Found 25 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Coagulation factor V
(Homo sapiens (Human)) | BDBM50376425
(CHEMBL1162108)Show SMILES OC(=O)c1cccc(c1)-c1ccc(C=c2c(=C)[nH]n(-c3ccc(Br)cc3)c2=O)o1 |w:13.13| Show InChI InChI=1S/C22H15BrN2O4/c1-13-19(21(26)25(24-13)17-7-5-16(23)6-8-17)12-18-9-10-20(29-18)14-3-2-4-15(11-14)22(27)28/h2-12,24H,1H2,(H,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.81E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Maastricht University
Curated by ChEMBL
| Assay Description
Inhibition of factor 5a-mediated prothrombin activation in human plasma by prothrombinase assay |
Proc Natl Acad Sci USA 104: 12697-702 (2007)
Article DOI: 10.1073/pnas.0701051104
BindingDB Entry DOI: 10.7270/Q2F190MG |
More data for this
Ligand-Target Pair | |
Coagulation factor V
(Homo sapiens (Human)) | BDBM50376418
(CHEMBL259312)Show SMILES CCOc1cc(\C=C2\NC(=O)N(Cc3ccccc3F)C2=O)ccc1OCc1ccc(cc1)C(O)=O Show InChI InChI=1S/C27H23FN2O6/c1-2-35-24-14-18(9-12-23(24)36-16-17-7-10-19(11-8-17)26(32)33)13-22-25(31)30(27(34)29-22)15-20-5-3-4-6-21(20)28/h3-14H,2,15-16H2,1H3,(H,29,34)(H,32,33)/b22-13+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Maastricht University
Curated by ChEMBL
| Assay Description
Inhibition of human factor 5a light chain binding to immobilized phospholipid by surface plasmon resonance assay |
Proc Natl Acad Sci USA 104: 12697-702 (2007)
Article DOI: 10.1073/pnas.0701051104
BindingDB Entry DOI: 10.7270/Q2F190MG |
More data for this
Ligand-Target Pair | |
Coagulation factor V
(Homo sapiens (Human)) | BDBM50376418
(CHEMBL259312)Show SMILES CCOc1cc(\C=C2\NC(=O)N(Cc3ccccc3F)C2=O)ccc1OCc1ccc(cc1)C(O)=O Show InChI InChI=1S/C27H23FN2O6/c1-2-35-24-14-18(9-12-23(24)36-16-17-7-10-19(11-8-17)26(32)33)13-22-25(31)30(27(34)29-22)15-20-5-3-4-6-21(20)28/h3-14H,2,15-16H2,1H3,(H,29,34)(H,32,33)/b22-13+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.51E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Maastricht University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant factor 5a C2 domain binding to immobilized phospholipid by surface plasmon resonance assay |
Proc Natl Acad Sci USA 104: 12697-702 (2007)
Article DOI: 10.1073/pnas.0701051104
BindingDB Entry DOI: 10.7270/Q2F190MG |
More data for this
Ligand-Target Pair | |
Coagulation factor V
(Homo sapiens (Human)) | BDBM50376419
(CHEMBL1162109)Show SMILES CC(C)NC[C@@H](O)Cn1c2-c3cnn(c3CCc2c2ccccc12)-c1ccccc1 |r| Show InChI InChI=1S/C25H28N4O/c1-17(2)26-14-19(30)16-28-23-11-7-6-10-20(23)21-12-13-24-22(25(21)28)15-27-29(24)18-8-4-3-5-9-18/h3-11,15,17,19,26,30H,12-14,16H2,1-2H3/t19-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Maastricht University
Curated by ChEMBL
| Assay Description
Inhibition of factor 5a-mediated prothrombin activation in human plasma by prothrombinase assay |
Proc Natl Acad Sci USA 104: 12697-702 (2007)
Article DOI: 10.1073/pnas.0701051104
BindingDB Entry DOI: 10.7270/Q2F190MG |
More data for this
Ligand-Target Pair | |
Coagulation factor V
(Homo sapiens (Human)) | BDBM50376423
(CHEMBL410427)Show SMILES COc1cc(ccc1-c1ccc(\C=C2/C(=O)NC(=O)N(C2=O)c2ccc3OCOc3c2)o1)[N+]([O-])=O Show InChI InChI=1S/C23H15N3O9/c1-32-19-9-13(26(30)31)2-5-15(19)17-7-4-14(35-17)10-16-21(27)24-23(29)25(22(16)28)12-3-6-18-20(8-12)34-11-33-18/h2-10H,11H2,1H3,(H,24,27,29)/b16-10+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Maastricht University
Curated by ChEMBL
| Assay Description
Inhibition of human factor 5a light chain binding to immobilized phospholipid by surface plasmon resonance assay |
Proc Natl Acad Sci USA 104: 12697-702 (2007)
Article DOI: 10.1073/pnas.0701051104
BindingDB Entry DOI: 10.7270/Q2F190MG |
More data for this
Ligand-Target Pair | |
Coagulation factor V
(Homo sapiens (Human)) | BDBM50376423
(CHEMBL410427)Show SMILES COc1cc(ccc1-c1ccc(\C=C2/C(=O)NC(=O)N(C2=O)c2ccc3OCOc3c2)o1)[N+]([O-])=O Show InChI InChI=1S/C23H15N3O9/c1-32-19-9-13(26(30)31)2-5-15(19)17-7-4-14(35-17)10-16-21(27)24-23(29)25(22(16)28)12-3-6-18-20(8-12)34-11-33-18/h2-10H,11H2,1H3,(H,24,27,29)/b16-10+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.53E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Maastricht University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant factor 5a C2 domain binding to immobilized phospholipid by surface plasmon resonance assay |
Proc Natl Acad Sci USA 104: 12697-702 (2007)
Article DOI: 10.1073/pnas.0701051104
BindingDB Entry DOI: 10.7270/Q2F190MG |
More data for this
Ligand-Target Pair | |
Coagulation factor V
(Homo sapiens (Human)) | BDBM50376422
(CHEMBL265687)Show SMILES OC(=O)c1cccc(c1)-n1[nH]c(=C)c(=Cc2ccc(o2)-c2ccc(cc2)[N+]([O-])=O)c1=O |w:14.15| Show InChI InChI=1S/C22H15N3O6/c1-13-19(21(26)24(23-13)17-4-2-3-15(11-17)22(27)28)12-18-9-10-20(31-18)14-5-7-16(8-6-14)25(29)30/h2-12,23H,1H2,(H,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.71E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Maastricht University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant factor 5a C2 domain binding to immobilized phospholipid by surface plasmon resonance assay |
Proc Natl Acad Sci USA 104: 12697-702 (2007)
Article DOI: 10.1073/pnas.0701051104
BindingDB Entry DOI: 10.7270/Q2F190MG |
More data for this
Ligand-Target Pair | |
Coagulation factor V
(Homo sapiens (Human)) | BDBM50376421
(CHEMBL410426)Show SMILES Cc1cc(-c2ccc(\C=C3\C(=O)NN(C3=O)c3cccc(Cl)c3)o2)c(cc1C)[N+]([O-])=O Show InChI InChI=1S/C22H16ClN3O5/c1-12-8-17(19(26(29)30)9-13(12)2)20-7-6-16(31-20)11-18-21(27)24-25(22(18)28)15-5-3-4-14(23)10-15/h3-11H,1-2H3,(H,24,27)/b18-11- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Maastricht University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant factor 5a C2 domain binding to immobilized phospholipid by surface plasmon resonance assay |
Proc Natl Acad Sci USA 104: 12697-702 (2007)
Article DOI: 10.1073/pnas.0701051104
BindingDB Entry DOI: 10.7270/Q2F190MG |
More data for this
Ligand-Target Pair | |
Coagulation factor VIII
(Homo sapiens (Human)) | BDBM50423622
(CHEMBL1614804)Show SMILES O[C@@H](COc1ccc(Cl)cc1Cl)Cn1c2ccccc2n(CCN2CCCCC2)c1=N |r| Show InChI InChI=1S/C23H28Cl2N4O2/c24-17-8-9-22(19(25)14-17)31-16-18(30)15-29-21-7-3-2-6-20(21)28(23(29)26)13-12-27-10-4-1-5-11-27/h2-3,6-9,14,18,26,30H,1,4-5,10-13,15-16H2/t18-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 7.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Maastricht University
Curated by ChEMBL
| Assay Description
Inhibition of human factor 8 binding to immobilized phospholipid by surface plasmon resonance assay |
Proc Natl Acad Sci USA 104: 12697-702 (2007)
Article DOI: 10.1073/pnas.0701051104
BindingDB Entry DOI: 10.7270/Q2F190MG |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Coagulation factor V
(Homo sapiens (Human)) | BDBM50376421
(CHEMBL410426)Show SMILES Cc1cc(-c2ccc(\C=C3\C(=O)NN(C3=O)c3cccc(Cl)c3)o2)c(cc1C)[N+]([O-])=O Show InChI InChI=1S/C22H16ClN3O5/c1-12-8-17(19(26(29)30)9-13(12)2)20-7-6-16(31-20)11-18-21(27)24-25(22(18)28)15-5-3-4-14(23)10-15/h3-11H,1-2H3,(H,24,27)/b18-11- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8.55E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Maastricht University
Curated by ChEMBL
| Assay Description
Inhibition of human factor 5a light chain binding to immobilized phospholipid by surface plasmon resonance assay |
Proc Natl Acad Sci USA 104: 12697-702 (2007)
Article DOI: 10.1073/pnas.0701051104
BindingDB Entry DOI: 10.7270/Q2F190MG |
More data for this
Ligand-Target Pair | |
Coagulation factor V
(Homo sapiens (Human)) | BDBM50376422
(CHEMBL265687)Show SMILES OC(=O)c1cccc(c1)-n1[nH]c(=C)c(=Cc2ccc(o2)-c2ccc(cc2)[N+]([O-])=O)c1=O |w:14.15| Show InChI InChI=1S/C22H15N3O6/c1-13-19(21(26)24(23-13)17-4-2-3-15(11-17)22(27)28)12-18-9-10-20(31-18)14-5-7-16(8-6-14)25(29)30/h2-12,23H,1H2,(H,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.56E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Maastricht University
Curated by ChEMBL
| Assay Description
Inhibition of human factor 5a light chain binding to immobilized phospholipid by surface plasmon resonance assay |
Proc Natl Acad Sci USA 104: 12697-702 (2007)
Article DOI: 10.1073/pnas.0701051104
BindingDB Entry DOI: 10.7270/Q2F190MG |
More data for this
Ligand-Target Pair | |
Coagulation factor VIII
(Homo sapiens (Human)) | BDBM50376417
(CHEMBL261865)Show SMILES [O-][N+](=O)c1ccc(COc2ccc(Cl)cc2C=C2C(=O)NC(=O)N(C2=O)c2ccccc2F)cc1 |w:16.16| Show InChI InChI=1S/C24H15ClFN3O6/c25-16-7-10-21(35-13-14-5-8-17(9-6-14)29(33)34)15(11-16)12-18-22(30)27-24(32)28(23(18)31)20-4-2-1-3-19(20)26/h1-12H,13H2,(H,27,30,32) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Maastricht University
Curated by ChEMBL
| Assay Description
Inhibition of human factor 8 binding to immobilized phospholipid by surface plasmon resonance assay |
Proc Natl Acad Sci USA 104: 12697-702 (2007)
Article DOI: 10.1073/pnas.0701051104
BindingDB Entry DOI: 10.7270/Q2F190MG |
More data for this
Ligand-Target Pair | |
Coagulation factor V
(Homo sapiens (Human)) | BDBM50376421
(CHEMBL410426)Show SMILES Cc1cc(-c2ccc(\C=C3\C(=O)NN(C3=O)c3cccc(Cl)c3)o2)c(cc1C)[N+]([O-])=O Show InChI InChI=1S/C22H16ClN3O5/c1-12-8-17(19(26(29)30)9-13(12)2)20-7-6-16(31-20)11-18-21(27)24-25(22(18)28)15-5-3-4-14(23)10-15/h3-11H,1-2H3,(H,24,27)/b18-11- | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8.95E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Maastricht University
Curated by ChEMBL
| Assay Description
Inhibition of factor 5a-mediated prothrombin activation in human plasma by prothrombinase assay |
Proc Natl Acad Sci USA 104: 12697-702 (2007)
Article DOI: 10.1073/pnas.0701051104
BindingDB Entry DOI: 10.7270/Q2F190MG |
More data for this
Ligand-Target Pair | |
Coagulation factor V
(Homo sapiens (Human)) | BDBM50376422
(CHEMBL265687)Show SMILES OC(=O)c1cccc(c1)-n1[nH]c(=C)c(=Cc2ccc(o2)-c2ccc(cc2)[N+]([O-])=O)c1=O |w:14.15| Show InChI InChI=1S/C22H15N3O6/c1-13-19(21(26)24(23-13)17-4-2-3-15(11-17)22(27)28)12-18-9-10-20(31-18)14-5-7-16(8-6-14)25(29)30/h2-12,23H,1H2,(H,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.19E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Maastricht University
Curated by ChEMBL
| Assay Description
Inhibition of factor 5a-mediated prothrombin activation in human plasma by prothrombinase assay |
Proc Natl Acad Sci USA 104: 12697-702 (2007)
Article DOI: 10.1073/pnas.0701051104
BindingDB Entry DOI: 10.7270/Q2F190MG |
More data for this
Ligand-Target Pair | |
Coagulation factor V
(Homo sapiens (Human)) | BDBM50423622
(CHEMBL1614804)Show SMILES O[C@@H](COc1ccc(Cl)cc1Cl)Cn1c2ccccc2n(CCN2CCCCC2)c1=N |r| Show InChI InChI=1S/C23H28Cl2N4O2/c24-17-8-9-22(19(25)14-17)31-16-18(30)15-29-21-7-3-2-6-20(21)28(23(29)26)13-12-27-10-4-1-5-11-27/h2-3,6-9,14,18,26,30H,1,4-5,10-13,15-16H2/t18-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Maastricht University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant factor 5a C2 domain binding to immobilized phospholipid by surface plasmon resonance assay |
Proc Natl Acad Sci USA 104: 12697-702 (2007)
Article DOI: 10.1073/pnas.0701051104
BindingDB Entry DOI: 10.7270/Q2F190MG |
More data for this
Ligand-Target Pair | |
Coagulation factor V
(Homo sapiens (Human)) | BDBM50376417
(CHEMBL261865)Show SMILES [O-][N+](=O)c1ccc(COc2ccc(Cl)cc2C=C2C(=O)NC(=O)N(C2=O)c2ccccc2F)cc1 |w:16.16| Show InChI InChI=1S/C24H15ClFN3O6/c25-16-7-10-21(35-13-14-5-8-17(9-6-14)29(33)34)15(11-16)12-18-22(30)27-24(32)28(23(18)31)20-4-2-1-3-19(20)26/h1-12H,13H2,(H,27,30,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.41E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Maastricht University
Curated by ChEMBL
| Assay Description
Inhibition of human factor 5a light chain binding to immobilized phospholipid by surface plasmon resonance assay |
Proc Natl Acad Sci USA 104: 12697-702 (2007)
Article DOI: 10.1073/pnas.0701051104
BindingDB Entry DOI: 10.7270/Q2F190MG |
More data for this
Ligand-Target Pair | |
Coagulation factor V
(Homo sapiens (Human)) | BDBM50376420
(CHEMBL1162110)Show SMILES OC(=O)c1ccccc1NC(=O)c1ccc(NC(=O)COc2ccc(Cl)cc2Cl)cc1 Show InChI InChI=1S/C22H16Cl2N2O5/c23-14-7-10-19(17(24)11-14)31-12-20(27)25-15-8-5-13(6-9-15)21(28)26-18-4-2-1-3-16(18)22(29)30/h1-11H,12H2,(H,25,27)(H,26,28)(H,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.41E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Maastricht University
Curated by ChEMBL
| Assay Description
Inhibition of human factor 5a light chain binding to immobilized phospholipid by surface plasmon resonance assay |
Proc Natl Acad Sci USA 104: 12697-702 (2007)
Article DOI: 10.1073/pnas.0701051104
BindingDB Entry DOI: 10.7270/Q2F190MG |
More data for this
Ligand-Target Pair | |
Coagulation factor V
(Homo sapiens (Human)) | BDBM50423622
(CHEMBL1614804)Show SMILES O[C@@H](COc1ccc(Cl)cc1Cl)Cn1c2ccccc2n(CCN2CCCCC2)c1=N |r| Show InChI InChI=1S/C23H28Cl2N4O2/c24-17-8-9-22(19(25)14-17)31-16-18(30)15-29-21-7-3-2-6-20(21)28(23(29)26)13-12-27-10-4-1-5-11-27/h2-3,6-9,14,18,26,30H,1,4-5,10-13,15-16H2/t18-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.57E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Maastricht University
Curated by ChEMBL
| Assay Description
Inhibition of human factor 5a light chain binding to immobilized phospholipid by surface plasmon resonance assay |
Proc Natl Acad Sci USA 104: 12697-702 (2007)
Article DOI: 10.1073/pnas.0701051104
BindingDB Entry DOI: 10.7270/Q2F190MG |
More data for this
Ligand-Target Pair | |
Coagulation factor V
(Homo sapiens (Human)) | BDBM50376420
(CHEMBL1162110)Show SMILES OC(=O)c1ccccc1NC(=O)c1ccc(NC(=O)COc2ccc(Cl)cc2Cl)cc1 Show InChI InChI=1S/C22H16Cl2N2O5/c23-14-7-10-19(17(24)11-14)31-12-20(27)25-15-8-5-13(6-9-15)21(28)26-18-4-2-1-3-16(18)22(29)30/h1-11H,12H2,(H,25,27)(H,26,28)(H,29,30) | PDB
MMDB
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KEGG
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B.MOAD
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CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.64E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Maastricht University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant factor 5a C2 domain binding to immobilized phospholipid by surface plasmon resonance assay |
Proc Natl Acad Sci USA 104: 12697-702 (2007)
Article DOI: 10.1073/pnas.0701051104
BindingDB Entry DOI: 10.7270/Q2F190MG |
More data for this
Ligand-Target Pair | |
Coagulation factor V
(Homo sapiens (Human)) | BDBM50376418
(CHEMBL259312)Show SMILES CCOc1cc(\C=C2\NC(=O)N(Cc3ccccc3F)C2=O)ccc1OCc1ccc(cc1)C(O)=O Show InChI InChI=1S/C27H23FN2O6/c1-2-35-24-14-18(9-12-23(24)36-16-17-7-10-19(11-8-17)26(32)33)13-22-25(31)30(27(34)29-22)15-20-5-3-4-6-21(20)28/h3-14H,2,15-16H2,1H3,(H,29,34)(H,32,33)/b22-13+ | PDB
MMDB
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KEGG
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CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.86E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Maastricht University
Curated by ChEMBL
| Assay Description
Inhibition of factor 5a-mediated prothrombin activation in human plasma by prothrombinase assay |
Proc Natl Acad Sci USA 104: 12697-702 (2007)
Article DOI: 10.1073/pnas.0701051104
BindingDB Entry DOI: 10.7270/Q2F190MG |
More data for this
Ligand-Target Pair | |
Coagulation factor V
(Homo sapiens (Human)) | BDBM50376417
(CHEMBL261865)Show SMILES [O-][N+](=O)c1ccc(COc2ccc(Cl)cc2C=C2C(=O)NC(=O)N(C2=O)c2ccccc2F)cc1 |w:16.16| Show InChI InChI=1S/C24H15ClFN3O6/c25-16-7-10-21(35-13-14-5-8-17(9-6-14)29(33)34)15(11-16)12-18-22(30)27-24(32)28(23(18)31)20-4-2-1-3-19(20)26/h1-12H,13H2,(H,27,30,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.19E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Maastricht University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant factor 5a C2 domain binding to immobilized phospholipid by surface plasmon resonance assay |
Proc Natl Acad Sci USA 104: 12697-702 (2007)
Article DOI: 10.1073/pnas.0701051104
BindingDB Entry DOI: 10.7270/Q2F190MG |
More data for this
Ligand-Target Pair | |
Coagulation factor V
(Homo sapiens (Human)) | BDBM50423622
(CHEMBL1614804)Show SMILES O[C@@H](COc1ccc(Cl)cc1Cl)Cn1c2ccccc2n(CCN2CCCCC2)c1=N |r| Show InChI InChI=1S/C23H28Cl2N4O2/c24-17-8-9-22(19(25)14-17)31-16-18(30)15-29-21-7-3-2-6-20(21)28(23(29)26)13-12-27-10-4-1-5-11-27/h2-3,6-9,14,18,26,30H,1,4-5,10-13,15-16H2/t18-/m1/s1 | PDB
MMDB
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PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.24E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Maastricht University
Curated by ChEMBL
| Assay Description
Inhibition of factor 5a-mediated prothrombin activation in human plasma by prothrombinase assay |
Proc Natl Acad Sci USA 104: 12697-702 (2007)
Article DOI: 10.1073/pnas.0701051104
BindingDB Entry DOI: 10.7270/Q2F190MG |
More data for this
Ligand-Target Pair | |
Coagulation factor V
(Homo sapiens (Human)) | BDBM50376417
(CHEMBL261865)Show SMILES [O-][N+](=O)c1ccc(COc2ccc(Cl)cc2C=C2C(=O)NC(=O)N(C2=O)c2ccccc2F)cc1 |w:16.16| Show InChI InChI=1S/C24H15ClFN3O6/c25-16-7-10-21(35-13-14-5-8-17(9-6-14)29(33)34)15(11-16)12-18-22(30)27-24(32)28(23(18)31)20-4-2-1-3-19(20)26/h1-12H,13H2,(H,27,30,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.81E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Maastricht University
Curated by ChEMBL
| Assay Description
Inhibition of factor 5a-mediated prothrombin activation in human plasma by prothrombinase assay |
Proc Natl Acad Sci USA 104: 12697-702 (2007)
Article DOI: 10.1073/pnas.0701051104
BindingDB Entry DOI: 10.7270/Q2F190MG |
More data for this
Ligand-Target Pair | |
Coagulation factor V
(Homo sapiens (Human)) | BDBM50376420
(CHEMBL1162110)Show SMILES OC(=O)c1ccccc1NC(=O)c1ccc(NC(=O)COc2ccc(Cl)cc2Cl)cc1 Show InChI InChI=1S/C22H16Cl2N2O5/c23-14-7-10-19(17(24)11-14)31-12-20(27)25-15-8-5-13(6-9-15)21(28)26-18-4-2-1-3-16(18)22(29)30/h1-11H,12H2,(H,25,27)(H,26,28)(H,29,30) | PDB
MMDB
Reactome pathway
KEGG
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| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.06E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Maastricht University
Curated by ChEMBL
| Assay Description
Inhibition of factor 5a-mediated prothrombin activation in human plasma by prothrombinase assay |
Proc Natl Acad Sci USA 104: 12697-702 (2007)
Article DOI: 10.1073/pnas.0701051104
BindingDB Entry DOI: 10.7270/Q2F190MG |
More data for this
Ligand-Target Pair | |
Coagulation factor V
(Homo sapiens (Human)) | BDBM50376423
(CHEMBL410427)Show SMILES COc1cc(ccc1-c1ccc(\C=C2/C(=O)NC(=O)N(C2=O)c2ccc3OCOc3c2)o1)[N+]([O-])=O Show InChI InChI=1S/C23H15N3O9/c1-32-19-9-13(26(30)31)2-5-15(19)17-7-4-14(35-17)10-16-21(27)24-23(29)25(22(16)28)12-3-6-18-20(8-12)34-11-33-18/h2-10H,11H2,1H3,(H,24,27,29)/b16-10+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.29E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Maastricht University
Curated by ChEMBL
| Assay Description
Inhibition of factor 5a-mediated prothrombin activation in human plasma by prothrombinase assay |
Proc Natl Acad Sci USA 104: 12697-702 (2007)
Article DOI: 10.1073/pnas.0701051104
BindingDB Entry DOI: 10.7270/Q2F190MG |
More data for this
Ligand-Target Pair | |
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