Affinity Data by PubMed id=18311898

PubMed code 18311898

Found 12 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Seed linoleate 13S-lipoxygenase-1 (Glycine max (soybean))	BDBM22340 ((5E)-5-[(3-nitrophenyl)methylidene]-2-(1,3-thiazol...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.91E+4	n/a	n/a	n/a	n/a	7.4	28
Aristotle University					Assay Description The tested compounds were added to the reaction mixture with soybean lipoxygenase. Enzyme reaction was initiated by the addition of sodium linoleate ...				J Med Chem 51: 1601-9 (2008) Article DOI: 10.1021/jm701496h BindingDB Entry DOI: 10.7270/Q2JM27XJ
Aristotle University					More data for this Ligand-Target Pair
Seed linoleate 13S-lipoxygenase-1 (Glycine max (soybean))	BDBM22337 ((5E)-5-[(4-hydroxy-3-methoxyphenyl)methylidene]-2-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.95E+4	n/a	n/a	n/a	n/a	7.4	28
Aristotle University					Assay Description The tested compounds were added to the reaction mixture with soybean lipoxygenase. Enzyme reaction was initiated by the addition of sodium linoleate ...				J Med Chem 51: 1601-9 (2008) Article DOI: 10.1021/jm701496h BindingDB Entry DOI: 10.7270/Q2JM27XJ
Aristotle University					More data for this Ligand-Target Pair
Seed linoleate 13S-lipoxygenase-1 (Glycine max (soybean))	BDBM22343 ((5E)-5-[(2-chlorophenyl)methylidene]-2-(1,3-thiazo...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.15E+5	n/a	n/a	n/a	n/a	7.4	28
Aristotle University					Assay Description The tested compounds were added to the reaction mixture with soybean lipoxygenase. Enzyme reaction was initiated by the addition of sodium linoleate ...				J Med Chem 51: 1601-9 (2008) Article DOI: 10.1021/jm701496h BindingDB Entry DOI: 10.7270/Q2JM27XJ
Aristotle University					More data for this Ligand-Target Pair
Seed linoleate 13S-lipoxygenase-1 (Glycine max (soybean))	BDBM22335 ((5E)-5-[(4-hydroxyphenyl)methylidene]-2-(1,3-thiaz...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.16E+5	n/a	n/a	n/a	n/a	7.4	28
Aristotle University					Assay Description The tested compounds were added to the reaction mixture with soybean lipoxygenase. Enzyme reaction was initiated by the addition of sodium linoleate ...				J Med Chem 51: 1601-9 (2008) Article DOI: 10.1021/jm701496h BindingDB Entry DOI: 10.7270/Q2JM27XJ
Aristotle University					More data for this Ligand-Target Pair
Seed linoleate 13S-lipoxygenase-1 (Glycine max (soybean))	BDBM22341 ((5E)-5-[(4-chlorophenyl)methylidene]-2-(1,3-thiazo...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+5	n/a	n/a	n/a	n/a	7.4	28
Aristotle University					Assay Description The tested compounds were added to the reaction mixture with soybean lipoxygenase. Enzyme reaction was initiated by the addition of sodium linoleate ...				J Med Chem 51: 1601-9 (2008) Article DOI: 10.1021/jm701496h BindingDB Entry DOI: 10.7270/Q2JM27XJ
Aristotle University					More data for this Ligand-Target Pair
Seed linoleate 13S-lipoxygenase-1 (Glycine max (soybean))	BDBM22338 ((5E)-5-[(4-methoxyphenyl)methylidene]-2-(1,3-thiaz...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.22E+5	n/a	n/a	n/a	n/a	7.4	28
Aristotle University					Assay Description The tested compounds were added to the reaction mixture with soybean lipoxygenase. Enzyme reaction was initiated by the addition of sodium linoleate ...				J Med Chem 51: 1601-9 (2008) Article DOI: 10.1021/jm701496h BindingDB Entry DOI: 10.7270/Q2JM27XJ
Aristotle University					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Ovis aries (Sheep))	BDBM22342 ((5E)-5-[(3-chlorophenyl)methylidene]-2-(1,3-thiazo...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.25E+5	n/a	n/a	n/a	n/a	8.0	37
Aristotle University					Assay Description The COX enzyme activities were measured using the COX Inhibitor Screening Assay kit provided by Cayman (Cayman, Chemical Co., Ann Arbor, MI). The ass...				J Med Chem 51: 1601-9 (2008) Article DOI: 10.1021/jm701496h BindingDB Entry DOI: 10.7270/Q2JM27XJ
Aristotle University					More data for this Ligand-Target Pair
Seed linoleate 13S-lipoxygenase-1 (Glycine max (soybean))	BDBM22342 ((5E)-5-[(3-chlorophenyl)methylidene]-2-(1,3-thiazo...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.26E+5	n/a	n/a	n/a	n/a	7.4	28
Aristotle University					Assay Description The tested compounds were added to the reaction mixture with soybean lipoxygenase. Enzyme reaction was initiated by the addition of sodium linoleate ...				J Med Chem 51: 1601-9 (2008) Article DOI: 10.1021/jm701496h BindingDB Entry DOI: 10.7270/Q2JM27XJ
Aristotle University					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Ovis aries (Sheep))	BDBM22339 ((5E)-5-[(4-nitrophenyl)methylidene]-2-(1,3-thiazol...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.41E+5	n/a	n/a	n/a	n/a	8.0	37
Aristotle University					Assay Description The COX enzyme activities were measured using the COX Inhibitor Screening Assay kit provided by Cayman (Cayman, Chemical Co., Ann Arbor, MI). The ass...				J Med Chem 51: 1601-9 (2008) Article DOI: 10.1021/jm701496h BindingDB Entry DOI: 10.7270/Q2JM27XJ
Aristotle University					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Ovis aries (Sheep))	BDBM22335 ((5E)-5-[(4-hydroxyphenyl)methylidene]-2-(1,3-thiaz...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.58E+5	n/a	n/a	n/a	n/a	8.0	37
Aristotle University					Assay Description The COX enzyme activities were measured using the COX Inhibitor Screening Assay kit provided by Cayman (Cayman, Chemical Co., Ann Arbor, MI). The ass...				J Med Chem 51: 1601-9 (2008) Article DOI: 10.1021/jm701496h BindingDB Entry DOI: 10.7270/Q2JM27XJ
Aristotle University					More data for this Ligand-Target Pair
Seed linoleate 13S-lipoxygenase-1 (Glycine max (soybean))	BDBM22339 ((5E)-5-[(4-nitrophenyl)methylidene]-2-(1,3-thiazol...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.51E+5	n/a	n/a	n/a	n/a	7.4	28
Aristotle University					Assay Description The tested compounds were added to the reaction mixture with soybean lipoxygenase. Enzyme reaction was initiated by the addition of sodium linoleate ...				J Med Chem 51: 1601-9 (2008) Article DOI: 10.1021/jm701496h BindingDB Entry DOI: 10.7270/Q2JM27XJ
Aristotle University					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM22342 ((5E)-5-[(3-chlorophenyl)methylidene]-2-(1,3-thiazo...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.62E+5	n/a	n/a	n/a	n/a	8.0	37
Aristotle University					Assay Description The COX enzyme activities were measured using the COX Inhibitor Screening Assay kit provided by Cayman (Cayman, Chemical Co., Ann Arbor, MI). The ass...				J Med Chem 51: 1601-9 (2008) Article DOI: 10.1021/jm701496h BindingDB Entry DOI: 10.7270/Q2JM27XJ
Aristotle University					More data for this Ligand-Target Pair

* indicates data uncertainty>20%