Affinity Data by PubMed id=18393489

PubMed code 18393489

Found 11 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM21975 ((4S)-16'-(2-aminoethyl)-9'-hydroxy-1,3,6',6'-tetra...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	41	-43.9	n/a	n/a	n/a	n/a	n/a	6.5	37
University of British Columbia					Assay Description The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...				J Med Chem 51: 2634-7 (2008) Article DOI: 10.1021/jm800143h BindingDB Entry DOI: 10.7270/Q2MK6B65
University of British Columbia					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM21979 (4,7-dihydro-1H-indole-4,7-dione \| Indolequinone, 1...) Show SMILES O=C1C=CC(=O)c2[nH]ccc12 \|c:2\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	190	-39.9	n/a	n/a	n/a	n/a	n/a	6.5	37
University of British Columbia					Assay Description The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...				J Med Chem 51: 2634-7 (2008) Article DOI: 10.1021/jm800143h BindingDB Entry DOI: 10.7270/Q2MK6B65
University of British Columbia					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM21982 (3-(2-aminoethyl)-5-(3-methyl-2,5-dioxo-1-propylimi...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	200	-39.8	n/a	n/a	n/a	n/a	n/a	6.5	37
University of British Columbia					Assay Description The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...				J Med Chem 51: 2634-7 (2008) Article DOI: 10.1021/jm800143h BindingDB Entry DOI: 10.7270/Q2MK6B65
University of British Columbia					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM21981 (Tryptamine quinone, 21 \| methyl 4-[3-(2-{[(benzylo...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	260	-39.1	n/a	n/a	n/a	n/a	n/a	6.5	37
University of British Columbia					Assay Description The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...				J Med Chem 51: 2634-7 (2008) Article DOI: 10.1021/jm800143h BindingDB Entry DOI: 10.7270/Q2MK6B65
University of British Columbia					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM21984 (Tryptamine quinone, 25 \| methyl 4-{4,7-dioxo-3-[2-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	260	-39.1	n/a	n/a	n/a	n/a	n/a	6.5	37
University of British Columbia					Assay Description The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...				J Med Chem 51: 2634-7 (2008) Article DOI: 10.1021/jm800143h BindingDB Entry DOI: 10.7270/Q2MK6B65
University of British Columbia					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM21980 (Indolequinone, 20 \| methyl 4-(4,7-dioxo-4,7-dihydr...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	420	-37.9	n/a	n/a	n/a	n/a	n/a	6.5	37
University of British Columbia					Assay Description The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...				J Med Chem 51: 2634-7 (2008) Article DOI: 10.1021/jm800143h BindingDB Entry DOI: 10.7270/Q2MK6B65
University of British Columbia					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM21976 (Tryptamine quinone, 9 \| benzyl N-[2-(4,7-dioxo-4,7...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.49E+3	-34.6	n/a	n/a	n/a	n/a	n/a	6.5	37
University of British Columbia					Assay Description The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...				J Med Chem 51: 2634-7 (2008) Article DOI: 10.1021/jm800143h BindingDB Entry DOI: 10.7270/Q2MK6B65
University of British Columbia					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM21977 (Tryptamine quinone, 13 \| benzyl N-{2-[5-(1,3-dioxo...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.09E+4	-29.5	n/a	n/a	n/a	n/a	n/a	6.5	37
University of British Columbia					Assay Description The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...				J Med Chem 51: 2634-7 (2008) Article DOI: 10.1021/jm800143h BindingDB Entry DOI: 10.7270/Q2MK6B65
University of British Columbia					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM21973 (1-Methyltryptophan, 1 \| 2-amino-3-(1-methyl-1H-ind...) Show SMILES Cn1cc(CC(N)C(O)=O)c2ccccc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	6.20E+4	-25.0	n/a	n/a	n/a	n/a	n/a	6.5	37
University of British Columbia					Assay Description The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...				J Med Chem 51: 2634-7 (2008) Article DOI: 10.1021/jm800143h BindingDB Entry DOI: 10.7270/Q2MK6B65
University of British Columbia					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM21978 (1H-indol-4-ol \| 4-hydroxyindole, 18) Show SMILES Oc1cccc2[nH]ccc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	6.5	37
University of British Columbia					Assay Description The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...				J Med Chem 51: 2634-7 (2008) Article DOI: 10.1021/jm800143h BindingDB Entry DOI: 10.7270/Q2MK6B65
University of British Columbia					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM21983 (3-(2-aminoethyl)-5,10-diphenyl-1H,4H,11H-anthracen...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	6.5	37
University of British Columbia					Assay Description The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...				J Med Chem 51: 2634-7 (2008) Article DOI: 10.1021/jm800143h BindingDB Entry DOI: 10.7270/Q2MK6B65
University of British Columbia					More data for this Ligand-Target Pair

* indicates data uncertainty>20%