BindingDB logo
myBDB logout

PubMed code 17576067

Compile data set for download or QSAR
Found 68 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50216040
PNG
(3-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)quin...)
Show SMILES COc1ccccc1N1CCN(CCCCn2cnc3ccccc3c2=O)CC1
Show InChI InChI=1S/C23H28N4O2/c1-29-22-11-5-4-10-21(22)26-16-14-25(15-17-26)12-6-7-13-27-18-24-20-9-3-2-8-19(20)23(27)28/h2-5,8-11,18H,6-7,12-17H2,1H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.20n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at human Dopamine receptor D2 isoform long expressed in HEK293 cells assessed as change in quinpirole-induced intracellular calci...

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50216045
PNG
(2-(4-(4-(2-methoxyphenyl)-1-piperazinyl)butyl)-1,2...)
Show SMILES O=C1N(CCCCN2CCN(CC2)c2ccccc2)S(=O)(=O)c2ccccc12
Show InChI InChI=1S/C21H25N3O3S/c25-21-19-10-4-5-11-20(19)28(26,27)24(21)13-7-6-12-22-14-16-23(17-15-22)18-8-2-1-3-9-18/h1-5,8-11H,6-7,12-17H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 4.10n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at human Dopamine receptor D2 isoform long expressed in HEK293 cells assessed as change in quinpirole-induced intracellular calci...

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50216046
PNG
(2-(4-(4-phenyl-1-piperazinyl)butyl)-1,2-benzisothi...)
Show SMILES COc1ccccc1N1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1
Show InChI InChI=1S/C22H27N3O4S/c1-29-20-10-4-3-9-19(20)24-16-14-23(15-17-24)12-6-7-13-25-22(26)18-8-2-5-11-21(18)30(25,27)28/h2-5,8-11H,6-7,12-17H2,1H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 6.20n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at human Dopamine receptor D2 isoform long expressed in HEK293 cells assessed as change in quinpirole-induced intracellular calci...

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50216044
PNG
(2-(4-(4-(3-a,a,a-trifluorotolyl)-1-piperazinyl)but...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCCN2Cc3ccccc3C2=O)CC1
Show InChI InChI=1S/C23H26F3N3O/c24-23(25,26)19-7-5-8-20(16-19)28-14-12-27(13-15-28)10-3-4-11-29-17-18-6-1-2-9-21(18)22(29)30/h1-2,5-9,16H,3-4,10-15,17H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 14n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from human Dopamine D3 receptor expressed in CHO cells

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50216044
PNG
(2-(4-(4-(3-a,a,a-trifluorotolyl)-1-piperazinyl)but...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCCN2Cc3ccccc3C2=O)CC1
Show InChI InChI=1S/C23H26F3N3O/c24-23(25,26)19-7-5-8-20(16-19)28-14-12-27(13-15-28)10-3-4-11-29-17-18-6-1-2-9-21(18)22(29)30/h1-2,5-9,16H,3-4,10-15,17H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 26n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at human Dopamine receptor D2 isoform long expressed in HEK293 cells assessed as change in quinpirole-induced intracellular calci...

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50216047
PNG
(2-(4-(4-phenyl-1-piperazinyl)butyl)-1-isoindolinon...)
Show SMILES COc1ccccc1N1CCN(CCCCN2Cc3ccccc3C2=O)CC1
Show InChI InChI=1S/C23H29N3O2/c1-28-22-11-5-4-10-21(22)25-16-14-24(15-17-25)12-6-7-13-26-18-19-8-2-3-9-20(19)23(26)27/h2-5,8-11H,6-7,12-18H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 30n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from human Dopamine D3 receptor expressed in CHO cells

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50216052
PNG
(2-(4-(4-(4-chlorophenyl)-1-piperazinyl)butyl)-1-is...)
Show SMILES Clc1ccc(cc1)N1CCN(CCCCN2Cc3ccccc3C2=O)CC1
Show InChI InChI=1S/C22H26ClN3O/c23-19-7-9-20(10-8-19)25-15-13-24(14-16-25)11-3-4-12-26-17-18-5-1-2-6-21(18)22(26)27/h1-2,5-10H,3-4,11-17H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 33.6n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50216047
PNG
(2-(4-(4-phenyl-1-piperazinyl)butyl)-1-isoindolinon...)
Show SMILES COc1ccccc1N1CCN(CCCCN2Cc3ccccc3C2=O)CC1
Show InChI InChI=1S/C23H29N3O2/c1-28-22-11-5-4-10-21(22)25-16-14-24(15-17-25)12-6-7-13-26-18-19-8-2-3-9-20(19)23(26)27/h2-5,8-11H,6-7,12-18H2,1H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 34n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at human Dopamine receptor D2 isoform long expressed in HEK293 cells assessed as change in quinpirole-induced intracellular calci...

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50216048
PNG
(2-(4-(4-(2-methoxyphenyl)-1-piperazinyl)butyl)-1-i...)
Show SMILES O=C1N(CCCCN2CCN(CC2)c2ccccc2)Cc2ccccc12
Show InChI InChI=1S/C22H27N3O/c26-22-21-11-5-4-8-19(21)18-25(22)13-7-6-12-23-14-16-24(17-15-23)20-9-2-1-3-10-20/h1-5,8-11H,6-7,12-18H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 35.8n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from human Dopamine D3 receptor expressed in CHO cells

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50216045
PNG
(2-(4-(4-(2-methoxyphenyl)-1-piperazinyl)butyl)-1,2...)
Show SMILES O=C1N(CCCCN2CCN(CC2)c2ccccc2)S(=O)(=O)c2ccccc12
Show InChI InChI=1S/C21H25N3O3S/c25-21-19-10-4-5-11-20(19)28(26,27)24(21)13-7-6-12-22-14-16-23(17-15-22)18-8-2-1-3-9-18/h1-5,8-11H,6-7,12-17H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 38n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from human Dopamine receptor D2 isoform long expressed in HEK293 cells

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50216041
PNG
(3-(4-(4-(2-methoxyphenyl)-1-piperazinyl)butyl)quin...)
Show SMILES O=c1n(CCCCN2CCN(CC2)c2ccccc2)cnc2ccccc12
Show InChI InChI=1S/C22H26N4O/c27-22-20-10-4-5-11-21(20)23-18-26(22)13-7-6-12-24-14-16-25(17-15-24)19-8-2-1-3-9-19/h1-5,8-11,18H,6-7,12-17H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 46n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from human Dopamine receptor D2 isoform long expressed in HEK293 cells

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50216048
PNG
(2-(4-(4-(2-methoxyphenyl)-1-piperazinyl)butyl)-1-i...)
Show SMILES O=C1N(CCCCN2CCN(CC2)c2ccccc2)Cc2ccccc12
Show InChI InChI=1S/C22H27N3O/c26-22-21-11-5-4-8-19(21)18-25(22)13-7-6-12-23-14-16-24(17-15-23)20-9-2-1-3-10-20/h1-5,8-11H,6-7,12-18H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 60n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at human Dopamine receptor D2 isoform long expressed in HEK293 cells assessed as change in quinpirole-induced intracellular calci...

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50216045
PNG
(2-(4-(4-(2-methoxyphenyl)-1-piperazinyl)butyl)-1,2...)
Show SMILES O=C1N(CCCCN2CCN(CC2)c2ccccc2)S(=O)(=O)c2ccccc12
Show InChI InChI=1S/C21H25N3O3S/c25-21-19-10-4-5-11-20(19)28(26,27)24(21)13-7-6-12-22-14-16-23(17-15-22)18-8-2-1-3-9-18/h1-5,8-11H,6-7,12-17H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 66n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from human Dopamine D3 receptor expressed in CHO cells

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50216053
PNG
(3-(4-(4-(3-a,a,a-trifluorotolyl)-1-piperazinyl)but...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCCn2cnc3ccccc3c2=O)CC1
Show InChI InChI=1S/C23H25F3N4O/c24-23(25,26)18-6-5-7-19(16-18)29-14-12-28(13-15-29)10-3-4-11-30-17-27-21-9-2-1-8-20(21)22(30)31/h1-2,5-9,16-17H,3-4,10-15H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 73n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from human Dopamine receptor D2 isoform long expressed in HEK293 cells

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50216047
PNG
(2-(4-(4-phenyl-1-piperazinyl)butyl)-1-isoindolinon...)
Show SMILES COc1ccccc1N1CCN(CCCCN2Cc3ccccc3C2=O)CC1
Show InChI InChI=1S/C23H29N3O2/c1-28-22-11-5-4-10-21(22)25-16-14-24(15-17-25)12-6-7-13-26-18-19-8-2-3-9-20(19)23(26)27/h2-5,8-11H,6-7,12-18H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 75.4n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50216039
PNG
(1-(4-(4-(2-methoxyphenyl)-1-piperazinyl)butyl)-ind...)
Show SMILES O=C1Cc2ccccc2N1CCCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C22H27N3O/c26-22-18-19-8-4-5-11-21(19)25(22)13-7-6-12-23-14-16-24(17-15-23)20-9-2-1-3-10-20/h1-5,8-11H,6-7,12-18H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 80n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from human Dopamine D3 receptor expressed in CHO cells

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50216048
PNG
(2-(4-(4-(2-methoxyphenyl)-1-piperazinyl)butyl)-1-i...)
Show SMILES O=C1N(CCCCN2CCN(CC2)c2ccccc2)Cc2ccccc12
Show InChI InChI=1S/C22H27N3O/c26-22-21-11-5-4-8-19(21)18-25(22)13-7-6-12-23-14-16-24(17-15-23)20-9-2-1-3-10-20/h1-5,8-11H,6-7,12-18H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 80n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50216044
PNG
(2-(4-(4-(3-a,a,a-trifluorotolyl)-1-piperazinyl)but...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCCN2Cc3ccccc3C2=O)CC1
Show InChI InChI=1S/C23H26F3N3O/c24-23(25,26)19-7-5-8-20(16-19)28-14-12-27(13-15-28)10-3-4-11-29-17-18-6-1-2-9-21(18)22(29)30/h1-2,5-9,16H,3-4,10-15,17H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 80.8n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50216053
PNG
(3-(4-(4-(3-a,a,a-trifluorotolyl)-1-piperazinyl)but...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCCn2cnc3ccccc3c2=O)CC1
Show InChI InChI=1S/C23H25F3N4O/c24-23(25,26)18-6-5-7-19(16-18)29-14-12-28(13-15-29)10-3-4-11-30-17-27-21-9-2-1-8-20(21)22(30)31/h1-2,5-9,16-17H,3-4,10-15H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 102n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from human Dopamine D3 receptor expressed in CHO cells

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50216051
PNG
(2-(4-(4-(3-a,a,a-trifluorotolyl)-1-piperazinyl)but...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1
Show InChI InChI=1S/C22H24F3N3O3S/c23-22(24,25)17-6-5-7-18(16-17)27-14-12-26(13-15-27)10-3-4-11-28-21(29)19-8-1-2-9-20(19)32(28,30)31/h1-2,5-9,16H,3-4,10-15H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 107n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from human Dopamine D3 receptor expressed in CHO cells

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50216051
PNG
(2-(4-(4-(3-a,a,a-trifluorotolyl)-1-piperazinyl)but...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1
Show InChI InChI=1S/C22H24F3N3O3S/c23-22(24,25)17-6-5-7-18(16-17)27-14-12-26(13-15-27)10-3-4-11-28-21(29)19-8-1-2-9-20(19)32(28,30)31/h1-2,5-9,16H,3-4,10-15H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 113n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from human Dopamine receptor D2 isoform long expressed in HEK293 cells

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50216047
PNG
(2-(4-(4-phenyl-1-piperazinyl)butyl)-1-isoindolinon...)
Show SMILES COc1ccccc1N1CCN(CCCCN2Cc3ccccc3C2=O)CC1
Show InChI InChI=1S/C23H29N3O2/c1-28-22-11-5-4-10-21(22)25-16-14-24(15-17-25)12-6-7-13-26-18-19-8-2-3-9-20(19)23(26)27/h2-5,8-11H,6-7,12-18H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 137n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at human Dopamine D5 receptor in HEK293 cells assessed as change in SKF 38393-induced intracellular calcium response

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50216050
PNG
(3-(4-(4-(4-chlorophenyl)-1-piperazinyl)butyl)quina...)
Show SMILES Clc1ccc(cc1)N1CCN(CCCCn2cnc3ccccc3c2=O)CC1
Show InChI InChI=1S/C22H25ClN4O/c23-18-7-9-19(10-8-18)26-15-13-25(14-16-26)11-3-4-12-27-17-24-21-6-2-1-5-20(21)22(27)28/h1-2,5-10,17H,3-4,11-16H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 140n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from human Dopamine receptor D2 isoform long expressed in HEK293 cells

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50216039
PNG
(1-(4-(4-(2-methoxyphenyl)-1-piperazinyl)butyl)-ind...)
Show SMILES O=C1Cc2ccccc2N1CCCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C22H27N3O/c26-22-18-19-8-4-5-11-21(19)25(22)13-7-6-12-23-14-16-24(17-15-23)20-9-2-1-3-10-20/h1-5,8-11H,6-7,12-18H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 153n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at human Dopamine receptor D2 isoform long expressed in HEK293 cells assessed as change in quinpirole-induced intracellular calci...

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50216039
PNG
(1-(4-(4-(2-methoxyphenyl)-1-piperazinyl)butyl)-ind...)
Show SMILES O=C1Cc2ccccc2N1CCCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C22H27N3O/c26-22-18-19-8-4-5-11-21(19)25(22)13-7-6-12-23-14-16-24(17-15-23)20-9-2-1-3-10-20/h1-5,8-11H,6-7,12-18H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 162n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from human Dopamine receptor D2 isoform long expressed in HEK293 cells

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50216043
PNG
(2-(4-(4-(4-chlorophenyl)-1-piperazinyl)butyl)-1,2-...)
Show SMILES Clc1ccc(cc1)N1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1
Show InChI InChI=1S/C21H24ClN3O3S/c22-17-7-9-18(10-8-17)24-15-13-23(14-16-24)11-3-4-12-25-21(26)19-5-1-2-6-20(19)29(25,27)28/h1-2,5-10H,3-4,11-16H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 177n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from human Dopamine receptor D2 isoform long expressed in HEK293 cells

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50216040
PNG
(3-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)quin...)
Show SMILES COc1ccccc1N1CCN(CCCCn2cnc3ccccc3c2=O)CC1
Show InChI InChI=1S/C23H28N4O2/c1-29-22-11-5-4-10-21(22)26-16-14-25(15-17-26)12-6-7-13-27-18-24-20-9-3-2-8-19(20)23(27)28/h2-5,8-11,18H,6-7,12-17H2,1H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 184n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from human Dopamine receptor D2 isoform long expressed in HEK293 cells

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50216046
PNG
(2-(4-(4-phenyl-1-piperazinyl)butyl)-1,2-benzisothi...)
Show SMILES COc1ccccc1N1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1
Show InChI InChI=1S/C22H27N3O4S/c1-29-20-10-4-3-9-19(20)24-16-14-23(15-17-24)12-6-7-13-25-22(26)18-8-2-5-11-21(18)30(25,27)28/h2-5,8-11H,6-7,12-17H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 187n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from human Dopamine D3 receptor expressed in CHO cells

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50216048
PNG
(2-(4-(4-(2-methoxyphenyl)-1-piperazinyl)butyl)-1-i...)
Show SMILES O=C1N(CCCCN2CCN(CC2)c2ccccc2)Cc2ccccc12
Show InChI InChI=1S/C22H27N3O/c26-22-21-11-5-4-8-19(21)18-25(22)13-7-6-12-23-14-16-24(17-15-23)20-9-2-1-3-10-20/h1-5,8-11H,6-7,12-18H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 189n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from human Dopamine receptor D2 isoform long expressed in HEK293 cells

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50216049
PNG
(1-(4-(4-(3-a,a,a-trifluorotolyl)-1-piperazinyl)but...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCCN2C(=O)Cc3ccccc23)CC1
Show InChI InChI=1S/C23H26F3N3O/c24-23(25,26)19-7-5-8-20(17-19)28-14-12-27(13-15-28)10-3-4-11-29-21-9-2-1-6-18(21)16-22(29)30/h1-2,5-9,17H,3-4,10-16H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 190n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50216042
PNG
(1-(4-(4-phenyl-1-piperazinyl)butyl)indolin-2-one |...)
Show SMILES COc1ccccc1N1CCN(CCCCN2C(=O)Cc3ccccc23)CC1
Show InChI InChI=1S/C23H29N3O2/c1-28-22-11-5-4-10-21(22)25-16-14-24(15-17-25)12-6-7-13-26-20-9-3-2-8-19(20)18-23(26)27/h2-5,8-11H,6-7,12-18H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 195n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from human Dopamine D3 receptor expressed in CHO cells

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50216054
PNG
(1-(4-(4-(4-chlorophenyl)-1-piperazinyl)butyl)indol...)
Show SMILES Clc1ccc(cc1)N1CCN(CCCCN2C(=O)Cc3ccccc23)CC1
Show InChI InChI=1S/C22H26ClN3O/c23-19-7-9-20(10-8-19)25-15-13-24(14-16-25)11-3-4-12-26-21-6-2-1-5-18(21)17-22(26)27/h1-2,5-10H,3-4,11-17H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 202n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50216043
PNG
(2-(4-(4-(4-chlorophenyl)-1-piperazinyl)butyl)-1,2-...)
Show SMILES Clc1ccc(cc1)N1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1
Show InChI InChI=1S/C21H24ClN3O3S/c22-17-7-9-18(10-8-17)24-15-13-23(14-16-24)11-3-4-12-25-21(26)19-5-1-2-6-20(19)29(25,27)28/h1-2,5-10H,3-4,11-16H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 230n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50216049
PNG
(1-(4-(4-(3-a,a,a-trifluorotolyl)-1-piperazinyl)but...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCCN2C(=O)Cc3ccccc23)CC1
Show InChI InChI=1S/C23H26F3N3O/c24-23(25,26)19-7-5-8-20(17-19)28-14-12-27(13-15-28)10-3-4-11-29-21-9-2-1-6-18(21)16-22(29)30/h1-2,5-9,17H,3-4,10-16H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 247n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from human Dopamine D3 receptor expressed in CHO cells

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50216042
PNG
(1-(4-(4-phenyl-1-piperazinyl)butyl)indolin-2-one |...)
Show SMILES COc1ccccc1N1CCN(CCCCN2C(=O)Cc3ccccc23)CC1
Show InChI InChI=1S/C23H29N3O2/c1-28-22-11-5-4-10-21(22)25-16-14-24(15-17-25)12-6-7-13-26-20-9-3-2-8-19(20)18-23(26)27/h2-5,8-11H,6-7,12-18H2,1H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 286n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at human Dopamine receptor D2 isoform long expressed in HEK293 cells assessed as change in quinpirole-induced intracellular calci...

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50216043
PNG
(2-(4-(4-(4-chlorophenyl)-1-piperazinyl)butyl)-1,2-...)
Show SMILES Clc1ccc(cc1)N1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1
Show InChI InChI=1S/C21H24ClN3O3S/c22-17-7-9-18(10-8-17)24-15-13-23(14-16-24)11-3-4-12-25-21(26)19-5-1-2-6-20(19)29(25,27)28/h1-2,5-10H,3-4,11-16H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 287n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from human Dopamine D3 receptor expressed in CHO cells

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50216040
PNG
(3-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)quin...)
Show SMILES COc1ccccc1N1CCN(CCCCn2cnc3ccccc3c2=O)CC1
Show InChI InChI=1S/C23H28N4O2/c1-29-22-11-5-4-10-21(22)26-16-14-25(15-17-26)12-6-7-13-27-18-24-20-9-3-2-8-19(20)23(27)28/h2-5,8-11,18H,6-7,12-17H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 306n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from human Dopamine D3 receptor expressed in CHO cells

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50216039
PNG
(1-(4-(4-(2-methoxyphenyl)-1-piperazinyl)butyl)-ind...)
Show SMILES O=C1Cc2ccccc2N1CCCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C22H27N3O/c26-22-18-19-8-4-5-11-21(19)25(22)13-7-6-12-23-14-16-24(17-15-23)20-9-2-1-3-10-20/h1-5,8-11H,6-7,12-18H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 313n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50216047
PNG
(2-(4-(4-phenyl-1-piperazinyl)butyl)-1-isoindolinon...)
Show SMILES COc1ccccc1N1CCN(CCCCN2Cc3ccccc3C2=O)CC1
Show InChI InChI=1S/C23H29N3O2/c1-28-22-11-5-4-10-21(22)25-16-14-24(15-17-25)12-6-7-13-26-18-19-8-2-3-9-20(19)23(26)27/h2-5,8-11H,6-7,12-18H2,1H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 319n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from human Dopamine receptor D2 isoform long expressed in HEK293 cells

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50216049
PNG
(1-(4-(4-(3-a,a,a-trifluorotolyl)-1-piperazinyl)but...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCCN2C(=O)Cc3ccccc23)CC1
Show InChI InChI=1S/C23H26F3N3O/c24-23(25,26)19-7-5-8-20(17-19)28-14-12-27(13-15-28)10-3-4-11-29-21-9-2-1-6-18(21)16-22(29)30/h1-2,5-9,17H,3-4,10-16H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 323n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from human Dopamine receptor D2 isoform long expressed in HEK293 cells

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50216042
PNG
(1-(4-(4-phenyl-1-piperazinyl)butyl)indolin-2-one |...)
Show SMILES COc1ccccc1N1CCN(CCCCN2C(=O)Cc3ccccc23)CC1
Show InChI InChI=1S/C23H29N3O2/c1-28-22-11-5-4-10-21(22)25-16-14-24(15-17-25)12-6-7-13-26-20-9-3-2-8-19(20)18-23(26)27/h2-5,8-11H,6-7,12-18H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 330n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50216046
PNG
(2-(4-(4-phenyl-1-piperazinyl)butyl)-1,2-benzisothi...)
Show SMILES COc1ccccc1N1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1
Show InChI InChI=1S/C22H27N3O4S/c1-29-20-10-4-3-9-19(20)24-16-14-23(15-17-24)12-6-7-13-25-22(26)18-8-2-5-11-21(18)30(25,27)28/h2-5,8-11H,6-7,12-17H2,1H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 360n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from human Dopamine receptor D2 isoform long expressed in HEK293 cells

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50216054
PNG
(1-(4-(4-(4-chlorophenyl)-1-piperazinyl)butyl)indol...)
Show SMILES Clc1ccc(cc1)N1CCN(CCCCN2C(=O)Cc3ccccc23)CC1
Show InChI InChI=1S/C22H26ClN3O/c23-19-7-9-20(10-8-19)25-15-13-24(14-16-25)11-3-4-12-26-21-6-2-1-5-18(21)17-22(26)27/h1-2,5-10H,3-4,11-17H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 375n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at human Dopamine receptor D2 isoform long expressed in HEK293 cells assessed as change in quinpirole-induced intracellular calci...

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50216045
PNG
(2-(4-(4-(2-methoxyphenyl)-1-piperazinyl)butyl)-1,2...)
Show SMILES O=C1N(CCCCN2CCN(CC2)c2ccccc2)S(=O)(=O)c2ccccc12
Show InChI InChI=1S/C21H25N3O3S/c25-21-19-10-4-5-11-20(19)28(26,27)24(21)13-7-6-12-22-14-16-23(17-15-22)18-8-2-1-3-9-18/h1-5,8-11H,6-7,12-17H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 386n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at human Dopamine D5 receptor in HEK293 cells assessed as change in SKF 38393-induced intracellular calcium response

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50216044
PNG
(2-(4-(4-(3-a,a,a-trifluorotolyl)-1-piperazinyl)but...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCCN2Cc3ccccc3C2=O)CC1
Show InChI InChI=1S/C23H26F3N3O/c24-23(25,26)19-7-5-8-20(16-19)28-14-12-27(13-15-28)10-3-4-11-29-17-18-6-1-2-9-21(18)22(29)30/h1-2,5-9,16H,3-4,10-15,17H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 387n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from human Dopamine receptor D2 isoform long expressed in HEK293 cells

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50216042
PNG
(1-(4-(4-phenyl-1-piperazinyl)butyl)indolin-2-one |...)
Show SMILES COc1ccccc1N1CCN(CCCCN2C(=O)Cc3ccccc23)CC1
Show InChI InChI=1S/C23H29N3O2/c1-28-22-11-5-4-10-21(22)25-16-14-24(15-17-25)12-6-7-13-26-20-9-3-2-8-19(20)18-23(26)27/h2-5,8-11H,6-7,12-18H2,1H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 405n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from human Dopamine receptor D2 isoform long expressed in HEK293 cells

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50216049
PNG
(1-(4-(4-(3-a,a,a-trifluorotolyl)-1-piperazinyl)but...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCCN2C(=O)Cc3ccccc23)CC1
Show InChI InChI=1S/C23H26F3N3O/c24-23(25,26)19-7-5-8-20(17-19)28-14-12-27(13-15-28)10-3-4-11-29-21-9-2-1-6-18(21)16-22(29)30/h1-2,5-9,17H,3-4,10-16H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 416n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at human Dopamine receptor D2 isoform long expressed in HEK293 cells assessed as change in quinpirole-induced intracellular calci...

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50216050
PNG
(3-(4-(4-(4-chlorophenyl)-1-piperazinyl)butyl)quina...)
Show SMILES Clc1ccc(cc1)N1CCN(CCCCn2cnc3ccccc3c2=O)CC1
Show InChI InChI=1S/C22H25ClN4O/c23-18-7-9-19(10-8-18)26-15-13-25(14-16-26)11-3-4-12-27-17-24-21-6-2-1-5-20(21)22(27)28/h1-2,5-10,17H,3-4,11-16H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 507n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50216041
PNG
(3-(4-(4-(2-methoxyphenyl)-1-piperazinyl)butyl)quin...)
Show SMILES O=c1n(CCCCN2CCN(CC2)c2ccccc2)cnc2ccccc12
Show InChI InChI=1S/C22H26N4O/c27-22-20-10-4-5-11-21(20)23-18-26(22)13-7-6-12-24-14-16-25(17-15-24)19-8-2-1-3-9-19/h1-5,8-11,18H,6-7,12-17H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 527n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from human Dopamine D3 receptor expressed in CHO cells

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50216052
PNG
(2-(4-(4-(4-chlorophenyl)-1-piperazinyl)butyl)-1-is...)
Show SMILES Clc1ccc(cc1)N1CCN(CCCCN2Cc3ccccc3C2=O)CC1
Show InChI InChI=1S/C22H26ClN3O/c23-19-7-9-20(10-8-19)25-15-13-24(14-16-25)11-3-4-12-26-17-18-5-1-2-6-21(18)22(26)27/h1-2,5-10H,3-4,11-17H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 660n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from human Dopamine D3 receptor expressed in CHO cells

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50216052
PNG
(2-(4-(4-(4-chlorophenyl)-1-piperazinyl)butyl)-1-is...)
Show SMILES Clc1ccc(cc1)N1CCN(CCCCN2Cc3ccccc3C2=O)CC1
Show InChI InChI=1S/C22H26ClN3O/c23-19-7-9-20(10-8-19)25-15-13-24(14-16-25)11-3-4-12-26-17-18-5-1-2-6-21(18)22(26)27/h1-2,5-10H,3-4,11-17H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 760n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from human Dopamine receptor D2 isoform long expressed in HEK293 cells

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50216046
PNG
(2-(4-(4-phenyl-1-piperazinyl)butyl)-1,2-benzisothi...)
Show SMILES COc1ccccc1N1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1
Show InChI InChI=1S/C22H27N3O4S/c1-29-20-10-4-3-9-19(20)24-16-14-23(15-17-24)12-6-7-13-25-22(26)18-8-2-5-11-21(18)30(25,27)28/h2-5,8-11H,6-7,12-17H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.13E+3n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50216054
PNG
(1-(4-(4-(4-chlorophenyl)-1-piperazinyl)butyl)indol...)
Show SMILES Clc1ccc(cc1)N1CCN(CCCCN2C(=O)Cc3ccccc23)CC1
Show InChI InChI=1S/C22H26ClN3O/c23-19-7-9-20(10-8-19)25-15-13-24(14-16-25)11-3-4-12-26-21-6-2-1-5-18(21)17-22(26)27/h1-2,5-10H,3-4,11-17H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.20E+3n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from human Dopamine D3 receptor expressed in CHO cells

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50216045
PNG
(2-(4-(4-(2-methoxyphenyl)-1-piperazinyl)butyl)-1,2...)
Show SMILES O=C1N(CCCCN2CCN(CC2)c2ccccc2)S(=O)(=O)c2ccccc12
Show InChI InChI=1S/C21H25N3O3S/c25-21-19-10-4-5-11-20(19)28(26,27)24(21)13-7-6-12-22-14-16-23(17-15-22)18-8-2-1-3-9-18/h1-5,8-11H,6-7,12-17H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.63E+3n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50216053
PNG
(3-(4-(4-(3-a,a,a-trifluorotolyl)-1-piperazinyl)but...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCCn2cnc3ccccc3c2=O)CC1
Show InChI InChI=1S/C23H25F3N4O/c24-23(25,26)18-6-5-7-19(16-18)29-14-12-28(13-15-29)10-3-4-11-30-17-27-21-9-2-1-8-20(21)22(30)31/h1-2,5-9,16-17H,3-4,10-15H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.70E+3n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50216054
PNG
(1-(4-(4-(4-chlorophenyl)-1-piperazinyl)butyl)indol...)
Show SMILES Clc1ccc(cc1)N1CCN(CCCCN2C(=O)Cc3ccccc23)CC1
Show InChI InChI=1S/C22H26ClN3O/c23-19-7-9-20(10-8-19)25-15-13-24(14-16-25)11-3-4-12-26-21-6-2-1-5-18(21)17-22(26)27/h1-2,5-10H,3-4,11-17H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.75E+3n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from human Dopamine receptor D2 isoform long expressed in HEK293 cells

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50216051
PNG
(2-(4-(4-(3-a,a,a-trifluorotolyl)-1-piperazinyl)but...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1
Show InChI InChI=1S/C22H24F3N3O3S/c23-22(24,25)17-6-5-7-18(16-17)27-14-12-26(13-15-27)10-3-4-11-28-21(29)19-8-1-2-9-20(19)32(28,30)31/h1-2,5-9,16H,3-4,10-15H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.76E+3n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50216050
PNG
(3-(4-(4-(4-chlorophenyl)-1-piperazinyl)butyl)quina...)
Show SMILES Clc1ccc(cc1)N1CCN(CCCCn2cnc3ccccc3c2=O)CC1
Show InChI InChI=1S/C22H25ClN4O/c23-18-7-9-19(10-8-18)26-15-13-25(14-16-26)11-3-4-12-27-17-24-21-6-2-1-5-20(21)22(27)28/h1-2,5-10,17H,3-4,11-16H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.78E+3n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from human Dopamine D3 receptor expressed in CHO cells

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50216040
PNG
(3-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)quin...)
Show SMILES COc1ccccc1N1CCN(CCCCn2cnc3ccccc3c2=O)CC1
Show InChI InChI=1S/C23H28N4O2/c1-29-22-11-5-4-10-21(22)26-16-14-25(15-17-26)12-6-7-13-27-18-24-20-9-3-2-8-19(20)23(27)28/h2-5,8-11,18H,6-7,12-17H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50216039
PNG
(1-(4-(4-(2-methoxyphenyl)-1-piperazinyl)butyl)-ind...)
Show SMILES O=C1Cc2ccccc2N1CCCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C22H27N3O/c26-22-18-19-8-4-5-11-21(19)25(22)13-7-6-12-23-14-16-24(17-15-23)20-9-2-1-3-10-20/h1-5,8-11H,6-7,12-18H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at human Dopamine D5 receptor in HEK293 cells assessed as change in SKF 38393-induced intracellular calcium response

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50216053
PNG
(3-(4-(4-(3-a,a,a-trifluorotolyl)-1-piperazinyl)but...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCCn2cnc3ccccc3c2=O)CC1
Show InChI InChI=1S/C23H25F3N4O/c24-23(25,26)18-6-5-7-19(16-18)29-14-12-28(13-15-29)10-3-4-11-30-17-27-21-9-2-1-8-20(21)22(30)31/h1-2,5-9,16-17H,3-4,10-15H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at human Dopamine receptor D2 isoform long expressed in HEK293 cells assessed as change in quinpirole-induced intracellular calci...

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50216051
PNG
(2-(4-(4-(3-a,a,a-trifluorotolyl)-1-piperazinyl)but...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1
Show InChI InChI=1S/C22H24F3N3O3S/c23-22(24,25)17-6-5-7-18(16-17)27-14-12-26(13-15-27)10-3-4-11-28-21(29)19-8-1-2-9-20(19)32(28,30)31/h1-2,5-9,16H,3-4,10-15H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at human Dopamine receptor D2 isoform long expressed in HEK293 cells assessed as change in quinpirole-induced intracellular calci...

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50216041
PNG
(3-(4-(4-(2-methoxyphenyl)-1-piperazinyl)butyl)quin...)
Show SMILES O=c1n(CCCCN2CCN(CC2)c2ccccc2)cnc2ccccc12
Show InChI InChI=1S/C22H26N4O/c27-22-20-10-4-5-11-21(20)23-18-26(22)13-7-6-12-24-14-16-25(17-15-24)19-8-2-1-3-9-19/h1-5,8-11,18H,6-7,12-17H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at human Dopamine receptor D2 isoform long expressed in HEK293 cells assessed as change in quinpirole-induced intracellular calci...

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50216048
PNG
(2-(4-(4-(2-methoxyphenyl)-1-piperazinyl)butyl)-1-i...)
Show SMILES O=C1N(CCCCN2CCN(CC2)c2ccccc2)Cc2ccccc12
Show InChI InChI=1S/C22H27N3O/c26-22-21-11-5-4-8-19(21)18-25(22)13-7-6-12-23-14-16-24(17-15-23)20-9-2-1-3-10-20/h1-5,8-11H,6-7,12-18H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at human Dopamine D5 receptor in HEK293 cells assessed as change in SKF 38393-induced intracellular calcium response

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50216050
PNG
(3-(4-(4-(4-chlorophenyl)-1-piperazinyl)butyl)quina...)
Show SMILES Clc1ccc(cc1)N1CCN(CCCCn2cnc3ccccc3c2=O)CC1
Show InChI InChI=1S/C22H25ClN4O/c23-18-7-9-19(10-8-18)26-15-13-25(14-16-26)11-3-4-12-27-17-24-21-6-2-1-5-20(21)22(27)28/h1-2,5-10,17H,3-4,11-16H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at human Dopamine receptor D2 isoform long expressed in HEK293 cells assessed as change in quinpirole-induced intracellular calci...

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50216041
PNG
(3-(4-(4-(2-methoxyphenyl)-1-piperazinyl)butyl)quin...)
Show SMILES O=c1n(CCCCN2CCN(CC2)c2ccccc2)cnc2ccccc12
Show InChI InChI=1S/C22H26N4O/c27-22-20-10-4-5-11-21(20)23-18-26(22)13-7-6-12-24-14-16-25(17-15-24)19-8-2-1-3-9-19/h1-5,8-11,18H,6-7,12-17H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50216043
PNG
(2-(4-(4-(4-chlorophenyl)-1-piperazinyl)butyl)-1,2-...)
Show SMILES Clc1ccc(cc1)N1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1
Show InChI InChI=1S/C21H24ClN3O3S/c22-17-7-9-18(10-8-17)24-15-13-23(14-16-24)11-3-4-12-25-21(26)19-5-1-2-6-20(19)29(25,27)28/h1-2,5-10H,3-4,11-16H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at human Dopamine receptor D2 isoform long expressed in HEK293 cells assessed as change in quinpirole-induced intracellular calci...

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50216052
PNG
(2-(4-(4-(4-chlorophenyl)-1-piperazinyl)butyl)-1-is...)
Show SMILES Clc1ccc(cc1)N1CCN(CCCCN2Cc3ccccc3C2=O)CC1
Show InChI InChI=1S/C22H26ClN3O/c23-19-7-9-20(10-8-19)25-15-13-24(14-16-25)11-3-4-12-26-17-18-5-1-2-6-21(18)22(26)27/h1-2,5-10H,3-4,11-17H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at human Dopamine receptor D2 isoform long expressed in HEK293 cells assessed as change in quinpirole-induced intracellular calci...

Bioorg Med Chem 15: 5811-8 (2007)


Article DOI: 10.1016/j.bmc.2007.06.002
BindingDB Entry DOI: 10.7270/Q27M07MZ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%