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PubMed code 17350258

Compile data set for download or QSAR
Found 27 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17617
PNG
(5,6-disubstituted anthranilic acid sulfonamide, 9i...)
Show SMILES COc1c(ccc(NS(=O)(=O)c2ccc(F)cc2)c1C(O)=O)-c1ccoc1
Show InChI InChI=1S/C18H14FNO6S/c1-25-17-14(11-8-9-26-10-11)6-7-15(16(17)18(21)22)20-27(23,24)13-4-2-12(19)3-5-13/h2-10,20H,1H3,(H,21,22)
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n/an/a 8n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

Bioorg Med Chem Lett 17: 2817-22 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.062
BindingDB Entry DOI: 10.7270/Q2PK0DD1
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17630
PNG
(5,6-disubstituted anthranilic acid sulfonamide, 19...)
Show SMILES CCc1ccc(NS(=O)(=O)c2ccccc2NCCCCN(C)C)c(C(O)=O)c1OC
Show InChI InChI=1S/C22H31N3O5S/c1-5-16-12-13-18(20(22(26)27)21(16)30-4)24-31(28,29)19-11-7-6-10-17(19)23-14-8-9-15-25(2)3/h6-7,10-13,23-24H,5,8-9,14-15H2,1-4H3,(H,26,27)
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n/an/a 10n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

Bioorg Med Chem Lett 17: 2817-22 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.062
BindingDB Entry DOI: 10.7270/Q2PK0DD1
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17616
PNG
(3-ethyl-6-[(4-fluorobenzene)sulfonamido]-2-methoxy...)
Show SMILES CCc1ccc(NS(=O)(=O)c2ccc(F)cc2)c(C(O)=O)c1OC
Show InChI InChI=1S/C16H16FNO5S/c1-3-10-4-9-13(14(16(19)20)15(10)23-2)18-24(21,22)12-7-5-11(17)6-8-12/h4-9,18H,3H2,1-2H3,(H,19,20)
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n/an/a 11n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

Bioorg Med Chem Lett 17: 2817-22 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.062
BindingDB Entry DOI: 10.7270/Q2PK0DD1
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17632
PNG
(3-ethyl-2-methoxy-6-[(2-{[2-(1-methylpyrrolidin-2-...)
Show SMILES CCc1ccc(NS(=O)(=O)c2ccccc2NCCC2CCCN2C)c(C(O)=O)c1OC
Show InChI InChI=1S/C23H31N3O5S/c1-4-16-11-12-19(21(23(27)28)22(16)31-3)25-32(29,30)20-10-6-5-9-18(20)24-14-13-17-8-7-15-26(17)2/h5-6,9-12,17,24-25H,4,7-8,13-15H2,1-3H3,(H,27,28)
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n/an/a 15n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

Bioorg Med Chem Lett 17: 2817-22 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.062
BindingDB Entry DOI: 10.7270/Q2PK0DD1
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17635
PNG
(5,6-disubstituted anthranilic acid sulfonamide, 19...)
Show SMILES CCN(CC)C\C=C/c1cc(F)ccc1S(=O)(=O)Nc1ccc(-c2ccoc2)c(OC)c1C(O)=O
Show InChI InChI=1S/C25H27FN2O6S/c1-4-28(5-2)13-6-7-17-15-19(26)8-11-22(17)35(31,32)27-21-10-9-20(18-12-14-34-16-18)24(33-3)23(21)25(29)30/h6-12,14-16,27H,4-5,13H2,1-3H3,(H,29,30)/b7-6-
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n/an/a 15n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

Bioorg Med Chem Lett 17: 2817-22 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.062
BindingDB Entry DOI: 10.7270/Q2PK0DD1
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17622
PNG
(2-chloro-3-ethyl-6-[(4-fluorobenzene)sulfonamido]b...)
Show SMILES CCc1ccc(NS(=O)(=O)c2ccc(F)cc2)c(C(O)=O)c1Cl
Show InChI InChI=1S/C15H13ClFNO4S/c1-2-9-3-8-12(13(14(9)16)15(19)20)18-23(21,22)11-6-4-10(17)5-7-11/h3-8,18H,2H2,1H3,(H,19,20)
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n/an/a 15n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

Bioorg Med Chem Lett 17: 2817-22 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.062
BindingDB Entry DOI: 10.7270/Q2PK0DD1
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17627
PNG
(2-(2-aminoethoxy)-3-ethyl-6-[(2-propylbenzene)sulf...)
Show SMILES CCCc1ccccc1S(=O)(=O)Nc1ccc(CC)c(OCCN)c1C(O)=O
Show InChI InChI=1S/C20H26N2O5S/c1-3-7-15-8-5-6-9-17(15)28(25,26)22-16-11-10-14(4-2)19(27-13-12-21)18(16)20(23)24/h5-6,8-11,22H,3-4,7,12-13,21H2,1-2H3,(H,23,24)
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n/an/a 16n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

Bioorg Med Chem Lett 17: 2817-22 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.062
BindingDB Entry DOI: 10.7270/Q2PK0DD1
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17611
PNG
(3-ethyl-6-[(4-fluorobenzene)sulfonamido]-2-methylb...)
Show SMILES CCc1ccc(NS(=O)(=O)c2ccc(F)cc2)c(C(O)=O)c1C
Show InChI InChI=1S/C16H16FNO4S/c1-3-11-4-9-14(15(10(11)2)16(19)20)18-23(21,22)13-7-5-12(17)6-8-13/h4-9,18H,3H2,1-2H3,(H,19,20)
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n/an/a 16n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

Bioorg Med Chem Lett 17: 2817-22 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.062
BindingDB Entry DOI: 10.7270/Q2PK0DD1
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17634
PNG
(5,6-disubstituted anthranilic acid sulfonamide, 19...)
Show SMILES COc1c(ccc(NS(=O)(=O)c2ccc(F)cc2NCCCN(C)C)c1C(O)=O)-c1ccoc1
Show InChI InChI=1S/C23H26FN3O6S/c1-27(2)11-4-10-25-19-13-16(24)5-8-20(19)34(30,31)26-18-7-6-17(15-9-12-33-14-15)22(32-3)21(18)23(28)29/h5-9,12-14,25-26H,4,10-11H2,1-3H3,(H,28,29)
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n/an/a 17n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

Bioorg Med Chem Lett 17: 2817-22 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.062
BindingDB Entry DOI: 10.7270/Q2PK0DD1
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17631
PNG
(3-ethyl-2-methoxy-6-[(2-{[3-(2-methylpiperidin-1-y...)
Show SMILES CCc1ccc(NS(=O)(=O)c2ccccc2NCCCN2CCCCC2C)c(C(O)=O)c1OC
Show InChI InChI=1S/C25H35N3O5S/c1-4-19-13-14-21(23(25(29)30)24(19)33-3)27-34(31,32)22-12-6-5-11-20(22)26-15-9-17-28-16-8-7-10-18(28)2/h5-6,11-14,18,26-27H,4,7-10,15-17H2,1-3H3,(H,29,30)
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n/an/a 18n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

Bioorg Med Chem Lett 17: 2817-22 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.062
BindingDB Entry DOI: 10.7270/Q2PK0DD1
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17618
PNG
(5,6-disubstituted anthranilic acid sulfonamide, 9j...)
Show SMILES COc1c(ccc(NS(=O)(=O)c2ccc(F)cc2Br)c1C(O)=O)-c1ccoc1
Show InChI InChI=1S/C18H13BrFNO6S/c1-26-17-12(10-6-7-27-9-10)3-4-14(16(17)18(22)23)21-28(24,25)15-5-2-11(20)8-13(15)19/h2-9,21H,1H3,(H,22,23)
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n/an/a 20n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

Bioorg Med Chem Lett 17: 2817-22 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.062
BindingDB Entry DOI: 10.7270/Q2PK0DD1
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17629
PNG
(2-(2-aminoethoxy)-6-({2-[3-(diethylamino)propyl]-4...)
Show SMILES CCN(CC)CCCc1cc(F)ccc1S(=O)(=O)Nc1ccc(CC)c(OCCN)c1C(O)=O
Show InChI InChI=1S/C24H34FN3O5S/c1-4-17-9-11-20(22(24(29)30)23(17)33-15-13-26)27-34(31,32)21-12-10-19(25)16-18(21)8-7-14-28(5-2)6-3/h9-12,16,27H,4-8,13-15,26H2,1-3H3,(H,29,30)
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n/an/a 24n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

Bioorg Med Chem Lett 17: 2817-22 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.062
BindingDB Entry DOI: 10.7270/Q2PK0DD1
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17633
PNG
(5,6-disubstituted anthranilic acid sulfonamide, 19...)
Show SMILES CCN(CC)C\C=C/c1cc(F)ccc1S(=O)(=O)Nc1ccc(CC)c(OC)c1C(O)=O
Show InChI InChI=1S/C23H29FN2O5S/c1-5-16-10-12-19(21(23(27)28)22(16)31-4)25-32(29,30)20-13-11-18(24)15-17(20)9-8-14-26(6-2)7-3/h8-13,15,25H,5-7,14H2,1-4H3,(H,27,28)/b9-8-
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n/an/a 26n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

Bioorg Med Chem Lett 17: 2817-22 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.062
BindingDB Entry DOI: 10.7270/Q2PK0DD1
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17624
PNG
(2-ethoxy-3-ethyl-6-[(4-fluorobenzene)sulfonamido]b...)
Show SMILES CCOc1c(CC)ccc(NS(=O)(=O)c2ccc(F)cc2)c1C(O)=O
Show InChI InChI=1S/C17H18FNO5S/c1-3-11-5-10-14(15(17(20)21)16(11)24-4-2)19-25(22,23)13-8-6-12(18)7-9-13/h5-10,19H,3-4H2,1-2H3,(H,20,21)
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n/an/a 38n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

Bioorg Med Chem Lett 17: 2817-22 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.062
BindingDB Entry DOI: 10.7270/Q2PK0DD1
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17625
PNG
(2-(2-aminoethoxy)-3-ethyl-6-[(4-fluorobenzene)sulf...)
Show SMILES CCc1ccc(NS(=O)(=O)c2ccc(F)cc2)c(C(O)=O)c1OCCN
Show InChI InChI=1S/C17H19FN2O5S/c1-2-11-3-8-14(15(17(21)22)16(11)25-10-9-19)20-26(23,24)13-6-4-12(18)5-7-13/h3-8,20H,2,9-10,19H2,1H3,(H,21,22)
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n/an/a 46n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

Bioorg Med Chem Lett 17: 2817-22 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.062
BindingDB Entry DOI: 10.7270/Q2PK0DD1
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17623
PNG
(5,6-disubstituted anthranilic acid sulfonamide, 9o...)
Show SMILES CCc1ccc(NS(=O)(=O)c2ccc(F)cc2)c(c1)C(O)=O
Show InChI InChI=1S/C15H14FNO4S/c1-2-10-3-8-14(13(9-10)15(18)19)17-22(20,21)12-6-4-11(16)5-7-12/h3-9,17H,2H2,1H3,(H,18,19)
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n/an/a 55n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

Bioorg Med Chem Lett 17: 2817-22 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.062
BindingDB Entry DOI: 10.7270/Q2PK0DD1
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17610
PNG
(3-ethenyl-6-[(4-fluorobenzene)sulfonamido]-2-methy...)
Show SMILES Cc1c(C=C)ccc(NS(=O)(=O)c2ccc(F)cc2)c1C(O)=O
Show InChI InChI=1S/C16H14FNO4S/c1-3-11-4-9-14(15(10(11)2)16(19)20)18-23(21,22)13-7-5-12(17)6-8-13/h3-9,18H,1H2,2H3,(H,19,20)
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n/an/a 60n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

Bioorg Med Chem Lett 17: 2817-22 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.062
BindingDB Entry DOI: 10.7270/Q2PK0DD1
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17628
PNG
(3-ethyl-2-methyl-6-(pyridine-2-sulfonamido)benzoic...)
Show SMILES CCc1ccc(NS(=O)(=O)c2ccccn2)c(C(O)=O)c1C
Show InChI InChI=1S/C15H16N2O4S/c1-3-11-7-8-12(14(10(11)2)15(18)19)17-22(20,21)13-6-4-5-9-16-13/h4-9,17H,3H2,1-2H3,(H,18,19)
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n/an/a 67n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

Bioorg Med Chem Lett 17: 2817-22 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.062
BindingDB Entry DOI: 10.7270/Q2PK0DD1
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17609
PNG
(5,6-disubstituted anthranilic acid sulfonamide, 9a...)
Show SMILES Cc1ccc(NS(=O)(=O)c2ccc(F)cc2)c(C(O)=O)c1C
Show InChI InChI=1S/C15H14FNO4S/c1-9-3-8-13(14(10(9)2)15(18)19)17-22(20,21)12-6-4-11(16)5-7-12/h3-8,17H,1-2H3,(H,18,19)
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n/an/a 78n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

Bioorg Med Chem Lett 17: 2817-22 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.062
BindingDB Entry DOI: 10.7270/Q2PK0DD1
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17612
PNG
(5,6-disubstituted anthranilic acid sulfonamide, 9d...)
Show SMILES CCCc1ccc(NS(=O)(=O)c2ccc(F)cc2)c(C(O)=O)c1C
Show InChI InChI=1S/C17H18FNO4S/c1-3-4-12-5-10-15(16(11(12)2)17(20)21)19-24(22,23)14-8-6-13(18)7-9-14/h5-10,19H,3-4H2,1-2H3,(H,20,21)
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n/an/a 150n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

Bioorg Med Chem Lett 17: 2817-22 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.062
BindingDB Entry DOI: 10.7270/Q2PK0DD1
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17621
PNG
(5,6-disubstituted anthranilic acid sulfonamide, 9m...)
Show SMILES COc1c(ccc(NS(=O)(=O)c2ccc(F)cc2)c1C(O)=O)-c1cn[nH]c1
Show InChI InChI=1S/C17H14FN3O5S/c1-26-16-13(10-8-19-20-9-10)6-7-14(15(16)17(22)23)21-27(24,25)12-4-2-11(18)3-5-12/h2-9,21H,1H3,(H,19,20)(H,22,23)
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n/an/a 280n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

Bioorg Med Chem Lett 17: 2817-22 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.062
BindingDB Entry DOI: 10.7270/Q2PK0DD1
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17619
PNG
(5,6-disubstituted anthranilic acid sulfonamide, 9k...)
Show SMILES COc1c(ccc(NS(=O)(=O)c2ccc(F)cc2Br)c1C(O)=O)-c1ccco1
Show InChI InChI=1S/C18H13BrFNO6S/c1-26-17-11(14-3-2-8-27-14)5-6-13(16(17)18(22)23)21-28(24,25)15-7-4-10(20)9-12(15)19/h2-9,21H,1H3,(H,22,23)
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n/an/a 1.00E+3n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

Bioorg Med Chem Lett 17: 2817-22 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.062
BindingDB Entry DOI: 10.7270/Q2PK0DD1
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17613
PNG
(3-butyl-6-[(4-fluorobenzene)sulfonamido]-2-methylb...)
Show SMILES CCCCc1ccc(NS(=O)(=O)c2ccc(F)cc2)c(C(O)=O)c1C
Show InChI InChI=1S/C18H20FNO4S/c1-3-4-5-13-6-11-16(17(12(13)2)18(21)22)20-25(23,24)15-9-7-14(19)8-10-15/h6-11,20H,3-5H2,1-2H3,(H,21,22)
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n/an/a 1.30E+3n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

Bioorg Med Chem Lett 17: 2817-22 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.062
BindingDB Entry DOI: 10.7270/Q2PK0DD1
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17615
PNG
(5,6-disubstituted anthranilic acid sulfonamide, 9g...)
Show SMILES CC(O)c1ccc(NS(=O)(=O)c2ccc(F)cc2)c(C(O)=O)c1C
Show InChI InChI=1S/C16H16FNO5S/c1-9-13(10(2)19)7-8-14(15(9)16(20)21)18-24(22,23)12-5-3-11(17)4-6-12/h3-8,10,18-19H,1-2H3,(H,20,21)
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n/an/a 2.50E+3n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

Bioorg Med Chem Lett 17: 2817-22 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.062
BindingDB Entry DOI: 10.7270/Q2PK0DD1
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17626
PNG
(2-(carboxymethoxy)-3-ethyl-6-[(4-fluorobenzene)sul...)
Show SMILES CCc1ccc(NS(=O)(=O)c2ccc(F)cc2)c(C(O)=O)c1OCC(O)=O
Show InChI InChI=1S/C17H16FNO7S/c1-2-10-3-8-13(15(17(22)23)16(10)26-9-14(20)21)19-27(24,25)12-6-4-11(18)5-7-12/h3-8,19H,2,9H2,1H3,(H,20,21)(H,22,23)
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n/an/a 5.80E+3n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

Bioorg Med Chem Lett 17: 2817-22 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.062
BindingDB Entry DOI: 10.7270/Q2PK0DD1
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17614
PNG
(5,6-disubstituted anthranilic acid sulfonamide, 9f...)
Show SMILES Cc1c(CO)ccc(NS(=O)(=O)c2ccc(F)cc2)c1C(O)=O
Show InChI InChI=1S/C15H14FNO5S/c1-9-10(8-18)2-7-13(14(9)15(19)20)17-23(21,22)12-5-3-11(16)4-6-12/h2-7,17-18H,8H2,1H3,(H,19,20)
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n/an/a 8.00E+3n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

Bioorg Med Chem Lett 17: 2817-22 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.062
BindingDB Entry DOI: 10.7270/Q2PK0DD1
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17620
PNG
(5,6-disubstituted anthranilic acid sulfonamide, 9l...)
Show SMILES COc1c(ccc(NS(=O)(=O)c2ccc(F)cc2Br)c1C(O)=O)-c1c[nH]cn1
Show InChI InChI=1S/C17H13BrFN3O5S/c1-27-16-10(13-7-20-8-21-13)3-4-12(15(16)17(23)24)22-28(25,26)14-5-2-9(19)6-11(14)18/h2-8,22H,1H3,(H,20,21)(H,23,24)
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n/an/a 3.60E+4n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

Bioorg Med Chem Lett 17: 2817-22 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.062
BindingDB Entry DOI: 10.7270/Q2PK0DD1
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%