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PubMed code 18260619

Compile data set for download or QSAR
Found 33 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM20954
PNG
(2-(4-methoxy-2,6-dimethylphenoxy)-3,6-dimethyl-4-(...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(OC)cc2C)c1C
Show InChI InChI=1S/C21H29NO3/c1-8-17(9-2)24-19-12-15(5)22-21(16(19)6)25-20-13(3)10-18(23-7)11-14(20)4/h10-12,17H,8-9H2,1-7H3
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n/an/a 2n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.

J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM20950
PNG
(2-(4-bromo-2,6-dimethylphenoxy)-3,6-dimethyl-4-(pe...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(Br)cc2C)c1C
Show InChI InChI=1S/C20H26BrNO2/c1-7-17(8-2)23-18-11-14(5)22-20(15(18)6)24-19-12(3)9-16(21)10-13(19)4/h9-11,17H,7-8H2,1-6H3
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n/an/a 2.60n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.

J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM20959
PNG
(2-Aryloxy-4-alkoxy-pyridine, 40 | 2-[4-(methoxymet...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(COC)cc2C)c1C
Show InChI InChI=1S/C22H31NO3/c1-8-19(9-2)25-20-12-16(5)23-22(17(20)6)26-21-14(3)10-18(13-24-7)11-15(21)4/h10-12,19H,8-9,13H2,1-7H3
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n/an/a 3.20n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.

J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM20949
PNG
(2-(4-chloro-2,6-dimethylphenoxy)-3,6-dimethyl-4-(p...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(Cl)cc2C)c1C
Show InChI InChI=1S/C20H26ClNO2/c1-7-17(8-2)23-18-11-14(5)22-20(15(18)6)24-19-12(3)9-16(21)10-13(19)4/h9-11,17H,7-8H2,1-6H3
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n/an/a 5.5n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.

J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM20933
PNG
(3,6-dimethyl-4-(pentan-3-yloxy)-2-(2,4,6-trimethyl...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C
Show InChI InChI=1S/C21H29NO2/c1-8-18(9-2)23-19-12-16(6)22-21(17(19)7)24-20-14(4)10-13(3)11-15(20)5/h10-12,18H,8-9H2,1-7H3
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n/an/a 6.80n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.

J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM20935
PNG
(2-Aryloxy-4-alkoxy-pyridine, 16 | 3-ethyl-6-methyl...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1CC
Show InChI InChI=1S/C22H31NO2/c1-8-18(9-2)24-20-13-17(7)23-22(19(20)10-3)25-21-15(5)11-14(4)12-16(21)6/h11-13,18H,8-10H2,1-7H3
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n/an/a 9.10n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.

J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM20947
PNG
(2-(2,6-dimethyl-4-propylphenoxy)-3,6-dimethyl-4-(p...)
Show SMILES CCCc1cc(C)c(Oc2nc(C)cc(OC(CC)CC)c2C)c(C)c1
Show InChI InChI=1S/C23H33NO2/c1-8-11-19-12-15(4)22(16(5)13-19)26-23-18(7)21(14-17(6)24-23)25-20(9-2)10-3/h12-14,20H,8-11H2,1-7H3
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n/an/a 9.80n/an/an/an/a7.022



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Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.

J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM20941
PNG
(2-Aryloxy-4-alkoxy-pyridine, 22 | 3-bromo-6-methyl...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1Br
Show InChI InChI=1S/C20H26BrNO2/c1-7-16(8-2)23-17-11-15(6)22-20(18(17)21)24-19-13(4)9-12(3)10-14(19)5/h9-11,16H,7-8H2,1-6H3
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n/an/a 9.80n/an/an/an/a7.022



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Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.

J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM20965
PNG
(2-pyridinoxy-4-alkoxy-pyridine, 14 | 3,6-dimethyl-...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)nc2C)c1C
Show InChI InChI=1S/C20H28N2O2/c1-8-17(9-2)23-18-11-14(5)22-20(15(18)6)24-19-12(3)10-13(4)21-16(19)7/h10-11,17H,8-9H2,1-7H3
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Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.

J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM20962
PNG
(2-Aryloxy-4-alkoxy-pyridine, 43 | 4-[(1-methoxybut...)
Show SMILES CCC(COC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C
Show InChI InChI=1S/C21H29NO3/c1-8-18(12-23-7)24-19-11-16(5)22-21(17(19)6)25-20-14(3)9-13(2)10-15(20)4/h9-11,18H,8,12H2,1-7H3
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n/an/a 11n/an/an/an/a7.022



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Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.

J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM20946
PNG
(2-(4-ethyl-2,6-dimethylphenoxy)-3,6-dimethyl-4-(pe...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(CC)cc2C)c1C
Show InChI InChI=1S/C22H31NO2/c1-8-18-11-14(4)21(15(5)12-18)25-22-17(7)20(13-16(6)23-22)24-19(9-2)10-3/h11-13,19H,8-10H2,1-7H3
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n/an/a 11n/an/an/an/a7.022



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Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.

J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM20951
PNG
(2-(4-iodo-2,6-dimethylphenoxy)-3,6-dimethyl-4-(pen...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(I)cc2C)c1C
Show InChI InChI=1S/C20H26INO2/c1-7-17(8-2)23-18-11-14(5)22-20(15(18)6)24-19-12(3)9-16(21)10-13(19)4/h9-11,17H,7-8H2,1-6H3
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n/an/a 12n/an/an/an/a7.022



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Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.

J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM20939
PNG
(2-Aryloxy-4-alkoxy-pyridine, 20 | 6-methyl-4-(pent...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1N
Show InChI InChI=1S/C20H28N2O2/c1-7-16(8-2)23-17-11-15(6)22-20(18(17)21)24-19-13(4)9-12(3)10-14(19)5/h9-11,16H,7-8,21H2,1-6H3
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n/an/a 12n/an/an/an/a7.022



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Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.

J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM20938
PNG
(2-Aryloxy-4-alkoxy-pyridine, 19 | 6-methyl-3-nitro...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1[N+]([O-])=O
Show InChI InChI=1S/C20H26N2O4/c1-7-16(8-2)25-17-11-15(6)21-20(18(17)22(23)24)26-19-13(4)9-12(3)10-14(19)5/h9-11,16H,7-8H2,1-6H3
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n/an/a 15n/an/an/an/a7.022



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Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.

J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM20964
PNG
(2-Aryloxy-4-alkoxy-pyridine, 13 | 3,6-dimethyl-4-[...)
Show SMILES CC\C(Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C)=C/C
Show InChI InChI=1S/C21H27NO2/c1-8-18(9-2)23-19-12-16(6)22-21(17(19)7)24-20-14(4)10-13(3)11-15(20)5/h8,10-12H,9H2,1-7H3/b18-8+
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n/an/a 16n/an/an/an/an/an/a



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Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.

J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM20952
PNG
(2-Aryloxy-4-alkoxy-pyridine, 33 | 4-{[3,6-dimethyl...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(cc2C)C(N)=O)c1C
Show InChI InChI=1S/C21H28N2O3/c1-7-17(8-2)25-18-11-14(5)23-21(15(18)6)26-19-12(3)9-16(20(22)24)10-13(19)4/h9-11,17H,7-8H2,1-6H3,(H2,22,24)
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n/an/a 18n/an/an/an/a7.022



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Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.

J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM20955
PNG
(2-(4-ethoxy-2,6-dimethylphenoxy)-3,6-dimethyl-4-(p...)
Show SMILES CCOc1cc(C)c(Oc2nc(C)cc(OC(CC)CC)c2C)c(C)c1
Show InChI InChI=1S/C22H31NO3/c1-8-18(9-2)25-20-13-16(6)23-22(17(20)7)26-21-14(4)11-19(24-10-3)12-15(21)5/h11-13,18H,8-10H2,1-7H3
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n/an/a 20n/an/an/an/a7.022



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Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.

J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM20940
PNG
(2-Aryloxy-4-alkoxy-pyridine, 21 | N,N,6-trimethyl-...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1N(C)C
Show InChI InChI=1S/C22H32N2O2/c1-9-18(10-2)25-19-13-17(6)23-22(20(19)24(7)8)26-21-15(4)11-14(3)12-16(21)5/h11-13,18H,9-10H2,1-8H3
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n/an/a 25n/an/an/an/a7.022



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Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.

J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM20961
PNG
(2-Aryloxy-4-alkoxy-pyridine, 42 | 4-(butan-2-yloxy...)
Show SMILES CCC(C)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C
Show InChI InChI=1S/C20H27NO2/c1-8-16(6)22-18-11-15(5)21-20(17(18)7)23-19-13(3)9-12(2)10-14(19)4/h9-11,16H,8H2,1-7H3
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n/an/a 28n/an/an/an/a7.022



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Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.

J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM20948
PNG
(2-(4-fluoro-2,6-dimethylphenoxy)-3,6-dimethyl-4-(p...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(F)cc2C)c1C
Show InChI InChI=1S/C20H26FNO2/c1-7-17(8-2)23-18-11-14(5)22-20(15(18)6)24-19-12(3)9-16(21)10-13(19)4/h9-11,17H,7-8H2,1-6H3
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Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.

J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM20960
PNG
(2-(4-{[3,6-dimethyl-4-(pentan-3-yloxy)pyridin-2-yl...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(cc2C)C(C)(C)O)c1C
Show InChI InChI=1S/C23H33NO3/c1-9-19(10-2)26-20-13-16(5)24-22(17(20)6)27-21-14(3)11-18(12-15(21)4)23(7,8)25/h11-13,19,25H,9-10H2,1-8H3
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n/an/a 40n/an/an/an/a7.022



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Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.

J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM20957
PNG
(2-Aryloxy-4-alkoxy-pyridine, 38 | 4-{[3,6-dimethyl...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C=O)cc2C)c1C
Show InChI InChI=1S/C21H27NO3/c1-7-18(8-2)24-19-11-15(5)22-21(16(19)6)25-20-13(3)9-17(12-23)10-14(20)4/h9-12,18H,7-8H2,1-6H3
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n/an/a 40n/an/an/an/a7.022



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Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.

J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM20958
PNG
((4-{[3,6-dimethyl-4-(pentan-3-yloxy)pyridin-2-yl]o...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(CO)cc2C)c1C
Show InChI InChI=1S/C21H29NO3/c1-7-18(8-2)24-19-11-15(5)22-21(16(19)6)25-20-13(3)9-17(12-23)10-14(20)4/h9-11,18,23H,7-8,12H2,1-6H3
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n/an/a 61n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.

J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM20934
PNG
(2-Aryloxy-4-alkoxy-pyridine, 15 | 6-ethyl-3-methyl...)
Show SMILES CCC(CC)Oc1cc(CC)nc(Oc2c(C)cc(C)cc2C)c1C
Show InChI InChI=1S/C22H31NO2/c1-8-18-13-20(24-19(9-2)10-3)17(7)22(23-18)25-21-15(5)11-14(4)12-16(21)6/h11-13,19H,8-10H2,1-7H3
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n/an/a 86n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.

J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM20963
PNG
(2-Aryloxy-4-alkoxy-pyridine, 44 | 3,6-Dimethyl-4-(...)
Show SMILES Cc1cc(C)c(Oc2nc(C)cc(OC3CCOC3)c2C)c(C)c1
Show InChI InChI=1S/C20H25NO3/c1-12-8-13(2)19(14(3)9-12)24-20-16(5)18(10-15(4)21-20)23-17-6-7-22-11-17/h8-10,17H,6-7,11H2,1-5H3
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n/an/a 100n/an/an/an/an/an/a



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.

J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM20945
PNG
(2-(2,6-dimethylphenoxy)-3,6-dimethyl-4-(pentan-3-y...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cccc2C)c1C
Show InChI InChI=1S/C20H27NO2/c1-7-17(8-2)22-18-12-15(5)21-20(16(18)6)23-19-13(3)10-9-11-14(19)4/h9-12,17H,7-8H2,1-6H3
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n/an/a 110n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.

J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM20956
PNG
(2-Aryloxy-4-alkoxy-pyridine, 37 | 2-[2,6-dimethyl-...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(OC(C)C)cc2C)c1C
Show InChI InChI=1S/C23H33NO3/c1-9-19(10-2)26-21-13-17(7)24-23(18(21)8)27-22-15(5)11-20(12-16(22)6)25-14(3)4/h11-14,19H,9-10H2,1-8H3
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n/an/a 110n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.

J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM20936
PNG
(2-Aryloxy-4-alkoxy-pyridine, 17 | 2-methyl-4-(pent...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1
Show InChI InChI=1S/C20H27NO2/c1-7-17(8-2)22-18-11-16(6)21-19(12-18)23-20-14(4)9-13(3)10-15(20)5/h9-12,17H,7-8H2,1-6H3
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n/an/a 150n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.

J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM20943
PNG
(2,3,5-trimethyl-4-(pentan-3-yloxy)-6-(2,4,6-trimet...)
Show SMILES CCC(CC)Oc1c(C)c(C)nc(Oc2c(C)cc(C)cc2C)c1C
Show InChI InChI=1S/C22H31NO2/c1-9-19(10-2)24-21-16(6)18(8)23-22(17(21)7)25-20-14(4)11-13(3)12-15(20)5/h11-12,19H,9-10H2,1-8H3
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n/an/a 180n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.

J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM20937
PNG
(2-Aryloxy-4-alkoxy-pyridine, 18 | methyl 6-methyl-...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C(=O)OC
Show InChI InChI=1S/C22H29NO4/c1-8-17(9-2)26-18-12-16(6)23-21(19(18)22(24)25-7)27-20-14(4)10-13(3)11-15(20)5/h10-12,17H,8-9H2,1-7H3
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n/an/a 470n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.

J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM20953
PNG
(2-Aryloxy-4-alkoxy-pyridine, 34 | 4-{[3,6-dimethyl...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(O)cc2C)c1C
Show InChI InChI=1S/C20H27NO3/c1-7-17(8-2)23-18-11-14(5)21-20(15(18)6)24-19-12(3)9-16(22)10-13(19)4/h9-11,17,22H,7-8H2,1-6H3
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n/an/a 1.40E+3n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.

J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM20942
PNG
(2-Aryloxy-4-alkoxy-pyridine, 23 | 6-methyl-4-(pent...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C(O)=O
Show InChI InChI=1S/C21H27NO4/c1-7-16(8-2)25-17-11-15(6)22-20(18(17)21(23)24)26-19-13(4)9-12(3)10-14(19)5/h9-11,16H,7-8H2,1-6H3,(H,23,24)
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n/an/a>1.00E+4n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.

J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM20944
PNG
(2-Aryloxy-4-alkoxy-pyridine, 25 | 3-ethyl-2,5-dime...)
Show SMILES CCC(CC)Oc1c(C)c(Oc2c(C)cc(C)cc2C)nc(C)c1CC
Show InChI InChI=1S/C23H33NO2/c1-9-19(10-2)25-22-17(7)23(24-18(8)20(22)11-3)26-21-15(5)12-14(4)13-16(21)6/h12-13,19H,9-11H2,1-8H3
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n/an/a>1.00E+4n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.

J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%