Found 3 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50476390
(CHEMBL426360)Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6]-[#6]=[#6])=[#6]\[#6]-[#8]P([#8])([#8])=O Show InChI InChI=1S/C17H29O4P/c1-5-8-17(13-14-21-22(18,19)20)12-7-11-16(4)10-6-9-15(2)3/h5,9,11,13H,1,6-8,10,12,14H2,2-4H3,(H2,18,19,20)/b16-11+,17-13+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description
Inhibition of farnesyltransferase assessed as farnesylation of Dansyl-GCVLS peptide |
J Med Chem 50: 3274-82 (2007)
Article DOI: 10.1021/jm0701829
BindingDB Entry DOI: 10.7270/Q2R49TJB |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50476389
(CHEMBL229376)Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](=[#6]\[#6]-[#8]P([#8])([#8])=O)C([#6])([#6])[#6] Show InChI InChI=1S/C18H33O4P/c1-15(2)9-7-10-16(3)11-8-12-17(18(4,5)6)13-14-22-23(19,20)21/h9,11,13H,7-8,10,12,14H2,1-6H3,(H2,19,20,21)/b16-11+,17-13- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description
Inhibition of farnesyltransferase assessed as farnesylation of Dansyl-GCVLS peptide |
J Med Chem 50: 3274-82 (2007)
Article DOI: 10.1021/jm0701829
BindingDB Entry DOI: 10.7270/Q2R49TJB |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50476391
(CHEMBL447845)Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6]\[#6]=[#6](\[#6])-[#6])=[#6]\[#6]-[#8]P([#8])([#8])=O Show InChI InChI=1S/C19H33O4P/c1-16(2)8-6-9-18(5)10-7-11-19(13-12-17(3)4)14-15-23-24(20,21)22/h8,10,12,14H,6-7,9,11,13,15H2,1-5H3,(H2,20,21,22)/b18-10+,19-14- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description
Inhibition of farnesyltransferase assessed as farnesylation of Dansyl-GCVLS peptide |
J Med Chem 50: 3274-82 (2007)
Article DOI: 10.1021/jm0701829
BindingDB Entry DOI: 10.7270/Q2R49TJB |
More data for this
Ligand-Target Pair | |
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