| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor alpha |
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| Ligand | BDBM50205081 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_454550 (CHEMBL886577) |
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| IC50 | 75±n/a nM |
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| Citation |  Devasthale, PV; Chen, S; Jeon, Y; Qu, F; Ryono, DE; Wang, W; Zhang, H; Cheng, L; Farrelly, D; Golla, R; Grover, G; Ma, Z; Moore, L; Seethala, R; Sun, W; Doweyko, AM; Chandrasena, G; Sleph, P; Hariharan, N; Cheng, PT Discovery of tertiary aminoacids as dual PPARalpha/gamma agonists-I. Bioorg Med Chem Lett17:2312-6 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peroxisome proliferator-activated receptor alpha |
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| Name: | Peroxisome proliferator-activated receptor alpha |
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| Synonyms: | NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha) |
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| Type: | Enzyme |
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| Mol. Mass.: | 52222.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07869 |
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| Residue: | 468 |
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| Sequence: | MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
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| BDBM50205081 |
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| n/a |
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| Name | BDBM50205081 |
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| Synonyms: | 2-((3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benzyl)(phenethyl)amino)acetic acid | CHEMBL246473 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H30N2O4 |
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| Mol. Mass. | 470.5595 |
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| SMILES | Cc1oc(nc1CCOc1cccc(CN(CCc2ccccc2)CC(O)=O)c1)-c1ccccc1 |
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| Structure | 
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