h3-5,7-8,10-15,25,27,34H,6,9,16-24,26H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opiate receptor in rat brain membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50202938
PNG
((+/-)-1-[3-(3'-fluorobiphenyl-2-yl)propyl]-4-[2-(4...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2ccccc2-c2cccc(F)c2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-21-23-40(24-22-39)34(29-12-14-31(35)15-13-29)26-38-19-17-37(18-20-38)16-6-9-28-7-3-4-11-33(28)30-8-5-10-32(36)25-30/h3-5,7-8,10-15,25,27,34H,6,9,16-24,26H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from delta opiate receptor in rat brain membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50202947
PNG
((+/-)-1-[3-(3-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2c(F)cccc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-22-24-40(25-23-39)34(29-13-15-30(35)16-14-29)26-38-20-18-37(19-21-38)17-7-11-32-31(10-6-12-33(32)36)28-8-4-3-5-9-28/h3-6,8-10,12-16,27,34H,7,11,17-26H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opiate receptor in rat brain membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50202924
PNG
((+/-)-1-[3-(4'-fluorobiphenyl-2-yl)propyl]-4-[2-(4...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2ccccc2-c2ccc(F)cc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-22-24-40(25-23-39)34(30-11-15-32(36)16-12-30)26-38-20-18-37(19-21-38)17-5-7-28-6-3-4-8-33(28)29-9-13-31(35)14-10-29/h3-4,6,8-16,27,34H,5,7,17-26H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opiate receptor in rat brain membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50202941
PNG
((+/-)-1-[3-(6-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2cccc(F)c2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-22-24-40(25-23-39)33(28-13-15-31(35)16-14-28)26-38-20-18-37(19-21-38)17-7-11-30-10-6-12-32(36)34(30)29-8-4-3-5-9-29/h3-6,8-10,12-16,27,33H,7,11,17-26H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opiate receptor in rat brain membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50202926
PNG
((+/-)-1-[3-(4-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2cc(F)ccc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-21-23-40(24-22-39)34(29-10-12-31(35)13-11-29)26-38-19-17-37(18-20-38)16-6-9-30-25-32(36)14-15-33(30)28-7-4-3-5-8-28/h3-5,7-8,10-15,25,27,34H,6,9,16-24,26H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from delta opiate receptor in rat brain membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50202929
PNG
((+/-)-1-[3-(3-chlorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2c(Cl)cccc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44ClFN4/c1-27(2)39-22-24-40(25-23-39)34(29-13-15-30(36)16-14-29)26-38-20-18-37(19-21-38)17-7-11-32-31(10-6-12-33(32)35)28-8-4-3-5-9-28/h3-6,8-10,12-16,27,34H,7,11,17-26H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opiate receptor in rat brain membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50202947
PNG
((+/-)-1-[3-(3-fluorobiphenyl-2-yl)propyl]-4-[2-(4-...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2c(F)cccc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-22-24-40(25-23-39)34(29-13-15-30(35)16-14-29)26-38-20-18-37(19-21-38)17-7-11-32-31(10-6-12-33(32)36)28-8-4-3-5-9-28/h3-6,8-10,12-16,27,34H,7,11,17-26H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from delta opiate receptor in rat brain membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50202933
PNG
((+/-)-1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazi...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2c(C)cccc2-c2ccccc2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C35H47FN4/c1-28(2)39-23-25-40(26-24-39)35(31-14-16-32(36)17-15-31)27-38-21-19-37(20-22-38)18-8-13-33-29(3)9-7-12-34(33)30-10-5-4-6-11-30/h4-7,9-12,14-17,28,35H,8,13,18-27H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from delta opiate receptor in rat brain membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50202938
PNG
((+/-)-1-[3-(3'-fluorobiphenyl-2-yl)propyl]-4-[2-(4...)
Show SMILES CC(C)N1CCN(CC1)C(CN1CCN(CCCc2ccccc2-c2cccc(F)c2)CC1)c1ccc(F)cc1 |w:9.10|
Show InChI InChI=1S/C34H44F2N4/c1-27(2)39-21-23-40(24-22-39)34(29-12-14-31(35)15-13-29)26-38-19-17-37(18-20-38)16-6-9-28-7-3-4-11-33(28)30-8-5-10-32(36)25-30/h3-5,7-8,10-15,25,27,34H,6,9,16-24,26H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opiate receptor in rat brain membranes

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50202972
PNG
((+/-)-1-(1-(4-fluorophenyl)-2-{4-[4-(1-naphthyl)bu...)
Show SMILES Fc1ccc(cc1)C(CN1CCN(CCCCc2cccc3ccccc23)CC1)N1CCN(CC1)c1ccccc1 |w:7.8|
Show InChI InChI=1S/C36H43FN4/c37-33-18-16-32(17-19-33)36(41-27-25-40(26-28-41)34-13-2-1-3-14-34)29-39-23-21-38(22-24-39)20-7-6-10-31-12-8-11-30-9-4-5-15-35(30)31/h1-5,8-9,11-19,36H,6-7,10,20-29H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]Nle4-D-Phe7-alpha-MSH from human MC4 receptor expressed in COS1 cells

Bioorg Med Chem 15: 1989-2005 (2007)


Article DOI: 10.1016/j.bmc.2006.12.039
BindingDB Entry DOI: 10.7270/Q2C53KHN
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%