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PubMed code 17292606

Compile data set for download or QSAR
Found 91 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205086
PNG
(2-((3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1cccc(CN(CC(O)=O)Cc2cccc3ccccc23)c1)-c1ccccc1
Show InChI InChI=1S/C32H30N2O4/c1-23-30(33-32(38-23)26-11-3-2-4-12-26)17-18-37-28-15-7-9-24(19-28)20-34(22-31(35)36)21-27-14-8-13-25-10-5-6-16-29(25)27/h2-16,19H,17-18,20-22H2,1H3,(H,35,36)
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n/an/a 34n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARalpha receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205080
PNG
(2-((3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1cccc(CN(CCCc2ccccc2)CC(O)=O)c1)-c1ccccc1
Show InChI InChI=1S/C30H32N2O4/c1-23-28(31-30(36-23)26-14-6-3-7-15-26)17-19-35-27-16-8-12-25(20-27)21-32(22-29(33)34)18-9-13-24-10-4-2-5-11-24/h2-8,10-12,14-16,20H,9,13,17-19,21-22H2,1H3,(H,33,34)
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n/an/a 51n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARalpha receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205086
PNG
(2-((3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1cccc(CN(CC(O)=O)Cc2cccc3ccccc23)c1)-c1ccccc1
Show InChI InChI=1S/C32H30N2O4/c1-23-30(33-32(38-23)26-11-3-2-4-12-26)17-18-37-28-15-7-9-24(19-28)20-34(22-31(35)36)21-27-14-8-13-25-10-5-6-16-29(25)27/h2-16,19H,17-18,20-22H2,1H3,(H,35,36)
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n/an/a 67n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARgamma receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205081
PNG
(2-((3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1cccc(CN(CCc2ccccc2)CC(O)=O)c1)-c1ccccc1
Show InChI InChI=1S/C29H30N2O4/c1-22-27(30-29(35-22)25-12-6-3-7-13-25)16-18-34-26-14-8-11-24(19-26)20-31(21-28(32)33)17-15-23-9-4-2-5-10-23/h2-14,19H,15-18,20-21H2,1H3,(H,32,33)
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n/an/a 75n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARalpha receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205089
PNG
(2-((3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1cccc(CN(CC(O)=O)Cc2cccc(Oc3ccccc3)c2)c1)-c1ccccc1
Show InChI InChI=1S/C34H32N2O5/c1-25-32(35-34(40-25)28-12-4-2-5-13-28)18-19-39-30-16-8-10-26(20-30)22-36(24-33(37)38)23-27-11-9-17-31(21-27)41-29-14-6-3-7-15-29/h2-17,20-21H,18-19,22-24H2,1H3,(H,37,38)
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n/an/a 83n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARalpha receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205072
PNG
(2-((3-phenoxybenzyl)(4-(2-(5-methyl-2-phenyloxazol...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CC(O)=O)Cc2cccc(Oc3ccccc3)c2)cc1)-c1ccccc1
Show InChI InChI=1S/C34H32N2O5/c1-25-32(35-34(40-25)28-10-4-2-5-11-28)19-20-39-29-17-15-26(16-18-29)22-36(24-33(37)38)23-27-9-8-14-31(21-27)41-30-12-6-3-7-13-30/h2-18,21H,19-20,22-24H2,1H3,(H,37,38)
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n/an/a 88n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARalpha receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205075
PNG
(2-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CC(O)=O)Cc2ccccn2)cc1)-c1ccccc1
Show InChI InChI=1S/C27H27N3O4/c1-20-25(29-27(34-20)22-7-3-2-4-8-22)14-16-33-24-12-10-21(11-13-24)17-30(19-26(31)32)18-23-9-5-6-15-28-23/h2-13,15H,14,16-19H2,1H3,(H,31,32)
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n/an/a 90n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARalpha receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205088
PNG
(2-((3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1cccc(CN(CC(O)=O)Cc2ccccc2)c1)-c1ccccc1
Show InChI InChI=1S/C28H28N2O4/c1-21-26(29-28(34-21)24-12-6-3-7-13-24)15-16-33-25-14-8-11-23(17-25)19-30(20-27(31)32)18-22-9-4-2-5-10-22/h2-14,17H,15-16,18-20H2,1H3,(H,31,32)
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n/an/a 90n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARalpha receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205089
PNG
(2-((3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1cccc(CN(CC(O)=O)Cc2cccc(Oc3ccccc3)c2)c1)-c1ccccc1
Show InChI InChI=1S/C34H32N2O5/c1-25-32(35-34(40-25)28-12-4-2-5-13-28)18-19-39-30-16-8-10-26(20-30)22-36(24-33(37)38)23-27-11-9-17-31(21-27)41-29-14-6-3-7-15-29/h2-17,20-21H,18-19,22-24H2,1H3,(H,37,38)
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n/an/a 110n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARgamma receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205079
PNG
(2-((3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1cccc(CN(CC(O)=O)Cc2ccc(Oc3ccccc3)cc2)c1)-c1ccccc1
Show InChI InChI=1S/C34H32N2O5/c1-25-32(35-34(40-25)28-10-4-2-5-11-28)19-20-39-31-14-8-9-27(21-31)23-36(24-33(37)38)22-26-15-17-30(18-16-26)41-29-12-6-3-7-13-29/h2-18,21H,19-20,22-24H2,1H3,(H,37,38)
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n/an/a 110n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARalpha receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205081
PNG
(2-((3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1cccc(CN(CCc2ccccc2)CC(O)=O)c1)-c1ccccc1
Show InChI InChI=1S/C29H30N2O4/c1-22-27(30-29(35-22)25-12-6-3-7-13-25)16-18-34-26-14-8-11-24(19-26)20-31(21-28(32)33)17-15-23-9-4-2-5-10-23/h2-14,19H,15-18,20-21H2,1H3,(H,32,33)
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n/an/a 134n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARgamma receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205074
PNG
(2-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CC(O)=O)Cc2cccc3ccccc23)cc1)-c1ccccc1
Show InChI InChI=1S/C32H30N2O4/c1-23-30(33-32(38-23)26-9-3-2-4-10-26)18-19-37-28-16-14-24(15-17-28)20-34(22-31(35)36)21-27-12-7-11-25-8-5-6-13-29(25)27/h2-17H,18-22H2,1H3,(H,35,36)
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n/an/a 140n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARalpha receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205078
PNG
(2-((3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1cccc(CN(CC(O)=O)Cc2ccc3ccccc3c2)c1)-c1ccccc1
Show InChI InChI=1S/C32H30N2O4/c1-23-30(33-32(38-23)27-10-3-2-4-11-27)16-17-37-29-13-7-8-24(19-29)20-34(22-31(35)36)21-25-14-15-26-9-5-6-12-28(26)18-25/h2-15,18-19H,16-17,20-22H2,1H3,(H,35,36)
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n/an/a 145n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARgamma receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205078
PNG
(2-((3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1cccc(CN(CC(O)=O)Cc2ccc3ccccc3c2)c1)-c1ccccc1
Show InChI InChI=1S/C32H30N2O4/c1-23-30(33-32(38-23)27-10-3-2-4-11-27)16-17-37-29-13-7-8-24(19-29)20-34(22-31(35)36)21-25-14-15-26-9-5-6-12-28(26)18-25/h2-15,18-19H,16-17,20-22H2,1H3,(H,35,36)
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n/an/a 149n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARalpha receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205083
PNG
(2-((3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1cccc(CN(CC(O)=O)Cc2ccc(OCc3ccccc3)cc2)c1)-c1ccccc1
Show InChI InChI=1S/C35H34N2O5/c1-26-33(36-35(42-26)30-12-6-3-7-13-30)19-20-40-32-14-8-11-29(21-32)23-37(24-34(38)39)22-27-15-17-31(18-16-27)41-25-28-9-4-2-5-10-28/h2-18,21H,19-20,22-25H2,1H3,(H,38,39)
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n/an/a 183n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARgamma receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50085044
PNG
((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Show SMILES Cc1oc(nc1CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(O)=O)cc1)-c1ccccc1
Show InChI InChI=1S/C34H30N2O5/c1-23-29(36-33(41-23)26-12-6-3-7-13-26)20-21-40-27-18-16-24(17-19-27)22-31(34(38)39)35-30-15-9-8-14-28(30)32(37)25-10-4-2-5-11-25/h2-19,31,35H,20-22H2,1H3,(H,38,39)/t31-/m0/s1
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n/an/a 217n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARgamma receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205073
PNG
(2-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CC(O)=O)Cc2ccc(Oc3ccccc3)cc2)cc1)-c1ccccc1
Show InChI InChI=1S/C34H32N2O5/c1-25-32(35-34(40-25)28-8-4-2-5-9-28)20-21-39-29-16-12-26(13-17-29)22-36(24-33(37)38)23-27-14-18-31(19-15-27)41-30-10-6-3-7-11-30/h2-19H,20-24H2,1H3,(H,37,38)
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n/an/a 227n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARgamma receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205079
PNG
(2-((3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1cccc(CN(CC(O)=O)Cc2ccc(Oc3ccccc3)cc2)c1)-c1ccccc1
Show InChI InChI=1S/C34H32N2O5/c1-25-32(35-34(40-25)28-10-4-2-5-11-28)19-20-39-31-14-8-9-27(21-31)23-36(24-33(37)38)22-26-15-17-30(18-16-26)41-29-12-6-3-7-13-29/h2-18,21H,19-20,22-24H2,1H3,(H,37,38)
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n/an/a 230n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARgamma receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205088
PNG
(2-((3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1cccc(CN(CC(O)=O)Cc2ccccc2)c1)-c1ccccc1
Show InChI InChI=1S/C28H28N2O4/c1-21-26(29-28(34-21)24-12-6-3-7-13-24)15-16-33-25-14-8-11-23(17-25)19-30(20-27(31)32)18-22-9-4-2-5-10-22/h2-14,17H,15-16,18-20H2,1H3,(H,31,32)
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n/an/a 240n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARgamma receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205076
PNG
(2-(((1H-indol-2-yl)methyl)(3-(2-(5-methyl-2-phenyl...)
Show SMILES Cc1oc(nc1CCOc1cccc(CN(CC(O)=O)Cc2cc3ccccc3[nH]2)c1)-c1ccccc1
Show InChI InChI=1S/C30H29N3O4/c1-21-27(32-30(37-21)23-9-3-2-4-10-23)14-15-36-26-12-7-8-22(16-26)18-33(20-29(34)35)19-25-17-24-11-5-6-13-28(24)31-25/h2-13,16-17,31H,14-15,18-20H2,1H3,(H,34,35)
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n/an/a 246n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARalpha receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM28681
PNG
(5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)...)
Show SMILES CN(CCOc1ccc(Cc2sc(=O)[nH]c2O)cc1)c1ccccn1
Show InChI InChI=1S/C18H19N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,22H,10-12H2,1H3,(H,20,23)
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n/an/a 256n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARgamma receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205087
PNG
(2-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CC(O)=O)Cc2ccc(o2)-c2ccccc2Cl)cc1)-c1ccccc1
Show InChI InChI=1S/C32H29ClN2O5/c1-22-29(34-32(39-22)24-7-3-2-4-8-24)17-18-38-25-13-11-23(12-14-25)19-35(21-31(36)37)20-26-15-16-30(40-26)27-9-5-6-10-28(27)33/h2-16H,17-21H2,1H3,(H,36,37)
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n/an/a 280n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARgamma receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205085
PNG
(2-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CC(O)=O)Cc2ccc(OCc3ccccc3)cc2)cc1)-c1ccccc1
Show InChI InChI=1S/C35H34N2O5/c1-26-33(36-35(42-26)30-10-6-3-7-11-30)20-21-40-31-16-12-27(13-17-31)22-37(24-34(38)39)23-28-14-18-32(19-15-28)41-25-29-8-4-2-5-9-29/h2-19H,20-25H2,1H3,(H,38,39)
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n/an/a 284n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARgamma receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205090
PNG
((2S)-2-(4-[2-(3-[2,4-DIFLUOROPHENYL]-1-HEPTYLUREID...)
Show SMILES CCCCCCCN(CCc1ccc(O[C@@](C)(CC)C(O)=O)cc1)C(=O)Nc1ccc(F)cc1F
Show InChI InChI=1S/C27H36F2N2O4/c1-4-6-7-8-9-17-31(26(34)30-24-15-12-21(28)19-23(24)29)18-16-20-10-13-22(14-11-20)35-27(3,5-2)25(32)33/h10-15,19H,4-9,16-18H2,1-3H3,(H,30,34)(H,32,33)/t27-/m0/s1
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n/an/a 348n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARalpha receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205083
PNG
(2-((3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1cccc(CN(CC(O)=O)Cc2ccc(OCc3ccccc3)cc2)c1)-c1ccccc1
Show InChI InChI=1S/C35H34N2O5/c1-26-33(36-35(42-26)30-12-6-3-7-13-30)19-20-40-32-14-8-11-29(21-32)23-37(24-34(38)39)22-27-15-17-31(18-16-27)41-25-28-9-4-2-5-10-28/h2-18,21H,19-20,22-25H2,1H3,(H,38,39)
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n/an/a 387n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARalpha receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205072
PNG
(2-((3-phenoxybenzyl)(4-(2-(5-methyl-2-phenyloxazol...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CC(O)=O)Cc2cccc(Oc3ccccc3)c2)cc1)-c1ccccc1
Show InChI InChI=1S/C34H32N2O5/c1-25-32(35-34(40-25)28-10-4-2-5-11-28)19-20-39-29-17-15-26(16-18-29)22-36(24-33(37)38)23-27-9-8-14-31(21-27)41-30-12-6-3-7-13-30/h2-18,21H,19-20,22-24H2,1H3,(H,37,38)
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n/an/a 480n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARgamma receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205076
PNG
(2-(((1H-indol-2-yl)methyl)(3-(2-(5-methyl-2-phenyl...)
Show SMILES Cc1oc(nc1CCOc1cccc(CN(CC(O)=O)Cc2cc3ccccc3[nH]2)c1)-c1ccccc1
Show InChI InChI=1S/C30H29N3O4/c1-21-27(32-30(37-21)23-9-3-2-4-10-23)14-15-36-26-12-7-8-22(16-26)18-33(20-29(34)35)19-25-17-24-11-5-6-13-28(24)31-25/h2-13,16-17,31H,14-15,18-20H2,1H3,(H,34,35)
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n/an/a 540n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARgamma receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205090
PNG
((2S)-2-(4-[2-(3-[2,4-DIFLUOROPHENYL]-1-HEPTYLUREID...)
Show SMILES CCCCCCCN(CCc1ccc(O[C@@](C)(CC)C(O)=O)cc1)C(=O)Nc1ccc(F)cc1F
Show InChI InChI=1S/C27H36F2N2O4/c1-4-6-7-8-9-17-31(26(34)30-24-15-12-21(28)19-23(24)29)18-16-20-10-13-22(14-11-20)35-27(3,5-2)25(32)33/h10-15,19H,4-9,16-18H2,1-3H3,(H,30,34)(H,32,33)/t27-/m0/s1
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n/an/a 670n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARgamma receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205082
PNG
(2-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CC(O)=O)Cc2ccc3ccccc3c2)cc1)-c1ccccc1
Show InChI InChI=1S/C32H30N2O4/c1-23-30(33-32(38-23)27-8-3-2-4-9-27)17-18-37-29-15-12-24(13-16-29)20-34(22-31(35)36)21-25-11-14-26-7-5-6-10-28(26)19-25/h2-16,19H,17-18,20-22H2,1H3,(H,35,36)
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n/an/a 680n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARalpha receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205074
PNG
(2-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CC(O)=O)Cc2cccc3ccccc23)cc1)-c1ccccc1
Show InChI InChI=1S/C32H30N2O4/c1-23-30(33-32(38-23)26-9-3-2-4-10-26)18-19-37-28-16-14-24(15-17-28)20-34(22-31(35)36)21-27-12-7-11-25-8-5-6-13-29(25)27/h2-17H,18-22H2,1H3,(H,35,36)
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n/an/a 767n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARgamma receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205080
PNG
(2-((3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1cccc(CN(CCCc2ccccc2)CC(O)=O)c1)-c1ccccc1
Show InChI InChI=1S/C30H32N2O4/c1-23-28(31-30(36-23)26-14-6-3-7-15-26)17-19-35-27-16-8-12-25(20-27)21-32(22-29(33)34)18-9-13-24-10-4-2-5-11-24/h2-8,10-12,14-16,20H,9,13,17-19,21-22H2,1H3,(H,33,34)
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n/an/a 773n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARgamma receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205073
PNG
(2-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CC(O)=O)Cc2ccc(Oc3ccccc3)cc2)cc1)-c1ccccc1
Show InChI InChI=1S/C34H32N2O5/c1-25-32(35-34(40-25)28-8-4-2-5-9-28)20-21-39-29-16-12-26(13-17-29)22-36(24-33(37)38)23-27-14-18-31(19-15-27)41-30-10-6-3-7-11-30/h2-19H,20-24H2,1H3,(H,37,38)
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n/an/a 970n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARalpha receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205077
PNG
(2-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES CCCCCCCN(CC(O)=O)Cc1ccc(OCCc2nc(oc2C)-c2ccccc2)cc1
Show InChI InChI=1S/C28H36N2O4/c1-3-4-5-6-10-18-30(21-27(31)32)20-23-13-15-25(16-14-23)33-19-17-26-22(2)34-28(29-26)24-11-8-7-9-12-24/h7-9,11-16H,3-6,10,17-21H2,1-2H3,(H,31,32)
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n/an/a 1.05E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARalpha receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205085
PNG
(2-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CC(O)=O)Cc2ccc(OCc3ccccc3)cc2)cc1)-c1ccccc1
Show InChI InChI=1S/C35H34N2O5/c1-26-33(36-35(42-26)30-10-6-3-7-11-30)20-21-40-31-16-12-27(13-17-31)22-37(24-34(38)39)23-28-14-18-32(19-15-28)41-25-29-8-4-2-5-9-29/h2-19H,20-25H2,1H3,(H,38,39)
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n/an/a 1.05E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARalpha receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205082
PNG
(2-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CC(O)=O)Cc2ccc3ccccc3c2)cc1)-c1ccccc1
Show InChI InChI=1S/C32H30N2O4/c1-23-30(33-32(38-23)27-8-3-2-4-9-27)17-18-37-29-15-12-24(13-16-29)20-34(22-31(35)36)21-25-11-14-26-7-5-6-10-28(26)19-25/h2-16,19H,17-18,20-22H2,1H3,(H,35,36)
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n/an/a 1.21E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARgamma receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50163728
PNG
((Benzyl-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-etho...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CC(O)=O)Cc2ccccc2)cc1)-c1ccccc1
Show InChI InChI=1S/C28H28N2O4/c1-21-26(29-28(34-21)24-10-6-3-7-11-24)16-17-33-25-14-12-23(13-15-25)19-30(20-27(31)32)18-22-8-4-2-5-9-22/h2-15H,16-20H2,1H3,(H,31,32)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARalpha receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50163728
PNG
((Benzyl-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-etho...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CC(O)=O)Cc2ccccc2)cc1)-c1ccccc1
Show InChI InChI=1S/C28H28N2O4/c1-21-26(29-28(34-21)24-10-6-3-7-11-24)16-17-33-25-14-12-23(13-15-25)19-30(20-27(31)32)18-22-8-4-2-5-9-22/h2-15H,16-20H2,1H3,(H,31,32)
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n/an/a 1.77E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARgamma receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205084
PNG
(2-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CCOCc2ccccc2)CC(O)=O)cc1)-c1ccccc1
Show InChI InChI=1S/C30H32N2O5/c1-23-28(31-30(37-23)26-10-6-3-7-11-26)16-18-36-27-14-12-24(13-15-27)20-32(21-29(33)34)17-19-35-22-25-8-4-2-5-9-25/h2-15H,16-22H2,1H3,(H,33,34)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARalpha receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205087
PNG
(2-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CC(O)=O)Cc2ccc(o2)-c2ccccc2Cl)cc1)-c1ccccc1
Show InChI InChI=1S/C32H29ClN2O5/c1-22-29(34-32(39-22)24-7-3-2-4-8-24)17-18-38-25-13-11-23(12-14-25)19-35(21-31(36)37)20-26-15-16-30(40-26)27-9-5-6-10-28(27)33/h2-16H,17-21H2,1H3,(H,36,37)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARalpha receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205092
PNG
(2-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CC(O)=O)Cc2ccc3OCOc3c2)cc1)-c1ccccc1
Show InChI InChI=1S/C29H28N2O6/c1-20-25(30-29(37-20)23-5-3-2-4-6-23)13-14-34-24-10-7-21(8-11-24)16-31(18-28(32)33)17-22-9-12-26-27(15-22)36-19-35-26/h2-12,15H,13-14,16-19H2,1H3,(H,32,33)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARalpha receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205077
PNG
(2-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES CCCCCCCN(CC(O)=O)Cc1ccc(OCCc2nc(oc2C)-c2ccccc2)cc1
Show InChI InChI=1S/C28H36N2O4/c1-3-4-5-6-10-18-30(21-27(31)32)20-23-13-15-25(16-14-23)33-19-17-26-22(2)34-28(29-26)24-11-8-7-9-12-24/h7-9,11-16H,3-6,10,17-21H2,1-2H3,(H,31,32)
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n/an/a 2.30E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARgamma receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50085044
PNG
((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Show SMILES Cc1oc(nc1CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(O)=O)cc1)-c1ccccc1
Show InChI InChI=1S/C34H30N2O5/c1-23-29(36-33(41-23)26-12-6-3-7-13-26)20-21-40-27-18-16-24(17-19-27)22-31(34(38)39)35-30-15-9-8-14-28(30)32(37)25-10-4-2-5-11-25/h2-19,31,35H,20-22H2,1H3,(H,38,39)/t31-/m0/s1
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n/an/a 2.87E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARalpha receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205075
PNG
(2-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CC(O)=O)Cc2ccccn2)cc1)-c1ccccc1
Show InChI InChI=1S/C27H27N3O4/c1-20-25(29-27(34-20)22-7-3-2-4-8-22)14-16-33-24-12-10-21(11-13-24)17-30(19-26(31)32)18-23-9-5-6-15-28-23/h2-13,15H,14,16-19H2,1H3,(H,31,32)
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n/an/a 2.90E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARgamma receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205092
PNG
(2-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CC(O)=O)Cc2ccc3OCOc3c2)cc1)-c1ccccc1
Show InChI InChI=1S/C29H28N2O6/c1-20-25(30-29(37-20)23-5-3-2-4-6-23)13-14-34-24-10-7-21(8-11-24)16-31(18-28(32)33)17-22-9-12-26-27(15-22)36-19-35-26/h2-12,15H,13-14,16-19H2,1H3,(H,32,33)
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n/an/a 3.29E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARgamma receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205084
PNG
(2-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CCOCc2ccccc2)CC(O)=O)cc1)-c1ccccc1
Show InChI InChI=1S/C30H32N2O5/c1-23-28(31-30(37-23)26-10-6-3-7-11-26)16-18-36-27-14-12-24(13-15-27)20-32(21-29(33)34)17-19-35-22-25-8-4-2-5-9-25/h2-15H,16-22H2,1H3,(H,33,34)
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n/an/a 4.56E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of fluorescein labeled ligand from PPARgamma receptor by fluorescence polarization assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205075
PNG
(2-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CC(O)=O)Cc2ccccn2)cc1)-c1ccccc1
Show InChI InChI=1S/C27H27N3O4/c1-20-25(29-27(34-20)22-7-3-2-4-8-22)14-16-33-24-12-10-21(11-13-24)17-30(19-26(31)32)18-23-9-5-6-15-28-23/h2-13,15H,14,16-19H2,1H3,(H,31,32)
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n/an/an/an/a 692n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARalpha receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205085
PNG
(2-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CC(O)=O)Cc2ccc(OCc3ccccc3)cc2)cc1)-c1ccccc1
Show InChI InChI=1S/C35H34N2O5/c1-26-33(36-35(42-26)30-10-6-3-7-11-30)20-21-40-31-16-12-27(13-17-31)22-37(24-34(38)39)23-28-14-18-32(19-15-28)41-25-29-8-4-2-5-9-29/h2-19H,20-25H2,1H3,(H,38,39)
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n/an/an/an/a 221n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARgamma receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205090
PNG
((2S)-2-(4-[2-(3-[2,4-DIFLUOROPHENYL]-1-HEPTYLUREID...)
Show SMILES CCCCCCCN(CCc1ccc(O[C@@](C)(CC)C(O)=O)cc1)C(=O)Nc1ccc(F)cc1F
Show InChI InChI=1S/C27H36F2N2O4/c1-4-6-7-8-9-17-31(26(34)30-24-15-12-21(28)19-23(24)29)18-16-20-10-13-22(14-11-20)35-27(3,5-2)25(32)33/h10-15,19H,4-9,16-18H2,1-3H3,(H,30,34)(H,32,33)/t27-/m0/s1
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n/an/an/an/a 249n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARgamma receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205079
PNG
(2-((3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1cccc(CN(CC(O)=O)Cc2ccc(Oc3ccccc3)cc2)c1)-c1ccccc1
Show InChI InChI=1S/C34H32N2O5/c1-25-32(35-34(40-25)28-10-4-2-5-11-28)19-20-39-31-14-8-9-27(21-31)23-36(24-33(37)38)22-26-15-17-30(18-16-26)41-29-12-6-3-7-13-29/h2-18,21H,19-20,22-24H2,1H3,(H,37,38)
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n/an/an/an/a 30n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARalpha receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205084
PNG
(2-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CCOCc2ccccc2)CC(O)=O)cc1)-c1ccccc1
Show InChI InChI=1S/C30H32N2O5/c1-23-28(31-30(37-23)26-10-6-3-7-11-26)16-18-36-27-14-12-24(13-15-27)20-32(21-29(33)34)17-19-35-22-25-8-4-2-5-9-25/h2-15H,16-22H2,1H3,(H,33,34)
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n/an/an/an/a 1.18E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARgamma receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205086
PNG
(2-((3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1cccc(CN(CC(O)=O)Cc2cccc3ccccc23)c1)-c1ccccc1
Show InChI InChI=1S/C32H30N2O4/c1-23-30(33-32(38-23)26-11-3-2-4-12-26)17-18-37-28-15-7-9-24(19-28)20-34(22-31(35)36)21-27-14-8-13-25-10-5-6-16-29(25)27/h2-16,19H,17-18,20-22H2,1H3,(H,35,36)
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n/an/an/an/a 36n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARgamma receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205083
PNG
(2-((3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1cccc(CN(CC(O)=O)Cc2ccc(OCc3ccccc3)cc2)c1)-c1ccccc1
Show InChI InChI=1S/C35H34N2O5/c1-26-33(36-35(42-26)30-12-6-3-7-13-30)19-20-40-32-14-8-11-29(21-32)23-37(24-34(38)39)22-27-15-17-31(18-16-27)41-25-28-9-4-2-5-10-28/h2-18,21H,19-20,22-25H2,1H3,(H,38,39)
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n/an/an/an/a 412n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARgamma receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205080
PNG
(2-((3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1cccc(CN(CCCc2ccccc2)CC(O)=O)c1)-c1ccccc1
Show InChI InChI=1S/C30H32N2O4/c1-23-28(31-30(36-23)26-14-6-3-7-15-26)17-19-35-27-16-8-12-25(20-27)21-32(22-29(33)34)18-9-13-24-10-4-2-5-11-24/h2-8,10-12,14-16,20H,9,13,17-19,21-22H2,1H3,(H,33,34)
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n/an/an/an/a 901n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARgamma receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205074
PNG
(2-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CC(O)=O)Cc2cccc3ccccc23)cc1)-c1ccccc1
Show InChI InChI=1S/C32H30N2O4/c1-23-30(33-32(38-23)26-9-3-2-4-10-26)18-19-37-28-16-14-24(15-17-28)20-34(22-31(35)36)21-27-12-7-11-25-8-5-6-13-29(25)27/h2-17H,18-22H2,1H3,(H,35,36)
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n/an/an/an/a 840n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARgamma receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205082
PNG
(2-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CC(O)=O)Cc2ccc3ccccc3c2)cc1)-c1ccccc1
Show InChI InChI=1S/C32H30N2O4/c1-23-30(33-32(38-23)27-8-3-2-4-9-27)17-18-37-29-15-12-24(13-16-29)20-34(22-31(35)36)21-25-11-14-26-7-5-6-10-28(26)19-25/h2-16,19H,17-18,20-22H2,1H3,(H,35,36)
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n/an/an/an/a 1.21E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARgamma receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205080
PNG
(2-((3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1cccc(CN(CCCc2ccccc2)CC(O)=O)c1)-c1ccccc1
Show InChI InChI=1S/C30H32N2O4/c1-23-28(31-30(36-23)26-14-6-3-7-15-26)17-19-35-27-16-8-12-25(20-27)21-32(22-29(33)34)18-9-13-24-10-4-2-5-11-24/h2-8,10-12,14-16,20H,9,13,17-19,21-22H2,1H3,(H,33,34)
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n/an/an/an/a 47n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARalpha receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205087
PNG
(2-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CC(O)=O)Cc2ccc(o2)-c2ccccc2Cl)cc1)-c1ccccc1
Show InChI InChI=1S/C32H29ClN2O5/c1-22-29(34-32(39-22)24-7-3-2-4-8-24)17-18-38-25-13-11-23(12-14-25)19-35(21-31(36)37)20-26-15-16-30(40-26)27-9-5-6-10-28(27)33/h2-16H,17-21H2,1H3,(H,36,37)
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n/an/an/an/a 871n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARalpha receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205081
PNG
(2-((3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1cccc(CN(CCc2ccccc2)CC(O)=O)c1)-c1ccccc1
Show InChI InChI=1S/C29H30N2O4/c1-22-27(30-29(35-22)25-12-6-3-7-13-25)16-18-34-26-14-8-11-24(19-26)20-31(21-28(32)33)17-15-23-9-4-2-5-10-23/h2-14,19H,15-18,20-21H2,1H3,(H,32,33)
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n/an/an/an/a 108n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARgamma receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205089
PNG
(2-((3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1cccc(CN(CC(O)=O)Cc2cccc(Oc3ccccc3)c2)c1)-c1ccccc1
Show InChI InChI=1S/C34H32N2O5/c1-25-32(35-34(40-25)28-12-4-2-5-13-28)18-19-39-30-16-8-10-26(20-30)22-36(24-33(37)38)23-27-11-9-17-31(21-27)41-29-14-6-3-7-15-29/h2-17,20-21H,18-19,22-24H2,1H3,(H,37,38)
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n/an/an/an/a 62n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARalpha receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205091
PNG
(2-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES CCC(CC)CN(CC(O)=O)Cc1ccc(OCCc2nc(oc2C)-c2ccccc2)cc1
Show InChI InChI=1S/C27H34N2O4/c1-4-21(5-2)17-29(19-26(30)31)18-22-11-13-24(14-12-22)32-16-15-25-20(3)33-27(28-25)23-9-7-6-8-10-23/h6-14,21H,4-5,15-19H2,1-3H3,(H,30,31)
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n/an/an/an/a 1.80E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARgamma receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205075
PNG
(2-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CC(O)=O)Cc2ccccn2)cc1)-c1ccccc1
Show InChI InChI=1S/C27H27N3O4/c1-20-25(29-27(34-20)22-7-3-2-4-8-22)14-16-33-24-12-10-21(11-13-24)17-30(19-26(31)32)18-23-9-5-6-15-28-23/h2-13,15H,14,16-19H2,1H3,(H,31,32)
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n/an/an/an/a 230n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARgamma receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205077
PNG
(2-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES CCCCCCCN(CC(O)=O)Cc1ccc(OCCc2nc(oc2C)-c2ccccc2)cc1
Show InChI InChI=1S/C28H36N2O4/c1-3-4-5-6-10-18-30(21-27(31)32)20-23-13-15-25(16-14-23)33-19-17-26-22(2)34-28(29-26)24-11-8-7-9-12-24/h7-9,11-16H,3-6,10,17-21H2,1-2H3,(H,31,32)
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n/an/an/an/a 136n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARgamma receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50163728
PNG
((Benzyl-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-etho...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CC(O)=O)Cc2ccccc2)cc1)-c1ccccc1
Show InChI InChI=1S/C28H28N2O4/c1-21-26(29-28(34-21)24-10-6-3-7-11-24)16-17-33-25-14-12-23(13-15-25)19-30(20-27(31)32)18-22-8-4-2-5-9-22/h2-15H,16-20H2,1H3,(H,31,32)
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n/an/an/an/a 3.60E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARgamma receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205083
PNG
(2-((3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1cccc(CN(CC(O)=O)Cc2ccc(OCc3ccccc3)cc2)c1)-c1ccccc1
Show InChI InChI=1S/C35H34N2O5/c1-26-33(36-35(42-26)30-12-6-3-7-13-30)19-20-40-32-14-8-11-29(21-32)23-37(24-34(38)39)22-27-15-17-31(18-16-27)41-25-28-9-4-2-5-10-28/h2-18,21H,19-20,22-25H2,1H3,(H,38,39)
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n/an/an/an/a 324n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARalpha receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205092
PNG
(2-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CC(O)=O)Cc2ccc3OCOc3c2)cc1)-c1ccccc1
Show InChI InChI=1S/C29H28N2O6/c1-20-25(30-29(37-20)23-5-3-2-4-6-23)13-14-34-24-10-7-21(8-11-24)16-31(18-28(32)33)17-22-9-12-26-27(15-22)36-19-35-26/h2-12,15H,13-14,16-19H2,1H3,(H,32,33)
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n/an/an/an/a 307n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARgamma receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM28681
PNG
(5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)...)
Show SMILES CN(CCOc1ccc(Cc2sc(=O)[nH]c2O)cc1)c1ccccn1
Show InChI InChI=1S/C18H19N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,22H,10-12H2,1H3,(H,20,23)
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n/an/an/an/a 35n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARgamma receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205076
PNG
(2-(((1H-indol-2-yl)methyl)(3-(2-(5-methyl-2-phenyl...)
Show SMILES Cc1oc(nc1CCOc1cccc(CN(CC(O)=O)Cc2cc3ccccc3[nH]2)c1)-c1ccccc1
Show InChI InChI=1S/C30H29N3O4/c1-21-27(32-30(37-21)23-9-3-2-4-10-23)14-15-36-26-12-7-8-22(16-26)18-33(20-29(34)35)19-25-17-24-11-5-6-13-28(24)31-25/h2-13,16-17,31H,14-15,18-20H2,1H3,(H,34,35)
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n/an/an/an/a 759n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARgamma receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205089
PNG
(2-((3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1cccc(CN(CC(O)=O)Cc2cccc(Oc3ccccc3)c2)c1)-c1ccccc1
Show InChI InChI=1S/C34H32N2O5/c1-25-32(35-34(40-25)28-12-4-2-5-13-28)18-19-39-30-16-8-10-26(20-30)22-36(24-33(37)38)23-27-11-9-17-31(21-27)41-29-14-6-3-7-15-29/h2-17,20-21H,18-19,22-24H2,1H3,(H,37,38)
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n/an/an/an/a 359n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARgamma receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205072
PNG
(2-((3-phenoxybenzyl)(4-(2-(5-methyl-2-phenyloxazol...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CC(O)=O)Cc2cccc(Oc3ccccc3)c2)cc1)-c1ccccc1
Show InChI InChI=1S/C34H32N2O5/c1-25-32(35-34(40-25)28-10-4-2-5-11-28)19-20-39-29-17-15-26(16-18-29)22-36(24-33(37)38)23-27-9-8-14-31(21-27)41-30-12-6-3-7-13-30/h2-18,21H,19-20,22-24H2,1H3,(H,37,38)
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n/an/an/an/a 4n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARalpha receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205092
PNG
(2-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CC(O)=O)Cc2ccc3OCOc3c2)cc1)-c1ccccc1
Show InChI InChI=1S/C29H28N2O6/c1-20-25(30-29(37-20)23-5-3-2-4-6-23)13-14-34-24-10-7-21(8-11-24)16-31(18-28(32)33)17-22-9-12-26-27(15-22)36-19-35-26/h2-12,15H,13-14,16-19H2,1H3,(H,32,33)
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n/an/an/an/a 128n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARalpha receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205077
PNG
(2-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES CCCCCCCN(CC(O)=O)Cc1ccc(OCCc2nc(oc2C)-c2ccccc2)cc1
Show InChI InChI=1S/C28H36N2O4/c1-3-4-5-6-10-18-30(21-27(31)32)20-23-13-15-25(16-14-23)33-19-17-26-22(2)34-28(29-26)24-11-8-7-9-12-24/h7-9,11-16H,3-6,10,17-21H2,1-2H3,(H,31,32)
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n/an/an/an/a 180n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARalpha receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205090
PNG
((2S)-2-(4-[2-(3-[2,4-DIFLUOROPHENYL]-1-HEPTYLUREID...)
Show SMILES CCCCCCCN(CCc1ccc(O[C@@](C)(CC)C(O)=O)cc1)C(=O)Nc1ccc(F)cc1F
Show InChI InChI=1S/C27H36F2N2O4/c1-4-6-7-8-9-17-31(26(34)30-24-15-12-21(28)19-23(24)29)18-16-20-10-13-22(14-11-20)35-27(3,5-2)25(32)33/h10-15,19H,4-9,16-18H2,1-3H3,(H,30,34)(H,32,33)/t27-/m0/s1
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n/an/an/an/a 71n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARalpha receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205082
PNG
(2-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CC(O)=O)Cc2ccc3ccccc3c2)cc1)-c1ccccc1
Show InChI InChI=1S/C32H30N2O4/c1-23-30(33-32(38-23)27-8-3-2-4-9-27)17-18-37-29-15-12-24(13-16-29)20-34(22-31(35)36)21-25-11-14-26-7-5-6-10-28(26)19-25/h2-16,19H,17-18,20-22H2,1H3,(H,35,36)
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n/an/an/an/a 618n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARalpha receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50085044
PNG
((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Show SMILES Cc1oc(nc1CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(O)=O)cc1)-c1ccccc1
Show InChI InChI=1S/C34H30N2O5/c1-23-29(36-33(41-23)26-12-6-3-7-13-26)20-21-40-27-18-16-24(17-19-27)22-31(34(38)39)35-30-15-9-8-14-28(30)32(37)25-10-4-2-5-11-25/h2-19,31,35H,20-22H2,1H3,(H,38,39)/t31-/m0/s1
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n/an/an/an/a 0.600n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARgamma receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205088
PNG
(2-((3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1cccc(CN(CC(O)=O)Cc2ccccc2)c1)-c1ccccc1
Show InChI InChI=1S/C28H28N2O4/c1-21-26(29-28(34-21)24-12-6-3-7-13-24)15-16-33-25-14-8-11-23(17-25)19-30(20-27(31)32)18-22-9-4-2-5-10-22/h2-14,17H,15-16,18-20H2,1H3,(H,31,32)
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n/an/an/an/a 295n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARgamma receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205074
PNG
(2-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CC(O)=O)Cc2cccc3ccccc23)cc1)-c1ccccc1
Show InChI InChI=1S/C32H30N2O4/c1-23-30(33-32(38-23)26-9-3-2-4-10-26)18-19-37-28-16-14-24(15-17-28)20-34(22-31(35)36)21-27-12-7-11-25-8-5-6-13-29(25)27/h2-17H,18-22H2,1H3,(H,35,36)
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n/an/an/an/a 21n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARalpha receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205084
PNG
(2-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CCOCc2ccccc2)CC(O)=O)cc1)-c1ccccc1
Show InChI InChI=1S/C30H32N2O5/c1-23-28(31-30(37-23)26-10-6-3-7-11-26)16-18-36-27-14-12-24(13-15-27)20-32(21-29(33)34)17-19-35-22-25-8-4-2-5-9-25/h2-15H,16-22H2,1H3,(H,33,34)
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n/an/an/an/a 726n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARalpha receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205076
PNG
(2-(((1H-indol-2-yl)methyl)(3-(2-(5-methyl-2-phenyl...)
Show SMILES Cc1oc(nc1CCOc1cccc(CN(CC(O)=O)Cc2cc3ccccc3[nH]2)c1)-c1ccccc1
Show InChI InChI=1S/C30H29N3O4/c1-21-27(32-30(37-21)23-9-3-2-4-10-23)14-15-36-26-12-7-8-22(16-26)18-33(20-29(34)35)19-25-17-24-11-5-6-13-28(24)31-25/h2-13,16-17,31H,14-15,18-20H2,1H3,(H,34,35)
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n/an/an/an/a 197n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARalpha receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205078
PNG
(2-((3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1cccc(CN(CC(O)=O)Cc2ccc3ccccc3c2)c1)-c1ccccc1
Show InChI InChI=1S/C32H30N2O4/c1-23-30(33-32(38-23)27-10-3-2-4-11-27)16-17-37-29-13-7-8-24(19-29)20-34(22-31(35)36)21-25-14-15-26-9-5-6-12-28(26)18-25/h2-15,18-19H,16-17,20-22H2,1H3,(H,35,36)
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n/an/an/an/a 313n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARalpha receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205078
PNG
(2-((3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1cccc(CN(CC(O)=O)Cc2ccc3ccccc3c2)c1)-c1ccccc1
Show InChI InChI=1S/C32H30N2O4/c1-23-30(33-32(38-23)27-10-3-2-4-11-27)16-17-37-29-13-7-8-24(19-29)20-34(22-31(35)36)21-25-14-15-26-9-5-6-12-28(26)18-25/h2-15,18-19H,16-17,20-22H2,1H3,(H,35,36)
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n/an/an/an/a 1.39E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARgamma receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50085044
PNG
((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-...)
Show SMILES Cc1oc(nc1CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(O)=O)cc1)-c1ccccc1
Show InChI InChI=1S/C34H30N2O5/c1-23-29(36-33(41-23)26-12-6-3-7-13-26)20-21-40-27-18-16-24(17-19-27)22-31(34(38)39)35-30-15-9-8-14-28(30)32(37)25-10-4-2-5-11-25/h2-19,31,35H,20-22H2,1H3,(H,38,39)/t31-/m0/s1
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n/an/an/an/a 321n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARalpha receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50163728
PNG
((Benzyl-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-etho...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CC(O)=O)Cc2ccccc2)cc1)-c1ccccc1
Show InChI InChI=1S/C28H28N2O4/c1-21-26(29-28(34-21)24-10-6-3-7-11-24)16-17-33-25-14-12-23(13-15-25)19-30(20-27(31)32)18-22-8-4-2-5-9-22/h2-15H,16-20H2,1H3,(H,31,32)
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n/an/an/an/a 4.02E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARalpha receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205073
PNG
(2-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CC(O)=O)Cc2ccc(Oc3ccccc3)cc2)cc1)-c1ccccc1
Show InChI InChI=1S/C34H32N2O5/c1-25-32(35-34(40-25)28-8-4-2-5-9-28)20-21-39-29-16-12-26(13-17-29)22-36(24-33(37)38)23-27-14-18-31(19-15-27)41-30-10-6-3-7-11-30/h2-19H,20-24H2,1H3,(H,37,38)
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n/an/an/an/a 35n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARalpha receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205073
PNG
(2-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CC(O)=O)Cc2ccc(Oc3ccccc3)cc2)cc1)-c1ccccc1
Show InChI InChI=1S/C34H32N2O5/c1-25-32(35-34(40-25)28-8-4-2-5-9-28)20-21-39-29-16-12-26(13-17-29)22-36(24-33(37)38)23-27-14-18-31(19-15-27)41-30-10-6-3-7-11-30/h2-19H,20-24H2,1H3,(H,37,38)
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n/an/an/an/a 52n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARgamma receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205081
PNG
(2-((3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1cccc(CN(CCc2ccccc2)CC(O)=O)c1)-c1ccccc1
Show InChI InChI=1S/C29H30N2O4/c1-22-27(30-29(35-22)25-12-6-3-7-13-25)16-18-34-26-14-8-11-24(19-26)20-31(21-28(32)33)17-15-23-9-4-2-5-10-23/h2-14,19H,15-18,20-21H2,1H3,(H,32,33)
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n/an/an/an/a 44n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARalpha receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205072
PNG
(2-((3-phenoxybenzyl)(4-(2-(5-methyl-2-phenyloxazol...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CC(O)=O)Cc2cccc(Oc3ccccc3)c2)cc1)-c1ccccc1
Show InChI InChI=1S/C34H32N2O5/c1-25-32(35-34(40-25)28-10-4-2-5-11-28)19-20-39-29-17-15-26(16-18-29)22-36(24-33(37)38)23-27-9-8-14-31(21-27)41-30-12-6-3-7-13-30/h2-18,21H,19-20,22-24H2,1H3,(H,37,38)
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n/an/an/an/a 391n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARgamma receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205085
PNG
(2-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CC(O)=O)Cc2ccc(OCc3ccccc3)cc2)cc1)-c1ccccc1
Show InChI InChI=1S/C35H34N2O5/c1-26-33(36-35(42-26)30-10-6-3-7-11-30)20-21-40-31-16-12-27(13-17-31)22-37(24-34(38)39)23-28-14-18-32(19-15-28)41-25-29-8-4-2-5-9-29/h2-19H,20-25H2,1H3,(H,38,39)
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n/an/an/an/a 189n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARalpha receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205086
PNG
(2-((3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1cccc(CN(CC(O)=O)Cc2cccc3ccccc23)c1)-c1ccccc1
Show InChI InChI=1S/C32H30N2O4/c1-23-30(33-32(38-23)26-11-3-2-4-12-26)17-18-37-28-15-7-9-24(19-28)20-34(22-31(35)36)21-27-14-8-13-25-10-5-6-16-29(25)27/h2-16,19H,17-18,20-22H2,1H3,(H,35,36)
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n/an/an/an/a 5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARalpha receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205079
PNG
(2-((3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1cccc(CN(CC(O)=O)Cc2ccc(Oc3ccccc3)cc2)c1)-c1ccccc1
Show InChI InChI=1S/C34H32N2O5/c1-25-32(35-34(40-25)28-10-4-2-5-11-28)19-20-39-31-14-8-9-27(21-31)23-36(24-33(37)38)22-26-15-17-30(18-16-26)41-29-12-6-3-7-13-29/h2-18,21H,19-20,22-24H2,1H3,(H,37,38)
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n/an/an/an/a 67n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARgamma receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))		BDBM50205087
PNG
(2-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1ccc(CN(CC(O)=O)Cc2ccc(o2)-c2ccccc2Cl)cc1)-c1ccccc1
Show InChI InChI=1S/C32H29ClN2O5/c1-22-29(34-32(39-22)24-7-3-2-4-8-24)17-18-38-25-13-11-23(12-14-25)19-35(21-31(36)37)20-26-15-16-30(40-26)27-9-5-6-10-28(27)33/h2-16H,17-21H2,1H3,(H,36,37)
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n/an/an/an/a 267n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARgamma receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))		BDBM50205088
PNG
(2-((3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benz...)
Show SMILES Cc1oc(nc1CCOc1cccc(CN(CC(O)=O)Cc2ccccc2)c1)-c1ccccc1
Show InChI InChI=1S/C28H28N2O4/c1-21-26(29-28(34-21)24-12-6-3-7-13-24)15-16-33-25-14-8-11-23(17-25)19-30(20-27(31)32)18-22-9-4-2-5-10-22/h2-14,17H,15-16,18-20H2,1H3,(H,31,32)
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n/an/an/an/a 22n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at PPARalpha receptor expressed in HEK293 cells by GAL4 transactivation assay

Bioorg Med Chem Lett 17: 2312-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.060
BindingDB Entry DOI: 10.7270/Q21N80ST
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%