Affinity Data by PubMed id=18922779

PubMed code 18922779

Found 12 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM26059 (5-nitro-2-[(1-phenyl-1H-1,2,3,4-tetrazol-5-yl)sulf...) Show SMILES [O-][N+](=O)c1cnc(Sc2nnnn2-c2ccccc2)s1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	183	n/a	n/a	n/a	n/a	7.8	0
Burnham Institute for Medical Research					Assay Description Compound was evaluated for its ability to disrupt the interaction of pepJIP1 with JNK1 by using DELFIA assay. DELFIA is a heterogeneous assay whereby...				Proc Natl Acad Sci U S A 105: 16809-13 (2008) Article DOI: 10.1073/pnas.0805677105 BindingDB Entry DOI: 10.7270/Q22N50K9
Burnham Institute for Medical Research					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM26058 (5-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-4-phenyl-4H...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	237	n/a	n/a	n/a	n/a	7.8	0
Burnham Institute for Medical Research					Assay Description Compound was evaluated for its ability to disrupt the interaction of pepJIP1 with JNK1 by using DELFIA assay. DELFIA is a heterogeneous assay whereby...				Proc Natl Acad Sci U S A 105: 16809-13 (2008) Article DOI: 10.1073/pnas.0805677105 BindingDB Entry DOI: 10.7270/Q22N50K9
Burnham Institute for Medical Research					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM26057 (4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-[(5-nitro-1...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	7.5	22
Burnham Institute for Medical Research					Assay Description Compounds were tested for their ability to inhibit JNK1 phosphorylation of ATF2 in the Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET)...				Proc Natl Acad Sci U S A 105: 16809-13 (2008) Article DOI: 10.1073/pnas.0805677105 BindingDB Entry DOI: 10.7270/Q22N50K9
Burnham Institute for Medical Research					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM26057 (4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-[(5-nitro-1...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	7.8	0
Burnham Institute for Medical Research					Assay Description Compound was evaluated for its ability to disrupt the interaction of pepJIP1 with JNK1 by using DELFIA assay. DELFIA is a heterogeneous assay whereby...				Proc Natl Acad Sci U S A 105: 16809-13 (2008) Article DOI: 10.1073/pnas.0805677105 BindingDB Entry DOI: 10.7270/Q22N50K9
Burnham Institute for Medical Research					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM26058 (5-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-4-phenyl-4H...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	7.5	22
Burnham Institute for Medical Research					Assay Description Compounds were tested for their ability to inhibit JNK1 phosphorylation of ATF2 in the Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET)...				Proc Natl Acad Sci U S A 105: 16809-13 (2008) Article DOI: 10.1073/pnas.0805677105 BindingDB Entry DOI: 10.7270/Q22N50K9
Burnham Institute for Medical Research					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM26059 (5-nitro-2-[(1-phenyl-1H-1,2,3,4-tetrazol-5-yl)sulf...) Show SMILES [O-][N+](=O)c1cnc(Sc2nnnn2-c2ccccc2)s1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	7.5	22
Burnham Institute for Medical Research					Assay Description Compounds were tested for their ability to inhibit JNK1 phosphorylation of ATF2 in the Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET)...				Proc Natl Acad Sci U S A 105: 16809-13 (2008) Article DOI: 10.1073/pnas.0805677105 BindingDB Entry DOI: 10.7270/Q22N50K9
Burnham Institute for Medical Research					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM26060 (4-methyl-2-[(1-phenyl-1H-1,2,3,4-tetrazol-5-yl)sul...) Show SMILES Cc1nc(Sc2nnnn2-c2ccccc2)sc1C(O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.50E+3	n/a	n/a	n/a	n/a	7.8	0
Burnham Institute for Medical Research					Assay Description Compound was evaluated for its ability to disrupt the interaction of pepJIP1 with JNK1 by using DELFIA assay. DELFIA is a heterogeneous assay whereby...				Proc Natl Acad Sci U S A 105: 16809-13 (2008) Article DOI: 10.1073/pnas.0805677105 BindingDB Entry DOI: 10.7270/Q22N50K9
Burnham Institute for Medical Research					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM26062 (4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-[(5-nitroth...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	7.8	0
Burnham Institute for Medical Research					Assay Description Compound was evaluated for its ability to disrupt the interaction of pepJIP1 with JNK1 by using DELFIA assay. DELFIA is a heterogeneous assay whereby...				Proc Natl Acad Sci U S A 105: 16809-13 (2008) Article DOI: 10.1073/pnas.0805677105 BindingDB Entry DOI: 10.7270/Q22N50K9
Burnham Institute for Medical Research					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM26061 (5-(benzylsulfanyl)-1-phenyl-1H-1,2,3,4-tetrazole \|...) Show SMILES C(Sc1nnnn1-c1ccccc1)c1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	7.8	0
Burnham Institute for Medical Research					Assay Description Compound was evaluated for its ability to disrupt the interaction of pepJIP1 with JNK1 by using DELFIA assay. DELFIA is a heterogeneous assay whereby...				Proc Natl Acad Sci U S A 105: 16809-13 (2008) Article DOI: 10.1073/pnas.0805677105 BindingDB Entry DOI: 10.7270/Q22N50K9
Burnham Institute for Medical Research					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM26060 (4-methyl-2-[(1-phenyl-1H-1,2,3,4-tetrazol-5-yl)sul...) Show SMILES Cc1nc(Sc2nnnn2-c2ccccc2)sc1C(O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	7.5	22
Burnham Institute for Medical Research					Assay Description Compounds were tested for their ability to inhibit JNK1 phosphorylation of ATF2 in the Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET)...				Proc Natl Acad Sci U S A 105: 16809-13 (2008) Article DOI: 10.1073/pnas.0805677105 BindingDB Entry DOI: 10.7270/Q22N50K9
Burnham Institute for Medical Research					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM26062 (4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-[(5-nitroth...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	7.5	22
Burnham Institute for Medical Research					Assay Description Compounds were tested for their ability to inhibit JNK1 phosphorylation of ATF2 in the Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET)...				Proc Natl Acad Sci U S A 105: 16809-13 (2008) Article DOI: 10.1073/pnas.0805677105 BindingDB Entry DOI: 10.7270/Q22N50K9
Burnham Institute for Medical Research					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM26061 (5-(benzylsulfanyl)-1-phenyl-1H-1,2,3,4-tetrazole \|...) Show SMILES C(Sc1nnnn1-c1ccccc1)c1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	7.5	22
Burnham Institute for Medical Research					Assay Description Compounds were tested for their ability to inhibit JNK1 phosphorylation of ATF2 in the Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET)...				Proc Natl Acad Sci U S A 105: 16809-13 (2008) Article DOI: 10.1073/pnas.0805677105 BindingDB Entry DOI: 10.7270/Q22N50K9
Burnham Institute for Medical Research					More data for this Ligand-Target Pair

Found 3 hits of Isothermal Titration Calorimetry Data.
Cell (A)	Syringe (B)	Cell Links	Syringe Links	ΔG° kJ/mole	-TΔS° kJ/mole	ΔH° kJ/mole	log K	pH	Temp °C
JNK2/JNK3 (Homo sapiens (Human))	BDBM26057 (4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-[(5-nitro-1...)	GoogleScholar KEGG PDB	CHEBI PC cid PC sid	n/a	n/a	n/a	5.09	7.40	25
Burnham Institute for Medical Research		GoogleScholar KEGG PDB	CHEBI PC cid PC sid	Proc Natl Acad Sci U S A 105: 16809-13 (2008)
Mitogen-Activated Protein Kinase 9 (JNK2) Mutant (C162S) (Homo sapiens (Human))	BDBM26057 (4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-[(5-nitro-1...)	GoogleScholar PDB	CHEBI PC cid PC sid	n/a	n/a	n/a	4.29	7.40	25
Burnham Institute for Medical Research		GoogleScholar PDB	CHEBI PC cid PC sid	Proc Natl Acad Sci U S A 105: 16809-13 (2008)
Mitogen-Activated Protein Kinase 9 (JNK2) Mutant (R127A) (Homo sapiens (Human))	BDBM26057 (4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-[(5-nitro-1...)	GoogleScholar PDB	CHEBI PC cid PC sid	n/a	n/a	n/a	4.83	7.40	25
Burnham Institute for Medical Research		GoogleScholar PDB	CHEBI PC cid PC sid	Proc Natl Acad Sci U S A 105: 16809-13 (2008)

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* indicates data uncertainty>20%