Found 16 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM20330
(3-[(4-tert-butylphenyl)methyl]-1-[(4-methanesulfon...)Show SMILES COc1cc(CNC(=S)NCc2ccc(cc2)C(C)(C)C)ccc1NS(C)(=O)=O Show InChI InChI=1S/C21H29N3O3S2/c1-21(2,3)17-9-6-15(7-10-17)13-22-20(28)23-14-16-8-11-18(19(12-16)27-4)24-29(5,25)26/h6-12,24H,13-14H2,1-5H3,(H2,22,23,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 3.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed as capsaicin-stimulated 45Ca2+ uptake |
Eur J Med Chem 44: 322-31 (2008)
Article DOI: 10.1016/j.ejmech.2008.02.026
BindingDB Entry DOI: 10.7270/Q2R49QJ3 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM20330
(3-[(4-tert-butylphenyl)methyl]-1-[(4-methanesulfon...)Show SMILES COc1cc(CNC(=S)NCc2ccc(cc2)C(C)(C)C)ccc1NS(C)(=O)=O Show InChI InChI=1S/C21H29N3O3S2/c1-21(2,3)17-9-6-15(7-10-17)13-22-20(28)23-14-16-8-11-18(19(12-16)27-4)24-29(5,25)26/h6-12,24H,13-14H2,1-5H3,(H2,22,23,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 50 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Displacement of [3H]resiniferatoxin from rat TRPV1 expressed in CHO cells by scintillation counting |
Eur J Med Chem 44: 322-31 (2008)
Article DOI: 10.1016/j.ejmech.2008.02.026
BindingDB Entry DOI: 10.7270/Q2R49QJ3 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM20315
(3-[(4-tert-butylphenyl)methyl]-1-[(4-methanesulfon...)Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)cc2)cc1 Show InChI InChI=1S/C20H27N3O2S2/c1-20(2,3)17-9-5-15(6-10-17)13-21-19(26)22-14-16-7-11-18(12-8-16)23-27(4,24)25/h5-12,23H,13-14H2,1-4H3,(H2,21,22,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 53.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed as capsaicin-stimulated 45Ca2+ uptake |
Eur J Med Chem 44: 322-31 (2008)
Article DOI: 10.1016/j.ejmech.2008.02.026
BindingDB Entry DOI: 10.7270/Q2R49QJ3 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM20315
(3-[(4-tert-butylphenyl)methyl]-1-[(4-methanesulfon...)Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)cc2)cc1 Show InChI InChI=1S/C20H27N3O2S2/c1-20(2,3)17-9-5-15(6-10-17)13-21-19(26)22-14-16-7-11-18(12-8-16)23-27(4,24)25/h5-12,23H,13-14H2,1-4H3,(H2,21,22,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 63 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Displacement of [3H]resiniferatoxin from rat TRPV1 expressed in CHO cells by scintillation counting |
Eur J Med Chem 44: 322-31 (2008)
Article DOI: 10.1016/j.ejmech.2008.02.026
BindingDB Entry DOI: 10.7270/Q2R49QJ3 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50248811
(CHEMBL475357 | N-(4-tert-Butylbenzyl)-N'-[5-(methy...)Show SMILES CC(C)(C)c1ccc(CNC(=S)NC2CCc3cc(NS(C)(=O)=O)ccc23)cc1 Show InChI InChI=1S/C22H29N3O2S2/c1-22(2,3)17-8-5-15(6-9-17)14-23-21(28)24-20-12-7-16-13-18(10-11-19(16)20)25-29(4,26)27/h5-6,8-11,13,20,25H,7,12,14H2,1-4H3,(H2,23,24,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 660 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Displacement of [3H]resiniferatoxin from rat TRPV1 expressed in CHO cells by scintillation counting |
Eur J Med Chem 44: 322-31 (2008)
Article DOI: 10.1016/j.ejmech.2008.02.026
BindingDB Entry DOI: 10.7270/Q2R49QJ3 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50248811
(CHEMBL475357 | N-(4-tert-Butylbenzyl)-N'-[5-(methy...)Show SMILES CC(C)(C)c1ccc(CNC(=S)NC2CCc3cc(NS(C)(=O)=O)ccc23)cc1 Show InChI InChI=1S/C22H29N3O2S2/c1-22(2,3)17-8-5-15(6-9-17)14-23-21(28)24-20-12-7-16-13-18(10-11-19(16)20)25-29(4,26)27/h5-6,8-11,13,20,25H,7,12,14H2,1-4H3,(H2,23,24,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 740 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed as capsaicin-stimulated 45Ca2+ uptake |
Eur J Med Chem 44: 322-31 (2008)
Article DOI: 10.1016/j.ejmech.2008.02.026
BindingDB Entry DOI: 10.7270/Q2R49QJ3 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50248812
(CHEMBL475358 | N-(4-tert-Butylbenzyl)-N'-[6-(methy...)Show SMILES CC(C)(C)c1ccc(CNC(=S)NC2CCCc3cc(NS(C)(=O)=O)ccc23)cc1 Show InChI InChI=1S/C23H31N3O2S2/c1-23(2,3)18-10-8-16(9-11-18)15-24-22(29)25-21-7-5-6-17-14-19(12-13-20(17)21)26-30(4,27)28/h8-14,21,26H,5-7,15H2,1-4H3,(H2,24,25,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.59E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Displacement of [3H]resiniferatoxin from rat TRPV1 expressed in CHO cells by scintillation counting |
Eur J Med Chem 44: 322-31 (2008)
Article DOI: 10.1016/j.ejmech.2008.02.026
BindingDB Entry DOI: 10.7270/Q2R49QJ3 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50248813
(CHEMBL474773 | N-(4-tert-Butylbenzyl)-N'-[4-methox...)Show SMILES COc1c2CCC(NC(=S)NCc3ccc(cc3)C(C)(C)C)c2ccc1NS(C)(=O)=O Show InChI InChI=1S/C23H31N3O3S2/c1-23(2,3)16-8-6-15(7-9-16)14-24-22(30)25-19-12-11-18-17(19)10-13-20(21(18)29-4)26-31(5,27)28/h6-10,13,19,26H,11-12,14H2,1-5H3,(H2,24,25,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.69E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed as capsaicin-stimulated 45Ca2+ uptake |
Eur J Med Chem 44: 322-31 (2008)
Article DOI: 10.1016/j.ejmech.2008.02.026
BindingDB Entry DOI: 10.7270/Q2R49QJ3 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50248843
(CHEMBL474191 | N-(4-tert-Butylbenzyl)-N'-[5-methox...)Show SMILES COc1c(NS(C)(=O)=O)ccc2C(CCCc12)NC(=S)NCc1ccc(cc1)C(C)(C)C Show InChI InChI=1S/C24H33N3O3S2/c1-24(2,3)17-11-9-16(10-12-17)15-25-23(31)26-20-8-6-7-19-18(20)13-14-21(22(19)30-4)27-32(5,28)29/h9-14,20,27H,6-8,15H2,1-5H3,(H2,25,26,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.75E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Displacement of [3H]resiniferatoxin from rat TRPV1 expressed in CHO cells by scintillation counting |
Eur J Med Chem 44: 322-31 (2008)
Article DOI: 10.1016/j.ejmech.2008.02.026
BindingDB Entry DOI: 10.7270/Q2R49QJ3 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50248813
(CHEMBL474773 | N-(4-tert-Butylbenzyl)-N'-[4-methox...)Show SMILES COc1c2CCC(NC(=S)NCc3ccc(cc3)C(C)(C)C)c2ccc1NS(C)(=O)=O Show InChI InChI=1S/C23H31N3O3S2/c1-23(2,3)16-8-6-15(7-9-16)14-24-22(30)25-19-12-11-18-17(19)10-13-20(21(18)29-4)26-31(5,27)28/h6-10,13,19,26H,11-12,14H2,1-5H3,(H2,24,25,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.82E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Displacement of [3H]resiniferatoxin from rat TRPV1 expressed in CHO cells by scintillation counting |
Eur J Med Chem 44: 322-31 (2008)
Article DOI: 10.1016/j.ejmech.2008.02.026
BindingDB Entry DOI: 10.7270/Q2R49QJ3 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50248812
(CHEMBL475358 | N-(4-tert-Butylbenzyl)-N'-[6-(methy...)Show SMILES CC(C)(C)c1ccc(CNC(=S)NC2CCCc3cc(NS(C)(=O)=O)ccc23)cc1 Show InChI InChI=1S/C23H31N3O2S2/c1-23(2,3)18-10-8-16(9-11-18)15-24-22(29)25-21-7-5-6-17-14-19(12-13-20(17)21)26-30(4,27)28/h8-14,21,26H,5-7,15H2,1-4H3,(H2,24,25,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.64E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed as capsaicin-stimulated 45Ca2+ uptake |
Eur J Med Chem 44: 322-31 (2008)
Article DOI: 10.1016/j.ejmech.2008.02.026
BindingDB Entry DOI: 10.7270/Q2R49QJ3 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50248844
(CHEMBL474192 | N-(4-tert-Butylbenzyl)-N'-[6-methox...)Show SMILES COc1cc2C(CCc2cc1NS(C)(=O)=O)NC(=S)NCc1ccc(cc1)C(C)(C)C Show InChI InChI=1S/C23H31N3O3S2/c1-23(2,3)17-9-6-15(7-10-17)14-24-22(30)25-19-11-8-16-12-20(26-31(5,27)28)21(29-4)13-18(16)19/h6-7,9-10,12-13,19,26H,8,11,14H2,1-5H3,(H2,24,25,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.37E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Displacement of [3H]resiniferatoxin from rat TRPV1 expressed in CHO cells by scintillation counting |
Eur J Med Chem 44: 322-31 (2008)
Article DOI: 10.1016/j.ejmech.2008.02.026
BindingDB Entry DOI: 10.7270/Q2R49QJ3 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50248843
(CHEMBL474191 | N-(4-tert-Butylbenzyl)-N'-[5-methox...)Show SMILES COc1c(NS(C)(=O)=O)ccc2C(CCCc12)NC(=S)NCc1ccc(cc1)C(C)(C)C Show InChI InChI=1S/C24H33N3O3S2/c1-24(2,3)17-11-9-16(10-12-17)15-25-23(31)26-20-8-6-7-19-18(20)13-14-21(22(19)30-4)27-32(5,28)29/h9-14,20,27H,6-8,15H2,1-5H3,(H2,25,26,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed as capsaicin-stimulated 45Ca2+ uptake |
Eur J Med Chem 44: 322-31 (2008)
Article DOI: 10.1016/j.ejmech.2008.02.026
BindingDB Entry DOI: 10.7270/Q2R49QJ3 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50248845
(CHEMBL516191 | N-(4-tert-Butylbenzyl)-N'-[7-methox...)Show SMILES COc1cc2C(CCCc2cc1NS(C)(=O)=O)NC(=S)NCc1ccc(cc1)C(C)(C)C Show InChI InChI=1S/C24H33N3O3S2/c1-24(2,3)18-11-9-16(10-12-18)15-25-23(31)26-20-8-6-7-17-13-21(27-32(5,28)29)22(30-4)14-19(17)20/h9-14,20,27H,6-8,15H2,1-5H3,(H2,25,26,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 6.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Displacement of [3H]resiniferatoxin from rat TRPV1 expressed in CHO cells by scintillation counting |
Eur J Med Chem 44: 322-31 (2008)
Article DOI: 10.1016/j.ejmech.2008.02.026
BindingDB Entry DOI: 10.7270/Q2R49QJ3 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50248844
(CHEMBL474192 | N-(4-tert-Butylbenzyl)-N'-[6-methox...)Show SMILES COc1cc2C(CCc2cc1NS(C)(=O)=O)NC(=S)NCc1ccc(cc1)C(C)(C)C Show InChI InChI=1S/C23H31N3O3S2/c1-23(2,3)17-9-6-15(7-10-17)14-24-22(30)25-19-11-8-16-12-20(26-31(5,27)28)21(29-4)13-18(16)19/h6-7,9-10,12-13,19,26H,8,11,14H2,1-5H3,(H2,24,25,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed as capsaicin-stimulated 45Ca2+ uptake |
Eur J Med Chem 44: 322-31 (2008)
Article DOI: 10.1016/j.ejmech.2008.02.026
BindingDB Entry DOI: 10.7270/Q2R49QJ3 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM20330
(3-[(4-tert-butylphenyl)methyl]-1-[(4-methanesulfon...)Show SMILES COc1cc(CNC(=S)NCc2ccc(cc2)C(C)(C)C)ccc1NS(C)(=O)=O Show InChI InChI=1S/C21H29N3O3S2/c1-21(2,3)17-9-6-15(7-10-17)13-22-20(28)23-14-16-8-11-18(19(12-16)27-4)24-29(5,25)26/h6-12,24H,13-14H2,1-5H3,(H2,22,23,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 32.4 | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description
Agonist activity at rat TRPV1 expressed in CHO cells by 45Ca2+ uptake assay |
Eur J Med Chem 44: 322-31 (2008)
Article DOI: 10.1016/j.ejmech.2008.02.026
BindingDB Entry DOI: 10.7270/Q2R49QJ3 |
More data for this
Ligand-Target Pair | |
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