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PubMed code 17462888

Compile data set for download or QSAR
Found 38 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50099581
PNG
(CHEMBL288131 | N-((2R,3R)-3-(4-ethylphenylsulfonam...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)Cc2ccc(NC(=O)c3cccc(OC)c3)cc12 |r|
Show InChI InChI=1S/C25H26N2O5S/c1-3-16-7-11-21(12-8-16)33(30,31)27-24-22-15-19(10-9-17(22)14-23(24)28)26-25(29)18-5-4-6-20(13-18)32-2/h4-13,15,23-24,27-28H,3,14H2,1-2H3,(H,26,29)/t23-,24-/m1/s1
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n/an/a 33n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50211550
PNG
((3S,4R)-4-(N-butyl-4-ethylphenylsulfonamido)-3-hyd...)
Show SMILES CCCCN([C@H]1[C@H](O)C(C)(C)Oc2ccc(cc12)C(=O)NCCc1ccccc1)S(=O)(=O)c1ccc(CC)cc1
Show InChI InChI=1S/C32H40N2O5S/c1-5-7-21-34(40(37,38)26-16-13-23(6-2)14-17-26)29-27-22-25(15-18-28(27)39-32(3,4)30(29)35)31(36)33-20-19-24-11-9-8-10-12-24/h8-18,22,29-30,35H,5-7,19-21H2,1-4H3,(H,33,36)/t29-,30+/m1/s1
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n/an/a 57n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50211518
PNG
((3S,4R)-N-ethyl-4-(4-ethylphenylsulfonamido)-3-hyd...)
Show SMILES CCN(CCNc1ccccc1)C(=O)c1ccc2OC(C)(C)[C@@H](O)[C@H](NS(=O)(=O)c3ccc(CC)cc3)c2c1
Show InChI InChI=1S/C30H37N3O5S/c1-5-21-12-15-24(16-13-21)39(36,37)32-27-25-20-22(14-17-26(25)38-30(3,4)28(27)34)29(35)33(6-2)19-18-31-23-10-8-7-9-11-23/h7-17,20,27-28,31-32,34H,5-6,18-19H2,1-4H3/t27-,28+/m1/s1
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n/an/a 77n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50211521
PNG
(CHEMBL388762 | N-((3S,4R)-6-(5-amino-3-phenyl-1H-p...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)C(C)(C)Oc2ccc(cc12)C(=O)n1nc(cc1N)-c1ccccc1
Show InChI InChI=1S/C29H30N4O5S/c1-4-18-10-13-21(14-11-18)39(36,37)32-26-22-16-20(12-15-24(22)38-29(2,3)27(26)34)28(35)33-25(30)17-23(31-33)19-8-6-5-7-9-19/h5-17,26-27,32,34H,4,30H2,1-3H3/t26-,27+/m1/s1
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n/an/a 79n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50211547
PNG
(CHEMBL228808 | N-((3R,4S)-6-((R)-2-((2,6-dimethylp...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@@H]1[C@@H](O)C(C)(C)Oc2ccc(cc12)C(=O)N1CCC[C@@H]1CNc1c(C)cccc1C
Show InChI InChI=1S/C33H41N3O5S/c1-6-23-12-15-26(16-13-23)42(39,40)35-30-27-19-24(14-17-28(27)41-33(4,5)31(30)37)32(38)36-18-8-11-25(36)20-34-29-21(2)9-7-10-22(29)3/h7,9-10,12-17,19,25,30-31,34-35,37H,6,8,11,18,20H2,1-5H3/t25-,30+,31-/m1/s1
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n/an/a 89n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50211514
PNG
(CHEMBL228809 | N-((S)-6-((S)-2-((2,6-dimethylpheny...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1CC(C)(C)Oc2ccc(cc12)C(=O)N1CCC[C@H]1CNc1c(C)cccc1C
Show InChI InChI=1S/C33H41N3O4S/c1-6-24-12-15-27(16-13-24)41(38,39)35-29-20-33(4,5)40-30-17-14-25(19-28(29)30)32(37)36-18-8-11-26(36)21-34-31-22(2)9-7-10-23(31)3/h7,9-10,12-17,19,26,29,34-35H,6,8,11,18,20-21H2,1-5H3/t26-,29-/m0/s1
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n/an/a 110n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50211537
PNG
((3S,4R)-4-(4-ethyl-N-neopentylphenylsulfonamido)-3...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N(CC(C)(C)C)[C@H]1[C@H](O)C(C)(C)Oc2ccc(cc12)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C33H42N2O5S/c1-7-23-13-16-26(17-14-23)41(38,39)35(22-32(2,3)4)29-27-21-25(15-18-28(27)40-33(5,6)30(29)36)31(37)34-20-19-24-11-9-8-10-12-24/h8-18,21,29-30,36H,7,19-20,22H2,1-6H3,(H,34,37)/t29-,30+/m1/s1
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n/an/a 120n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50211535
PNG
(CHEMBL387993 | N-((3S,4R)-6-((S)-2-((2,6-dimethylp...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)C(C)(C)Oc2ccc(cc12)C(=O)N1CCC[C@H]1CNc1c(C)cccc1C
Show InChI InChI=1S/C33H41N3O5S/c1-6-23-12-15-26(16-13-23)42(39,40)35-30-27-19-24(14-17-28(27)41-33(4,5)31(30)37)32(38)36-18-8-11-25(36)20-34-29-21(2)9-7-10-22(29)3/h7,9-10,12-17,19,25,30-31,34-35,37H,6,8,11,18,20H2,1-5H3/t25-,30+,31-/m0/s1
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n/an/a 120n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50211525
PNG
((3S,4R)-4-(4-ethyl-N-(pyridin-2-ylmethyl)phenylsul...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N(Cc1ccccn1)[C@H]1[C@H](O)C(C)(C)Oc2ccc(cc12)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C34H37N3O5S/c1-4-24-13-16-28(17-14-24)43(40,41)37(23-27-12-8-9-20-35-27)31-29-22-26(15-18-30(29)42-34(2,3)32(31)38)33(39)36-21-19-25-10-6-5-7-11-25/h5-18,20,22,31-32,38H,4,19,21,23H2,1-3H3,(H,36,39)/t31-,32+/m1/s1
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n/an/a 120n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50211542
PNG
(CHEMBL230251 | N-((3S,4R)-6-((R)-2-((2,6-dimethylp...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)C(C)(C)Oc2ccc(cc12)C(=O)N1CCC[C@@H]1CNc1c(C)cccc1C
Show InChI InChI=1S/C33H41N3O5S/c1-6-23-12-15-26(16-13-23)42(39,40)35-30-27-19-24(14-17-28(27)41-33(4,5)31(30)37)32(38)36-18-8-11-25(36)20-34-29-21(2)9-7-10-22(29)3/h7,9-10,12-17,19,25,30-31,34-35,37H,6,8,11,18,20H2,1-5H3/t25-,30-,31+/m1/s1
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n/an/a 130n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50211523
PNG
((3S,4R)-4-(4-ethyl-N-(pyridin-3-ylmethyl)phenylsul...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N(Cc1cccnc1)[C@H]1[C@H](O)C(C)(C)Oc2ccc(cc12)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C34H37N3O5S/c1-4-24-12-15-28(16-13-24)43(40,41)37(23-26-11-8-19-35-22-26)31-29-21-27(14-17-30(29)42-34(2,3)32(31)38)33(39)36-20-18-25-9-6-5-7-10-25/h5-17,19,21-22,31-32,38H,4,18,20,23H2,1-3H3,(H,36,39)/t31-,32+/m1/s1
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n/an/a 130n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50211520
PNG
((3S,4R)-3-hydroxy-2,2-dimethyl-N-phenethyl-4-(2-(t...)
Show SMILES CC1(C)Oc2ccc(cc2[C@@H](NS(=O)(=O)c2ccccc2OC(F)(F)F)[C@@H]1O)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C27H27F3N2O6S/c1-26(2)24(33)23(32-39(35,36)22-11-7-6-10-21(22)38-27(28,29)30)19-16-18(12-13-20(19)37-26)25(34)31-15-14-17-8-4-3-5-9-17/h3-13,16,23-24,32-33H,14-15H2,1-2H3,(H,31,34)/t23-,24+/m1/s1
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n/an/a 150n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50211541
PNG
((3S,4R)-N-(2-fluorobenzyl)-N-ethyl-4-(4-ethylpheny...)
Show SMILES CCN(Cc1ccccc1F)C(=O)c1ccc2OC(C)(C)[C@@H](O)[C@H](NS(=O)(=O)c3ccc(CC)cc3)c2c1
Show InChI InChI=1S/C29H33FN2O5S/c1-5-19-11-14-22(15-12-19)38(35,36)31-26-23-17-20(13-16-25(23)37-29(3,4)27(26)33)28(34)32(6-2)18-21-9-7-8-10-24(21)30/h7-17,26-27,31,33H,5-6,18H2,1-4H3/t26-,27+/m1/s1
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n/an/a 170n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50211548
PNG
((3S,4R)-N-((S)-1-benzylpyrrolidin-3-yl)-N-ethyl-4-...)
Show SMILES CCN([C@H]1CCN(Cc2ccccc2)C1)C(=O)c1ccc2OC(C)(C)[C@@H](O)[C@H](NS(=O)(=O)c3ccc(CC)cc3)c2c1
Show InChI InChI=1S/C33H41N3O5S/c1-5-23-12-15-27(16-13-23)42(39,40)34-30-28-20-25(14-17-29(28)41-33(3,4)31(30)37)32(38)36(6-2)26-18-19-35(22-26)21-24-10-8-7-9-11-24/h7-17,20,26,30-31,34,37H,5-6,18-19,21-22H2,1-4H3/t26-,30+,31-/m0/s1
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n/an/a 170n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50211517
PNG
((3S,4R)-3-hydroxy-2,2-dimethyl-N-phenethyl-4-(4-(t...)
Show SMILES CC1(C)Oc2ccc(cc2[C@@H](NS(=O)(=O)c2ccc(cc2)C(F)(F)F)[C@@H]1O)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C27H27F3N2O5S/c1-26(2)24(33)23(32-38(35,36)20-11-9-19(10-12-20)27(28,29)30)21-16-18(8-13-22(21)37-26)25(34)31-15-14-17-6-4-3-5-7-17/h3-13,16,23-24,32-33H,14-15H2,1-2H3,(H,31,34)/t23-,24+/m1/s1
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n/an/a 200n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50211534
PNG
((3R,4S)-N-((S)-1-benzylpyrrolidin-3-yl)-N-ethyl-4-...)
Show SMILES CCN([C@H]1CCN(Cc2ccccc2)C1)C(=O)c1ccc2OC(C)(C)[C@H](O)[C@@H](NS(=O)(=O)c3ccc(CC)cc3)c2c1
Show InChI InChI=1S/C33H41N3O5S/c1-5-23-12-15-27(16-13-23)42(39,40)34-30-28-20-25(14-17-29(28)41-33(3,4)31(30)37)32(38)36(6-2)26-18-19-35(22-26)21-24-10-8-7-9-11-24/h7-17,20,26,30-31,34,37H,5-6,18-19,21-22H2,1-4H3/t26-,30-,31+/m0/s1
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n/an/a 200n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50211546
PNG
((3S,4R)-N-((R)-1-benzylpyrrolidin-3-yl)-N-ethyl-4-...)
Show SMILES CCN([C@@H]1CCN(Cc2ccccc2)C1)C(=O)c1ccc2OC(C)(C)[C@@H](O)[C@H](NS(=O)(=O)c3ccc(CC)cc3)c2c1
Show InChI InChI=1S/C33H41N3O5S/c1-5-23-12-15-27(16-13-23)42(39,40)34-30-28-20-25(14-17-29(28)41-33(3,4)31(30)37)32(38)36(6-2)26-18-19-35(22-26)21-24-10-8-7-9-11-24/h7-17,20,26,30-31,34,37H,5-6,18-19,21-22H2,1-4H3/t26-,30-,31+/m1/s1
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n/an/a 210n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50211527
PNG
((3R,4S)-N-((R)-1-benzylpyrrolidin-3-yl)-N-ethyl-4-...)
Show SMILES CCN([C@@H]1CCN(Cc2ccccc2)C1)C(=O)c1ccc2OC(C)(C)[C@H](O)[C@@H](NS(=O)(=O)c3ccc(CC)cc3)c2c1
Show InChI InChI=1S/C33H41N3O5S/c1-5-23-12-15-27(16-13-23)42(39,40)34-30-28-20-25(14-17-29(28)41-33(3,4)31(30)37)32(38)36(6-2)26-18-19-35(22-26)21-24-10-8-7-9-11-24/h7-17,20,26,30-31,34,37H,5-6,18-19,21-22H2,1-4H3/t26-,30+,31-/m1/s1
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n/an/a 220n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50211538
PNG
(4-ethyl-N-((3S,4R)-3-hydroxy-2,2-dimethyl-6-((phen...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)C(C)(C)Oc2ccc(CNCCc3ccccc3)cc12
Show InChI InChI=1S/C28H34N2O4S/c1-4-20-10-13-23(14-11-20)35(32,33)30-26-24-18-22(12-15-25(24)34-28(2,3)27(26)31)19-29-17-16-21-8-6-5-7-9-21/h5-15,18,26-27,29-31H,4,16-17,19H2,1-3H3/t26-,27+/m1/s1
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n/an/a 240n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50211533
PNG
((3S,4R)-4-(4-ethylphenylsulfonamido)-3-hydroxy-2,2...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)C(C)(C)Oc2ccc(cc12)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C28H32N2O5S/c1-4-19-10-13-22(14-11-19)36(33,34)30-25-23-18-21(12-15-24(23)35-28(2,3)26(25)31)27(32)29-17-16-20-8-6-5-7-9-20/h5-15,18,25-26,30-31H,4,16-17H2,1-3H3,(H,29,32)/t25-,26+/m1/s1
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n/an/a 260n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50211529
PNG
((3S,4R)-4-(4-ethylphenylsulfonamido)-3-hydroxy-2,2...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)C(C)(C)Oc2ccc(cc12)C(=O)Nc1ccccc1
Show InChI InChI=1S/C26H28N2O5S/c1-4-17-10-13-20(14-11-17)34(31,32)28-23-21-16-18(25(30)27-19-8-6-5-7-9-19)12-15-22(21)33-26(2,3)24(23)29/h5-16,23-24,28-29H,4H2,1-3H3,(H,27,30)/t23-,24+/m1/s1
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n/an/a 260n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50211536
PNG
(CHEMBL389891 | N-((3R,4S)-6-((S)-2-((2,6-dimethylp...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@@H]1[C@@H](O)C(C)(C)Oc2ccc(cc12)C(=O)N1CCC[C@H]1CNc1c(C)cccc1C
Show InChI InChI=1S/C33H41N3O5S/c1-6-23-12-15-26(16-13-23)42(39,40)35-30-27-19-24(14-17-28(27)41-33(4,5)31(30)37)32(38)36-18-8-11-25(36)20-34-29-21(2)9-7-10-22(29)3/h7,9-10,12-17,19,25,30-31,34-35,37H,6,8,11,18,20H2,1-5H3/t25-,30-,31+/m0/s1
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n/an/a 260n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50211544
PNG
((3S,4R)-4-(N-((1H-imidazol-4-yl)methyl)-4-ethylphe...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N(Cc1cnc[nH]1)[C@H]1[C@H](O)C(C)(C)Oc2ccc(cc12)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C32H36N4O5S/c1-4-22-10-13-26(14-11-22)42(39,40)36(20-25-19-33-21-35-25)29-27-18-24(12-15-28(27)41-32(2,3)30(29)37)31(38)34-17-16-23-8-6-5-7-9-23/h5-15,18-19,21,29-30,37H,4,16-17,20H2,1-3H3,(H,33,35)(H,34,38)/t29-,30+/m1/s1
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n/an/a 280n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50211530
PNG
((3S,4R)-4-(4-ethylphenylsulfonamido)-3-hydroxy-N,2...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)C(C)(C)Oc2ccc(cc12)C(=O)N(C)c1ccccc1
Show InChI InChI=1S/C27H30N2O5S/c1-5-18-11-14-21(15-12-18)35(32,33)28-24-22-17-19(13-16-23(22)34-27(2,3)25(24)30)26(31)29(4)20-9-7-6-8-10-20/h6-17,24-25,28,30H,5H2,1-4H3/t24-,25+/m1/s1
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n/an/a 280n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50211526
PNG
(CHEMBL231203 | N-((3S,4R)-4-(4-ethylphenylsulfonam...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)C(C)(C)Oc2ccc(NC(=O)c3cccc(OC)c3)cc12
Show InChI InChI=1S/C27H30N2O6S/c1-5-17-9-12-21(13-10-17)36(32,33)29-24-22-16-19(11-14-23(22)35-27(2,3)25(24)30)28-26(31)18-7-6-8-20(15-18)34-4/h6-16,24-25,29-30H,5H2,1-4H3,(H,28,31)/t24-,25+/m1/s1
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n/an/a 290n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50211519
PNG
((3S,4R)-4-(4-ethyl-N-isobutylphenylsulfonamido)-3-...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N(CC(C)C)[C@H]1[C@H](O)C(C)(C)Oc2ccc(cc12)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C32H40N2O5S/c1-6-23-12-15-26(16-13-23)40(37,38)34(21-22(2)3)29-27-20-25(14-17-28(27)39-32(4,5)30(29)35)31(36)33-19-18-24-10-8-7-9-11-24/h7-17,20,22,29-30,35H,6,18-19,21H2,1-5H3,(H,33,36)/t29-,30+/m1/s1
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n/an/a 320n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50211528
PNG
((3S,4R)-3-hydroxy-2,2-dimethyl-4-(3-methylphenylsu...)
Show SMILES Cc1cccc(c1)S(=O)(=O)N[C@H]1[C@H](O)C(C)(C)Oc2ccc(cc12)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C27H30N2O5S/c1-18-8-7-11-21(16-18)35(32,33)29-24-22-17-20(12-13-23(22)34-27(2,3)25(24)30)26(31)28-15-14-19-9-5-4-6-10-19/h4-13,16-17,24-25,29-30H,14-15H2,1-3H3,(H,28,31)/t24-,25+/m1/s1
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n/an/a 340n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50211515
PNG
((3S,4R)-3-hydroxy-2,2-dimethyl-4-(4-methylphenylsu...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)C(C)(C)Oc2ccc(cc12)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C27H30N2O5S/c1-18-9-12-21(13-10-18)35(32,33)29-24-22-17-20(11-14-23(22)34-27(2,3)25(24)30)26(31)28-16-15-19-7-5-4-6-8-19/h4-14,17,24-25,29-30H,15-16H2,1-3H3,(H,28,31)/t24-,25+/m1/s1
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n/an/a 400n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50211539
PNG
((3S,4R)-4-(4-ethylphenylsulfonamido)-3-hydroxy-2,2...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)C(C)(C)Oc2ccc(cc12)S(=O)(=O)NCCc1ccccc1
Show InChI InChI=1S/C27H32N2O6S2/c1-4-19-10-12-21(13-11-19)37(33,34)29-25-23-18-22(14-15-24(23)35-27(2,3)26(25)30)36(31,32)28-17-16-20-8-6-5-7-9-20/h5-15,18,25-26,28-30H,4,16-17H2,1-3H3/t25-,26+/m1/s1
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n/an/a 510n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50211545
PNG
((3S,4R)-4-(4-ethylphenylsulfonamido)-3-hydroxy-2,2...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)C(C)(C)Oc2ccc(cc12)C(=O)NCCc1ccccn1
Show InChI InChI=1S/C27H31N3O5S/c1-4-18-8-11-21(12-9-18)36(33,34)30-24-22-17-19(10-13-23(22)35-27(2,3)25(24)31)26(32)29-16-14-20-7-5-6-15-28-20/h5-13,15,17,24-25,30-31H,4,14,16H2,1-3H3,(H,29,32)/t24-,25+/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50211549
PNG
((3S,4R)-3-hydroxy-4-(4-methoxyphenylsulfonamido)-2...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)C(C)(C)Oc2ccc(cc12)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C27H30N2O6S/c1-27(2)25(30)24(29-36(32,33)21-12-10-20(34-3)11-13-21)22-17-19(9-14-23(22)35-27)26(31)28-16-15-18-7-5-4-6-8-18/h4-14,17,24-25,29-30H,15-16H2,1-3H3,(H,28,31)/t24-,25+/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50211543
PNG
((3S,4R)-3-hydroxy-2,2-dimethyl-N-phenethyl-4-(phen...)
Show SMILES CC1(C)Oc2ccc(cc2[C@@H](NS(=O)(=O)c2ccccc2)[C@@H]1O)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C26H28N2O5S/c1-26(2)24(29)23(28-34(31,32)20-11-7-4-8-12-20)21-17-19(13-14-22(21)33-26)25(30)27-16-15-18-9-5-3-6-10-18/h3-14,17,23-24,28-29H,15-16H2,1-2H3,(H,27,30)/t23-,24+/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50211540
PNG
((3R,4S)-4-(4-ethylphenylsulfonamido)-3-hydroxy-2,2...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@@H]1[C@@H](O)C(C)(C)Oc2ccc(cc12)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C28H32N2O5S/c1-4-19-10-13-22(14-11-19)36(33,34)30-25-23-18-21(12-15-24(23)35-28(2,3)26(25)31)27(32)29-17-16-20-8-6-5-7-9-20/h5-15,18,25-26,30-31H,4,16-17H2,1-3H3,(H,29,32)/t25-,26+/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50211516
PNG
((3S,4R)-4-(4-fluorophenylsulfonamido)-3-hydroxy-2,...)
Show SMILES CC1(C)Oc2ccc(cc2[C@@H](NS(=O)(=O)c2ccc(F)cc2)[C@@H]1O)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C26H27FN2O5S/c1-26(2)24(30)23(29-35(32,33)20-11-9-19(27)10-12-20)21-16-18(8-13-22(21)34-26)25(31)28-15-14-17-6-4-3-5-7-17/h3-13,16,23-24,29-30H,14-15H2,1-2H3,(H,28,31)/t23-,24+/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50211531
PNG
((3S,4R)-3-hydroxy-2,2-dimethyl-4-(4-nitrophenylsul...)
Show SMILES CC1(C)Oc2ccc(cc2[C@@H](NS(=O)(=O)c2ccc(cc2)[N+]([O-])=O)[C@@H]1O)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C26H27N3O7S/c1-26(2)24(30)23(28-37(34,35)20-11-9-19(10-12-20)29(32)33)21-16-18(8-13-22(21)36-26)25(31)27-15-14-17-6-4-3-5-7-17/h3-13,16,23-24,28,30H,14-15H2,1-2H3,(H,27,31)/t23-,24+/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50211522
PNG
((3S,4R)-4-(4-ethylphenylsulfonamido)-3-hydroxy-N-(...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)C(C)(C)Oc2ccc(cc12)C(=O)Nc1cccc(OC)c1
Show InChI InChI=1S/C27H30N2O6S/c1-5-17-9-12-21(13-10-17)36(32,33)29-24-22-15-18(11-14-23(22)35-27(2,3)25(24)30)26(31)28-19-7-6-8-20(16-19)34-4/h6-16,24-25,29-30H,5H2,1-4H3,(H,28,31)/t24-,25+/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50211524
PNG
((3S,4R)-4-(4-Ethyl-benzenesulfonylamino)-3-hydroxy...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)C(C)(C)Oc2ccc(cc12)C(N)=NCCc1ccccc1 |w:27.30|
Show InChI InChI=1S/C28H33N3O4S/c1-4-19-10-13-22(14-11-19)36(33,34)31-25-23-18-21(12-15-24(23)35-28(2,3)26(25)32)27(29)30-17-16-20-8-6-5-7-9-20/h5-15,18,25-26,31-32H,4,16-17H2,1-3H3,(H2,29,30)/t25-,26+/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50211532
PNG
((3S,4R)-N-(2-(1H-imidazol-4-yl)ethyl)-4-(4-ethylph...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)C(C)(C)Oc2ccc(cc12)C(=O)NCCc1cnc[nH]1
Show InChI InChI=1S/C25H30N4O5S/c1-4-16-5-8-19(9-6-16)35(32,33)29-22-20-13-17(7-10-21(20)34-25(2,3)23(22)30)24(31)27-12-11-18-14-26-15-28-18/h5-10,13-15,22-23,29-30H,4,11-12H2,1-3H3,(H,26,28)(H,27,31)/t22-,23+/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells

Bioorg Med Chem Lett 17: 3271-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.020
BindingDB Entry DOI: 10.7270/Q2S75G0V
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%